[{"id": 163, "slug": "antibody-responses-to-sras-cov-2-in-covid-19-patients-the-perspective-applicatio", "title": "Antibody responses to SRAS-CoV-2 in COVID-19 patients: the perspective application of serological tests in clinical practice", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Etudier le profil de la r\u00e9ponse aigu\u00eb des anticorps chez les patients COVID-19, et \u00e9laborer des propositions pour l'utilisation des dosages d'anticorps dans la pratique clinique", "verbose_date": "26.03.2020", "authors": "Quan-Xin L ", "specialties": [{"id": 12, "name": "Infectiologie"}], "category": {"id": 3, "name": "Diagnostique", "icon": "icon-heat"}, "journal": {"id": 85, "name": "Pre-prints"}, "link": "https://www.dropbox.com/s/y66i6ggi5fi57ek/2020.03.18.20038018v1.full.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "IgM et IgG devraient \u00eatre dos\u00e9es simultan\u00e9ment au d\u00e9but de l'infection\u00a0car pas de cin\u00e9tique claire\u00a0\r\nLe crit\u00e8re de diagnostic s\u00e9rologique est fait sur la\u00a0s\u00e9roconversion\u00a0ou sur \u00abl'augmentation \u2265 4 fois du titre d'IgG\u00bb et convient \u00e0 la majorit\u00e9 des patients COVID-19 (34/41 patients ici).\r\nLe test s\u00e9rologique\u00a0pourrait \u00eatre utile pour le diagnostic de l'infection par le SRAS-CoV-2 chez les suspects et les contacts \u00e9troits avec RT-PCR n\u00e9gative.", "objectives": "1) Pre-Print (pas encore de reviewing)2) On ne sait pas si l'\u00e9valuation est en aveugle, \u00e9tude r\u00e9trospective3) M\u00e9thodologie mauvaise pour \u00e9tudier la sensibilit\u00e9 sp\u00e9cificit\u00e9 des tests s\u00e9rologiques pour le diagnostic de COVID-19 chez patients avec RT-PCR n\u00e9gative\"", "methods": "Etudier le profil de la r\u00e9ponse aigu\u00eb des anticorps chez les patients COVID-19, et \u00e9laborer des propositions pour l'utilisation des dosages d'anticorps dans la pratique clinique", "topics": ["Diagnostique", "Infectiologie"], "author_list": [{"id": 159, "name": "Quan-Xin L "}], "publication_date": "2020-03-26"}, {"id": 486, "slug": "co-rads-a-categorical-ct-assessment-scheme-for-patients-with-suspected-covid-19-", "title": "CO-RADS - A categorical CT assessment scheme for patients with suspected COVID-19: definition and evaluation", "has_other_authors": true, "impact_factor": {"id": 3, "name": "Interm\u00e9diaire", "posts_count": 140, "color": "orange", "order": 2}, "goals_plain": "Pr\u00e9sentation de la d\u00e9finition du CO-RADS, un sch\u00e9ma d'\u00e9valuation normalis\u00e9 de l'atteinte pulmonaire du COVID-19 au scanner thoracique et d'une \u00e9tude observationnelle pour \u00e9valuer la variabilit\u00e9 interobservateur et la pr\u00e9cision diagnostique.", "verbose_date": "29.04.2020", "authors": "Prokop M", "specialties": [{"id": 3, "name": "Radiologie"}], "category": {"id": 3, "name": "Diagnostique", "icon": "icon-heat"}, "journal": {"id": 51, "name": "Radiology"}, "link": "https://pubs.rsna.org/doi/pdf/10.1148/radiol.2020201473", "findings": "", "take_away": "", "relevance_level": "Cette classification semble int\u00e9ressante pour participer au diagnostic\u00a0d'infection au SARS-CoV-2. Cependant, les signes radiologiques peuvent mettre un certain temps \u00e0 se manifester apr\u00e8s le d\u00e9but de l'infection. Il faut donc temp\u00e9rer les scores CO-RADS 1 et 2 s'ils sont proches du d\u00e9but des sympt\u00f4mes.\nL'accord entre les observateurs semble mod\u00e9r\u00e9 \u00e0 l'exception des scores CO-RADS 1 et 5 o\u00f9\u00a0l'accord est substantiel.", "objectives": "- \u00c9tude multicentrique, r\u00e9trospective- \u00c9valuation en aveugle- S\u00e9lection des images randomis\u00e9e- Petit effectif : 105 scanners, 8 observateurs- Phase aigu\u00eb de la pand\u00e9mie (g\u00e9n\u00e9ralisation non \u00e9vidente \u00e0 d'autres contextes)- Diagnostic clinique de COVID-19 prenant en compte la radiologie", "methods": "Pr\u00e9sentation de la d\u00e9finition du CO-RADS, un sch\u00e9ma d'\u00e9valuation normalis\u00e9 de l'atteinte pulmonaire du COVID-19 au scanner thoracique et d'une \u00e9tude observationnelle pour \u00e9valuer la variabilit\u00e9 interobservateur et la pr\u00e9cision diagnostique.", "pubmed_id": "32339082\n32101510\n32224299\n30066248\n32155105\n32074444\n32159775\n32073353\n31992387\n32255413\n32077789\n30575184\n31498744\n32229322\n32324653\n32219885\n32191587", "doi": "10.1148/radiol.2020201473", "abstract": "Purpose To introduce the COVID-19 Reporting and Data System (CO-RADS) for standardized assessment of pulmonary involvement of COVID-19 on non-enhanced chest CT and report its initial interobserver agreement and performance. Methods The Dutch Radiological Society (NVvR) developed CO-RADS based on other efforts for standardization, such as Lung-RADS or BI-RADS. CO-RADS assesses the suspicion for pulmonary involvement of COVID-19 on a scale from 1 (very low) to 5 (very high). The system is meant to be used in patients presenting with moderate to severe symptoms of COVID-19. The system was evaluated using 105 chest CTs of patients admitted to the hospital with clinical suspicion of COVID-19 in whom RT-PCR was performed (62 +/- 16 years, 61 men, 53 with positive RT-PCR). Eight observers assessed the scans using CO-RADS. Fleiss' kappa was calculated, and scores of individual observers were compared to the median of the remaining seven observers. The resulting area under the receiver operating characteristics curve (AUC) was compared to results from RT-PCR and clinical diagnosis of COVID-19. Results There was absolute agreement among observers in 573 (68.2%) of 840 observations. Fleiss' kappa was 0.47 (95% confidence interval (CI) 0.45-0.47), with the highest kappa for CO-RADS categories 1 (0.58, 95% CI 0.54-0.62) and 5 (0.68, 95% CI 0.65-0.72). The average AUC was 0.91 (95% CI 0.85-0.97) for predicting RT-PCR outcome and 0.95 (95% CI 0.91-0.99) for clinical diagnosis. The false negative rate for CO-RADS 1 was 9/161 (5.6%, 95% CI 1.0-10%), and the false positive rate for CO-RADS 5 was 1/286 (0.3%, 95% CI 0-1.0%). Conclusions CO-RADS is a categorical assessment scheme for pulmonary involvement of COVID-19 on non-enhanced chest CT providing very good performance for predicting COVID-19 in patients with moderate to severe symptoms and has a substantial interobserver agreement, especially for categories 1 and 5.", "topics": ["Diagnostique", "Radiologie"], "author_list": [{"id": 454, "name": "Prokop M"}], "publication_date": "2020-04-29"}, {"id": 652, "slug": "a-randomized-trial-of-hydroxychloroquine-as-postexposure-prophylaxis-for-covid-1", "title": "A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19", "has_other_authors": true, "impact_factor": {"id": 5, "name": "Fort", "posts_count": 5, "color": "green", "order": 1}, "goals_plain": "Evaluer l'efficacit\u00e9 de l'hydroxychloroquine compar\u00e9 \u00e0 un placebo pour pr\u00e9venir le d\u00e9veloppement de la maladie COVID-19 apr\u00e8s exposition (prise prophylactique)", "verbose_date": "04.06.2020", "authors": "Boulware DR", "specialties": [{"id": 7, "name": "Transversale"}, {"id": 5, "name": "Virologie"}, {"id": 12, "name": "Infectiologie"}, {"id": 8, "name": "Pneumologie"}], "category": {"id": 4, "name": "Th\u00e9rapeutique", "icon": "icon-med"}, "journal": {"id": 22, "name": "NEJM"}, "link": "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2016638?articleTools=true", "findings": "", "take_away": "", "relevance_level": "Le traitement pr\u00e9ventif (prophylaxie) par hydroxychloroquine chez des sujets expos\u00e9s au SARS-CoV-2 n'a pas montr\u00e9 une efficacit\u00e9 sup\u00e9rieure par rapport un placebo sur l'apparition de la maladie au 14\u00b0 jour : baisse non significative\u00a0de 2.4% de l'incidence de la maladie par hydroxychloroquine (11.8% vs 14.3% d'infections COVID-19).\nLes effets ind\u00e9sirables \u00e9taient significativement plus fr\u00e9quents chez les sujets trait\u00e9s par hydroxychloroquine (40% vs 17%), bien qu'aucun effet ind\u00e9sirable grave, notamment cardiaque, n'a \u00e9t\u00e9 r\u00e9pertori\u00e9\nAinsi, le traitement par hydroxychloroquine n'a pas fait preuve de son int\u00e9r\u00eat en prophylactique pour le moment", "objectives": "Cet essai clinique randomis\u00e9, contr\u00f4l\u00e9 en double aveugle est plut\u00f4t bien men\u00e9 et reste l'un des essais les plus robustes disponibles actuellement sur ce traitement. Son recrutement pragmatique approche l'effet en vie r\u00e9el. Il persiste malgr\u00e9 tout quelque biais :- Changement des crit\u00e8res d'inclusion en cours d'essai introduisant de l'h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 dans l'\u00e9chantillon- Risque de biais de m\u00e9morisation et de biais de classement du fait de la m\u00e9thodologie de recueil des donn\u00e9es choisie (par auto-questionnaire \u00e0 distance) et de la possibilit\u00e9 de d\u00e9c\u00e8s non retrouv\u00e9- Le diagnostic de COVID-19 (crit\u00e8re de jugement principal) peut \u00eatre bas\u00e9 uniquement sur la symptomatologie clinique du patient recueillie par questionnaire (pas obligation de test PCR). Les crit\u00e8res d\u00e9finis sont plut\u00f4t robustes et en l'absence de confirmation virologique, les patients sont class\u00e9s en \"cas probables\", mais il persiste un risque de biais de classement- Le suivi des sujets peut ne pas \u00eatre assez long (mesure \u00e0 J14), certains patients d\u00e9veloppant les sympt\u00f4mes apr\u00e8s 3 semaines et non prise en compte des cas asymptomatiques repr\u00e9sentant une part non n\u00e9gligeable des infections COVID-19- Plan d'analyse statistique robuste, y compris les analyses interm\u00e9diaires, mais utilisation d'un test non-param\u00e9trique alors qu'un test param\u00e9trique aurait certainement pu \u00eatre r\u00e9alis\u00e9- Echantillon plut\u00f4t f\u00e9minin de patients jeunes et en bonne sant\u00e9, non repr\u00e9sentatif de l'ensemble de la population infect\u00e9e par le SARS-CoV-2 : bais du travailleur sain possible (majorit\u00e9 de professionnels de sant\u00e9)- Adh\u00e9sion des patients diff\u00e9rente entre les groupes avec observance moindre chez les sujets prenant de l'hydroxychloroquine mais caus\u00e9e par les effets ind\u00e9sirables du traitement", "methods": "Evaluer l'efficacit\u00e9 de l'hydroxychloroquine compar\u00e9 \u00e0 un placebo pour pr\u00e9venir le d\u00e9veloppement de la maladie COVID-19 apr\u00e8s exposition (prise prophylactique)", "pubmed_id": "32492293\n31995857\n32392282\n32363212\n32220208\n32150618\n32450107\n16115318\n32134909\n31078660\n32305587\n32379955\n32324530\n32298247\n32194981\n32344449\n32383125", "doi": "10.1056/NEJMoa2016638", "abstract": "Coronavirus disease 2019 (Covid-19) occurs after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). For persons who are exposed, the standard of care is observation and quarantine. Whether hydroxychloroquine can prevent symptomatic infection after SARS-CoV-2 exposure is unknown.\nWe conducted a randomized, double-blind, placebo-controlled trial across the United States and parts of Canada testing hydroxychloroquine as postexposure prophylaxis. We enrolled adults who had household or occupational exposure to someone with confirmed Covid-19 at a distance of less than 6 ft for more than 10 minutes while wearing neither a face mask nor an eye shield (high-risk exposure) or while wearing a face mask but no eye shield (moderate-risk exposure). Within 4 days after exposure, we randomly assigned participants to receive either placebo or hydroxychloroquine (800 mg once, followed by 600 mg in 6 to 8 hours, then 600 mg daily for 4 additional days). The primary outcome was the incidence of either laboratory-confirmed Covid-19 or illness compatible with Covid-19 within 14 days.\nWe enrolled 821 asymptomatic participants. Overall, 87.6% of the participants (719 of 821) reported a high-risk exposure to a confirmed Covid-19 contact. The incidence of new illness compatible with Covid-19 did not differ significantly between participants receiving hydroxychloroquine (49 of 414 [11.8%]) and those receiving placebo (58 of 407 [14.3%]); the absolute difference was -2.4 percentage points (95% confidence interval, -7.0 to 2.2; P\u2009=\u20090.35). Side effects were more common with hydroxychloroquine than with placebo (40.1% vs. 16.8%), but no serious adverse reactions were reported.\nAfter high-risk or moderate-risk exposure to Covid-19, hydroxychloroquine did not prevent illness compatible with Covid-19 or confirmed infection when used as postexposure prophylaxis within 4 days after exposure. (Funded by David Baszucki and Jan Ellison Baszucki and others; ClinicalTrials.gov number, NCT04308668.).", "topics": ["Th\u00e9rapeutique", "Transversale", "Virologie", "Infectiologie", "Pneumologie"], "author_list": [{"id": 613, "name": "Boulware DR"}], "publication_date": "2020-06-04"}, {"id": 221, "slug": "absence-of-contamination-of-personal-protective-equipment-ppe-by-severe-acute-re", "title": "Absence of contamination of personal protective equipment (PPE) by severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Evaluer la s\u00e9curit\u00e9 de l'allongement de la dur\u00e9e d'utilisation des \u00e9quipements de protection personnelle", "verbose_date": "31.03.2020", "authors": "Ong S ", "specialties": [{"id": 2, "name": "Hygi\u00e8ne"}], "category": {"id": 2, "name": "Autres", "icon": "icon-other"}, "journal": {"id": 106, "name": "Infect Control Hosp Epidemiol"}, "link": "https://www.dropbox.com/s/uxuj0ivxidyoihk/absence_of_contamination_of_personal_protective_equipment_ppe_by_severe_acute_respiratory_syndrome_coronavirus_2_sarscov2.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Etonnamment dans cette \u00e9tude aucun pr\u00e9l\u00e8vement sur le mat\u00e9riel de protection de soignants s'occupant de malades COVID-19 n'a \u00e9t\u00e9 test\u00e9 positif au SARS-CoV-2. Mais les limites de l'\u00e9tude sont nombreuses et ne permettent pas de conclure \u00e0 l'absence de contamination des masques et lunettes de protection apr\u00e8s soins d'un patient infect\u00e9 et donc \u00e0 l'absence de risque d'allongement de leur dur\u00e9e d'utilisation.", "objectives": "1) Effectif de moyenne importance2) Ne prend pas en compte la contamination par les a\u00e9rosols (patients non ventil\u00e9s, pas de gestes g\u00e9n\u00e9rateurs d'a\u00e9rosols avant les pr\u00e9l\u00e8vements)3) Tous les patients s\u00e9lectionn\u00e9s n'\u00e9taient pas symptomatiques4) Technique de pr\u00e9l\u00e8vement des masques N95 peu sensible5) Patients en chambre \u00e0 pression n\u00e9gative6) Pas de pr\u00e9l\u00e8vement de l'environnement direct du patient dans la chambre pour corr\u00e9lation\"", "methods": "Evaluer la s\u00e9curit\u00e9 de l'allongement de la dur\u00e9e d'utilisation des \u00e9quipements de protection personnelle", "pubmed_id": "32213231", "doi": "10.1017/ice.2020.91", "abstract": null, "topics": ["Autres", "Hygi\u00e8ne"], "author_list": [{"id": 212, "name": "Ong S "}], "publication_date": "2020-03-31"}, {"id": 286, "slug": "remdesivir-for-severe-acute-respiratory-syndrome-coronavirus-2-causing-covid-19-", "title": "Remdesivir for severe acute respiratory syndrome coronavirus 2 causing COVID-19: An evaluation of the evidence", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Evaluer la faisabilit\u00e9 d'un essai clinique sur le traitement des infections \u00e0 SARS-CoV-2 par remdesivir", "verbose_date": "06.04.2020", "authors": "Cao YC", "specialties": [{"id": 12, "name": "Infectiologie"}, {"id": 8, "name": "Pneumologie"}], "category": {"id": 4, "name": "Th\u00e9rapeutique", "icon": "icon-med"}, "journal": {"id": 69, "name": "Travel Med Infect Dis"}, "link": "https://www.dropbox.com/s/kxof20vm3qad8m2/1-s2.0-S1477893920301162-main.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Le remdesivir semble \u00eatre un traitement prometeur du COVID-19. De plus ample essais clinique sont n\u00e9cessaire. Dufait de la capacit\u00e9 de mutation du SARS-CoV-2, ces \u00e9tudes sont d'autant plus importante pour \u00e9viter l'apparition de mutation du fait de traitement \u00e0 l'aveugle.\r\n2 essais clinique sont en cours.", "objectives": "- Pre-print- Analyse bibliographique", "methods": "Evaluer la faisabilit\u00e9 d'un essai clinique sur le traitement des infections \u00e0 SARS-CoV-2 par remdesivir", "pubmed_id": "32247927\n31978945\n32020029\n29414327\n19198616\n32105609\n32054787\n31774950\n32074444\n15030519\n30755068\n32015507\n26934220\n32022370\n31924756\n31967327\n22446091\n32009228", "doi": "10.1016/j.tmaid.2020.101647", "abstract": "The novel coronavirus infection that initially found at the end of 2019 has attracted great attention. So far, the number of infectious cases has increased globally to more than 100 thousand and the outbreak has been defined as a pandemic situation, but there are still no \"specific drug\" available. Relevant reports have pointed out the novel coronavirus has 80% homology with SARS. In the difficulty where new synthesized drug cannot be applied immediately to patients, \"conventional drug in new use\" becomes a feasible solution. The first medication experience of the recovered patients in the US has led remdesivir to be the \"specific drug\". China has also taken immediate action to put remdesivir into clinical trials with the purpose of applying it into clinical therapeutics for Corona Virus Disease 2019 (COVID-19). We started from the structure, immunogenicity, and pathogenesis of coronavirus infections of the novel coronavirus. Further, we analyzed the pharmacological actions and previous trials of remdesivir to identify the feasibility of conducting experiments on COVID-19.", "topics": ["Th\u00e9rapeutique", "Infectiologie", "Pneumologie"], "author_list": [{"id": 274, "name": "Cao YC"}], "publication_date": "2020-04-06"}, {"id": 502, "slug": "association-of-viral-load-with-serum-biomakers-among-covid-19-cases", "title": "Association of viral load with serum biomakers among COVID-19 cases", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Recherche de l'association de la charge virale avec les IgM anti-SARS-CoV-2 (IgM), la prot\u00e9ine C-r\u00e9active (PCR) et le s\u00e9rum amylo\u00efde A (SAA) chez les patients COVID-19 \u00e0 l'admission, pour trouver les indices qui peuvent faciliter la pr\u00e9vention et le traitement de cette maladie infectieuse.", "verbose_date": "02.05.2020", "authors": "Shi F", "specialties": [{"id": 5, "name": "Virologie"}], "category": {"id": 2, "name": "Autres", "icon": "icon-other"}, "journal": {"id": 200, "name": "Virology"}, "link": "https://www.dropbox.com/s/8ci1nv5wwa1kory/1-s2.0-S0042682220300787-main.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Dans cette \u00e9tude, tant la prot\u00e9ine C-r\u00e9active (PCR) que\u00a0la s\u00e9rum amylo\u00efde A (SAA)\u00a0ont\u00a0montr\u00e9 des valeurs plus \u00e9lev\u00e9es \u00e0 mesure que la maladie s'aggravait bien que des significations statistiques n'aient \u00e9t\u00e9 trouv\u00e9es que pour la PCR.\nChez les patients avec IgM + il n'y a pas de diff\u00e9rences significatives de la charge virale en fonction des manifestations cliniques.\u00a0Au contraire, il existe une diff\u00e9rence entre les patients avec IgM -,\u00a0la charge virale augmente \u00e0 mesure que l'on s'\u00e9loigne de l'apparition des sympt\u00f4mes (diff\u00e9rence entre la charge virale \u00e0 6-9J et \u00e0 9-12J, p<0.05,\u00a0et\u00a0la charge virale \u00e0 9-12J entre les patients atteints de pneumopathie avec IgM + et IgM -, p<0.001).\nSelon l'\u00e9tude la combinaison des IgM et de la PCR/SAA avec certaines informations cliniques (le temps apr\u00e8s l'apparition les sympt\u00f4mes et leur gravit\u00e9) peut donner des suggestions sur la charge virale et le jugement de l'\u00e9tat des patients atteints de COVID-19\u00a0mais l'\u00e9chantillon test\u00e9 est petit et les r\u00e9sultats doivent \u00eatre test\u00e9s sur des populations plus importantes.", "objectives": "Faible:1) \u00e9tude observationelle2) petit \u00e9chantillon (n=114)", "methods": "Recherche de l'association de la charge virale avec les IgM anti-SARS-CoV-2 (IgM), la prot\u00e9ine C-r\u00e9active (PCR) et le s\u00e9rum amylo\u00efde A (SAA) chez les patients COVID-19 \u00e0 l'admission, pour trouver les indices qui peuvent faciliter la pr\u00e9vention et le traitement de cette maladie infectieuse.", "pubmed_id": "32452410\n32092483\n32077115\n23936359\n25081498\n28267794\n32080991\n31122611\n32213337\n32065057\n31312858\n32031583\n32105638\n32106567\n32074444\n32031570\n32112082\n28377336\n27523492\n32007143", "doi": "10.1016/j.virol.2020.04.011", "abstract": "Since SARS-CoV-2 spreads rapidly around the world, data have been needed on the natural fluctuation of viral load and clinical indicators associated with it. We measured and compared viral loads of SARS-CoV-2 from pharyngeal swab, IgM anti-SARS-CoV-2, CRP and SAA from serum of 114 COVID-19 patients on admission. Positive rates of IgM anti-SARS-CoV-2, CRP and SAA were 80.7%, 36% and 75.4% respectively. Among IgM-positive patients, viral loads showed different trends among cases with different severity, While viral loads of IgM-negative patients tended to increase along with the time after onset. As the worsening of severity, the positive rates of CRP and SAA also showed trends of increase. Different CRP/SAA type showed associations with viral loads in patients in different severity and different time after onset. Combination of the IgM and CRP/SAA with time after onset and severity may give suggestions on the viral load and condition judgment of COVID-19 patients.", "topics": ["Autres", "Virologie"], "author_list": [{"id": 470, "name": "Shi F"}], "publication_date": "2020-05-02"}, {"id": 604, "slug": "modeling-the-impact-of-mass-influenza-vaccination-and-public-health-intervention", "title": "Modeling the impact of mass influenza vaccination and public health interventions on COVID-19 epidemics with limited detection capability", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Mod\u00e9liser l\u2019impact d\u2019une am\u00e9lioration de la politique de vaccination contre la grippe saisonni\u00e8re sur la propagation du COVID-19 dans un contexte de capacit\u00e9 de test limit\u00e9e.", "verbose_date": "19.05.2020", "authors": "Li Q", "specialties": [{"id": 7, "name": "Transversale"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 238, "name": "Mathematical Biosciences"}, "link": "https://www.sciencedirect.com/science/article/pii/S0025556420300638", "findings": "", "take_away": "", "relevance_level": "Augmenter la capacit\u00e9 de test est un point crucial dans la ma\u00eetrise de l\u2019\u00e9pid\u00e9mie.\nIl en va de m\u00eame de la mise en place de la distanciation sociale, des mesures barri\u00e8res et de la mise en quarantaine des individus suspect\u00e9s qui s\u2019av\u00e8rent d\u2019autant plus efficaces dans un contexte de capacit\u00e9 de test limit\u00e9e.\nL'augmentation du taux de couverture vaccinale contre la grippe peut consid\u00e9rablement r\u00e9duire le nombre cumul\u00e9 de cas faussement suspect\u00e9s de COVID-19 et donc, le nombre de personnes contamin\u00e9es lors de leur mise en quarantaine. Cela aurait aussi pour effet de limiter le nombre de personnes \u00e0 tester du fait de leurs sympt\u00f4mes grippaux et donc de retarder la saturation des capacit\u00e9s de test r\u00e9duisant encore le bilan de l\u2019\u00e9pid\u00e9mie.", "objectives": "Le mod\u00e8le \u00e9pid\u00e9miologique se base sur un certain nombre d\u2019hypoth\u00e8ses non v\u00e9rifi\u00e9es \u00e0 ce jour, comme la concomitance des p\u00e9riodes de forte contagiosit\u00e9 du COVID-19 et de la grippe saisonni\u00e8re. D\u2019autres hypoth\u00e8ses simplificatrices devraient conduire \u00e0 nuancer les r\u00e9sultats, comme le fait que le vaccin contre la grippe saisonni\u00e8re est consid\u00e9r\u00e9 comme \u00e9tant 100\u00a0% efficace. Par ailleurs si certains param\u00e8tres du mod\u00e8le se basent sur des donn\u00e9es d\u00e9clar\u00e9es par le NHPRC, beaucoup ne sont qu\u2019estim\u00e9s par les auteurs.Enfin, les auteurs ne proposent pas d\u2019\u00e9tude de sensibilit\u00e9 du mod\u00e8le au choix de leurs param\u00e8tres ne permettant pas de se faire une id\u00e9e de la robustesse de leurs r\u00e9sultats.", "methods": "Mod\u00e9liser l\u2019impact d\u2019une am\u00e9lioration de la politique de vaccination contre la grippe saisonni\u00e8re sur la propagation du COVID-19 dans un contexte de capacit\u00e9 de test limit\u00e9e.", "pubmed_id": "32507746\n32099934\n32277878\n32145465\n32291278\n28787234\n32057211\n29845606\n32350060\n32171948\n32360770\n32046137\n32198088\n13678898", "doi": "10.1016/j.mbs.2020.108378", "abstract": "The emerging coronavirus SARS-CoV-2 has caused a COVID-19 pandemic. SARS-CoV-2 causes a generally mild, but sometimes severe and even life-threatening infection, known as COVID-19. Currently, there exist no effective vaccines or drugs and, as such, global public authorities have so far relied upon non pharmaceutical interventions (NPIs). Since COVID-19 symptoms are aspecific and may resemble a common cold, if it should come back with a seasonal pattern and coincide with the influenza season, this would be particularly challenging, overwhelming and straining the healthcare systems, particularly in resource-limited contexts, and would increase the likelihood of nosocomial transmission. In the present study, we devised a mathematical model focusing on the treatment of people complaining of influenza-like-illness (ILI) symptoms, potentially at risk of contracting COVID-19 or other emerging/re-emerging respiratory infectious agents during their admission at the health-care setting, who will occupy the detection kits causing a severe shortage of testing resources. The model is used to assess the effect of mass influenza vaccination on the spread of COVID-19 and other respiratory pathogens in the case of a coincidence of the outbreak with the influenza season. Here, we show that increasing influenza vaccine uptake or enhancing the public health interventions would facilitate the management of respiratory outbreaks coinciding with the peak flu season, especially, compensate the shortage of the detection resources. However, how to increase influenza vaccination coverage rate remains challenging. Public health decision- and policy-makers should adopt evidence-informed strategies to improve influenza vaccine uptake.", "topics": ["Epid\u00e9miologique", "Transversale"], "author_list": [{"id": 498, "name": "Li Q"}], "publication_date": "2020-05-19"}, {"id": 97, "slug": "covid-19-considercytokine-stormsyndromes-andimmunosuppression", "title": "COVID-19: considercytokine stormsyndromes andimmunosuppression", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Comprendre l'impact et la surveillance de la d\u00e9charge cytokinique dans les formes s\u00e9v\u00e8res de COVID-19", "verbose_date": "13.03.2020", "authors": "Mehta P", "specialties": [{"id": 7, "name": "Transversale"}], "category": {"id": 4, "name": "Th\u00e9rapeutique", "icon": "icon-med"}, "journal": {"id": 70, "name": "The Lancet"}, "link": "https://www.dropbox.com/s/2t021779eyhf1fi/PIIS0140673620306280.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Pour les patients avec forme s\u00e9v\u00e8re, surveiller l'inflammation en particulier la ferritin\u00e9mie car risque de sHLH fatale par d\u00e9charge cytokinique Piste th\u00e9rapeutique avec le tocilizumab", "objectives": "Faible : 1) Correspondance sans processus de blind reviewing2) Uniquement bas\u00e9 sur la bibliographie pr\u00e9c\u00e9dente et l'analyse de l'auteur3) Pas de m\u00e9thodologie exp\u00e9rimentale permettant de confirmer ces propos", "methods": "Comprendre l'impact et la surveillance de la d\u00e9charge cytokinique dans les formes s\u00e9v\u00e8res de COVID-19", "topics": ["Th\u00e9rapeutique", "Transversale"], "author_list": [{"id": 103, "name": "Mehta P"}], "publication_date": "2020-03-13"}, {"id": 513, "slug": "pooling-of-samples-for-testing-for-sars-cov-2-in-asymptomatic-people", "title": "Pooling of samples for testing for SARS-CoV-2 in asymptomatic people", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Proposer une m\u00e9thode d\u2019optimisation des tests de PCR sur COVID-19 pour les patients asymptomatiques par regroupement des \u00e9chantillons.", "verbose_date": "01.05.2020", "authors": "Lohset S", "specialties": [{"id": 5, "name": "Virologie"}, {"id": 12, "name": "Infectiologie"}], "category": {"id": 3, "name": "Diagnostique", "icon": "icon-heat"}, "journal": {"id": 74, "name": "Lancet Infect Dis"}, "link": "https://www.thelancet.com/action/showPdf?pii=S1473-3099%2820%2930362-5", "findings": "", "take_away": "", "relevance_level": "\u2192 En regroupant les \u00e9chantillons en pool, et en sous-\u00e9chantillonnant les pools dont la PCR s'av\u00e9rait positive avant un second test, les auteurs ont pu grandement r\u00e9duire le nombre de tests n\u00e9cessaires.\r\n\u2192 Les valeurs Ct des pools contenant des \u00e9chantillons positifs semblent comprises entre 22 et 29, soit environ 5 de plus que pour les \u00e9chantillons test\u00e9s individuellement.\r\n\u2192 M\u00eame lorsque la valeur Ct d\u2019un \u00e9chantillon obtenue lors d\u2019un test individuel est faible, il semble possible de la d\u00e9tecter au sein d\u2019un \u00e9chantillon large ( pool de 30 \u00e9chantillons).", "objectives": "Correspondance relay\u00e9e par le Lancet sur une \u00e9tude non review\u00e9e. L\u2019article ne pr\u00e9cise pas les crit\u00e8res d\u2019inclusion dans la cohorte (symptomatique ou pas\u00a0?). Et l\u2019absence de tests de contr\u00f4le individuels syst\u00e9matiques ne permet pas de s\u2019assurer qu\u2019il n\u2019y avait effectivement que 23 \u00e9chantillons positifs.", "methods": "Proposer une m\u00e9thode d\u2019optimisation des tests de PCR sur COVID-19 pour les patients asymptomatiques par regroupement des \u00e9chantillons.", "pubmed_id": "32530425", "doi": "10.1016/S1473-3099(20)30362-5", "abstract": null, "topics": ["Diagnostique", "Virologie", "Infectiologie"], "author_list": [{"id": 481, "name": "Lohset S"}], "publication_date": "2020-05-01"}, {"id": 71, "slug": "covid-19-uk-starts-social-distancing-after-new-model-points-to-260-000-potential", "title": "Covid-19: UK starts social distancing after new model points to 260 000 potential deaths", "has_other_authors": false, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Comprendre le changement de la prise en charge du COVID-19 par le Royaume-Uni", "verbose_date": "18.03.2020", "authors": "Mahase E", "specialties": [{"id": 7, "name": "Transversale"}], "category": {"id": 2, "name": "Autres", "icon": "icon-other"}, "journal": {"id": 57, "name": "BMJ"}, "link": "https://www.dropbox.com/s/qm805zmnb09s8vh/bmj.m1089.full.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Possible sous \u00e9valuation des besoins de soins intensifs", "objectives": "Faible : lettre \u00e0 l'\u00e9diteur rapportant un autre article", "methods": "Comprendre le changement de la prise en charge du COVID-19 par le Royaume-Uni", "pubmed_id": "32184205", "doi": "10.1136/bmj.m1089", "abstract": null, "topics": ["Autres", "Transversale"], "author_list": [{"id": 81, "name": "Mahase E"}], "publication_date": "2020-03-18"}, {"id": 616, "slug": "epidemiology-clinical-course-and-outcomes-of-critically-ill-adults-with-covid-19", "title": "Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Caract\u00e9riser l'\u00e9pid\u00e9miologie, l'\u00e9volution clinique et les facteurs de risque de mortalit\u00e9 \u00e0 l'h\u00f4pital parmi une cohorte d'adultes atteints d'une maladie grave li\u00e9e au COVID-19.", "verbose_date": "22.05.2020", "authors": "Cummings MJ", "specialties": [{"id": 7, "name": "Transversale"}, {"id": 4, "name": "Anesth\u00e9sie-R\u00e9animation"}, {"id": 12, "name": "Infectiologie"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 12, "name": "Lancet"}, "link": "https://www.thelancet.com/action/showPdf?pii=S0140-6736%2820%2931189-2", "findings": "", "take_away": "", "relevance_level": "La maladie grave chez les patients COVID-19 hospitalis\u00e9s \u00e0 New York est courante et associ\u00e9e \u00e0 une fr\u00e9quence \u00e9lev\u00e9e de ventilation m\u00e9canique invasive, un dysfonctionnement des organes extrapulmonaires et une mortalit\u00e9 hospitali\u00e8re importante. Des associations ind\u00e9pendantes entre les biomarqueurs de l'inflammation (IL-6) et de thrombose (D-dim\u00e8re) et la mortalit\u00e9 sont trouv\u00e9s dans cette \u00e9tude.", "objectives": "Cohorte prospective, multicentrique mais uniquement \u00e0 New York, n=257Au moins 28 jours d'observation pour chaque patient, mais 94 (37%) \u00e9taient toujours hospitalis\u00e9s \u00e0 la date de pointTests RT-PCR externalis\u00e9s avant le 10 marsInclusion des patients avec un examen quotidien des admissions \u00e0 l'h\u00f4pital dans les dossiers \u00e9lectroniquesFormulaire d'enregistrement de cas standardis\u00e985 (72%) ont re\u00e7u de l'hydroxychloroquine, 23 (9%) ont re\u00e7u du remdesivir, 68 (26%) patients ont re\u00e7u des corticost\u00e9ro\u00efdes et 44 (17%) ont re\u00e7u des antagonistes des r\u00e9cepteurs de l'IL-6.", "methods": "Caract\u00e9riser l'\u00e9pid\u00e9miologie, l'\u00e9volution clinique et les facteurs de risque de mortalit\u00e9 \u00e0 l'h\u00f4pital parmi une cohorte d'adultes atteints d'une maladie grave li\u00e9e au COVID-19.", "pubmed_id": "32511638", "doi": "10.1101/2020.04.15.20067157", "abstract": "Nearly 30,000 patients with coronavirus disease-2019 (COVID-19) have been hospitalized in New York City as of April 14th, 2020. Data on the epidemiology, clinical course, and outcomes of critically ill patients with COVID-19 in this setting are needed.\nWe prospectively collected clinical, biomarker, and treatment data on critically ill adults with laboratory-confirmed-COVID-19 admitted to two hospitals in northern Manhattan between March 2nd and April 1st, 2020. The primary outcome was in-hospital mortality. Secondary outcomes included frequency and duration of invasive mechanical ventilation, frequency of vasopressor use and renal-replacement-therapy, and time to clinical deterioration following hospital admission. The relationship between clinical risk factors, biomarkers, and in-hospital mortality was modeled using Cox-proportional-hazards regression. Each patient had at least 14 days of observation.\nOf 1,150 adults hospitalized with COVID-19 during the study period, 257 (22%) were critically ill. The median age was 62 years (interquartile range [IQR] 51-72); 170 (66%) were male. Two-hundred twelve (82%) had at least one chronic illness, the most common of which were hypertension (63%; 162/257) and diabetes mellitus (36%; 92/257). One-hundred-thirty-eight patients (54%) were obese, and 13 (5%) were healthcare workers. As of April 14th, 2020, in-hospital mortality was 33% (86/257); 47% (122/257) of patients remained hospitalized. Two-hundred-one (79%) patients received invasive mechanical ventilation (median 13 days [IQR 9-17]), and 54% (138/257) and 29% (75/257) required vasopressors and renal-replacement-therapy, respectively. The median time to clinical deterioration following hospital admission was 3 days (IQR 1-6). Older age, hypertension, chronic lung disease, and higher concentrations of interleukin-6 and d-dimer at admission were independently associated with in-hospital mortality.\nCritical illness among patients hospitalized with COVID-19 in New York City is common and associated with a high frequency of invasive mechanical ventilation, extra-pulmonary organ dysfunction, and substantial in-hospital mortality.", "topics": ["Epid\u00e9miologique", "Transversale", "Anesth\u00e9sie-R\u00e9animation", "Infectiologie"], "author_list": [{"id": 579, "name": "Cummings MJ"}], "publication_date": "2020-05-22"}, {"id": 364, "slug": "prognostic-value-of-nt-probnp-in-patients-with-severe-covid-19", "title": "Prognostic value of NT-proBNP in patients with severe COVID-19", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "D\u00e9terminer la valeur pronostique d'une \u00e9l\u00e9vation des NT-proBNP chez les patients atteints de forme s\u00e9v\u00e8re de COVID-19 ", "verbose_date": "17.04.2020", "authors": "Gao L", "specialties": [{"id": 12, "name": "Infectiologie"}, {"id": 4, "name": "Anesth\u00e9sie-R\u00e9animation"}, {"id": 8, "name": "Pneumologie"}], "category": {"id": 6, "name": "Pronostique", "icon": "icon-chat"}, "journal": {"id": 156, "name": "Respir Res"}, "link": "https://respiratory-research.biomedcentral.com/track/pdf/10.1186/s12931-020-01352-w", "findings": "", "take_away": "", "relevance_level": "L\u2019\u00e9l\u00e9vation des NT-proBNP> 88,64 pg/mL semblerait \u00eatre un facteur ind\u00e9pendant pr\u00e9dictif de mortalit\u00e9 chez les patients s\u00e9v\u00e8res atteints de COVID-19", "objectives": "Etude observationnelle r\u00e9trospective, n = 54, monocentrique, crit\u00e8res de s\u00e9v\u00e9rit\u00e9 criticables", "methods": "D\u00e9terminer la valeur pronostique d'une \u00e9l\u00e9vation des NT-proBNP chez les patients atteints de forme s\u00e9v\u00e8re de COVID-19", "pubmed_id": "32293449\n32114747\n32081636\n32092539\n32125455\n28062628\n32071063\n32211816\n31986264\n32096367\n32055771\n20511643\n31411279\n32085846\n32118393\n29351514\n17142170\n29325222\n27081112\n24957908\n23714366\n10969042", "doi": "10.1186/s12931-020-01352-w", "abstract": "The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China has been declared a public health emergency of international concern. The cardiac injury is a common condition among the hospitalized patients with COVID-19. However, whether N terminal pro B type natriuretic peptide (NT-proBNP) predicted outcome of severe COVID-19 patients was unknown.\nThe study initially enrolled 102 patients with severe COVID-19 from a continuous sample. After screening out the ineligible cases, 54 patients were analyzed in this study. The primary outcome was in-hospital death defined as the case fatality rate. Research information and following-up data were obtained from their medical records.\nThe best cut-off value of NT-proBNP for predicting in-hospital death was 88.64\u2009pg/mL with the sensitivity for 100% and the specificity for 66.67%. Patients with high NT-proBNP values (>\u200988.64\u2009pg/mL) had a significantly increased risk of death during the days of following-up compared with those with low values (\u226488.64\u2009pg/mL). After adjustment for potential risk factors, NT-proBNP was independently correlated with in-hospital death.\nNT-proBNP might be an independent risk factor for in-hospital death in patients with severe COVID-19.\nClinicalTrials, NCT04292964. Registered 03 March 2020.", "topics": ["Pronostique", "Infectiologie", "Anesth\u00e9sie-R\u00e9animation", "Pneumologie"], "author_list": [{"id": 351, "name": "Gao L"}], "publication_date": "2020-04-17"}, {"id": 134, "slug": "rational-use-of-face-masks-in-the-covid-19-pandemic", "title": "Rational use of face masks in the COVID-19 pandemic", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Comparaison des recommandations sur l'utilisation des masques selon diff\u00e9rentes sources.", "verbose_date": "25.03.2020", "authors": "Feng S ", "specialties": [{"id": 2, "name": "Hygi\u00e8ne"}], "category": {"id": 2, "name": "Autres", "icon": "icon-other"}, "journal": {"id": 87, "name": "Lancet Respir Med"}, "link": "https://www.dropbox.com/s/bxz1kvdjl5wup6i/PIIS221326002030134X.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Devant les probl\u00e8mes d'approvisionnement en masque, il pourrait \u00eatre int\u00e9ressant de r\u00e9server les masques aux personnes pour lesquelles l'infection serait plus \u00e0 risque, aux expositions \u00e0 des situations \u00e0 haut risque de contamination.\r\nDu fait de la pr\u00e9sence de personnes infect\u00e9es asymptomatiques, un port de masque plus g\u00e9n\u00e9ralis\u00e9 pourrait \u00eatre int\u00e9ressant.", "objectives": "- Listing des pratiques et recommandations\"", "methods": "Comparaison des recommandations sur l'utilisation des masques selon diff\u00e9rentes sources.", "pubmed_id": "32203710", "doi": "10.1016/S2213-2600(20)30134-X", "abstract": null, "topics": ["Autres", "Hygi\u00e8ne"], "author_list": [{"id": 131, "name": "Feng S "}], "publication_date": "2020-03-25"}, {"id": 526, "slug": "risk-of-qt-interval-prolongation-associated-with-use-of-hydroxychloroquine-with-", "title": "Risk of QT Interval Prolongation Associated With Use of Hydroxychloroquine With or Without Concomitant Azithromycin Among Hospitalized Patients Testing Positive for Coronavirus Disease 2019 (COVID-19)", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Caract\u00e9riser le risque et le degr\u00e9 d'allongement de l'intervalle QT chez les patients atteints de COVID-19 en association avec leur utilisation d'hydroxychloroquine avec ou sans azithromycine concomitante.", "verbose_date": "05.05.2020", "authors": "Mercuro NJ", "specialties": [{"id": 7, "name": "Transversale"}, {"id": 17, "name": "Cardiologie et maladies m\u00e9taboliques"}], "category": {"id": 4, "name": "Th\u00e9rapeutique", "icon": "icon-med"}, "journal": {"id": 99, "name": "JAMA Cardiol"}, "link": "https://www.dropbox.com/s/3bex34dglw0hmyi/10.1001%40jamacardio.2020.1834.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Dans cette \u00e9tude de cohorte, les patients qui ont re\u00e7u de l'hydroxychloroquine pour le traitement de la pneumonie associ\u00e9e \u00e0 COVID-19 pr\u00e9sentaient un risque \u00e9lev\u00e9 d'allongement de l'intervalle QTc, et le traitement concomitant avec l'azithromycine \u00e9tait associ\u00e9 \u00e0 des modifications plus importantes de l'intervalle QTc.\nCertains patients ont eu des effets ind\u00e9sirables des m\u00e9dicaments, dont un cas de torsades de pointes avec administration d'hydroxychloroquine et d'azithromycine.\nIl est absolument n\u00e9cessaire de mener des \u00e9tudes rigoureuses \u00e0 grande \u00e9chelle et de proc\u00e9der \u00e0 une \u00e9valuation des risques et des avantages avant de lancer la th\u00e9rapie COVID-19, en accordant une attention particuli\u00e8re aux interactions m\u00e9dicamenteuses, aux manifestations cardiaques, aux \u00e9lectrocardiogrammes de routine et \u00e0 la surveillance des \u00e9lectrolytes.", "objectives": "-\tEtude observationnelle de cohorte r\u00e9trospective et monocentrique-\tN=90-\tBien que l'administration d'hydroxychloroquine et d'azithromycine ait probablement contribu\u00e9 aux effets ind\u00e9sirables observ\u00e9s des m\u00e9dicaments, on ne peut pas exclure la cardiomyopathie ou la myocardite associ\u00e9es au COVID-19.-\tSans bras de contr\u00f4le, on ne peut pas conclure que l'hydroxychloroquine et l'azithromycine ont conf\u00e9r\u00e9 un risque cardiotoxique accru.-\tIl reste possible que le v\u00e9ritable degr\u00e9 d'allongement de l'intervalle QTc ait \u00e9t\u00e9 sous-estim\u00e9, compte tenu de la variation des pratiques cliniques et d'une p\u00e9riode de suivi limit\u00e9e : 45 patients sont rest\u00e9s hospitalis\u00e9s, et 19 patients n'ont pas subi d'\u00e9lectrocardiogrammes de suivi.-\tIl se peut que les groupes \u00e0 haut risque n'aient pas \u00e9t\u00e9 repr\u00e9sent\u00e9s, car les directives institutionnelles d\u00e9conseillent l'hydroxychloroquine aux personnes dont l'intervalle QTc de base est prolong\u00e9. -\tDe nombreux facteurs dans cette petite cohorte d'adultes atteints de maladies complexes, souvent graves, pourraient \u00e9galement avoir confondu les points terminaux cliniques et de s\u00e9curit\u00e9.", "methods": "Caract\u00e9riser le risque et le degr\u00e9 d'allongement de l'intervalle QT chez les patients atteints de COVID-19 en association avec leur utilisation d'hydroxychloroquine avec ou sans azithromycine concomitante.", "pubmed_id": "32356863\n22591294\n32020029\n23716032\n32205204\n32330277\n32283123\n32200663\n32075365\n32240719", "doi": "10.1001/jamacardio.2020.1834", "abstract": "Administration of hydroxychloroquine with or without azithromycin for the treatment of coronavirus disease 2019 (COVID-19)-associated pneumonia carries increased risk of corrected QT (QTc) prolongation and cardiac arrhythmias.\nTo characterize the risk and degree of QT prolongation in patients with COVID-19 in association with their use of hydroxychloroquine with or without concomitant azithromycin.\nThis was a cohort study performed at an academic tertiary care center in Boston, Massachusetts, of patients hospitalized with at least 1 positive COVID-19 nasopharyngeal polymerase chain reaction test result and clinical findings consistent with pneumonia who received at least 1 day of hydroxychloroquine from March 1, 2020, through April 7, 2020.\nChange in QT interval after receiving hydroxychloroquine with or without azithromycin; occurrence of other potential adverse drug events.\nAmong 90 patients given hydroxychloroquine, 53 received concomitant azithromycin; 44 (48.9%) were female, and the mean (SD) body mass index was 31.5 (6.6). Hypertension (in 48 patients [53.3%]) and diabetes mellitus (in 26 patients [28.9%]) were the most common comorbid conditions. The overall median (interquartile range) baseline QTc was 455 (430-474) milliseconds (hydroxychloroquine, 473 [454-487] milliseconds vs hydroxychloroquine and azithromycin, 442 [427-461] milliseconds; P\u2009<\u2009.001). Those receiving concomitant azithromycin had a greater median (interquartile range) change in QT interval (23 [10-40] milliseconds) compared with those receiving hydroxychloroquine alone (5.5 [-15.5 to 34.25] milliseconds; P\u2009=\u2009.03). Seven patients (19%) who received hydroxychloroquine monotherapy developed prolonged QTc of 500 milliseconds or more, and 3 patients (3%) had a change in QTc of 60 milliseconds or more. Of those who received concomitant azithromycin, 11 of 53 (21%) had prolonged QTc of 500 milliseconds or more and 7 of 53 (13 %) had a change in QTc of 60 milliseconds or more. The likelihood of prolonged QTc was greater in those who received concomitant loop diuretics (adjusted odds ratio, 3.38 [95% CI, 1.03-11.08]) or had a baseline QTc of 450 milliseconds or more (adjusted odds ratio, 7.11 [95% CI, 1.75-28.87]). Ten patients had hydroxychloroquine discontinued early because of potential adverse drug events, including intractable nausea, hypoglycemia, and 1 case of torsades de pointes.\nIn this cohort study, patients who received hydroxychloroquine for the treatment of pneumonia associated with COVID-19 were at high risk of QTc prolongation, and concurrent treatment with azithromycin was associated with greater changes in QTc. Clinicians should carefully weigh risks and benefits if considering hydroxychloroquine and azithromycin, with close monitoring of QTc and concomitant medication usage.", "topics": ["Th\u00e9rapeutique", "Transversale", "Cardiologie et maladies m\u00e9taboliques"], "author_list": [{"id": 493, "name": "Mercuro NJ"}], "publication_date": "2020-05-05"}, {"id": 623, "slug": "lifestyle-risk-factors-inflammatory-mechanisms-and-covid-19-hospitalization-a-co", "title": "Lifestyle Risk Factors, Inflammatory Mechanisms, and COVID-19 Hospitalization: A Community-Based Cohort Study of 387,109 Adults in UK", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Evaluer l'association entre facteurs de risque li\u00e9s au mode de vie (tabagisme, consommation d'alcool, inactivit\u00e9 physique, surpoids) et risque d'hospitalisation pour infection COVID-19.", "verbose_date": "25.05.2020", "authors": "Hamer M", "specialties": [{"id": 7, "name": "Transversale"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 109, "name": "Brain Behav Immun"}, "link": "https://www.sciencedirect.com/science/article/pii/S088915912030996X", "findings": "", "take_away": "", "relevance_level": "- Les RR pour chaque facteurs de risque li\u00e9s au mode de vie apr\u00e8s ajustement sont : 1,32 pour l'activit\u00e9 physique, 1,42 pour le tabagisme, 2,05 pour l'ob\u00e9sit\u00e9. Pas d'association significative pour la consommation excessive d'alcool.\n- Relation dose-effet entre score de facteurs de risque li\u00e9s au mode de vie et risque d'hospitalisation COVID-19, jusqu'\u00e0 x 4,41.\n- Un syndrome inflammatoire de bas niveau associ\u00e9 aux modes de vie \u00e0 risque pourrait m\u00e9dier ce risque observ\u00e9.\n- Fraction attribuable \u00e0 la population pour la combinaison tabagisme, inactivit\u00e9 physique et IMC>25 s'\u00e9levant \u00e0 51,4%.", "objectives": "- \u00e9tude de cohorte prospective- nombre de cas relativement faible- la p\u00e9riode d'int\u00e9r\u00eat est courte et tr\u00e8s \u00e9loign\u00e9e de la derni\u00e8re \u00e9valuation des facteurs de risque (> 10 ans)- biais de classement tr\u00e8s probable car l'\u00e9v\u00e8nement pris en compte est une hospitalisation avec un test SARS-CoV-2 positif (les tests \u00e9tant r\u00e9serv\u00e9s \u00e0 cette p\u00e9riode \u00e0 des personnes hospitalis\u00e9es et pr\u00e9sentant des sympt\u00f4mes compatibles COVID-19) et non pas des personnes avec diagnostic de COVID-19 s\u00e9v\u00e8re n\u00e9cessitant une hospitalisation au sens strict.- analyse de sous groupe semblant r\u00e9alis\u00e9e \u00e0 posteriori (non d\u00e9taill\u00e9e dans les m\u00e9thodes).- pre-proof", "methods": "Evaluer l'association entre facteurs de risque li\u00e9s au mode de vie (tabagisme, consommation d'alcool, inactivit\u00e9 physique, surpoids) et risque d'hospitalisation pour infection COVID-19.", "pubmed_id": "32454138", "doi": "10.1016/j.bbi.2020.05.059", "abstract": "We conducted the first large-scale general population study on lifestyle risk factors (smoking, physical inactivity, obesity, and excessive alcohol intake) for COVID-19 using prospective cohort data with national registry linkage to hospitalisation. Participants were 387,109 men and women (56.4\u00a0\u00b1\u00a08.8\u00a0yr; 55.1% women) residing in England from UK Biobank study. Physical activity, smoking, and alcohol intake, were assessed by questionnaire at baseline (2006-2010). Body mass index, from measured height and weight, was used as an indicator of overall obesity. Outcome was cases of COVID-19 serious enough to warrant a hospital admission from 16-March-2020 to 26-April-2020. There were 760 COVID-19 cases. After adjustment for age, sex and mutually for each lifestyle factor, physical inactivity (Relative risk, 1.32, 95% confidence interval, 1.10, 1.58), smoking (1.42;1.12, 1.79) and obesity (2.05 ;1.68, 2.49) but not heavy alcohol consumption (1.12; 0.93, 1.35) were all related to COVID-19. We also found a dose-dependent increase in risk of COVID-19 with less favourable lifestyle scores, such that participants in the most adverse category had 4-fold higher risk (4.41; 2.52-7.71) compared to people with the most optimal lifestyle. C-reactive protein levels were associated with elevated risk of COVID-19 in a dose-dependent manner, and partly (10-16%) explained associations between adverse lifestyle and COVID-19. Based on UK risk factor prevalence estimates, unhealthy behaviours in combination accounted for up to 51% of the population attributable fraction of severe COVID-19. Our findings suggest that an unhealthy lifestyle synonymous with an elevated risk of non-communicable disease is also a risk factor for COVID-19 hospital admission, which might be partly explained by low grade inflammation. Adopting simple lifestyle changes could lower the risk of severe infection.", "topics": ["Epid\u00e9miologique", "Transversale"], "author_list": [{"id": 586, "name": "Hamer M"}], "publication_date": "2020-05-25"}, {"id": 170, "slug": "turbulent-gas-clouds-and-respiratory-pathogen-emissions-potential-implications-f", "title": "Turbulent Gas Clouds and Respiratory Pathogen Emissions: Potential Implications for Reducing Transmission of COVID-19", "has_other_authors": false, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Pr\u00e9senter un nouveau mod\u00e8le de transmission et de caract\u00e9risation des gouttelettes pour les virus tels que le SRAS-CoV-2", "verbose_date": "27.03.2020", "authors": "Bourouiba L", "specialties": [{"id": 7, "name": "Transversale"}, {"id": 2, "name": "Hygi\u00e8ne"}], "category": {"id": 2, "name": "Autres", "icon": "icon-other"}, "journal": {"id": 23, "name": "JAMA"}, "link": "https://www.dropbox.com/s/fpjris70e80zf34/10.1001%40jama.2020.4756.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Proposition d'un nouveau mod\u00e8le de transmission du virus par voie a\u00e9rienne : les expectorations sont constitu\u00e9es de nuages de gaz contenant des gouttelettes de tailles diff\u00e9rentes (ayant surmont\u00e9 le mod\u00e8le dichotomique de Wells qui divisait les gouttelettes en petites et grandes).\n\r\nLa distance de s\u00e9curit\u00e9 entre les personnes recommand\u00e9e par l'OMS pour limiter la transmission de 1 m pourrait \u00eatre une distance sous-estim\u00e9e car\u00a0les gouttelettes transport\u00e9es par le nuage de gaz atteignent des distances de 7-8 m.\n\r\nL'\u00e9vaporation des gouttelettes, et donc leur survie sur les surfaces, d\u00e9pend non seulement de leur taille, mais aussi de la turbulence et de la vitesse du nuage de gaz et des conditions environnementales (humidit\u00e9 et temp\u00e9rature)", "objectives": "1) \u00c9ditorial", "methods": "Pr\u00e9senter un nouveau mod\u00e8le de transmission et de caract\u00e9risation des gouttelettes pour les virus tels que le SRAS-CoV-2", "pubmed_id": "32215590", "doi": "10.1001/jama.2020.4756", "abstract": null, "topics": ["Autres", "Transversale", "Hygi\u00e8ne"], "author_list": [{"id": 165, "name": "Bourouiba L"}], "publication_date": "2020-03-27"}, {"id": 630, "slug": "the-effect-of-control-strategies-to-reduce-social-mixing-on-outcomes-of-the-covi", "title": "The effect of control strategies to reduce social mixing on outcomes of the COVID-19 epidemic in Wuhan, China: a modelling study", "has_other_authors": true, "impact_factor": {"id": 3, "name": "Interm\u00e9diaire", "posts_count": 140, "color": "orange", "order": 2}, "goals_plain": "L'\u00e9tude vise \u00e0 pr\u00e9dire l'impact des mesures de confinement/d\u00e9confinement sur le nombre de personnes infect\u00e9es par le Covid19 \u00e0 Wuhan, en s'appuyant sur la connaissance des fr\u00e9quences de contact entre individus par classe d'\u00e2ge et par localisation des contacts (\u00e9cole, foyer, travail...)", "verbose_date": "25.05.2020", "authors": "Prem K", "specialties": [{"id": 21, "name": "Confinement/D\u00e9confinement"}], "category": {"id": 8, "name": "Mod\u00e9lisation", "icon": "icon-all"}, "journal": {"id": 140, "name": "Lancet Public Health"}, "link": "https://www.sciencedirect.com/science/article/pii/S2468266720300736", "findings": "", "take_away": "", "relevance_level": "En l'absence de certitudes sur certains param\u00e8tres \u00e9pid\u00e9miologiques, les auteurs concluent qu'un d\u00e9confinement tardif de Wuhan (Avril plut\u00f4t que Mars) devrait \u00eatre privil\u00e9gi\u00e9 par les autorit\u00e9s.", "objectives": "Mod\u00e8le int\u00e9ressant car prenant en compte la diversit\u00e9 des situations de contact social (\u00e9cole, famille, travail, etc.). Les incertitudes qui p\u00e8sent sur les param\u00e8tres du mod\u00e8le rendent son interpr\u00e9tation subtile.  Comme le font remarquer les auteurs, des mesures de confinement qui m\u00e8nent \u00e0 une plus grande compartimentation des interactions sociales devraient en toute logique \u00eatre trait\u00e9es avec un mod\u00e8le prenant en compte le r\u00e9seau des interactions au niveau individuel, ce que ce mod\u00e8le ne fait pas. Le traitement de la susceptibilit\u00e9/infectiosit\u00e9 des jeunes classes d'\u00e2ge serait probablement \u00e0 modifier compte tenu de ce que l'on sait d\u00e9sormais sur le Covid19 chez les sujets jeunes.", "methods": "L'\u00e9tude vise \u00e0 pr\u00e9dire l'impact des mesures de confinement/d\u00e9confinement sur le nombre de personnes infect\u00e9es par le Covid19 \u00e0 Wuhan, en s'appuyant sur la connaissance des fr\u00e9quences de contact entre individus par classe d'\u00e2ge et par localisation des contacts (\u00e9cole, foyer, travail...)", "pubmed_id": "32220655\n31995857\n15141212\n12713743\n32171059\n21771290\n3591813\n14562094\n16968863\n32046816\n18366252\n32027585\n32046819\n31986261\n12766206\n31978945\n12599052\n19364743\n9263464\n10470046\n19943919\n32353347\n32145768\n31387486\n31641189\n32014114\n28898249\n32105609\n32019669\n32150618\n22427793\n32112714\n29669545\n32322691", "doi": "10.1016/S2468-2667(20)30073-6", "abstract": "In December, 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus, emerged in Wuhan, China. Since then, the city of Wuhan has taken unprecedented measures in response to the outbreak, including extended school and workplace closures. We aimed to estimate the effects of physical distancing measures on the progression of the COVID-19 epidemic, hoping to provide some insights for the rest of the world.\nTo examine how changes in population mixing have affected outbreak progression in Wuhan, we used synthetic location-specific contact patterns in Wuhan and adapted these in the presence of school closures, extended workplace closures, and a reduction in mixing in the general community. Using these matrices and the latest estimates of the epidemiological parameters of the Wuhan outbreak, we simulated the ongoing trajectory of an outbreak in Wuhan using an age-structured susceptible-exposed-infected-removed (SEIR) model for several physical distancing measures. We fitted the latest estimates of epidemic parameters from a transmission model to data on local and internationally exported cases from Wuhan in an age-structured epidemic framework and investigated the age distribution of cases. We also simulated lifting of the control measures by allowing people to return to work in a phased-in way and looked at the effects of returning to work at different stages of the underlying outbreak (at the beginning of March or April).\nOur projections show that physical distancing measures were most effective if the staggered return to work was at the beginning of April; this reduced the median number of infections by more than 92% (IQR 66-97) and 24% (13-90) in mid-2020 and end-2020, respectively. There are benefits to sustaining these measures until April in terms of delaying and reducing the height of the peak, median epidemic size at end-2020, and affording health-care systems more time to expand and respond. However, the modelled effects of physical distancing measures vary by the duration of infectiousness and the role school children have in the epidemic.\nRestrictions on activities in Wuhan, if maintained until April, would probably help to delay the epidemic peak. Our projections suggest that premature and sudden lifting of interventions could lead to an earlier secondary peak, which could be flattened by relaxing the interventions gradually. However, there are limitations to our analysis, including large uncertainties around estimates of R\nBill & Melinda Gates Foundation, National Institute for Health Research, Wellcome Trust, and Health Data Research UK.", "topics": ["Mod\u00e9lisation", "Confinement/D\u00e9confinement"], "author_list": [{"id": 593, "name": "Prem K"}], "publication_date": "2020-05-25"}, {"id": 529, "slug": "covid-19-presenting-with-ophthalmoparesis-from-cranial-nerve-palsy", "title": "COVID-19 presenting with ophthalmoparesis from cranial nerve palsy", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Description de deux cas de patients pr\u00e9sentant une infection Covid-19 associ\u00e9e \u00e0 des neuropathies cr\u00e2niennes.", "verbose_date": "05.05.2020", "authors": "Dinkin M", "specialties": [{"id": 18, "name": "Neurologie"}], "category": {"id": 6, "name": "Pronostique", "icon": "icon-chat"}, "journal": {"id": 171, "name": "Neurology"}, "link": "https://n.neurology.org/content/neurology/early/2020/04/28/WNL.0000000000009700.full.pdf", "findings": "", "take_away": "", "relevance_level": "La survenue de sympt\u00f4mes neurologiques apr\u00e8s quelques jours du d\u00e9but de l'infection oriente vers une infection directe.\nDans le contexte de la pand\u00e9mie Covid-19, il faudrait consid\u00e9rer une infection au SARS-Cov-2 chez les patients qui pr\u00e9sentent des neuropathies cr\u00e2niennes m\u00eame avec une symptomatologie mod\u00e9r\u00e9e.\nD'autres \u00e9tudes sont n\u00e9cessaires pour comprendre l'histoire naturelle et le pronostic des neuropathies cr\u00e2niennes chez les patients avec une infection SARS-Cov-2 et d\u00e9terminer le meilleur traitement.", "objectives": "- Echantillon tr\u00e8s peu repr\u00e9sentatif- Donn\u00e9es limit\u00e9es (raison invoqu\u00e9e : limiter le risque de transmission).", "methods": "Description de deux cas de patients pr\u00e9sentant une infection Covid-19 associ\u00e9e \u00e0 des neuropathies cr\u00e2niennes.", "pubmed_id": "32358218", "doi": "10.1212/WNL.0000000000009700", "abstract": "Neurological complications of COVID-19 are not well described. We report two patients who were diagnosed with COVID-19 after presenting with diplopia and ophthalmoparesis.", "topics": ["Pronostique", "Neurologie"], "author_list": [{"id": 496, "name": "Dinkin M"}], "publication_date": "2020-05-05"}, {"id": 612, "slug": "artificial-intelligenceenabled-rapid-diagnosis-of-patients-with-covid-19", "title": "Artificial intelligence\u2013enabled rapid diagnosis of patients with COVID-19", "has_other_authors": true, "impact_factor": {"id": 3, "name": "Interm\u00e9diaire", "posts_count": 140, "color": "orange", "order": 2}, "goals_plain": "Evaluation d'un algorithme de diagnostic d'infection \u00e0 SARS-CoV-2 prenant en compte les donn\u00e9es cliniques, \u00e9pid\u00e9miologiques, et de scanner thoracique, utilisant l'intelligence artificielle.", "verbose_date": "20.05.2020", "authors": "Mei X", "specialties": [{"id": 5, "name": "Virologie"}, {"id": 12, "name": "Infectiologie"}, {"id": 3, "name": "Radiologie"}], "category": {"id": 3, "name": "Diagnostique", "icon": "icon-heat"}, "journal": {"id": 115, "name": "Nature Med"}, "link": "https://www.nature.com/articles/s41591-020-0931-3.pdf", "findings": "", "take_away": "", "relevance_level": "Face \u00e0 la p\u00e9nurie de test de d\u00e9pistage par RT-PCR, le scanner thoracique pourrait s'av\u00e9rer int\u00e9ressant. Cet article pr\u00e9sente un algorithme utilisant l'intelligence artificielle comme outil\u00a0diagnostique se basant sur les donn\u00e9es du scanner et les donn\u00e9es cliniques et biologiques. Les performances de l'algorithme semblent \u00eatre meilleures que celles du\u00a0radiologue de r\u00e9f\u00e9rence pour l'\u00e9chantillon donn\u00e9.\nDe plus amples \u00e9tudes seront cependant n\u00e9cessaires pour pouvoir confirmer les r\u00e9sultats.", "objectives": "- Etude r\u00e9trospective sur des effectifs r\u00e9duits (905 patients)- Population d'\u00e9tude avec beaucoup de patients COVID+ (g\u00e9n\u00e9ralisation non \u00e9vidente)", "methods": "Evaluation d'un algorithme de diagnostic d'infection \u00e0 SARS-CoV-2 prenant en compte les donn\u00e9es cliniques, \u00e9pid\u00e9miologiques, et de scanner thoracique, utilisant l'intelligence artificielle.", "pubmed_id": "32427924", "doi": "10.1038/s41591-020-0931-3", "abstract": "For diagnosis of coronavirus disease 2019 (COVID-19), a SARS-CoV-2 virus-specific reverse transcriptase polymerase chain reaction (RT-PCR) test is routinely used. However, this test can take up to 2\u2009d to complete, serial testing may be required to rule out the possibility of false negative results and there is currently a shortage of RT-PCR test kits, underscoring the urgent need for alternative methods for rapid and accurate diagnosis of patients with COVID-19. Chest computed tomography (CT) is a valuable component in the evaluation of patients with suspected SARS-CoV-2 infection. Nevertheless, CT alone may have limited negative predictive value for ruling out SARS-CoV-2 infection, as some patients may have normal radiological findings at early stages of the disease. In this study, we used artificial intelligence (AI) algorithms to integrate chest CT findings with clinical symptoms, exposure history and laboratory testing to rapidly diagnose patients who are positive for COVID-19. Among a total of 905 patients tested by real-time RT-PCR assay and next-generation sequencing RT-PCR, 419 (46.3%) tested positive for SARS-CoV-2. In a test set of 279 patients, the AI system achieved an area under the curve of 0.92 and had equal sensitivity as compared to a senior thoracic radiologist. The AI system also improved the detection of patients who were positive for COVID-19 via RT-PCR who presented with normal CT scans, correctly identifying 17 of 25 (68%) patients, whereas radiologists classified all of these patients as COVID-19 negative. When CT scans and associated clinical history are available, the proposed AI system can help to rapidly diagnose COVID-19 patients.", "topics": ["Diagnostique", "Virologie", "Infectiologie", "Radiologie"], "author_list": [{"id": 575, "name": "Mei X"}], "publication_date": "2020-05-20"}, {"id": 336, "slug": "prevalence-of-venous-thromboembolism-in-patients-with-severe-novel-coronavirus-p", "title": "Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "D\u00e9terminer l\u2019incidence de la MTEV et d\u00e9crire les caract\u00e9ristiques de sa population chez des patients atteints de pneumopathie s\u00e9v\u00e8re \u00e0 Covid-19 hospitalis\u00e9s en r\u00e9animation", "verbose_date": "15.04.2020", "authors": "Cui S", "specialties": [{"id": 7, "name": "Transversale"}, {"id": 4, "name": "Anesth\u00e9sie-R\u00e9animation"}, {"id": 17, "name": "Cardiologie et maladies m\u00e9taboliques"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 96, "name": "J Thromb Haemostasis"}, "link": "https://onlinelibrary.wiley.com/doi/epdf/10.1111/jth.14830", "findings": "", "take_away": "", "relevance_level": "Incidence \u00e9lev\u00e9e de thrombose veineuse des membres inf\u00e9rieurs (25%) parmis ces patients atteints de pneumopathie s\u00e9v\u00e8res \u00e0 Covid-19 en r\u00e9animation\r\nUn taux seuil de D-dim\u00e8res \u00e0 1,5 \u00b5g/mL pour aider le diagnostique pourrait \u00eatre int\u00e9ressant dans cette population.", "objectives": "Etude r\u00e9trospective, monocentrique, n = 81, tr\u00e8s peu d\u2019information sur les crit\u00e8res diagnostiques, a priori seules les thromboses veineuses des membres inf\u00e9rieurs ont \u00e9t\u00e9 comptabilis\u00e9es", "methods": "D\u00e9terminer l\u2019incidence de la MTEV et d\u00e9crire les caract\u00e9ristiques de sa population chez des patients atteints de pneumopathie s\u00e9v\u00e8re \u00e0 Covid-19 hospitalis\u00e9s en r\u00e9animation", "pubmed_id": "32271988", "doi": "10.1111/jth.14830", "abstract": "Three\u00a0months ago, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) broke out in Wuhan, China, and spread rapidly around the world. Severe novel coronavirus pneumonia (NCP) patients have abnormal blood coagulation function, but their venous thromboembolism (VTE) prevalence is still rarely mentioned.\nTo determine the incidence of VTE in patients with severe NCP.\nIn this study, 81 severe NCP patients in the intensive care unit (ICU) of Union Hospital (Wuhan, China) were enrolled. The results of conventional coagulation parameters and lower limb vein ultrasonography of these patients were retrospectively collected and analyzed.\nThe incidence of VTE in these patients was 25% (20/81), of which 8 patients with VTE events died. The VTE group was different from the non-VTE group in age, lymphocyte counts, activated partial thromboplastin time (APTT), D-dimer, etc. If 1.5\u00a0\u00b5g/mL was used as the D-dimer cut-off value to predicting VTE, the sensitivity was 85.0%, the specificity was 88.5%, and the negative predictive value (NPV) was 94.7%.\nThe incidence of VTE in patients with severe NCP is 25% (20/81), which may be related to poor prognosis. The significant increase of D-dimer in severe NCP patients is a good index for identifying high-risk groups of VTE.", "topics": ["Epid\u00e9miologique", "Transversale", "Anesth\u00e9sie-R\u00e9animation", "Cardiologie et maladies m\u00e9taboliques"], "author_list": [{"id": 323, "name": "Cui S"}], "publication_date": "2020-04-15"}, {"id": 552, "slug": "recognizing-covid-19-related-myocarditis-the-possible-pathophysiology-and-propos", "title": "Recognizing COVID-19-related myocarditis: the possible pathophysiology and proposed guideline for diagnosis and management", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Myocardite \u00e0 COVID, physiopathologie et propositions de recommandations pour le diagnostic et la prise en charge.", "verbose_date": "07.05.2020", "authors": "Siripanthong B", "specialties": [{"id": 4, "name": "Anesth\u00e9sie-R\u00e9animation"}, {"id": 17, "name": "Cardiologie et maladies m\u00e9taboliques"}], "category": {"id": 3, "name": "Diagnostique", "icon": "icon-heat"}, "journal": {"id": 216, "name": "Heart Rythm"}, "link": "https://www.sciencedirect.com/science/article/pii/S1547527120304227", "findings": "", "take_away": "", "relevance_level": "La physiopathologie semble \u00eatre une combinaison entre une atteinte par le virus directement et des atteintes cardiaques li\u00e9es \u00e0 la r\u00e9ponse immunitaire de l'h\u00f4te. Les signes cliniques retrouv\u00e9s sont des troubles ECG, des modifications des biomarqueurs et une alt\u00e9ration de la fonction cardiaque. L'IRM cardiaque est la r\u00e9f\u00e9rence et si non disponible, le coroscanner peut aider \u00e0 l'exclusion de maladie coronaire et identifier des signes d'inflammation myocardique. L'infarctus du myocarde doit toujours \u00eatre envisag\u00e9. La biopsie myocardique peut \u00eatre\u00a0envisag\u00e9e en cas de diagnostic incertain (PCR). L'arythmie est r\u00e9guli\u00e8rement retrouv\u00e9e sans que l'on connaisse r\u00e9ellement sa physiopathologie. Les patients doivent \u00eatre surveill\u00e9s et trait\u00e9s de mani\u00e8re adapt\u00e9e. L'\u00e9volution \u00e0 long-terme de ces patients, y compris les plus l\u00e9gers, reste inconnue.", "objectives": "M\u00e9thodologie non expliqu\u00e9e. Donn\u00e9es peu fiables actuellement car petites s\u00e9ries.", "methods": "Myocardite \u00e0 COVID, physiopathologie et propositions de recommandations pour le diagnostic et la prise en charge.", "pubmed_id": "32387246", "doi": "10.1016/j.hrthm.2020.05.001", "abstract": "Human coronavirus-associated myocarditis is known, and a number of coronavirus disease 19 (COVID-19)-related myocarditis cases have been reported. The pathophysiology of COVID-19-related myocarditis is thought to be a combination of direct viral injury and cardiac damage due to the host's immune response. COVID-19 myocarditis diagnosis should be guided by insights from previous coronavirus and other myocarditis experience. The clinical findings include changes in electrocardiogram and cardiac biomarkers, and impaired cardiac function. When cardiac magnetic resonance imaging is not feasible, cardiac computed tomographic angiography with delayed myocardial imaging may serve to exclude significant coronary artery disease and identify myocardial inflammatory patterns. Because many COVID-19 patients have cardiovascular comorbidities, myocardial infarction should be considered. If the diagnosis remains uncertain, an endomyocardial biopsy may help identify active cardiac infection through viral genome amplification and possibly refine the treatment risks of systemic immunosuppression. Arrhythmias are not uncommon in COVID-19 patients, but the pathophysiology is still speculative. Nevertheless, clinicians should be vigilant to provide prompt monitoring and treatment. The long-term impact of COVID-19 myocarditis, including the majority of mild cases, remains unknown.", "topics": ["Diagnostique", "Anesth\u00e9sie-R\u00e9animation", "Cardiologie et maladies m\u00e9taboliques"], "author_list": [{"id": 518, "name": "Siripanthong B"}], "publication_date": "2020-05-07"}, {"id": 206, "slug": "frequency-and-distribution-of-chest-radiographic-findings-in-covid-19-positive-p", "title": "Frequency and Distribution of Chest Radiographic Findings in COVID-19 Positive Patients", "has_other_authors": true, "impact_factor": {"id": 3, "name": "Interm\u00e9diaire", "posts_count": 140, "color": "orange", "order": 2}, "goals_plain": "D\u00e9crire l'\u00e9volution dans le temps et la gravit\u00e9 des signes en radiographie thoracique conventionnelle et les corr\u00e9ler avec les r\u00e9sultats de PCR pour le SARS-Cov-2", "verbose_date": "31.03.2020", "authors": "Wong HYF ", "specialties": [{"id": 3, "name": "Radiologie"}], "category": {"id": 3, "name": "Diagnostique", "icon": "icon-heat"}, "journal": {"id": 51, "name": "Radiology"}, "link": "https://www.dropbox.com/s/2um989xxrrn4l4z/radiol.2020201160.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Radiographie thoracique = moyen de diagnostic ou de suivi satisfaisant (Sensibilit\u00e9 de 69%) \u00e0 d\u00e9faut du scanner\r\nOn retrouve les m\u00eames signes radiographiques : consolidation et opacit\u00e9s en verre d\u00e9poli plut\u00f4t p\u00e9riph\u00e9riques et dans les zones inf\u00e9rieures avec dans la moiti\u00e9 des cas une atteinte bilat\u00e9rale. L'\u00e9panchement pleural est rare. Les signes sont r\u00e9solutifs en 12 jours.", "objectives": "- Cohorte h\u00e9t\u00e9rog\u00e8ne avec petit effectif dont la repr\u00e9sentativit\u00e9 est discutable de Hong-Kong- Examens plut\u00f4t bien conduits avec double lecture", "methods": "D\u00e9crire l'\u00e9volution dans le temps et la gravit\u00e9 des signes en radiographie thoracique conventionnelle et les corr\u00e9ler avec les r\u00e9sultats de PCR pour le SARS-Cov-2", "pubmed_id": "32216717\n32101510\n32017661\n32073353\n32083985\n32077789\n32132196\n29903755\n32134681\n32183934\n32100485\n32053470\n31986264\n32191587\n18195376\n32174129\n32113880", "doi": "10.1148/radiol.2020201160", "abstract": "Background Current COVID-19 radiological literature is dominated by CT and a detailed description of chest x-ray (CXR) appearances in relation to the disease time course is lacking. Purpose To describe the time course and severity of the CXR findings of COVID-19 and correlate these with real time reverse transcription polymerase chain reaction (RT-PCR) testing for SARS-Cov-2 nucleic acid. Materials and Methods Retrospective study of COVID-19 patients with RT-PCR confirmation and CXRs admitted across 4 hospitals evaluated between January and March 2020. Baseline and serial CXRs (total 255 CXRs) were reviewed along with RT-PCRs. Correlation with concurrent CTs (total 28 CTs) was made when available. Two radiologists scored each CXR in consensus for: consolidation, ground glass opacity (GGO), location and pleural fluid. A severity index was determined for each lung. The lung scores were summed to produce the final severity score. Results There were 64 patients (26 men, mean age 56\u00b119 years). Of these, 58, 44 and 38 patients had positive initial RT-PCR (91%, [CI: 81-96%]), abnormal baseline CXR (69%, [CI: 56-80%]) and positive initial RT-PCR with abnormal baseline CXR (59 [CI:46-71%]) respectively. Six patients (9%) showed CXR abnormalities before eventually testing positive on RT-PCR. Sensitivity of initial RT-PCR (91% [95% CI: 83-97%]) was higher than baseline CXR (69% [95% CI: 56-80%]) (", "topics": ["Diagnostique", "Radiologie"], "author_list": [{"id": 198, "name": "Wong HYF "}], "publication_date": "2020-03-31"}, {"id": 664, "slug": "to-isolate-or-not-to-isolate-a-theoretical-framework-for-disease-control-via-con", "title": "To isolate, or not to isolate: a theoretical framework for disease control via contact tracing.", "has_other_authors": true, "impact_factor": {"id": 4, "name": "Ind\u00e9termin\u00e9", "posts_count": 12, "color": "gray", "order": 4}, "goals_plain": "Le but de cet article est d'\u00e9tudier les moyens de contr\u00f4le d'une \u00e9pid\u00e9mie gr\u00e2ce \u00e0 un certain nombre de param\u00e8tres de contr\u00f4le : les tests permettant d'isoler des individus contagieux ; des m\u00e9canismes de distanciation sociale permettant de diminuer le taux de contagion ; et une application de suivi de contacts.", "verbose_date": "27.05.2020", "authors": "Lunz D", "specialties": [{"id": 21, "name": "Confinement/D\u00e9confinement"}, {"id": 12, "name": "Infectiologie"}], "category": {"id": 8, "name": "Mod\u00e9lisation", "icon": "icon-all"}, "journal": {"id": 85, "name": "Pre-prints"}, "link": "https://www.medrxiv.org/content/10.1101/2020.05.26.20113340v1.full.pdf", "findings": "", "take_away": "", "relevance_level": "Cet article utilise un mod\u00e8le type SIR pour \u00e9tudier l'impact d'une application de contact tracing, adoss\u00e9e \u00e0 des tests de d\u00e9pistage, sur l'\u00e9volution de l'\u00e9pid\u00e9mie. Il montre l'existence d'un choix optimal de seuil d'exposition qui minimise le nombre de personnes plac\u00e9es en quarantaine tout en \u00e9vitant la propagation de l'\u00e9pid\u00e9mie.", "objectives": "Ainsi que les auteurs l'indiquent, ce mod\u00e8le est bas\u00e9 sur une \u00e9tude \"en champ moyen\", et n'est par cons\u00e9quent valide que dans l'hypoth\u00e8se o\u00f9 le nombre d'infect\u00e9s repr\u00e9sente une proportion suffisamment petite de la population. De plus, ce mod\u00e8le type SIR sous-entend que toutes les \"\u00e9tapes\" par lesquelles passent des individus ont des dur\u00e9es exponentielles, y compris par exemple le temps pass\u00e9 en quarantaine. Cependant, il para\u00eet raisonnable de postuler que des \u00e9quations retard\u00e9es, ou bien  des mod\u00e8les individus-centr\u00e9s devraient montrer  des comportements similaires.\nPlusieurs d'hypoth\u00e8ses simplificatrices faites par les auteurs doivent \u00eatre mentionn\u00e9es : - la quarantaine est parfaite (un individu infect\u00e9 mis en quarantaine ne contamine personne, et les individus utilisant l'application respectent parfaitement la quarantaine), et le co\u00fbt de la mise en quarantaine des individus infect\u00e9s n'est pas consid\u00e9r\u00e9 ; - la distribution de la p\u00e9riode d'exposition subie par la population saine ne d\u00e9pend pas du nombre d'infect\u00e9s.\nC'est un article tr\u00e8s bien \u00e9crit, qui \u00e9tudie l'influence de plusieurs param\u00e8tres cl\u00e9s du mod\u00e8le de l'\u00e9pid\u00e9mie de COVID19 propos\u00e9. L'introduction de la notion d'exposition est probablement tr\u00e8s pertinente pour \u00e9tudier la probl\u00e9matique de contact-tracing.", "methods": "Le but de cet article est d'\u00e9tudier les moyens de contr\u00f4le d'une \u00e9pid\u00e9mie gr\u00e2ce \u00e0 un certain nombre de param\u00e8tres de contr\u00f4le : les tests permettant d'isoler des individus contagieux ; des m\u00e9canismes de distanciation sociale permettant de diminuer le taux de contagion ; et une application de suivi de contacts.", "topics": ["Mod\u00e9lisation", "Confinement/D\u00e9confinement", "Infectiologie"], "author_list": [{"id": 624, "name": "Lunz D"}], "publication_date": "2020-05-27"}, {"id": 628, "slug": "correlation-between-immune-response-and-self-reported-depression-during-convales", "title": "Correlation between immune response and self-reported depression during convalescence from COVID-19", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Etudier le lien entre la r\u00e9ponse immunitaire et la d\u00e9pression rapport\u00e9e par les patients COVID-19 convalescents lors de la quatorzaine post-hospitalisation.", "verbose_date": "27.05.2020", "authors": "Yuan B", "specialties": [{"id": 22, "name": "Immunit\u00e9"}, {"id": 6, "name": "Psychiatrie"}], "category": {"id": 6, "name": "Pronostique", "icon": "icon-chat"}, "journal": {"id": 109, "name": "Brain Behav Immun"}, "link": "https://www.dropbox.com/s/v7v4w49fmzn9hmh/10.1016%40j.bbi.2020.05.062.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Une d\u00e9pression autod\u00e9clar\u00e9e a \u00e9t\u00e9 observ\u00e9e \u00e0 un stade pr\u00e9coce chez les patients convalescents atteints de COVID-19, et des changements dans la fonction immunitaire \u00e9taient apparents au cours du suivi \u00e0 court terme de ces patients. Les patients souffrant de d\u00e9pression autod\u00e9clar\u00e9e ont pr\u00e9sent\u00e9 une r\u00e9ponse immunitaire accrue, comme l'indique l'augmentation du sang blanc le nombre de neutrophiles, ainsi que le rapport neutrophiles / lymphocytes.", "objectives": "Pre-proofQuestionnaire en ligne, monocentrique, avec donn\u00e9es d\u00e9claratives sur la d\u00e9pression n=96 avec r\u00e9ponse au questionnaire en ligne et biologique ?Beaucoup d'informations manquantes dans la m\u00e9thodologie et les r\u00e9sultatsDate des pr\u00e9l\u00e8vements sanguins ? Date par rapport au d\u00e9but des sympt\u00f4mes ? Analyse par rapport \u00e0 la ventilation m\u00e9canique, ECMO, etc... dans les formes s\u00e9v\u00e8res ?", "methods": "Etudier le lien entre la r\u00e9ponse immunitaire et la d\u00e9pression rapport\u00e9e par les patients COVID-19 convalescents lors de la quatorzaine post-hospitalisation.", "pubmed_id": "32464158\n4724142\n14221692\n31185948\n9224908\n23870425\n28697416\n30988501\n5172928\n15338536\n28645055\n29490259\n32032543\n21062471\n32226291\n26037806\n20015486\n27978453\n31994742\n15324539", "doi": "10.1016/j.bbi.2020.05.062", "abstract": "Self-reported depression has been observed in coronavirus disease-2019 (COVID-19) patients, infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), during discharge from the hospital. However, the cause of this self-reported depression during the convalescent period remains unclear. Here, we report the mental health status of 96 convalescent COVID-19 patients who were surveyed using an online questionnaire at the Shenzhen Samii Medical Center from March 2 to March 12, 2020 in Shenzhen, China. After obtaining their informed consent, we retrospectively analyzed the clinical characteristics of patients, including routine blood and biochemical data. The results suggested that patients with self-reported depression exhibited increased immune response, as indicated by increased white blood cell and neutrophil counts, as well as neutrophil-to-lymphocyte ratio. However, the mechanism linking self-reported depression to these cellular changes needs further study. In conclusion, self-reported depression occurred at an early stage in convalescent COVID-19 patients, and changes in immune function were apparent during short-term follow-up of these patients after discharge. Appropriate psychological interventions are necessary, and changes in immune function should be emphasized during long-term follow up of these patients.", "topics": ["Pronostique", "Immunit\u00e9", "Psychiatrie"], "author_list": [{"id": 591, "name": "Yuan B"}], "publication_date": "2020-05-27"}, {"id": 520, "slug": "hypolipidemia-is-associated-with-the-severity-of-covid-19", "title": "Hypolipidemia is associated with the severity of COVID-19", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Analyser le profil lipidique de patients COVID-19, par s\u00e9v\u00e9rit\u00e9, en comparaison \u00e0 celui de t\u00e9moins appari\u00e9s.", "verbose_date": "04.05.2020", "authors": "Wei X", "specialties": [{"id": 7, "name": "Transversale"}, {"id": 17, "name": "Cardiologie et maladies m\u00e9taboliques"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 206, "name": "J Clinical Lipid"}, "link": "https://www.dropbox.com/s/ozps848se1u5p1v/1-s2.0-S1933287420300787-main.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Les patients COVID-19 semblent pr\u00e9senter une hypolipid\u00e9mie, m\u00eame dans les formes l\u00e9g\u00e8res, int\u00e9ressant le cholest\u00e9rol total via le LDL-cholest\u00e9rol et le HDL-cholest\u00e9rol. Cette hypolipid\u00e9mie para\u00eet s'aggraver avec la s\u00e9v\u00e9rit\u00e9 de la maladie. Son \u00e9volution au cours de l'infection reste \u00e0 explorer ainsi que le(s) m\u00e9canisme(s) qui en sont \u00e0 l'origine.", "objectives": "- Etude r\u00e9trospective monocentrique (-)- Comparaison \u00e0 des t\u00e9moins appari\u00e9s sur l'\u00e2ge et le sexe (+)- Inclusion de patients hospitalis\u00e9s uniquement (-)- Crit\u00e8res d'\u00e9ligibilit\u00e9 non d\u00e9taill\u00e9s (-)- Pas d'exclusion des sujets avec ant\u00e9c\u00e9dent de dyslipid\u00e9mie (-)- Dosage chez les patients COVID-19 possiblement r\u00e9alis\u00e9 \u00e0 diff\u00e9rents stades de la maladie (-)- Pas de d\u00e9tail de l'\u00e9volution du bilan lipidique au cours de la maladie (-)- Risque de perturbation du bilan lipidique chez les patients COVID-19 s'\u00e9tant auto-m\u00e9diqu\u00e9s (-)- Effectif total cons\u00e9quent (+)- Groupe de patients COVID-19 critiques de faible effectif (-)", "methods": "Analyser le profil lipidique de patients COVID-19, par s\u00e9v\u00e9rit\u00e9, en comparaison \u00e0 celui de t\u00e9moins appari\u00e9s.", "pubmed_id": "32430154", "doi": "10.1016/j.jacl.2020.04.008", "abstract": "Many patients with coronavirus disease 2019 (COVID-19) suffer multiple organ dysfunctions. However, whether patients develop dyslipidemia is unknown.\nIn this study, we aimed to investigate the pathological alterations of low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), and total cholesterol (TC) in COVID-19 patients and their relationships with the disease severity.\nA retrospective study was performed to examine serum levels of LDL-c, HDL-c, and TC on 597 COVID-19 patients (mild: 394; severe, 171; critical: 32) who were hospitalized in our center between February 1 and March 3, 2020. Age- and gender-matched normal subjects (n\u00a0=\u00a050) who had routine laboratory lipid tests between October 1 and November 1, 2019 in our center were included as the control group.\nLDL-c and TC levels were significantly lower in COVID-19 patients as compared with normal subjects (P\u00a0<\u00a0.001). There were significant and gradual decreases in levels of LDL-c (median (IQR) in mg/dL, mild: 91 (76, 104); severe: 86 (69, 102); critical: 69 (48, 81); P\u00a0<\u00a0.02) and TC (mild: 173 (148, 203); severe: 167 (138, 197); critical: 125 (95, 162); P\u00a0<\u00a0.05) across all three groups. HDL-c levels only decreased significantly in critical cases as compared with levels in mild and severe cases. LDL-c and TC levels inversely correlated with C-reactive protein and interleukin-6, and positively correlated with the number of lymphocytes in patients.\nDevelopment of hypolipidemia begins in patients with mild symptoms. It progressively becomes worse in an association with the disease severity.", "topics": ["Epid\u00e9miologique", "Transversale", "Cardiologie et maladies m\u00e9taboliques"], "author_list": [{"id": 474, "name": "Wei X"}], "publication_date": "2020-05-04"}, {"id": 404, "slug": "venous-thrombosis-and-arteriosclerosis-obliterans-of-lower-extremities-in-a-very", "title": "Venous thrombosis and arteriosclerosis obliterans of lower extremities in a very severe patient with 2019 novel coronavirus disease: a case report", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Identification du risque de thrombose veineuse profonde et d'art\u00e9riopathie oblit\u00e9rante des membres inf\u00e9rieurs chez les patients COVID-19.", "verbose_date": "21.04.2020", "authors": "Zhou B", "specialties": [{"id": 7, "name": "Transversale"}, {"id": 17, "name": "Cardiologie et maladies m\u00e9taboliques"}], "category": {"id": 3, "name": "Diagnostique", "icon": "icon-heat"}, "journal": {"id": 96, "name": "J Thromb Haemostasis"}, "link": "https://link.springer.com/content/pdf/10.1007/s11239-020-02084-w.pdf", "findings": "", "take_away": "", "relevance_level": "La stratification du risque de thrombose veineuse profonde et d'art\u00e9riopathie oblit\u00e9rante est essentielle chez les patients atteints de COVID-19 pour r\u00e9duire la morbidit\u00e9 et la mortalit\u00e9.\r\nLes facteurs de risque pour le d\u00e9veloppement de ces pathologies chez les patients COVID-19 sont nombreux: hypercoagulation, stase sanguine, l\u00e9sions endoth\u00e9liales, taux \u00e9lev\u00e9 de cytokines et de TNF\u03b1 (IL 2, IL 7, IL 10, G CSF, IP 10, MCP 1, MIP 1 A), rhabdomyolyse et le d\u00e9s\u00e9quilibre \u00e9lectrolytique et l'acidose qui en r\u00e9sultent.", "objectives": "1) Case report\"", "methods": "Identification du risque de thrombose veineuse profonde et d'art\u00e9riopathie oblit\u00e9rante des membres inf\u00e9rieurs chez les patients COVID-19.", "topics": ["Diagnostique", "Transversale", "Cardiologie et maladies m\u00e9taboliques"], "author_list": [{"id": 386, "name": "Zhou B"}], "publication_date": "2020-04-21"}, {"id": 343, "slug": "neuropsychiatric-adverse-events-of-chloroquine-a-real-world-pharmacovigilance-st", "title": "Neuropsychiatric adverse events of chloroquine: A real-world pharmacovigilance study using the FAERS database", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Etudier le lien entre prise de chloroquine/mefloquine et le survenue d'effets secondaires neuropsychiatriques", "verbose_date": "15.04.2020", "authors": "Sato K", "specialties": [{"id": 7, "name": "Transversale"}, {"id": 6, "name": "Psychiatrie"}, {"id": 12, "name": "Infectiologie"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 85, "name": "Pre-prints"}, "link": "https://www.medrxiv.org/content/10.1101/2020.04.10.20061358v1.full.pdf", "findings": "", "take_away": "", "relevance_level": "Cette \u00e9tude sugg\u00e8re de la chloroquine et l'hydroxychloroquine pourraient engendrer des effets ind\u00e9sirables d'ordre neuropsychiatriques mais dont on ignore l'incidence. Ces r\u00e9sultats seraient \u00e0 valider \u00e0 l'aide d'une \u00e9tude de cohorte.", "objectives": "- biais de notification (possibilit\u00e9 d'une sur- ou d'une sous-d\u00e9claration des effets ind\u00e9sirables neuropsychiatriques)- calcul de l'incidence de ces effets ind\u00e9sirables impossible avec ces donn\u00e9es- pas de prise en compte de l'utilisation simultan\u00e9e d'autres m\u00e9dicaments ou des ant\u00e9c\u00e9dents personnels- la notion de suicide pouvait \u00eatre confondue avec intoxication m\u00e9dicamenteuse volontaire avec la chloroquine/mefloquine- pas de prise en compte du d\u00e9lai entre prise et survenue de l'effet ind\u00e9sirable, ni de la dose utilis\u00e9e", "methods": "Etudier le lien entre prise de chloroquine/mefloquine et le survenue d'effets secondaires neuropsychiatriques", "topics": ["Epid\u00e9miologique", "Transversale", "Psychiatrie", "Infectiologie"], "author_list": [{"id": 329, "name": "Sato K"}], "publication_date": "2020-04-15"}, {"id": 668, "slug": "group-testing-as-a-strategy-for-the-epidemiologic-monitoring-of-covid-19", "title": "Group testing as a strategy for the epidemiologic monitoring of COVID-19", "has_other_authors": true, "impact_factor": {"id": 4, "name": "Ind\u00e9termin\u00e9", "posts_count": 12, "color": "gray", "order": 4}, "goals_plain": "L'article d\u00e9crit une m\u00e9thodologie statistique pour \u00e9valuer la pr\u00e9valence de la maladie dans une population en s'appuyant sur une strat\u00e9gie de \"Group testing\" afin d'\u00e9conomiser le nombre de tests RT-PCR utilis\u00e9s. Diff\u00e9rents scenarii sont d\u00e9taill\u00e9s.", "verbose_date": "08.06.2020", "authors": "Brault V", "specialties": [{"id": 12, "name": "Infectiologie"}], "category": {"id": 8, "name": "Mod\u00e9lisation", "icon": "icon-all"}, "journal": {"id": 85, "name": "Pre-prints"}, "link": "https://arxiv.org/abs/2005.06776", "findings": "", "take_away": "", "relevance_level": "Tr\u00e8s bonne approche m\u00e9thodologique avec une r\u00e9daction de l'article tr\u00e8s p\u00e9dagogique. Des donn\u00e9es de RT-PCR suppl\u00e9mentaires seraient n\u00e9cessaires pour valider l'approche statistique dans diff\u00e9rents contextes ou diff\u00e9rents protocoles de collecte d'\u00e9chantillons biologiques pour estimer la charge virale.", "objectives": "L'article est tr\u00e8s bien r\u00e9dig\u00e9 car le lecteur est guid\u00e9 en partant d'un cas id\u00e9aliste o\u00f9 il n'existe pas de faux n\u00e9gatifs dans les tests PCR. Sur cette base, un premier mod\u00e8le est d\u00e9crit pour estimer un intervalle de confiance de la pr\u00e9valence de la maladie en utilisant une strat\u00e9gie de group testing. Ce mod\u00e8le est ensuite enrichi pour prendre en compte le cas r\u00e9el avec des faux n\u00e9gatifs. Pour cela, un jeu de donn\u00e9es publiques a \u00e9t\u00e9 utilis\u00e9. Il serait fort int\u00e9ressant de pouvoir appliquer la m\u00eame m\u00e9thodologie sur d'autres jeux de donn\u00e9es afin d'\u00e9valuer comment l'approche peut se g\u00e9n\u00e9raliser et donc ainsi envisager son utilisation dans un contexte \u00e9pid\u00e9miologique/clinique.", "methods": "L'article d\u00e9crit une m\u00e9thodologie statistique pour \u00e9valuer la pr\u00e9valence de la maladie dans une population en s'appuyant sur une strat\u00e9gie de \"Group testing\" afin d'\u00e9conomiser le nombre de tests RT-PCR utilis\u00e9s. Diff\u00e9rents scenarii sont d\u00e9taill\u00e9s.", "topics": ["Mod\u00e9lisation", "Infectiologie"], "author_list": [{"id": 627, "name": "Brault V"}], "publication_date": "2020-06-08"}, {"id": 73, "slug": "lower-mortality-of-covid-19-by-early-recognition-and-intervention-experience-fro", "title": "Lower mortality of COVID-19 by early recognition and intervention: experience from Jiangsu Province", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "d\u00e9crire leur prise en charge th\u00e9rapeutique adopt\u00e9e dans leur r\u00e9gion de Chine", "verbose_date": "18.03.2020", "authors": "Sun Q", "specialties": [{"id": 4, "name": "Anesth\u00e9sie-R\u00e9animation"}], "category": {"id": 4, "name": "Th\u00e9rapeutique", "icon": "icon-med"}, "journal": {"id": 58, "name": "Ann Intensive Care"}, "link": "https://www.dropbox.com/s/4hh7n6qanct2jv6/s13613-020-00650-2.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Description de leur PEC :- d\u00e9pistage pr\u00e9coce- tous les patients PC \u00e9taient d\u00e9pist\u00e9s ensuite 2 fois tous les jours, - fr\u00e9quence respiratoire, fr\u00e9quence cardiaque, sauration en O2 \u00e9taient monitor\u00e9s r\u00e9guli\u00e8rement- si sat<93%, FR>30/min, FC>120/min ou tout autre signe de d\u00e9faillance d'organe \u00e9tait enregistr\u00e9, les patients \u00e9taient transf\u00e9r\u00e9s en soins intensifsL'\u00e2ge, le taux de lymphocytes, l'apport d'O2 et les images radiologiques de l\u00e9sions pulmonaires sont des facteurs de risque ind\u00e9pendants de progression de PC vers une forme s\u00e9v\u00e8re. Ils ont \u00e9tabli un syst\u00e8me d'alerte pr\u00e9coce combinant ces 4 facteurs pour identifier les patients \u00e0 haut risque et les garder sous monitorage \u00e9troit. 3 points ont montr\u00e9 leur efficacit\u00e9 dans le traitement et pr\u00e9viennent l'intubation :- pour les patients en SDRA ou avec des l\u00e9sions extensives au scan thoracique : oxyg\u00e8ne aux lunettes, haut d\u00e9bit ou ventilation m\u00e9canique non invasive \u00e9taient utilis\u00e9s- une r\u00e9animation liquidienne restrictive dans le cadre d'une perfusion tissulaire ad\u00e9quate est r\u00e9alis\u00e9e pour soulager l'oed\u00e8me pulmonaire- une position d\u00e9cubitus ventral pendant l'\u00e9veil a montr\u00e9 des effets significatifs sur l'oxyg\u00e9ation", "objectives": "Faible - lettre \u00e0 l'\u00e9diteur - description d'une \u00e9tude retrospective mais pas de chiffres publi\u00e9s - plus de 600 cas de pneumonie \u00e0 coronavirus dans cette province", "methods": "d\u00e9crire leur prise en charge th\u00e9rapeutique adopt\u00e9e dans leur r\u00e9gion de Chine", "pubmed_id": "32189136\n23688302\n32040667\n31978945\n30416787\n32035507\n32014114\n32031570\n31986264\n32043978\n32123994\n32123989\n32032529\n32035533\n32004066\n32043983", "doi": "10.1186/s13613-020-00650-2", "abstract": null, "topics": ["Th\u00e9rapeutique", "Anesth\u00e9sie-R\u00e9animation"], "author_list": [{"id": 83, "name": "Sun Q"}], "publication_date": "2020-03-18"}, {"id": 166, "slug": "clinical-and-microbiological-effect-of-a-combination-of-hydroxychloroquine-and-a", "title": "Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: an observational study", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Explorer la charge virale par culture celllulaire comme outil pour la contagiosit\u00e9 et donc d\u00e9terminer la sortie des patients des services de maladies infectieuses", "verbose_date": "27.03.2020", "authors": "La Scola B ", "specialties": [{"id": 5, "name": "Virologie"}], "category": {"id": 6, "name": "Pronostique", "icon": "icon-chat"}, "journal": {"id": 85, "name": "Pre-prints"}, "link": "https://www.dropbox.com/s/6a00hh1etucfd44/La-Scola-et-al.3-IHU-draft.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Propose la culture cellulaire pour d\u00e9terminer la sortie des patients COVID-19 : si Ct >= \u00e0 34, sortie possible", "objectives": "1) Pre-print (pas encore de reviewing)2) Non indiqu\u00e9 si \u00e9valuation en aveugle3) 129 cultures cellulaires possibles / 183 RT PCR + (70%)4) Dans d'autres \u00e9tudes, \u00e9chantillons de selles positifs plus longtemps (voir article Prolonged presence of SRAS-CoV-2 viral RNA in faecal samples)5) Co\u00fbt et faisabilit\u00e9 d'une telle m\u00e9thode (temps d'obtention des r\u00e9sultats, mat\u00e9riel dans les labos?)6) \"\"Sur la base de ces donn\u00e9es, nous pouvons d\u00e9duire qu'avec notre syst\u00e8me, les patients avec des valeurs Ct \u00e9gales ou sup\u00e9rieures \u00e0 34 n'excr\u00e8tent pas de particules virales infectieuses\"\" mais in vitro\"", "methods": "Explorer la charge virale par culture celllulaire comme outil pour la contagiosit\u00e9 et donc d\u00e9terminer la sortie des patients des services de maladies infectieuses", "topics": ["Pronostique", "Virologie"], "author_list": [{"id": 161, "name": "La Scola B "}], "publication_date": "2020-03-27"}, {"id": 662, "slug": "acute-myocarditis-and-multisystem-inflammatory-emerging-disease-following-sars-c", "title": "Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "D\u00e9crire les caract\u00e9ristiques, la prise en charge et l'\u00e9volution clinique d'enfants admis en soins intensifs p\u00e9diatriques suite \u00e0 un choc cardiog\u00e9nique secondaire \u00e0 une myocardite aigu\u00eb avec une suspicion d'infection \u00e0 SARS-CoV-2.", "verbose_date": "05.06.2020", "authors": "Grimaud M", "specialties": [{"id": 4, "name": "Anesth\u00e9sie-R\u00e9animation"}, {"id": 12, "name": "Infectiologie"}, {"id": 9, "name": "P\u00e9diatrie"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 58, "name": "Ann Intensive Care"}, "link": "https://annalsofintensivecare.springeropen.com/track/pdf/10.1186/s13613-020-00690-8", "findings": "", "take_away": "", "relevance_level": "Sur une s\u00e9rie de 20 enfants :\n- Age m\u00e9dian 10 ans (2,9-15) avec autant de filles que de gar\u00e7ons\n- Fi\u00e8vre + douleurs abdominales intenses + vomissements initialement (n=20)\n- Tableau de choc (20 hypotendus et tachycardes) sur myocardite aigu\u00eb (FEVG m\u00e9diane 35%) \u00e0 l'admission (m\u00e9diane 6 jours)\n-\u00a0 Syndrome inflammatoire (CRP m\u00e9diane 94 mg/L) sans cause microbienne autre que SARS-CoV-2 (19 pr\u00e9sentant une PCR et/ou une s\u00e9rologie positive, 1 pr\u00e9sentant un scanner thoracique typique)\n- Tous on n\u00e9cessit\u00e9 un support inotrope positif initial et ont \u00e9t\u00e9 trait\u00e9s par immunoglobulines IV \u00e0 2g/kg\n- Tous ont surv\u00e9cu et r\u00e9cup\u00e9r\u00e9 un FEVG normal \u00e0 leur sortie.", "objectives": "- Etude observationnelle descriptive r\u00e9trospective", "methods": "D\u00e9crire les caract\u00e9ristiques, la prise en charge et l'\u00e9volution clinique d'enfants admis en soins intensifs p\u00e9diatriques suite \u00e0 un choc cardiog\u00e9nique secondaire \u00e0 une myocardite aigu\u00eb avec une suspicion d'infection \u00e0 SARS-CoV-2.", "pubmed_id": "32488505\n32187458\n32030529\n32318865\n32345617\n32267485\n22273753\n19403470\n32347323\n28356445\n32219363\n32320004\n32293910\n32219357\n32211816", "doi": "10.1186/s13613-020-00690-8", "abstract": "A recent increase in children admitted with hypotensive shock and fever in the context of the COVID-19 outbreak requires an urgent characterization and assessment of the involvement of SARS-CoV-2 infection. This is a case series performed at 4 academic tertiary care centers in Paris of all the children admitted to the pediatric intensive care unit (PICU) with shock, fever and suspected SARS-CoV-2 infection between April 15th and April 27th, 2020.\n20 critically ill children admitted for shock had an acute myocarditis (left ventricular ejection fraction, 35% (25-55); troponin, 269\u00a0ng/mL (31-4607)), and arterial hypotension with mainly vasoplegic clinical presentation. The first symptoms before PICU admission were intense abdominal pain and fever for 6\u00a0days (1-10). All children had highly elevated C-reactive protein (>\u200994\u00a0mg/L) and procalcitonin (>\u20091.6\u00a0ng/mL) without microbial cause. At least one feature of Kawasaki disease was found in all children (fever, n\u2009=\u200920, skin rash, n\u2009=\u200910; conjunctivitis, n\u2009=\u20096; cheilitis, n\u2009=\u20095; adenitis, n\u2009=\u20092), but none had the typical form. SARS-CoV-2 PCR and serology were positive for 10 and 15 children, respectively. One child had both negative SARS-CoV-2 PCR and serology, but had a typical SARS-CoV-2 chest tomography scan. All children but one needed an inotropic/vasoactive drug support (epinephrine, n\u2009=\u200912; milrinone, n\u2009=\u200910; dobutamine, n\u2009=\u20096, norepinephrine, n\u2009=\u20094) and 8 were intubated. All children received intravenous immunoglobulin (2\u00a0g per kilogram) with adjuvant corticosteroids (n\u2009=\u20092), IL 1 receptor antagonist (n\u2009=\u20091) or a monoclonal antibody against IL-6 receptor (n\u2009=\u20091). All children survived and were afebrile with a full left ventricular function recovery at PICU discharge.\nAcute myocarditis with intense systemic inflammation and atypical Kawasaki disease is an emerging severe pediatric disease following SARS-CoV-2 infection. Early recognition of this disease is needed and referral to an expert center is recommended. A delayed and inappropriate host immunological response is suspected. While underlying mechanisms remain unclear, further investigations are required to target an optimal treatment.", "topics": ["Epid\u00e9miologique", "Anesth\u00e9sie-R\u00e9animation", "Infectiologie", "P\u00e9diatrie"], "author_list": [{"id": 622, "name": "Grimaud M"}], "publication_date": "2020-06-05"}, {"id": 256, "slug": "the-cardiovascular-burden-of-coronavirus-disease-2019-covid-19-with-a-focus-on-c", "title": "The cardiovascular burden of coronavirus disease 2019 (COVID-19) with a focus on congenital heart disease", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "R\u00e9sumer les effets cardiaques d'une infection \u00e0 SARS-CoV-2 et les implications possibles pour les patients atteints de pathologies cardiaques cong\u00e9nitales.", "verbose_date": "07.04.2020", "authors": "Tan W", "specialties": [{"id": 7, "name": "Transversale"}, {"id": 17, "name": "Cardiologie et maladies m\u00e9taboliques"}], "category": {"id": 2, "name": "Autres", "icon": "icon-other"}, "journal": {"id": 122, "name": "Int J Cardiol"}, "link": "https://www.internationaljournalofcardiology.com/article/S0167-5273(20)31593-X/pdf", "findings": "", "take_away": "", "relevance_level": "- Du fait de l'impact cardiaque du COVID-19, les patients atteint de pathologies cardiovasculaire cong\u00e9nitales sont \u00e0 haut risque\r\n- Manque de donn\u00e9e sur cette population \u00e0 risque\r\n- N\u00e9cessit\u00e9 d'\u00e9tudier les sp\u00e9cificit\u00e9s de l'infection dans cette population", "objectives": "- Pas de donn\u00e9e ou \u00e9tudes sur les infections \u00e0 SARS-CoV-2 chez les patients atteints de pathologie cardiovasculaire cong\u00e9nitales.- Beaucoup d'\u00e9l\u00e9ments rapport\u00e9s non prouv\u00e9s\"", "methods": "R\u00e9sumer les effets cardiaques d'une infection \u00e0 SARS-CoV-2 et les implications possibles pour les patients atteints de pathologies cardiaques cong\u00e9nitales.", "pubmed_id": "32248966", "doi": "10.1016/j.ijcard.2020.03.063", "abstract": "Coronavirus disease 2019 (COVID-19), caused by a novel betacoronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first described in a cluster of patients presenting with pneumonia symptoms in Wuhan, China, in December of 2019. Over the past few months, COVID-19 has developed into a worldwide pandemic, with over 400,000 documented cases globally as of March 24, 2020. The SARS-CoV-2 virus is most likely of zoonotic origin, but has been shown to have effective human-to-human transmission. COVID-19 results in mild symptoms in the majority of infected patients, but can cause severe lung injury, cardiac injury, and death. Given the novel nature of COVID-19, no established treatment beyond supportive care exists currently, but extensive public-health measures to reduce person-to-person transmission of COVID-19 have been implemented globally to curb the spread of disease, reduce the burden on healthcare systems, and protect vulnerable populations, including the elderly and those with underlying medical comorbidities. Since this is an emerging infectious disease, there is, as of yet, limited data on the effects of this infection on patients with cardiovascular disease, particularly so for those with congenital heart disease. We summarize herewith the early experience with COVID-19 and consider the potential applicability to and implications for patients with cardiovascular disease in general and congenital heart disease in particular.", "topics": ["Autres", "Transversale", "Cardiologie et maladies m\u00e9taboliques"], "author_list": [{"id": 245, "name": "Tan W"}], "publication_date": "2020-04-07"}, {"id": 85, "slug": "lidocaine-during-intubation-and-extubation-in-patients-with-coronavirus-disease-", "title": "Lidocaine during intubation and extubation in patients with coronavirus disease (COVID-19)", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Proposer une m\u00e9thode pour r\u00e9duire la toux induite par l'intubation et l'extubation (administration intraveineuse d'une dose unique de lidoca\u00efne)", "verbose_date": "16.03.2020", "authors": "Aminnejad R", "specialties": [{"id": 4, "name": "Anesth\u00e9sie-R\u00e9animation"}], "category": {"id": 4, "name": "Th\u00e9rapeutique", "icon": "icon-med"}, "journal": {"id": 64, "name": "Can J Anaesth"}, "link": "https://www.dropbox.com/s/lxhbheqy5rlog0t/Aminnejad2020_Article_LidocaineDuringIntubationAndEx.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "L'administration intraveineuse de lidoca\u00efne pendant la pr\u00e9-intubation et avant l'extubation r\u00e9duit le m\u00e9canisme de la toux induite (voie de transmission interhumaine de SARS-CoV-2). Pas d'effets secondaires significatifs.", "objectives": "Faible 1) Lettre \u00e0 l'\u00e9diteur 2) Nombre des cas analys\u00e9s inconnu", "methods": "Proposer une m\u00e9thode pour r\u00e9duire la toux induite par l'intubation et l'extubation (administration intraveineuse d'une dose unique de lidoca\u00efne)", "pubmed_id": "32180173", "doi": "10.1007/s12630-020-01627-2", "abstract": null, "topics": ["Th\u00e9rapeutique", "Anesth\u00e9sie-R\u00e9animation"], "author_list": [{"id": 95, "name": "Aminnejad R"}], "publication_date": "2020-03-16"}, {"id": 591, "slug": "an-outbreak-of-severe-kawasaki-like-disease-at-the-italian-epicentre-of-the-sars", "title": "An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "D\u00e9crire l'incidence et les caract\u00e9ristiques des nouveaux patients atteints de la maladie de Kawasaki admis dans un centre hospitalier de Bergame pendant l'\u00e9pid\u00e9mie de SARS-CoV-2.", "verbose_date": "15.05.2020", "authors": "Verdoni L", "specialties": [{"id": 4, "name": "Anesth\u00e9sie-R\u00e9animation"}, {"id": 12, "name": "Infectiologie"}, {"id": 17, "name": "Cardiologie et maladies m\u00e9taboliques"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 12, "name": "Lancet"}, "link": "https://www.thelancet.com/action/showPdf?pii=S0140-6736%2820%2931103-X", "findings": "", "take_away": "", "relevance_level": "Dans la r\u00e9gion de Bergame en Italie, Incidence 30 fois plus \u00e9lev\u00e9e de la maladie\u00a0de Kawasaki.\nLes enfants diagnostiqu\u00e9s apr\u00e8s le d\u00e9but de l'\u00e9pid\u00e9mie de SARS-CoV-2 ont montr\u00e9 des signes de r\u00e9ponse immunitaire au virus, \u00e9taient plus \u00e2g\u00e9s, avaient un taux plus \u00e9lev\u00e9 d'atteinte cardiaque et des caract\u00e9ristiques de SAM. L'\u00e9pid\u00e9mie de SRAS-CoV-2 \u00e9tait associ\u00e9e \u00e0 une incidence \u00e9lev\u00e9e d'une forme grave de la maladie de Kawasaki.\nUne \u00e9pid\u00e9mie similaire de maladie de type Kawasaki est attendue dans les pays touch\u00e9s par l'\u00e9pid\u00e9mie de SARS-CoV-2.", "objectives": "S\u00e9rie de cas, n=10 cas depuis f\u00e9vrier 2020 (+19 cas sur les 5 ann\u00e9es pr\u00e9c\u00e9dentes)Monocentrique", "methods": "D\u00e9crire l'incidence et les caract\u00e9ristiques des nouveaux patients atteints de la maladie de Kawasaki admis dans un centre hospitalier de Bergame pendant l'\u00e9pid\u00e9mie de SARS-CoV-2.", "pubmed_id": "32410760", "doi": "10.1016/S0140-6736(20)31103-X", "abstract": "The Bergamo province, which is extensively affected by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic, is a natural observatory of virus manifestations in the general population. In the past month we recorded an outbreak of Kawasaki disease; we aimed to evaluate incidence and features of patients with Kawasaki-like disease diagnosed during the SARS-CoV-2 epidemic.\nAll patients diagnosed with a Kawasaki-like disease at our centre in the past 5 years were divided according to symptomatic presentation before (group 1) or after (group 2) the beginning of the SARS-CoV-2 epidemic. Kawasaki- like presentations were managed as Kawasaki disease according to the American Heart Association indications. Kawasaki disease shock syndrome (KDSS) was defined by presence of circulatory dysfunction, and macrophage activation syndrome (MAS) by the Paediatric Rheumatology International Trials Organisation criteria. Current or previous infection was sought by reverse-transcriptase quantitative PCR in nasopharyngeal and oropharyngeal swabs, and by serological qualitative test detecting SARS-CoV-2 IgM and IgG, respectively.\nGroup 1 comprised 19 patients (seven boys, 12 girls; aged 3\u00b70 years [SD 2\u00b75]) diagnosed between Jan 1, 2015, and Feb 17, 2020. Group 2 included ten patients (seven boys, three girls; aged 7\u00b75 years [SD 3\u00b75]) diagnosed between Feb 18 and April 20, 2020; eight of ten were positive for IgG or IgM, or both. The two groups differed in disease incidence (group 1 vs group 2, 0\u00b73 vs ten per month), mean age (3\u00b70 vs 7\u00b75 years), cardiac involvement (two of 19 vs six of ten), KDSS (zero of 19 vs five of ten), MAS (zero of 19 vs five of ten), and need for adjunctive steroid treatment (three of 19 vs eight of ten; all p<0\u00b701).\nIn the past month we found a 30-fold increased incidence of Kawasaki-like disease. Children diagnosed after the SARS-CoV-2 epidemic began showed evidence of immune response to the virus, were older, had a higher rate of cardiac involvement, and features of MAS. The SARS-CoV-2 epidemic was associated with high incidence of a severe form of Kawasaki disease. A similar outbreak of Kawasaki-like disease is expected in countries involved in the SARS-CoV-2 epidemic.\nNone.", "topics": ["Epid\u00e9miologique", "Anesth\u00e9sie-R\u00e9animation", "Infectiologie", "Cardiologie et maladies m\u00e9taboliques"], "author_list": [{"id": 555, "name": "Verdoni L"}], "publication_date": "2020-05-15"}, {"id": 665, "slug": "association-of-hypertension-and-antihypertensive-treatment-with-covid-19-mortali", "title": "Association of hypertension and antihypertensive treatment with COVID-19 mortality: a retrospective observational study", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Tester l'hypoth\u00e8se selon laquelle le traitement de l'hypertension, en particulier avec les inhibiteurs du SRAA, pourrait avoir un impact sur la mortalit\u00e9 des patients atteints de COVID-19.", "verbose_date": "08.06.2020", "authors": "Gao C", "specialties": [{"id": 12, "name": "Infectiologie"}, {"id": 17, "name": "Cardiologie et maladies m\u00e9taboliques"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 34, "name": "Eur Heart J"}, "link": "https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehaa433/5851436", "findings": "", "take_away": "", "relevance_level": "Les patients trait\u00e9s par des inhibiteurs du SRAA n'ont pas \u00e9t\u00e9 expos\u00e9s \u00e0 un risque de mortalit\u00e9 plus \u00e9lev\u00e9 dans cette \u00e9tude et une m\u00e9ta-analyse dans laquelle les donn\u00e9es publi\u00e9es pr\u00e9c\u00e9demment ont \u00e9t\u00e9 regroup\u00e9es a montr\u00e9 que l'utilisation d'inhibiteurs du SRAA pouvait \u00eatre associ\u00e9e \u00e0 un risque de mortalit\u00e9 plus faible. N\u00e9anmoins, en raison de la nature observationnelle de l'\u00e9tude, les r\u00e9sultats doivent \u00eatre interpr\u00e9t\u00e9s avec prudence et consid\u00e9r\u00e9s comme ne pr\u00e9sentant aucun risque suppl\u00e9mentaire \u00e9vident de poursuivre l'utilisation des inhibiteurs du SRAA chez les patients atteints d'une infection par COVID-19.", "objectives": "-\t\u00c9tude observationnelle r\u00e9trospective monocentrique-\tBien que l'\u00e9tude actuelle ait recrut\u00e9 2 877 patients, seuls 183 patients avec des inhibiteurs du SRAA et 527 patients avec des inhibiteurs non-SRAA ont \u00e9t\u00e9 compar\u00e9s. Les conclusions doivent \u00eatre interpr\u00e9t\u00e9es avec prudence.", "methods": "Tester l'hypoth\u00e8se selon laquelle le traitement de l'hypertension, en particulier avec les inhibiteurs du SRAA, pourrait avoir un impact sur la mortalit\u00e9 des patients atteints de COVID-19.", "pubmed_id": "32498076", "doi": "10.1093/eurheartj/ehaa433", "abstract": "It remains unknown whether the treatment of hypertension influences the mortality of patients diagnosed with coronavirus disease 2019 (COVID-19).\nThis is a retrospective observational study of all patients admitted with COVID-19 to Huo Shen Shan Hospital. The hospital was dedicated solely to the treatment of COVID-19 in Wuhan, China. Hypertension and the treatments were stratified according to the medical history or medications administrated prior to the infection. Among 2877 hospitalized patients, 29.5% (850/2877) had a history of hypertension. After adjustment for confounders, patients with hypertension had a two-fold increase in the relative risk of mortality as compared with patients without hypertension [4.0% vs. 1.1%, adjusted hazard ratio (HR) 2.12, 95% confidence interval (CI) 1.17-3.82, P = 0.013]. Patients with a history of hypertension but without antihypertensive treatment (n = 140) were associated with a significantly higher risk of mortality compared with those with antihypertensive treatments (n = 730) (7.9% vs. 3.2%, adjusted HR 2.17, 95% CI 1.03-4.57, P = 0.041). The mortality rates were similar between the renin-angiotensin-aldosterone system (RAAS) inhibitor (4/183) and non-RAAS inhibitor (19/527) cohorts (2.2% vs. 3.6%, adjusted HR 0.85, 95% CI 0.28-2.58, P = 0.774). However, in a study-level meta-analysis of four studies, the result showed that patients with RAAS inhibitor use tend to have a lower risk of mortality (relative risk 0.65, 95% CI 0.45-0.94, P = 0.20).\nWhile hypertension and the discontinuation of antihypertensive treatment are suspected to be related to increased risk of mortality, in this retrospective observational analysis, we did not detect any harm of RAAS inhibitors in patients infected with COVID-19. However, the results should be considered as exploratory and interpreted cautiously.", "topics": ["Epid\u00e9miologique", "Infectiologie", "Cardiologie et maladies m\u00e9taboliques"], "author_list": [{"id": 625, "name": "Gao C"}], "publication_date": "2020-06-08"}, {"id": 112, "slug": "clinical-course-and-risk-factors-for-mortality-of-adult-inpatients-with-covid-19", "title": "Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohortstudy", "has_other_authors": true, "impact_factor": {"id": 3, "name": "Interm\u00e9diaire", "posts_count": 140, "color": "orange", "order": 2}, "goals_plain": "Identifier les caract\u00e9ristiques des patients atteint de Covid-19 et les facteurs de risque de d\u00e9c\u00e8s", "verbose_date": "11.03.2020", "authors": "Zhou F", "specialties": [{"id": 7, "name": "Transversale"}], "category": {"id": 6, "name": "Pronostique", "icon": "icon-chat"}, "journal": {"id": 70, "name": "The Lancet"}, "link": "https://www.dropbox.com/s/rf4iygmoz1t637h/PIIS0140673620305663.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "- Facteurs de risque de mortalit\u00e9 : \u00e2ge sup\u00e9rieur \u00e0 70 ans, comorbidit\u00e9s (HTA, diab\u00e8te, coronaropathie)- Signes de gravit\u00e9 : FR > 24, score SOFA > 6, GB>10G, lymphocytes<0,02G, creat>133, lactate>245, tropo>28, D-Dim\u00e8re>1 -> ces 3 derniers marqueurs augmentent au cours du temps chez les patients non survivants- Chronologie d'apparition des sympt\u00f4mes : d'abord toux + fi\u00e8vre, dyspn\u00e9e \u00e0 J6, puis disparition toux + fi\u00e8vre mais besoin de soins intensifs vers J12.", "objectives": "Interm\u00e9diaire :1) Etude \u00e9pid\u00e9miologique de cohorte bien conduite avec nombreux facteurs \u00e9tudi\u00e9s2) Faible effectif de patients d\u00e9c\u00e9d\u00e9s avec h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 importante", "methods": "Identifier les caract\u00e9ristiques des patients atteint de Covid-19 et les facteurs de risque de d\u00e9c\u00e8s", "topics": ["Pronostique", "Transversale"], "author_list": [{"id": 118, "name": "Zhou F"}], "publication_date": "2020-03-11"}, {"id": 47, "slug": "supporting-clinicians-during-the-covid-19-pandemic", "title": "Supporting Clinicians During the COVID-19 Pandemic", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Suggestions pratiques pour assurer le bien-\u00eatre psychophysique des travailleurs de la sant\u00e9 pendant la pand\u00e9mie COVID-19.", "verbose_date": "20.03.2020", "authors": "Dewey C", "specialties": [{"id": 6, "name": "Psychiatrie"}], "category": {"id": 2, "name": "Autres", "icon": "icon-other"}, "journal": {"id": 41, "name": "Ann Intern Med"}, "link": "https://annals.org/aim/fullarticle/2763592/supporting-clinicians-during-covid-19-pandemic", "findings": "", "take_away": "", "relevance_level": "1) Information claire et directe (source centrale, d\u00e9finition des protocoles)2) Organisation pratique du travail: heures de travail d\u00e9finies, temps de sommeil ad\u00e9quat, eau, snacks sains/chargeurs t\u00e9l\u00e9phonique/toilettes sur le poste de travail)3) Soutien \u00e9motionnel: identification des professionnels de la sant\u00e9 mentale 4) R\u00e9duire les activit\u00e9s non essentielles5) Formation crois\u00e9e et de rotation des dirigeants pour \u00e9viter l'\u00e9puisement des dirigeants", "objectives": "Faible", "methods": "Suggestions pratiques pour assurer le bien-\u00eatre psychophysique des travailleurs de la sant\u00e9 pendant la pand\u00e9mie COVID-19.", "pubmed_id": "32196544", "doi": "10.7326/M20-1033", "abstract": null, "topics": ["Autres", "Psychiatrie"], "author_list": [{"id": 57, "name": "Dewey C"}], "publication_date": "2020-03-20"}, {"id": 670, "slug": "monitoring-and-predicting-sars-cov-2-epidemic-in-france-after-deconfinement-usin", "title": "Monitoring and predicting SARS-CoV-2 epidemic in France after deconfinement using a multiscale age-dependent rate model", "has_other_authors": true, "impact_factor": {"id": 4, "name": "Ind\u00e9termin\u00e9", "posts_count": 12, "color": "gray", "order": 4}, "goals_plain": "", "verbose_date": "08.06.2020", "authors": "Reingruber J", "specialties": [{"id": 12, "name": "Infectiologie"}], "category": {"id": 8, "name": "Mod\u00e9lisation", "icon": "icon-all"}, "journal": {"id": 85, "name": "Pre-prints"}, "link": "https://hal.archives-ouvertes.fr/hal-02592264v1", "findings": "", "take_away": "", "relevance_level": "", "objectives": "Very efficient use of available data. The authors focus on a detailed description of the epidemic dynamics among 5 age groups in 5 regions in France, which is highly relevant. The description of the model is clear, as is the whole manuscript. Addressed questions are of crucial importance for the post-lockdown period.\nThere are some minor limitations:- the model overestimates the number of recovered individuals for the group 70+ starting around day 20 after lockdown, and the authors mention that the \"exact reason is unclear, a possible explanation could be that the number of interactions for this group further decreased during lockdown\".- In order to describe contacts after lockdown very few data have been used so values used are arbitrary- References do not appear in the preprint.", "methods": "", "topics": ["Mod\u00e9lisation", "Infectiologie"], "author_list": [{"id": 629, "name": "Reingruber J"}], "publication_date": "2020-06-08"}, {"id": 517, "slug": "reninangiotensinaldosterone-system-inhibitors-and-risk-of-covid-19", "title": "Renin\u2013Angiotensin\u2013Aldosterone System Inhibitors and Risk of Covid-19", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Evaluer la relation entre les traitements de premi\u00e8re ligne de l'hypertension (inhibiteurs de l'enzyme de conversion (IEC), antagonistes des r\u00e9cepteurs de l'angiotensine (ARA), \u03b2-bloquants, antagonistes calciques, diur\u00e9tiques thiazidiques (DT)) et la probabilit\u00e9 d'un test positif ou n\u00e9gatif au COVID-19, la probabilit\u00e9 de maladie grave (hospitalisation en soins intensifs, ventilation m\u00e9canique ou d\u00e9c\u00e8s).", "verbose_date": "04.05.2020", "authors": "Reynolds HR", "specialties": [{"id": 7, "name": "Transversale"}, {"id": 17, "name": "Cardiologie et maladies m\u00e9taboliques"}], "category": {"id": 6, "name": "Pronostique", "icon": "icon-chat"}, "journal": {"id": 22, "name": "NEJM"}, "link": "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2008975?articleTools=true", "findings": "", "take_away": "", "relevance_level": "Il n'y avait aucune association entre une seule classe de m\u00e9dicaments et une probabilit\u00e9 accrue de r\u00e9sultat positif. Aucun des m\u00e9dicaments examin\u00e9s n'\u00e9tait associ\u00e9 \u00e0 une augmentation statistique significative du risque de maladie grave chez les patients test\u00e9s positifs.", "objectives": "Etude observationnelle avec ajustement a posteriori du fait de l'analyse par score de propension.Pas de pr\u00e9sentation de la comparaison des caract\u00e9ristiques des groupes initiaux et des groupes inclus dans l'analyse par score de propension.Recueil des r\u00e9sultats des tests dans un dossier m\u00e9dical \u00e9lectronique, mais possibilit\u00e9 de tests dans d'autres syst\u00e8mes de soins non r\u00e9pertori\u00e9s sur celui-ci / recueil du traitement m\u00e9dicamenteux sur un dossier \u00e9lectronique. Pas de standardisation dans la m\u00e9thode diagnostique et la r\u00e9p\u00e9tition des tests si premier r\u00e9sultat n\u00e9gatif.74% des patients test\u00e9s inclus (exclus car pas de r\u00e9sultat au test ou des r\u00e9sultats incoh\u00e9rents / pas de consultation, de passage aux urgences ou d'hospitalisation notifi\u00e9 dans le dossier).15% des patients trait\u00e9s par ARA (hypertendus ou dans l'ensemble des patients) non appari\u00e9s et donc non inclus dans l'analyse par score de propension.Dans le tableau 3, diff\u00e9rence dans les effectifs entre les patients appari\u00e9s (or th\u00e9oriquement ratio 1:1).", "methods": "Evaluer la relation entre les traitements de premi\u00e8re ligne de l'hypertension (inhibiteurs de l'enzyme de conversion (IEC), antagonistes des r\u00e9cepteurs de l'angiotensine (ARA), \u03b2-bloquants, antagonistes calciques, diur\u00e9tiques thiazidiques (DT)) et la probabilit\u00e9 d'un test positif ou n\u00e9gatif au COVID-19, la probabilit\u00e9 de maladie grave (hospitalisation en soins intensifs, ventilation m\u00e9canique ou d\u00e9c\u00e8s).", "pubmed_id": "32356628\n30422889\n27738071\n27269252\n18940180\n29897923\n15897343\n9802183\n32109013\n32228222\n17688881\n14647384\n30700139\n10342782\n17510605\n32171062\n32227760\n27742253", "doi": "10.1056/NEJMoa2008975", "abstract": "There is concern about the potential of an increased risk related to medications that act on the renin-angiotensin-aldosterone system in patients exposed to coronavirus disease 2019 (Covid-19), because the viral receptor is angiotensin-converting enzyme 2 (ACE2).\nWe assessed the relation between previous treatment with ACE inhibitors, angiotensin-receptor blockers, beta-blockers, calcium-channel blockers, or thiazide diuretics and the likelihood of a positive or negative result on Covid-19 testing as well as the likelihood of severe illness (defined as intensive care, mechanical ventilation, or death) among patients who tested positive. Using Bayesian methods, we compared outcomes in patients who had been treated with these medications and in untreated patients, overall and in those with hypertension, after propensity-score matching for receipt of each medication class. A difference of at least 10 percentage points was prespecified as a substantial difference.\nAmong 12,594 patients who were tested for Covid-19, a total of 5894 (46.8%) were positive; 1002 of these patients (17.0%) had severe illness. A history of hypertension was present in 4357 patients (34.6%), among whom 2573 (59.1%) had a positive test; 634 of these patients (24.6%) had severe illness. There was no association between any single medication class and an increased likelihood of a positive test. None of the medications examined was associated with a substantial increase in the risk of severe illness among patients who tested positive.\nWe found no substantial increase in the likelihood of a positive test for Covid-19 or in the risk of severe Covid-19 among patients who tested positive in association with five common classes of antihypertensive medications.", "topics": ["Pronostique", "Transversale", "Cardiologie et maladies m\u00e9taboliques"], "author_list": [{"id": 485, "name": "Reynolds HR"}], "publication_date": "2020-05-04"}, {"id": 425, "slug": "covid-19-infection-may-cause-ketosis-and-ketoacidosis", "title": "COVID-19 infection may cause ketosis and ketoacidosis", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "D\u00e9crire les ph\u00e9nom\u00e8nes de c\u00e9tose et d\u2019acidoc\u00e9tose chez les patients atteints de COVID-19 ", "verbose_date": "23.04.2020", "authors": "Li J", "specialties": [{"id": 17, "name": "Cardiologie et maladies m\u00e9taboliques"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 178, "name": "Diabetes Obes Metab"}, "link": "https://dom-pubs.onlinelibrary.wiley.com/doi/epdf/10.1111/dom.14057", "findings": "", "take_away": "", "relevance_level": "L\u2019infection \u00e0 COVID-19 pourrait entra\u00eener une c\u00e9tose ou une acido-c\u00e9tose chez des patients diab\u00e9tiques ou non. La c\u00e9tose est associ\u00e9e \u00e0 une augmentation de la dur\u00e9e de s\u00e9jour et de la mortalit\u00e9, mais le fait d'\u00eatre diab\u00e9tique n\u2019augmenterait que la dur\u00e9e de s\u00e9jour parmi les patients avec c\u00e9tose, sans augmentation de la mortalit\u00e9. \u2028Le ph\u00e9nom\u00e8ne de c\u00e9tose pourrait \u00eatre expliqu\u00e9 par un m\u00e9tabolisme augment\u00e9 des graisses dans l\u2019infection \u00e0 COVID-19 mais n\u00e9cessite plus d'investigations.", "objectives": "Etude de cohorte r\u00e9trospective, peu de patients surtout parmis le groupe c\u00e9tose, pas d'information sur le ou les centres d'inclusion", "methods": "D\u00e9crire les ph\u00e9nom\u00e8nes de c\u00e9tose et d\u2019acidoc\u00e9tose chez les patients atteints de COVID-19", "pubmed_id": "32314455\n30754085\n22945490\n32109013\n22104427\n14988248\n26975543\n11194218\n31986264\n32007143\n31982728", "doi": "10.1111/dom.14057", "abstract": "The present study included 658 hospitalized patients with confirmed COVID-19. Forty-two (6.4%) out of 658 patients presented with ketosis on admission with no obvious fever or diarrhoea. They had a median (interquartile range [IQR]) age of 47.0 (38.0-70.3) years, and 16 (38.1%) were men. Patients with ketosis were younger (median age 47.0 vs. 58.0\u2009years; P = 0.003) and had a greater prevalence of fatigue (31.0% vs. 10.6%; P\u2009<\u20090.001), diabetes (35.7% vs. 18.5%; P = 0.007) and digestive disorders (31.0% vs. 12.0%; P\u2009<\u20090.001). They had a longer median (IQR) length of hospital stay (19.0 [12.8-33.3] vs. 16.0 [10.0-24.0] days; P\u2009<\u20090.001) and a higher mortality rate (21.4% vs. 8.9%; P = 0.017). Three (20.0%) out of the 15 patients with diabetic ketosis developed acidosis, five patients (26.7%) with diabetic ketosis died, and one of these (25.0%) presented with acidosis. Two (7.4%) and four (14.3%) of the 27 non-diabetic ketotic patients developed severe acidosis and died, respectively, and one (25.0%) of these presented with acidosis. This suggests that COVID-19 infection caused ketosis or ketoacidosis, and induced diabetic ketoacidosis for those with diabetes. Ketosis increased the length of hospital stay and mortality. Meanwhile, diabetes increased the length of hospital stay for patients with ketosis but had no effect on their mortality.", "topics": ["Epid\u00e9miologique", "Cardiologie et maladies m\u00e9taboliques"], "author_list": [{"id": 255, "name": "Li J"}], "publication_date": "2020-04-23"}, {"id": 423, "slug": "a-multinational-multicentre-study-on-the-psychological-outcomes-and-associated-p", "title": "A Multinational, Multicentre Study on the Psychological Outcomes and Associated Physical Symptoms Amongst Healthcare Workers During COVID-19 Outbreak", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Etudier l'association entre les effets psychologiques et les sympt\u00f4mes physiques chez les personnels hospitaliers", "verbose_date": "23.04.2020", "authors": "Chew N", "specialties": [{"id": 6, "name": "Psychiatrie"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 109, "name": "Brain Behav Immun"}, "link": "https://www.dropbox.com/s/mkam8cmb7h8tue6/10.1016%40j.bbi.2020.04.049.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Association significative entre la pr\u00e9valence des sympt\u00f4mes physiques et les r\u00e9sultats des tests psychologiques chez les personnels hospitaliers. Ceux qui pr\u00e9sentaient des sympt\u00f4mes physiques avaient des taux plus \u00e9lev\u00e9s de d\u00e9pression, d'anxi\u00e9t\u00e9, de stress et de stress post-traumatique. Ceux avec des sympt\u00f4mes physiques avaient des scores moyens plus \u00e9lev\u00e9s dans les sous-\u00e9chelles IES-R, DASS 2. A \u00e9tudier : interventions psychologiques pour les personnels pr\u00e9sentant des sympt\u00f4mes physiques.", "objectives": "1) Pre-proof2) Questionnaire auto-administr\u00e9 avec renseignement sur les sympt\u00f4mes physiques dans le mois pr\u00e9c\u00e9dent, sujet \u00e0 des biais de m\u00e9morisation3) Pas de renseignement sur le statut COVID-19 (douleurs pharyng\u00e9es, toux, crachats) ou sur le travail r\u00e9el aupr\u00e8s de patients COVID-19, sur le port d'\u00e9quipement de protection individuelle (c\u00e9phal\u00e9es)4) Niveau socio-\u00e9conomique et niveau d'\u00e9tude non \u00e9tudi\u00e95) Quasiment 2 mois pour la passation du questionnaire, long \u00e0 l'\u00e9chelle de l'\u00e9volution de la pand\u00e9mie", "methods": "Etudier l'association entre les effets psychologiques et les sympt\u00f4mes physiques chez les personnels hospitaliers", "pubmed_id": "32330593\n7877126\n15697046\n26270268\n17975685\n14705607\n15913861\n16060914\n16145182\n24642046\n6664683", "doi": "10.1016/j.bbi.2020.04.049", "abstract": "Since the declaration of the coronavirus 2019 (COVID-19) outbreak as pandemic, there are reports on the increased prevalence of physical symptoms observed in the general population. We investigated the association between psychological outcomes and physical symptoms among healthcare workers.\nHealthcare workers from 5 major hospitals, involved in the care for COVID-19 patients, in Singapore and India were invited to participate in a study by performing a self-administered questionnaire within the period of February 19 to April 17, 2020. Healthcare workers included doctors, nurses, allied healthcare workers, administrators, clerical staff and maintenance workers. This questionnaire collected information on demographics, medical history, symptom prevalence in the past month, Depression Anxiety Stress Scales (DASS-21) and the Impact of Events Scale-Revised (IES-R) instrument. The prevalence of physical symptoms displayed by healthcare workers and the associations between physical symptoms and psychological outcomes of depression, anxiety, stress, and post-traumatic stress disorder (PTSD) were evaluated.\nOut of the 906 healthcare workers who participated in the survey, 48 (5.3%) screened positive for moderate to very-severe depression, 79 (8.7%) for moderate to extremely-severe anxiety, 20 (2.2%) for moderate to extremely-severe stress, and 34 (3.8%) for moderate to severe levels of psychological distress. The commonest reported symptom was headache (32.3%), with a large number of participants (33.4%) reporting more than four symptoms. Participants who had experienced symptoms in the preceding month were more likely to be older, have pre-existing comorbidities and a positive screen for depression, anxiety, stress, and PTSD. After adjusting for age, gender and comorbidities, it was found that depression (OR 2.79, 95% CI 1.54-5.07, p\u00a0=\u00a00.001), anxiety (OR 2.18, 95% CI 1.36-3.48, p\u00a0=\u00a00.001), stress (OR 3.06, 95% CI 1.27-7.41, p\u00a0=\u00a00.13), and PTSD (OR 2.20, 95% CI 1.12-4.35, p\u00a0=\u00a00.023) remained significantly associated with the presence of physical symptoms experienced in the preceding month. Linear regression revealed that the presence of physical symptoms was associated with higher mean scores in the IES-R, DASS Anxiety, Stress and Depression subscales.\nOur study demonstrates a significant association between the prevalence of physical symptoms and psychological outcomes among healthcare workers during the COVID-19 outbreak. We postulate that this association may be bi-directional, and that timely psychological interventions for healthcare workers with physical symptoms should be considered once an infection has been excluded.", "topics": ["Epid\u00e9miologique", "Psychiatrie"], "author_list": [{"id": 403, "name": "Chew N"}], "publication_date": "2020-04-23"}, {"id": 12, "slug": "coronavirus-disease-2019-covid-19-and-cardiovascular-disease", "title": "Coronavirus Disease 2019 (COVID-19) and Cardiovascular Disease", "has_other_authors": false, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "resumer les connaissances sur les comorbidit\u00e9s cardiaques", "verbose_date": "25.03.2020", "authors": "Clerkin KJ", "specialties": [{"id": 17, "name": "Cardiologie et maladies m\u00e9taboliques"}, {"id": 7, "name": "Transversale"}], "category": {"id": 2, "name": "Autres", "icon": "icon-other"}, "journal": {"id": 9, "name": "Circulation"}, "link": "https://www.dropbox.com/s/nlp76y7kxihspkp/CIRCULATIONAHA.120.046941.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Les l\u00e9sion myocardiaques sont pr\u00e9sentes dans plus d'un quart des cas critiques\nPour le moment ne pas changer ou arreter un ttt par ACEinhibiteur, ARB ou autre antago RAAS chez un infect\u00e9 COVID car pas d'efficacit\u00e9 d\u00e9montr\u00e9.\nLes reco disent de continuer les transplantation cardiac sans changer les ttt immunosup tant qu'on s'assure que le receveur n'\u00e9tait pas positif au virus et n'a pas d'exposition ou de symptomes 2 \u00e0 4 semaines avant.\r\nLes donneurs positifs ou suspect\u00e9 de COVID doivent etre \u00e9vit\u00e9s, ceux ayant eu le COVID doivent avoir eu un test negatif (PCR) depuis au moins 14 jours.\nTraitement : (voir article pour les m\u00e9canismes d'action de ces ttt) devpmt de :vaccin et anticorps monoclonaux anti SARS-CoV-2, ACE2 recombinants, la serine protease inhibitor camostat mesylate bloquerait la TMPRSS2, redemsevir, favipiravir, tocilizumab, sarilumab.\r\nLa chloroquine et hydroxychloroquine, lopinavir/ritonavir ne semble pas efficace, idem pour oseltamivir, arbidol,", "objectives": "Faible- revue de biblio existante sur le sujet- pas de m\u00e9thodo sur la recherche des articles", "methods": "resumer les connaissances sur les comorbidit\u00e9s cardiaques", "topics": ["Autres", "Cardiologie et maladies m\u00e9taboliques", "Transversale"], "author_list": [{"id": 23, "name": "Clerkin KJ"}], "publication_date": "2020-03-25"}, {"id": 669, "slug": "introductions-and-early-spread-of-sars-cov-2-in-france", "title": "Introductions and early spread of SARS-CoV-2 in France", "has_other_authors": true, "impact_factor": {"id": 4, "name": "Ind\u00e9termin\u00e9", "posts_count": 12, "color": "gray", "order": 4}, "goals_plain": "Etudier comment l'\u00e9pid\u00e9mie de SARS-Cov-2 a commenc\u00e9 dans le nord de la France.\r\n ", "verbose_date": "08.06.2020", "authors": "Gambaro F", "specialties": [{"id": 12, "name": "Infectiologie"}], "category": {"id": 8, "name": "Mod\u00e9lisation", "icon": "icon-all"}, "journal": {"id": 85, "name": "Pre-prints"}, "link": "https://www.biorxiv.org/content/10.1101/2020.04.24.059576v2", "findings": "", "take_away": "", "relevance_level": "Le virus SARS-Cov-2 a \u00e9t\u00e9 introduit plusieurs fois dans le nord de la France par des voyageurs arrivant de l'\u00e9tranger. Les mesures d'isolement des personnes symptomatiques ont permis de contr\u00f4ler plusieurs introductions du virus, mais elles n'ont pas emp\u00each\u00e9 le d\u00e9veloppement de l'\u00e9pid\u00e9mie.", "objectives": "Les donn\u00e9es de cette \u00e9tude semblent disponibles. Il serait int\u00e9ressant de les r\u00e9analyser avec des mod\u00e8les phylodynamiques, pour estimer des param\u00e8tres d\u00e9mographiques ou g\u00e9n\u00e9tiques du virus. Mais cela a peut-\u00eatre d\u00e9j\u00e0 \u00e9t\u00e9 fait par des \u00e9quipes travaillant sur la phylodynamique du virus ? Les donn\u00e9es contenant les lieux de collecte des s\u00e9quences, une structure spatiale pourrait \u00eatre introduite dans le mod\u00e8le.", "methods": "Etudier comment l'\u00e9pid\u00e9mie de SARS-Cov-2 a commenc\u00e9 dans le nord de la France.", "topics": ["Mod\u00e9lisation", "Infectiologie"], "author_list": [{"id": 628, "name": "Gambaro F"}], "publication_date": "2020-06-08"}, {"id": 643, "slug": "characterization-and-clinical-course-of-1000-patients-with-coronavirus-disease-2", "title": "Characterization and clinical course of 1000 patients with coronavirus disease 2019 in New York: retrospective case series", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Caract\u00e9riser le parcours clinique d'adultes admis dans un centre hospitalier avec un SARS-CoV-2 confirm\u00e9.", "verbose_date": "02.06.2020", "authors": "Argenziano MG", "specialties": [{"id": 7, "name": "Transversale"}], "category": {"id": 6, "name": "Pronostique", "icon": "icon-chat"}, "journal": {"id": 57, "name": "BMJ"}, "link": "https://www.bmj.com/content/bmj/369/bmj.m1996.full.pdf", "findings": "", "take_away": "", "relevance_level": "- 3 sympt\u00f4mes les plus fr\u00e9quents : toux (73,2%), fi\u00e8vre (72,8%), dyspn\u00e9e (63,1%)\n- 3 comorbidit\u00e9s principales : HTA (60,1%), ob\u00e9sit\u00e9 (48,3%) et diab\u00e8te (37,2%)\n- 3 classes th\u00e9rapeutiques les plus utilis\u00e9s \u00e0 domcile : statines (36,1%), IEC ou ARA-2 (28,4%), AINS (25%)\n- Association significative entre l'\u00e2ge, l'IMC, une infection par VIH ou une insuffisance r\u00e9nale pr\u00e9existantes et le d\u00e9c\u00e8s.\n- Parmi les patients hospitalis\u00e9s :\u00a0 33,9% d'insuffisance r\u00e9nale aigu\u00eb et 13,8% n\u00e9cessitant une dialyse (78 et 35,2% en soins intensifs) ; 35,2% de d\u00e9tresse respiratoire aigu\u00eb (89,8% en soins intensifs).\n- D\u00e9lai d'intubation semblant bimodal : premier pic \u00e0 J3-J4\u00a0 du d\u00e9but des sympt\u00f4mes et second \u00e0 J9.", "objectives": "- S\u00e9rie de cas r\u00e9trospective : \u00e9tude observationnelle descriptive monocentrique- Modification \u00e0 2 reprises des crit\u00e8res menant \u00e0 la r\u00e9alisation d'une RT-PCR SARS-CoV-2 : biais de s\u00e9lection", "methods": "Caract\u00e9riser le parcours clinique d'adultes admis dans un centre hospitalier avec un SARS-CoV-2 confirm\u00e9.", "pubmed_id": "32471884\n18929686\n32171076\n32250385\n26605174\n22954664\n32160451\n31986264\n32442528\n32191259\n32202722\n32109013\n30481669\n32212516\n19747383\n12682465\n32302078\n32294339\n32320003\n12421743\n32227758", "doi": "10.1136/bmj.m1996", "abstract": "To characterize patients with coronavirus disease 2019 (covid-19) in a large New York City medical center and describe their clinical course across the emergency department, hospital wards, and intensive care units.\nRetrospective manual medical record review.\nNewYork-Presbyterian/Columbia University Irving Medical Center, a quaternary care academic medical center in New York City.\nThe first 1000 consecutive patients with a positive result on the reverse transcriptase polymerase chain reaction assay for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who presented to the emergency department or were admitted to hospital between 1 March and 5 April 2020. Patient data were manually abstracted from electronic medical records.\nCharacterization of patients, including demographics, presenting symptoms, comorbidities on presentation, hospital course, time to intubation, complications, mortality, and disposition.\nOf the first 1000 patients, 150 presented to the emergency department, 614 were admitted to hospital (not intensive care units), and 236 were admitted or transferred to intensive care units. The most common presenting symptoms were cough (732/1000), fever (728/1000), and dyspnea (631/1000). Patients in hospital, particularly those treated in intensive care units, often had baseline comorbidities including hypertension, diabetes, and obesity. Patients admitted to intensive care units were older, predominantly male (158/236, 66.9%), and had long lengths of stay (median 23 days, interquartile range 12-32 days); 78.0% (184/236) developed acute kidney injury and 35.2% (83/236) needed dialysis. Only 4.4% (6/136) of patients who required mechanical ventilation were first intubated more than 14 days after symptom onset. Time to intubation from symptom onset had a bimodal distribution, with modes at three to four days, and at nine days. As of 30 April, 90 patients remained in hospital and 211 had died in hospital.\nPatients admitted to hospital with covid-19 at this medical center faced major morbidity and mortality, with high rates of acute kidney injury and inpatient dialysis, prolonged intubations, and a bimodal distribution of time to intubation from symptom onset.", "topics": ["Pronostique", "Transversale"], "author_list": [{"id": 605, "name": "Argenziano MG"}], "publication_date": "2020-06-02"}, {"id": 139, "slug": "hand-hygiene-and-the-novel-coronavirus-pandemic-the-role-of-healthcare-workers", "title": "Hand hygiene and the novel coronavirus pandemic: The role of healthcare workers", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Promotion de l'hygi\u00e8ne des mains - composante essentielle de la pr\u00e9vention et du contr\u00f4le de la propagation du SRAS-CoV-2", "verbose_date": "25.03.2020", "authors": "Lotfinejad N ", "specialties": [{"id": 2, "name": "Hygi\u00e8ne"}], "category": {"id": 2, "name": "Autres", "icon": "icon-other"}, "journal": {"id": 6, "name": "J Hosp Infect"}, "link": "https://www.dropbox.com/s/lv8dhnihpmqvufp/PIIS019567012030116X.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "1) Hygi\u00e8ne des mains = m\u00e9canisme crucial de contr\u00f4le de la diffusion de SRAS-CoV-2:\r\n- utiliser SHA ayant de l'\u00e9thanol(80% v/v) ou de l'isopropanol(75% v/v) (OMS)\r\n- 5 moments: avant de toucher un patient, avant des proc\u00e9dures propres ou aseptiques, apr\u00e8s un exposition \u00e0 un fluide corporel ou un risque, apr\u00e8s avoir touch\u00e9 un patient at apr\u00e9s avoir touch\u00e9 l'environnement du patient (OMS)\n\r\n2) Utiliser des masques:\r\n- masques N95 pour les soignants en cas de a\u00e9rosol provenant de patients COVID-19\r\n- masque chirurgical pour patients suspects COVID 19\u00a0\n\r\n3) Les infirmi\u00e8res et les sages-femmes jouent un r\u00f4le cl\u00e9 dans la s\u00e9curit\u00e9 et la qualit\u00e9 des soins et dans la r\u00e9duction des infections nosocomiales :\u00a0\r\n- assurer un nombre suffisant d'infirmi\u00e8res, d'\u00e9quipements de protection individuelle, de formation sur le lavage des mains et l'utilisation des EPI", "objectives": "1) \u00c9ditorial2) Recommandations de l'auteur bas\u00e9es sur la litt\u00e9rature", "methods": "Promotion de l'hygi\u00e8ne des mains - composante essentielle de la pr\u00e9vention et du contr\u00f4le de la propagation du SRAS-CoV-2", "pubmed_id": "32201339\n28453839\n26220070\n21146207\n31986264\n12765882\n31189085\n32061313\n31517975", "doi": "10.1016/j.jhin.2020.03.017", "abstract": null, "topics": ["Autres", "Hygi\u00e8ne"], "author_list": [{"id": 136, "name": "Lotfinejad N "}], "publication_date": "2020-03-25"}, {"id": 70, "slug": "early-release-identifying-and-interrupting-superspreading-events-implications-fo", "title": "Early Release - Identifying and Interrupting Superspreading Events\u2014 Implications for Control of Severe Acute Respiratory Syndrome Coronavirus 2", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Evaluer et pr\u00e9venir l'impact des superspreading event (SSE) sur le nombre de cas.", "verbose_date": "18.03.2020", "authors": "Frieden TR", "specialties": [{"id": 7, "name": "Transversale"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 28, "name": "Emerg Infect Dis"}, "link": "https://wwwnc.cdc.gov/eid/article/26/6/20-0495_article", "findings": "", "take_away": "", "relevance_level": "La diss\u00e9mination du COVID19 est possiblement li\u00e9 \u00e0 des \"superspreading event\" (SSE). Il conviendrait alors de les d\u00e9pister afin de prendre des mesures sp\u00e9cifiques, en plus des mesures g\u00e9n\u00e9rales, pour ralentir l'\u00e9pid\u00e9mie.", "objectives": "Faible :1) Donn\u00e9es issues d'\u00e9pid\u00e9mie pr\u00e9c\u00e9dente (SARS, MERS, grippe, ebola)2) R\u00f4le des SSE dans la diss\u00e9mination du COVID19 ne sera connu qu'\u00e0 post\u00e9riori", "methods": "Evaluer et pr\u00e9venir l'impact des superspreading event (SSE) sur le nombre de cas.", "topics": ["Epid\u00e9miologique", "Transversale"], "author_list": [{"id": 80, "name": "Frieden TR"}], "publication_date": "2020-03-18"}, {"id": 224, "slug": "diabetes-is-a-risk-factor-for-the-progression-and-prognosis-of-covid19", "title": "Diabetes is a risk factor for the progression and prognosis of COVID\u201019", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Evaluation de la pr\u00e9sence de diab\u00e8te comme facteur pronostic d'une infection \u00e0 SARS-CoV-2.", "verbose_date": "01.04.2020", "authors": "Guo W", "specialties": [{"id": 17, "name": "Cardiologie et maladies m\u00e9taboliques"}, {"id": 7, "name": "Transversale"}], "category": {"id": 6, "name": "Pronostique", "icon": "icon-chat"}, "journal": {"id": 108, "name": "\"Diabetes Metab Res Rev \""}, "link": "https://onlinelibrary.wiley.com/doi/epdf/10.1002/dmrr.3319", "findings": "", "take_away": "", "relevance_level": "- R\u00e9sultats d'interpr\u00e9tation difficile :\r\n* facteurs de confusion d\u00fb aux autres comorbit\u00e9s\r\n* groupe non comparable pour la population ne pr\u00e9sentant pas de comorbidit\u00e9 autre que le diab\u00e8te\r\n- Les patients atteints de diab\u00e8te seraient :\r\n* plus \u00e0 risque de pneumonie s\u00e9v\u00e8re\r\n* plus \u00e0 risque de lib\u00e9ration d'enzymes li\u00e9es aux l\u00e9sions tissulaires\r\n* plus \u00e0 risque de r\u00e9ponses inflammatoires incontr\u00f4l\u00e9es excessives et d'\u00e9tat hypercoagulable\r\n* les taux s\u00e9riques de biomarqueurs li\u00e9s \u00e0 l'inflammation tels que l'IL-6, la prot\u00e9ine C r\u00e9active, la ferritine s\u00e9rique et l'indice de coagulation, le D-dim\u00e8re, \u00e9taient significativement plus \u00e9lev\u00e9s (p <0,01)", "objectives": "- groupes non comparables (pour la population sans comorbidit\u00e9 autre que diab\u00e8te)   - Facteurs de confusions (autres comorbidit\u00e9)", "methods": "Evaluation de la pr\u00e9sence de diab\u00e8te comme facteur pronostic d'une infection \u00e0 SARS-CoV-2.", "pubmed_id": "32233013\n32075877\n23182884\n19333547\n23333525\n12021080\n16007521\n2266090\n25262977\n31986264\n32007143\n22976756\n32233013\n12547890\n16759303\n27381687\n27081112\n27570063\n16007097\n10924499\n10601511", "doi": "10.1002/dmrr.3319", "abstract": "To figure out whether diabetes is a risk factor influencing the progression and prognosis of 2019 novel coronavirus disease (COVID-19).\nA total of 174 consecutive patients confirmed with COVID-19 were studied. Demographic data, medical history, symptoms and signs, laboratory findings, chest computed tomography (CT) as well the treatment measures were collected and analysed.\nWe found that COVID-19 patients without other comorbidities but with diabetes (n = 24) were at higher risk of severe pneumonia, release of tissue injury-related enzymes, excessive uncontrolled inflammation responses and hypercoagulable state associated with dysregulation of glucose metabolism. Furthermore, serum levels of inflammation-related biomarkers such as IL-6, C-reactive protein, serum ferritin and coagulation index, D-dimer, were significantly higher (P <\u2009.01) in diabetic patients compared with those without, suggesting that patients with diabetes are more susceptible to an inflammatory storm eventually leading to rapid deterioration of COVID-19.\nOur data support the notion that diabetes should be considered as a risk factor for a rapid progression and bad prognosis of COVID-19. More intensive attention should be paid to patients with diabetes, in case of rapid deterioration.", "topics": ["Pronostique", "Cardiologie et maladies m\u00e9taboliques", "Transversale"], "author_list": [{"id": 215, "name": "Guo W"}], "publication_date": "2020-04-01"}, {"id": 663, "slug": "stochasticity-and-heterogeneity-in-the-transmission-dynamics-of-sars-cov-2", "title": "Stochasticity and heterogeneity in the transmission dynamics of SARS-CoV-2", "has_other_authors": true, "impact_factor": {"id": 4, "name": "Ind\u00e9termin\u00e9", "posts_count": 12, "color": "gray", "order": 4}, "goals_plain": "L'objectif de ce travail est d'insister sur le fait que l'\u00e9pid\u00e9mie de COVID-19 est principalement port\u00e9e par des \u00e9v\u00e9nements SSEs.", "verbose_date": "27.05.2020", "authors": "Althouse BM", "specialties": [{"id": 21, "name": "Confinement/D\u00e9confinement"}, {"id": 12, "name": "Infectiologie"}], "category": {"id": 8, "name": "Mod\u00e9lisation", "icon": "icon-all"}, "journal": {"id": 85, "name": "Pre-prints"}, "link": "https://arxiv.org/pdf/2005.13689.pdf", "findings": "", "take_away": "", "relevance_level": "L'\u00e9pid\u00e9mie de COVID-19 semble en grande partie propag\u00e9e par des \u00e9v\u00e9nements de super-contamination (super-spreading event -- SSE). Pour mod\u00e9liser ces SSEs, utiliser une loi n\u00e9gative binomiale est plus adapt\u00e9 qu'utiliser une loi de Poisson, ce qui a un effet sur les pr\u00e9dictions faites sur l'\u00e9volution de l'\u00e9pid\u00e9mie.", "objectives": "L'article est tr\u00e8s agr\u00e9able \u00e0 lire, et est abondamment sourc\u00e9 avec de nombreux exemples d'\u00e9v\u00e9nements de type SSE. Les \u00e9l\u00e9ments de preuve sont d\u2019avantage bas\u00e9s sur de l'observation qualitative que sur de l'analyse de donn\u00e9es, les auteurs mentionnant le caract\u00e8re \"al\u00e9atoire\" des foyers d'infection qui indique une faible probabilit\u00e9 pour un foyer de se fixer. L'objectif de cet article est de mettre l'accent sur l'existence d'\u00e9v\u00e9nements SSE et leur impact dans la mod\u00e9lisation de l'\u00e9pid\u00e9mie de COVID-19, et dans sa pr\u00e9vention.", "methods": "L'objectif de ce travail est d'insister sur le fait que l'\u00e9pid\u00e9mie de COVID-19 est principalement port\u00e9e par des \u00e9v\u00e9nements SSEs.", "topics": ["Mod\u00e9lisation", "Confinement/D\u00e9confinement", "Infectiologie"], "author_list": [{"id": 623, "name": "Althouse BM"}], "publication_date": "2020-05-27"}, {"id": 530, "slug": "lymphopenia-is-associated-with-severe-coronavirus-disease-2019-covid-19-infectio", "title": "Lymphopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A systemic review and meta-analysis", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Revue syst\u00e9mique et m\u00e9ta-analyse : Etude du lien entre taux de lymphocytes et s\u00e9v\u00e9rit\u00e9 du COVID-19. ", "verbose_date": "05.05.2020", "authors": "Zhao Q", "specialties": [{"id": 7, "name": "Transversale"}, {"id": 12, "name": "Infectiologie"}], "category": {"id": 6, "name": "Pronostique", "icon": "icon-chat"}, "journal": {"id": 18, "name": "Int J Infect Dis"}, "link": "https://www.ijidonline.com/action/showPdf?pii=S1201-9712%2820%2930301-5", "findings": "", "take_away": "", "relevance_level": "La lymphop\u00e9nie et son taux (dans cette \u00e9tude seuil \u00e0 0,31 x 10*9) sont des marqueurs pr\u00e9coces essentiels pour identifier les patients \u00e0 risque de forme s\u00e9v\u00e8res.\u00a0\nN\u00e9cessit\u00e9 d'\u00e9tude prospective pour \u00e9tudier la cin\u00e9tique des lymphocytes.", "objectives": "- Pr\u00e9 proof - M\u00e9ta analyse mais avec un faible nombre d'articles et tous r\u00e9trospectifs- Score MINORS faible- Grande h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 des r\u00e9sultats des diff\u00e9rents articles mais non d\u00fbe \u00e0 des biais selon l'analyse de l'article - Grande h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 des d\u00e9finitions - Etude a un temps T qui n'\u00e9value pas donc les fluctuations cliniques ni biologiques - MAIS similitudes de r\u00e9sultats retrouv\u00e9s avec le SARS de 2002", "methods": "Revue syst\u00e9mique et m\u00e9ta-analyse : Etude du lien entre taux de lymphocytes et s\u00e9v\u00e9rit\u00e9 du COVID-19.", "pubmed_id": "32376308\n12734147\n32176772\n32170865\n32293753\n32167524\n32181911\n32171952\n16095942\n32118640\n32203188\n31986264\n29064576\n32203186\n31953166\n32202240\n15254784\n32109013\n32077115\n32171076\n12682352\n32247050\n32031570\n32195311\n32048163\n32214079\n32105632", "doi": "10.1016/j.ijid.2020.04.086", "abstract": "Coronavirus Disease 2019 (COVID-19) is a new respiratory and systemic disease which needs quick identification of potential critical patients. This meta-analysis aimed to explore the relationship between lymphocyte count and the severity of COVID-19.\nA comprehensive systematic literature search was carried out to find studies published from December 2019 to 22 March 2020 from five databases. The language of literatures included English and Chinese. Mean difference (MD) of lymphocyte count in COVID-19 patients with or without severe disease and odds ratio (OR) of lymphopenia for severe form of COVID-19 was evaluated with this meta-analysis.\nOverall 13 case-series with a total of 2282 cases were included in the study. The pooled analysis showed that lymphocyte count was significantly lower in severe COVID-19 patients (MD -0.31\u00d710\nLymphopenia is a prominent part of severe COVID-19 and a lymphocyte count of less than 1.5\u00d710", "topics": ["Pronostique", "Transversale", "Infectiologie"], "author_list": [{"id": 349, "name": "Zhao Q"}], "publication_date": "2020-05-05"}, {"id": 295, "slug": "first-wave-covid-19-transmissibility-and-severity-in-china-outside-hubei-after-c", "title": "First-wave COVID-19 transmissibility and severity in China outside Hubei after control measures, and second-wave scenario planning: a modelling impact assessment", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Evaluer l'impact de la transmission et de la gravit\u00e9 du COVID-19 lors de la premi\u00e8re vague en Chine \u00e0 l'ext\u00e9rieur du Hubei, ainsi que de la possible deuxi\u00e8me vague", "verbose_date": "10.04.2020", "authors": "Leung K", "specialties": [{"id": 7, "name": "Transversale"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 12, "name": "Lancet"}, "link": "https://www.thelancet.com/action/showPdf?pii=S0140-6736%2820%2930746-7", "findings": "", "take_away": "", "relevance_level": "Le taux de reproduction instantan\u00e9 des cas de COVID-19 (Rt) semble \u00eatre un marqueur utile pour suivre l'\u00e9volution de l'\u00e9pid\u00e9mie en fonction des modifications des mesures de restriction de la propagation du virus. Un all\u00e8gement de ces mesures permettant une r\u00e9augmentation du Rt au dessus de 1 pourrait \u00eatre n\u00e9faste sur les plans sanitaire et \u00e9conomique et met en \u00e9vidence un \u00e9quilibre d\u00e9licat entre maintien et rel\u00e2chement des mesures de limitation de la transmission de la COVID-19.\r\nDans cette \u00e9tude la l\u00e9talit\u00e9 de la maladie semblait corr\u00e9l\u00e9e, en Chine, au PIB/hab des r\u00e9gions.\r\nCes mod\u00e8les, bien qu'ils n\u00e9cessiteraient s\u00fbrement d'\u00eatre valid\u00e9s sur des donn\u00e9es plus compl\u00e8tes et plus fiables, montrent l'importance d'un suivi pr\u00e9cis et en temps r\u00e9el du nombre de cas et de l'activit\u00e9 \u00e9conomique d'une r\u00e9gion donn\u00e9e. En Chine il a \u00e9t\u00e9 observ\u00e9 que l'utilisation de moteurs de recherche et de r\u00e9seaux sociaux \u00e9tait corr\u00e9l\u00e9e \u00e0 la fois au niveau d'activit\u00e9 \u00e9conomique du pays et au Rt.", "objectives": "- Compilation de grosses donn\u00e9es \u00e9pid\u00e9miologiques- Se pose la question de la fiabilit\u00e9 des donn\u00e9es chinoises- Mod\u00e9lisations int\u00e9ressantes et plut\u00f4t robustes- nombreuses donn\u00e9es manquantes imput\u00e9es (date de d\u00e9but des sympt\u00f4mes, caract\u00e8re import\u00e9 ou non des cas)", "methods": "Evaluer l'impact de la transmission et de la gravit\u00e9 du COVID-19 lors de la premi\u00e8re vague en Chine \u00e0 l'ext\u00e9rieur du Hubei, ainsi que de la possible deuxi\u00e8me vague", "pubmed_id": "32277878", "doi": "10.1016/S0140-6736(20)30746-7", "abstract": "As of March 18, 2020, 13\u2008415 confirmed cases and 120 deaths related to coronavirus disease 2019 (COVID-19) in mainland China, outside Hubei province-the epicentre of the outbreak-had been reported. Since late January, massive public health interventions have been implemented nationwide to contain the outbreak. We provide an impact assessment of the transmissibility and severity of COVID-19 during the first wave in mainland Chinese locations outside Hubei.\nWe estimated the instantaneous reproduction number (R\nIn all selected cities and provinces, the R\nThe first wave of COVID-19 outside of Hubei has abated because of aggressive non-pharmaceutical interventions. However, given the substantial risk of viral reintroduction, particularly from overseas importation, close monitoring of R\nHealth and Medical Research Fund, Hong Kong, China.", "topics": ["Epid\u00e9miologique", "Transversale"], "author_list": [{"id": 284, "name": "Leung K"}], "publication_date": "2020-04-10"}, {"id": 542, "slug": "deep-learning-based-multi-view-fusion-model-for-screening-2019-novel-coronavirus", "title": "Deep learning-based multi-view fusion model for screening 2019 novel coronavirus pneumonia: a multicentre study", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "D\u00e9velopper une m\u00e9thode d\u2019assistance pour les radiologues, bas\u00e9e sur l\u2019apprentissage par deep learning pour le diagnostic du COVID-19 par analyse d\u2019images d\u2019examens de tomodensitom\u00e9trie thoracique.", "verbose_date": "06.05.2020", "authors": "Wu X", "specialties": [{"id": 3, "name": "Radiologie"}], "category": {"id": 3, "name": "Diagnostique", "icon": "icon-heat"}, "journal": {"id": 26, "name": "Eur J Radiol"}, "link": "https://www.ejradiology.com/action/showPdf?pii=S0720-048X%2820%2930230-8", "findings": "", "take_away": "", "relevance_level": "Le mod\u00e8le d\u00e9velopp\u00e9 par les auteurs fournit un test pour l\u2019instant relativement peu fiable, mais qui ouvrirait de bonnes perspectives s\u2019il \u00e9tait entra\u00een\u00e9 par deep learning avec un nombre d\u2019images significativement plus grand.", "objectives": "L\u2019apprentissage du r\u00e9seau de neurones est effectu\u00e9 sans calibrage pr\u00e9alable. Dans ces conditions, le nombre de cas n\u00e9cessaires pour l\u2019entra\u00eenement est plus classiquement de l\u2019ordre de 105 que de 300. Il n\u2019est donc pas \u00e9tonnant d\u2019obtenir un test de si faible qualit\u00e9. Pour rappel, les \u00e9chantillons \u00e9taient constitu\u00e9s de 75 % de patients positifs. Une pr\u00e9vision constante (qui pr\u00e9voit syst\u00e9matiquement que le patient est positif) obtiendrait une pr\u00e9cision de 75 %.", "methods": "D\u00e9velopper une m\u00e9thode d\u2019assistance pour les radiologues, bas\u00e9e sur l\u2019apprentissage par deep learning pour le diagnostic du COVID-19 par analyse d\u2019images d\u2019examens de tomodensitom\u00e9trie thoracique.", "pubmed_id": "32408222\n32191588\n32101510\n28930698\n30334786\n32155105\n32017662\n28981409\n31002322\n31986261\n30224757", "doi": "10.1016/j.ejrad.2020.109041", "abstract": "To develop a deep learning-based method to assist radiologists to fast and accurately identify patients with COVID-19 by CT images.\nWe retrospectively collected chest CT images of 495 patients from three hospitals in China. 495 datasets were randomly divided into 395 cases (80%, 294 of COVID-19, 101 of other pneumonia) of the training set, 50 cases (10%, 37 of COVID-19, 13 of other pneumonia) of the validation set and 50 cases (10%, 37 of COVID-19, 13 of other pneumonia) of the testing set. We trained a multi-view fusion model using deep learning network to screen patients with COVID-19 using CT images with the maximum lung regions in axial, coronal and sagittal views. The performance of the proposed model was evaluated by both the validation and testing sets.\nThe multi-view deep learning fusion model achieved the area under the receiver-operating characteristics curve (AUC) of 0.732, accuracy of 0.700, sensitivity of 0.730 and specificity of 0.615 in validation set. In the testing set, we can achieve AUC, accuracy, sensitivity and specificity of 0.819, 0.760, 0.811 and 0.615 respectively.\nBased on deep learning method, the proposed diagnosis model trained on multi-view images of chest CT images showed great potential to improve the efficacy of diagnosis and mitigate the heavy workload of radiologists for the initial screening of COVID-19 pneumonia.", "topics": ["Diagnostique", "Radiologie"], "author_list": [{"id": 507, "name": "Wu X"}], "publication_date": "2020-05-06"}, {"id": 500, "slug": "does-sars-cov-2-invade-the-brain-translational-lessons-from-animal-models", "title": "Does SARS-Cov-2 invade the brain? Translational lessons from animal models", "has_other_authors": true, "impact_factor": {"id": 3, "name": "Interm\u00e9diaire", "posts_count": 140, "color": "orange", "order": 2}, "goals_plain": "Description des connaissances actuelles des mod\u00e8les pr\u00e9c\u00e9dents d'infections \u00e0 coronavirus et de leur pertinence potentielle pour COVID-19.", "verbose_date": "28.04.2020", "authors": "Natoli S", "specialties": [{"id": 18, "name": "Neurologie"}], "category": {"id": 2, "name": "Autres", "icon": "icon-other"}, "journal": {"id": 181, "name": "Eur J Neurol"}, "link": "https://onlinelibrary.wiley.com/doi/epdf/10.1111/ene.14277", "findings": "", "take_away": "", "relevance_level": "Les coronavirus humains sont principalement des agents pathog\u00e8nes respiratoires.\r\nDes rapports ant\u00e9rieurs sugg\u00e8rent que le SRAS-CoV et le MERS-CoV peuvent occasionnellement causer des infections du SNC cliniquement pertinentes.\r\nEn fait, les mod\u00e8les animaux sugg\u00e8rent une invasion de ces virus par le SNC, soit par le bulbe olfactif, soit par la diss\u00e9mination sanguine de monocytes infect\u00e9s et activ\u00e9s passant \u00e0 travers une barri\u00e8re h\u00e9mato-enc\u00e9phalique perm\u00e9able du fait de la r\u00e9ponse inflammatoire syst\u00e9mique.", "objectives": "-\tRevue exhaustive avec des conclusions prudentes-\tM\u00e9thode non d\u00e9crite dans les d\u00e9tails", "methods": "Description des connaissances actuelles des mod\u00e8les pr\u00e9c\u00e9dents d'infections \u00e0 coronavirus et de leur pertinence potentielle pour COVID-19.", "pubmed_id": "32333487\n12459472\n24065148\n14647384\n25281913\n16043521\n15016862\n15141376\n32054787\n16322745\n17079315\n16415928\n23835475\n16759866\n32142651\n27901465\n24062443\n26869154\n32065055\n32075877\n15030709\n23532101\n12690092\n25589660\n10982334\n18495771\n30416428\n23486063\n14702500\n14633895\n21325420\n29451201\n23552422\n15141377\n25600929\n28748673\n26184451\n32246917\n15992768\n26671446\n15452265\n16760397\n15356152", "doi": "10.1111/ene.14277", "abstract": "The current coronavirus disease (COVID-19) outbreak, caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has raised the possibility of potential neurotropic properties of this virus. Indeed, neurological sequelae of SARS-CoV-2 infection have already been reported and highlight the relevance of considering the neurological impact of coronavirus (CoV) from a translational perspective. Animal models of SARS and Middle East respiratory syndrome, caused by structurally similar CoVs during the 2002 and 2012 epidemics, have provided valuable data on nervous system involvement by CoVs and the potential for central nervous system spread of SARS-CoV-2. One key finding that may unify these pathogens is that all require angiotensin-converting enzyme 2 as a cell entry receptor. The CoV spike glycoprotein, by which SARS-CoV-2 binds to cell membranes, binds angiotensin-converting enzyme 2 with a higher affinity compared with SARS-CoV. The expression of this receptor in neurons and endothelial cells hints that SARS-CoV-2 may have higher neuroinvasive potential compared with previous CoVs. However, it remains to be determined how such invasiveness might contribute to respiratory failure or cause direct neurological damage. Both direct and indirect mechanisms may be of relevance. Clinical heterogeneity potentially driven by differential host immune-mediated responses will require extensive investigation. Development of disease models to anticipate emerging neurological complications and to explore mechanisms of direct or immune-mediated pathogenicity in the short and medium term is therefore of great importance. In this brief review, we describe the current knowledge from models of previous CoV infections and discuss their potential relevance to COVID-19.", "topics": ["Autres", "Neurologie"], "author_list": [{"id": 468, "name": "Natoli S"}], "publication_date": "2020-04-28"}, {"id": 555, "slug": "autopsy-findings-and-venous-thromboembolism-in-patients-with-covid-19-a-prospect", "title": "Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study", "has_other_authors": true, "impact_factor": {"id": 3, "name": "Interm\u00e9diaire", "posts_count": 140, "color": "orange", "order": 2}, "goals_plain": "Valider et comparer les donn\u00e9es cliniques du COVID-19 avec les donn\u00e9es d'autopsie m\u00e9dicale, d'autopsie virtuelle et de tests virologiques", "verbose_date": "08.05.2020", "authors": "Wichmann D", "specialties": [{"id": 7, "name": "Transversale"}], "category": {"id": 2, "name": "Autres", "icon": "icon-other"}, "journal": {"id": 41, "name": "Ann Intern Med"}, "link": "https://www.acpjournals.org/doi/10.7326/M20-2003", "findings": "", "take_away": "", "relevance_level": "Les donn\u00e9es cliniques du COVID-19 sont coh\u00e9rentes avec celles retrouv\u00e9es en autopsie chez des patients d\u00e9c\u00e9d\u00e9s de l'infection : infiltrats pulmonaires bilat\u00e9raux et maladies thrombo-emboliques retrouv\u00e9es sur les 12 autopsies r\u00e9alis\u00e9es\nM\u00eame en post-mortem et au moins jusqu'\u00e0 5 jours apr\u00e8s le d\u00e9c\u00e8s, l'ARN du SARS-CoV-2\u00a0reste d\u00e9tectable avec une vir\u00e9mie mod\u00e9r\u00e9e au niveau pulmonaire (100% des cas). Il est fr\u00e9quemment retrouv\u00e9 \u00e9galement au niveau pharyng\u00e9 et parfois au niveau cardiaque, h\u00e9patique ou r\u00e9nal", "objectives": "- Etude de cohorte avec recrutement prospectif, cons\u00e9cutif et syst\u00e9matique de tous les patients avec infection confirm\u00e9e \u00e0 SARS-CoV-2- Protocole d'autopsie satisfaisant et tests virologiques performants- R\u00e9sultats coh\u00e9rents- Mais faible effectif (n=12)- Pas de preuve du risque infectieux repr\u00e9sent\u00e9 par cette vir\u00e9mie mod\u00e9r\u00e9e en post-mortem", "methods": "Valider et comparer les donn\u00e9es cliniques du COVID-19 avec les donn\u00e9es d'autopsie m\u00e9dicale, d'autopsie virtuelle et de tests virologiques", "topics": ["Autres", "Transversale"], "author_list": [{"id": 521, "name": "Wichmann D"}], "publication_date": "2020-05-08"}, {"id": 344, "slug": "classification-system-and-case-definition-for-sars-cov-2-infection-in-pregnant-w", "title": "Classification system and case definition for SARS-CoV-2 infection in pregnant women, fetuses, and neonates", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Pr\u00e9senter un syst\u00e8me de classification des infections par le SARS-CoV-2 maternelles-foetales-n\u00e9onatales.", "verbose_date": "15.04.2020", "authors": "Shah PS", "specialties": [{"id": 11, "name": "Gyn\u00e9cologie Obst\u00e9trique"}, {"id": 9, "name": "P\u00e9diatrie"}], "category": {"id": 6, "name": "Pronostique", "icon": "icon-chat"}, "journal": {"id": 148, "name": "Acta Obstet Gynecol Scand"}, "link": "https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/aogs.13870", "findings": "", "take_away": "", "relevance_level": "Un syst\u00e8me de classification des infections par le SARS-CoV-2 maternelles-foetales-n\u00e9onatales pourrait aider les professionnels de la sant\u00e9 et permettre des \u00e9tudes \u00e9pid\u00e9miologiques \u00e0 grande \u00e9chelle. Les crit\u00e8res propos\u00e9s sont bas\u00e9s sur les preuves actuelles, donc ces cat\u00e9gories devront peut-\u00eatre \u00eatre modifi\u00e9es.", "objectives": "Les crit\u00e8res propos\u00e9s sont bas\u00e9s sur les preuves actuelles, donc ces cat\u00e9gories devront peut-\u00eatre \u00eatre modifi\u00e9es.Ce syst\u00e8me de classification d\u00e9pend de la disponibilit\u00e9 de tests diagnostiques fiables et les nouvelles m\u00e9thodes peuvent entra\u00eener sa modification. Les tests de lait maternel, les pr\u00e9l\u00e8vements cutan\u00e9s maternels ou rectaux n'ont pas \u00e9t\u00e9 inclus dans la classification propos\u00e9e.", "methods": "Pr\u00e9senter un syst\u00e8me de classification des infections par le SARS-CoV-2 maternelles-foetales-n\u00e9onatales.", "pubmed_id": "32277845\n24928290\n32215579\n32215598\n32151335\n32154287\n32215589\n32141062\n32180426\n32238084\n32215581\n15724041\n8950557", "doi": "10.1111/aogs.13870", "abstract": null, "topics": ["Pronostique", "Gyn\u00e9cologie Obst\u00e9trique", "P\u00e9diatrie"], "author_list": [{"id": 330, "name": "Shah PS"}], "publication_date": "2020-04-15"}, {"id": 251, "slug": "blockchain-and-artificial-intelligence-technology-for-novel-coronavirus-disease-", "title": "Blockchain and Artificial Intelligence Technology for Novel Coronavirus Disease-19 Self-Testing", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Proposer et discuter l'utilisation d'une blockchain et de l'intelligence artificielle pour la gestion de l'\u00e9pid\u00e9mie de COVID-19 dans les pays \u00e0 ressources limit\u00e9es comme les pays d'Afrique sub-saharienne", "verbose_date": "06.04.2020", "authors": "Mashamba-Thompson TP", "specialties": [{"id": 7, "name": "Transversale"}], "category": {"id": 3, "name": "Diagnostique", "icon": "icon-heat"}, "journal": {"id": 118, "name": "Diagnostics"}, "link": "https://www.dropbox.com/s/fv8cgy9kqmkvrf8/diagnostics-10-00198.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Dans des pays \u00e0 ressources de sant\u00e9 limit\u00e9es, l'apport des technologies type block-chain et intelligence artificielle coupl\u00e9es \u00e0 un diagnostic de masse pourrait permettre de mieux contr\u00f4ler la pand\u00e9mie de COVID-19. N\u00e9anmoins il s'agirait d'une application nouvelle et qui manque d'exp\u00e9rimentation pr\u00e9alable.", "objectives": "- lettre \u00e0 l'\u00e9diteur- pas d'exp\u00e9rimentation/\u00e9tude sur l'utilisation de blockchain ou de l'IA \u00e0 des fins diagnostiques\"", "methods": "Proposer et discuter l'utilisation d'une blockchain et de l'intelligence artificielle pour la gestion de l'\u00e9pid\u00e9mie de COVID-19 dans les pays \u00e0 ressources limit\u00e9es comme les pays d'Afrique sub-saharienne", "pubmed_id": "32244841\n31986257\n32172596\n28270379\n30987333\n31035241\n29029814\n29186013\n26850905\n32110875\n24312185", "doi": "10.3390/diagnostics10040198", "abstract": "The novel coronavirus disease 19 (COVID-19) is rapidly spreading with a rising death toll and transmission rate reported in high income countries rather than in low income countries. The overburdened healthcare systems and poor disease surveillance systems in resource-limited settings may struggle to cope with this COVID-19 outbreak and this calls for a tailored strategic response for these settings. Here, we recommend a low cost blockchain and artificial intelligence-coupled self-testing and tracking systems for COVID-19 and other emerging infectious diseases. Prompt deployment and appropriate implementation of the proposed system have the potential to curb the transmissions of COVID-19 and the related mortalities, particularly in settings with poor access to laboratory infrastructure.", "topics": ["Diagnostique", "Transversale"], "author_list": [{"id": 241, "name": "Mashamba-Thompson TP"}], "publication_date": "2020-04-06"}, {"id": 391, "slug": "covid-19-transmission-in-mainland-china-is-associated-with-temperature-and-humid", "title": "COVID-19 transmission in Mainland China is associated with temperature and humidity: A time-series analysis", "has_other_authors": false, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "\u00c9tudier le lien entre param\u00e8tres m\u00e9t\u00e9orologiques (temp\u00e9rature et humidit\u00e9) et \u00e9volution du nombre journalier de cas de COVID-19 en Chine afin de mieux pr\u00e9dire l'\u00e9volution possible de la pand\u00e9mie.", "verbose_date": "20.04.2020", "authors": "Hongchao Q", "specialties": [{"id": 7, "name": "Transversale"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 166, "name": "Science of The Total Environment"}, "link": "https://reader.elsevier.com/reader/sd/pii/S0048969720322956?token=8157A05FB36454C69B6810273E09138F02112CF9A86E49BA91E5B22587B582699244F7109A8D29004B4D7A9DC3D506DB", "findings": "", "take_away": "", "relevance_level": "Comme cela avait pu \u00eatre mis en \u00e9vidence pour le SARS-CoV-1, le MERS-CoV ou encore la grippe, les conditions m\u00e9t\u00e9orologiques semblent avoir un effet sur l'\u00e9volution de l'\u00e9pid\u00e9mie de COVID-19. Dans le mod\u00e8le le plus fiable de cette \u00e9tude, portant sur la province de Hubei, il semble que l'augmentation de la temp\u00e9rature ou de l'humidit\u00e9 relative est associ\u00e9e \u00e0 une diminution de nombre de nouveaux cas journaliers de COVID-19 avec cependant une interaction entre ces deux param\u00e8tres qu'il semblera importante \u00e0 int\u00e9grer dans de futures \u00e9tudes sur le sujet. Celles-ci sont n\u00e9cessaires pour confirmer les r\u00e9sultats observ\u00e9s dans la province de Hubei avec plus de d'uniformit\u00e9 entre r\u00e9gions g\u00e9ographiques.", "objectives": "- pr\u00e9-proof- quantification de l'adoption par la population des mesures barri\u00e8res approch\u00e9e par un index discutable- hypoth\u00e8se utilis\u00e9e de stabilit\u00e9 du nombre de sujets \u00e0 risque contestable- extrapolation des donn\u00e9es m\u00e9t\u00e9orologiques d'une seule ville \u00e0 toute sa province- petits effectifs dans certaines provinces- nombreux cas import\u00e9s du Hubei dans certaines provinces- probables facteurs de confusion non pris en compte notamment les interventions de sant\u00e9 publique mises en place ou encore le statut socio-\u00e9conomique des provinces- existences de doutes quant \u00e0 l'authenticit\u00e9 des chiffres chinois", "methods": "\u00c9tudier le lien entre param\u00e8tres m\u00e9t\u00e9orologiques (temp\u00e9rature et humidit\u00e9) et \u00e9volution du nombre journalier de cas de COVID-19 en Chine afin de mieux pr\u00e9dire l'\u00e9volution possible de la pand\u00e9mie.", "pubmed_id": "32335405", "doi": "10.1016/j.scitotenv.2020.138778", "abstract": "COVID-19 has become a pandemic. The influence of meteorological factors on the transmission and spread of COVID-19 is of interest. This study sought to examine the associations of daily average temperature (AT) and relative humidity (ARH) with the daily counts of COVID-19 cases in 30 Chinese provinces (in Hubei from December 1, 2019 to February 11, 2020 and in other provinces from January 20, 2020 to Februarys 11, 2020). A Generalized Additive Model (GAM) was fitted to quantify the province-specific associations between meteorological variables and the daily cases of COVID-19 during the study periods. In the model, the 14-day exponential moving averages (EMAs) of AT and ARH, and their interaction were included with time trend and health-seeking behavior adjusted. Their spatial distributions were visualized. AT and ARH showed significantly negative associations with COVID-19 with a significant interaction between them (0.04, 95% confidence interval: 0.004-0.07) in Hubei. Every 1\u00a0\u00b0C increase in the AT led to a decrease in the daily confirmed cases by 36% to 57% when ARH was in the range from 67% to 85.5%. Every 1% increase in ARH led to a decrease in the daily confirmed cases by 11% to 22% when AT was in the range from 5.04\u00a0\u00b0C to 8.2\u00a0\u00b0C. However, these associations were not consistent throughout Mainland China.", "topics": ["Epid\u00e9miologique", "Transversale"], "author_list": [{"id": 376, "name": "Hongchao Q"}], "publication_date": "2020-04-20"}, {"id": 74, "slug": "covid-19-infection-epidemic-the-medical-management-strategies-in-heilongjiang-pr", "title": "COVID-19 infection epidemic: the medical management strategies in Heilongjiang Province, China", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Description r\u00e9trospective de ce qui a \u00e9t\u00e9 mis en place pour la gestion de la crise", "verbose_date": "18.03.2020", "authors": "Wang H", "specialties": [{"id": 4, "name": "Anesth\u00e9sie-R\u00e9animation"}], "category": {"id": 4, "name": "Th\u00e9rapeutique", "icon": "icon-med"}, "journal": {"id": 59, "name": "Crit Care"}, "link": "https://www.dropbox.com/s/83b1inzlrc9yaha/s13054-020-2832-8.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Description de leur PEC : - protection du staff medical : des protocoles d'entra\u00eenements aux gestes barri\u00e8res (lavage des mains, \u00e9quipements de protections, \u00e9limination s\u00fbre des d\u00e9chets, et protocole de gestion des urgences)  - pr\u00e9vention de la sant\u00e9 mentale du personnel  - suivi des conditions physiques du personnel : examens m\u00e9dicaux, prise de sang, scanner thoracique, examen journalier des symptomes respiratoires et de la temp\u00e9rature. Test COVID au moindre symptome.  - \u00e9quipements de protection : masques, lunettes, \u00e9crans faciaux et v\u00eatements d'isolation \u00e9tanche.  - organisation de la ressource m\u00e9dicale : ils ont cr\u00e9\u00e9 une \u00e9quipe multidisciplinaire : soins intensif, urgences, infectiologues, pneumologues, psychiatres, hygi\u00e8ne, administration et personnel infirmier. Les personnels \u00e9taient redistribu\u00e9s sur toute la province en fonction des besoins. lls ont cr\u00e9e 4 groupes m\u00e9dicaux : 1 a Wuhan, 1 dans les \"cliniques fi\u00e8vres\" (triage des patients fi\u00e9vreux, test diag, isolement des cas), 1 dans les hopitaux COVID, 1 pour la qualit\u00e9 (groupe qui se d\u00e9pla\u00e7ait pour v\u00e9rifier les prises en charge, r\u00e9pondait aux questions, s'assurait de la bonne sant\u00e9 des \u00e9quipes) - chemin des patients : fie\u00e8re -> FEVER CLINIC -> distinction des patients COVID positifs et negatifs, si \u00e9pid\u00e9miologie et clinique \u00e9vocatrices -> masque, scanner thoracique, biologie, isolement, puis si test positif -> isolement, information CDC, transfert dans les hopitaux COVID - strategie de management des \u00e9quipes m\u00e9dicales : pneumologues et infectiologues traitent les formes l\u00e9g\u00e8res, les r\u00e9animateurs les formes s\u00e9v\u00e8res. - utilisation d'une plateforme : pour pr\u00e9venir la diffusion du virus, les chirurgies non urgentes et des soins ambulatoires. La t\u00e9l\u00e9medecine a \u00e9t\u00e9 d\u00e9velopp\u00e9e pour prodiguer des consultations gratuites", "objectives": "Faible :  - description r\u00e9trospective de ce qui a \u00e9t\u00e9 mis en place pour la gestion de la crise", "methods": "Description r\u00e9trospective de ce qui a \u00e9t\u00e9 mis en place pour la gestion de la crise", "pubmed_id": "32188482\n31986264\n32007143\n32031570", "doi": "10.1186/s13054-020-2832-8", "abstract": null, "topics": ["Th\u00e9rapeutique", "Anesth\u00e9sie-R\u00e9animation"], "author_list": [{"id": 84, "name": "Wang H"}], "publication_date": "2020-03-18"}, {"id": 649, "slug": "physical-distancing-face-masks-and-eye-protection-to-prevent-person-to-person-tr", "title": "Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis", "has_other_authors": true, "impact_factor": {"id": 3, "name": "Interm\u00e9diaire", "posts_count": 140, "color": "orange", "order": 2}, "goals_plain": "Etudier l'efficacit\u00e9 de la distanciation sociale, des masques faciaux et des protections oculaires sur la transmission du SARS-CoV-2 dans les lieux publics et dans les \u00e9tablissements de sant\u00e9", "verbose_date": "03.06.2020", "authors": "Chu D", "specialties": [{"id": 7, "name": "Transversale"}, {"id": 12, "name": "Infectiologie"}, {"id": 2, "name": "Hygi\u00e8ne"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 12, "name": "Lancet"}, "link": "https://www.thelancet.com/action/showPdf?pii=S0140-6736%2820%2931142-9", "findings": "", "take_away": "", "relevance_level": "Les r\u00e9sultats de cette revue syst\u00e9matique avec m\u00e9ta-analyse ont montr\u00e9 :\r\n\t\nqu'une distance de 1 m\u00e8tre au minimum r\u00e9duisait le risque d'infection \u00e0 coronavirus d'au moins 4 fois et le risque diminue d'autant plus que la distance augmente\nque l'utilisation de masques, m\u00eame grand public,\u00a0r\u00e9duisait d'un facteur 7 le risque d'infection et ce d'autant plus s'il est utilis\u00e9 dans le contexte du soin ou si un masque FFP2 est utilis\u00e9\nque l'utilisation de protection oculaire r\u00e9duisait d'un facteur 4 le risque d'infection", "objectives": "- Revue syst\u00e9matique avec strat\u00e9gie de recherche bien conduite- M\u00e9ta-analyse avec statistiques robustes- Aucune \u00e9tude randomis\u00e9e retrouv\u00e9e, que des \u00e9tudes observationnelles- Forte h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 entre les \u00e9tudes et possible biais de publication non r\u00e9ellement \u00e9valu\u00e9 (pas de funnel plot par exemple)- Inclusion des articles avec infection \u00e0 d'autres coronavirus (SARS et MERS)- Inclusion de cas probables (pas uniquement de cas confirm\u00e9s)", "methods": "Etudier l'efficacit\u00e9 de la distanciation sociale, des masques faciaux et des protections oculaires sur la transmission du SARS-CoV-2 dans les lieux publics et dans les \u00e9tablissements de sant\u00e9", "pubmed_id": "32497510\n32131908\n32203710\n14609453\n18436948\n29140516\n15555351\n32142885\n16870029\n26384679\n16434750\n23413265\n15030685\n18806349\n16022801\n15030692\n16014825\n16907978\n31866469\n27222710\n25418612\n14767817\n15061941\n21803546\n23116689\n27191038\n19284644\n32371934\n31711912\n15473141\n15030689\n15030686\n15030695\n15825024\n25775931\n27475739\n25589399\n27005372\n17366443\n15030690\n26796947\n16778970\n10789670\n19797474\n17217552\n11491414\n31666061\n24655721\n30347031\n27767011\n14681507\n32298249\n15030696\n12737864\n15160401\n19631508\n17262914\n21195583", "doi": "10.1016/S0140-6736(20)31142-9", "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19 and is spread person-to-person through close contact. We aimed to investigate the effects of physical distance, face masks, and eye protection on virus transmission in health-care and non-health-care (eg, community) settings.\nWe did a systematic review and meta-analysis to investigate the optimum distance for avoiding person-to-person virus transmission and to assess the use of face masks and eye protection to prevent transmission of viruses. We obtained data for SARS-CoV-2 and the betacoronaviruses that cause severe acute respiratory syndrome, and Middle East respiratory syndrome from 21 standard WHO-specific and COVID-19-specific sources. We searched these data sources from database inception to May 3, 2020, with no restriction by language, for comparative studies and for contextual factors of acceptability, feasibility, resource use, and equity. We screened records, extracted data, and assessed risk of bias in duplicate. We did frequentist and Bayesian meta-analyses and random-effects meta-regressions. We rated the certainty of evidence according to Cochrane methods and the GRADE approach. This study is registered with PROSPERO, CRD42020177047.\nOur search identified 172 observational studies across 16 countries and six continents, with no randomised controlled trials and 44 relevant comparative studies in health-care and non-health-care settings (n=25\u2008697 patients). Transmission of viruses was lower with physical distancing of 1 m or more, compared with a distance of less than 1 m (n=10\u2008736, pooled adjusted odds ratio [aOR] 0\u00b718, 95% CI 0\u00b709 to 0\u00b738; risk difference [RD] -10\u00b72%, 95% CI -11\u00b75 to -7\u00b75; moderate certainty); protection was increased as distance was lengthened (change in relative risk [RR] 2\u00b702 per m; p\nThe findings of this systematic review and meta-analysis support physical distancing of 1 m or more and provide quantitative estimates for models and contact tracing to inform policy. Optimum use of face masks, respirators, and eye protection in public and health-care settings should be informed by these findings and contextual factors. Robust randomised trials are needed to better inform the evidence for these interventions, but this systematic appraisal of currently best available evidence might inform interim guidance.\nWorld Health Organization.", "topics": ["Epid\u00e9miologique", "Transversale", "Infectiologie", "Hygi\u00e8ne"], "author_list": [{"id": 610, "name": "Chu D"}], "publication_date": "2020-06-03"}, {"id": 554, "slug": "androgen-deprivation-therapies-for-prostate-cancer-and-risk-of-infection-by-sars", "title": "Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (n=4532)", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Tester l'hypoth\u00e8se selon laquelle les anti-androg\u00e8nes peuvent \u00eatre un facteur protecteur de l'infection \u00e0 SARS-CoV-2 chez les patients pr\u00e9sentant un cancer de la prostate, du fait de leur inhibition de la transcription de la prot\u00e9ase TMPRSS2\r\n\r\nPour cela, \u00e9valuation dans la r\u00e9gion italienne de Veneto la fr\u00e9quence de l'infection COVID-19 parmi :\r\n\r\n1- patients atteints par un cancer\r\n\r\n2- patients atteints par un cancer de la prostate\r\n\r\n3- patients atteints par un cancer de la prostate trait\u00e9 avec ou sans anti-androg\u00e8nes et enfin \u00e9valuer la s\u00e9v\u00e9rit\u00e9 de l'infection \u00e0 SARS-CoV-2 parmi ces 2 sous-populations.", "verbose_date": "08.05.2020", "authors": "Montopoli M", "specialties": [{"id": 7, "name": "Transversale"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 218, "name": "Annals Oncol"}, "link": "https://www.annalsofoncology.org/article/S0923-7534(20)39797-0/pdf", "findings": "", "take_away": "", "relevance_level": "Sur 9280 patients COVID-19 + avec documentation biologique, dans la r\u00e9gion de Veneto :\nLa\u00a0 pr\u00e9valence de l'infection \u00e9tait sup\u00e9rieure chez les femmes (56% de femmes vs. 44% d'hommes) mais les hommes \u00e9taient majoritaires en : hospitalisation (60% d'hommes vs. 40% de femmes), soins intensifs (78% vs. 22%) et en termes de d\u00e9c\u00e8s (62% vs. 38%).\nParmi la population masculine infect\u00e9e (n=4532) : 9,5% \u00e9taient porteurs d'un cancer et 1,3% d'un cancer de la prostate parmi ceux-ci seulement 4 recevaient un traitement par anti-androg\u00e8nes.\nLa population g\u00e9n\u00e9rale paraissait donc plus \u00e0 risque de d\u00e9velopper l'infection COVID-19 que les hommes trait\u00e9s par anti-androg\u00e8nes pour un cancer de la prostate (OR 4.05; 95% CI 1.55-10.59), r\u00e9sultat similaire en comparant les porteurs d'un cancer avec les hommes trait\u00e9s par anti-androg\u00e8nes pour un cancer de la prostate\u00a0(OR 5.17; 95% CI 2.02-13.40).", "objectives": "\u00c9tude observationnelle transversale descriptive.Effectif extr\u00eamement faible de patients infect\u00e9s trait\u00e9s par anti-androg\u00e8nes (n=4).", "methods": "Tester l'hypoth\u00e8se selon laquelle\u00a0les anti-androg\u00e8nes peuvent \u00eatre un facteur protecteur de l'infection \u00e0 SARS-CoV-2 chez les patients pr\u00e9sentant un\u00a0cancer de la prostate, du fait de leur inhibition de la transcription de la prot\u00e9ase TMPRSS2\nPour cela, \u00e9valuation\u00a0dans la r\u00e9gion italienne de Veneto la fr\u00e9quence de l'infection COVID-19 parmi :\n1- patients atteints par un cancer\n2- patients atteints par un cancer de la prostate\n3- patients atteints par un cancer de la prostate trait\u00e9 avec ou sans anti-androg\u00e8nes et enfin \u00e9valuer la s\u00e9v\u00e9rit\u00e9 de l'infection \u00e0 SARS-CoV-2 parmi ces 2 sous-populations.", "topics": ["Epid\u00e9miologique", "Transversale"], "author_list": [{"id": 520, "name": "Montopoli M"}], "publication_date": "2020-05-08"}, {"id": 605, "slug": "acute-chloroquine-poisoning-a-comprehensive-experimental-toxicology-assessment-o", "title": "Acute chloroquine poisoning: A comprehensive experimental toxicology assessment of the role of diazepam", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Evaluer les potentiels effets protecteurs du diaz\u00e9pam (indiqu\u00e9 en cas d'intoxication) dans des mod\u00e8les exp\u00e9rimentaux de cardiotoxicit\u00e9 li\u00e9s \u00e0 la chloroquine", "verbose_date": "19.05.2020", "authors": "Hughes DA", "specialties": [{"id": 12, "name": "Infectiologie"}, {"id": 18, "name": "Neurologie"}, {"id": 17, "name": "Cardiologie et maladies m\u00e9taboliques"}], "category": {"id": 4, "name": "Th\u00e9rapeutique", "icon": "icon-med"}, "journal": {"id": 239, "name": "Br J Pharmacol"}, "link": "https://www.dropbox.com/s/8ufxvx47obeta8y/10.1111%40bph.15101.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Ni le diaz\u00e9pam, ni d'autres ligands des sites de liaison des benzodiaz\u00e9pines, ne prot\u00e8gent contre ou n'att\u00e9nuent la cardiotoxicit\u00e9 de la chloroquine. Le diaz\u00e9pam semble augmenter les effets des inotropes positifs dans la r\u00e9duction de la cardiotoxicit\u00e9 de la chloroquine", "objectives": "In vitro et in vivo chez la souris et le lapinPas d'aveugle", "methods": "Evaluer les potentiels effets protecteurs du diaz\u00e9pam (indiqu\u00e9 en cas d'intoxication) dans des mod\u00e8les exp\u00e9rimentaux de cardiotoxicit\u00e9 li\u00e9s \u00e0 la chloroquine", "pubmed_id": "32415690", "doi": "10.1111/bph.15101", "abstract": "Resurgence in the use of chloroquine as a putative treatment for COVID-19 has seen recent cases of fatal toxicity due to unintentional overdoses. Protocols for the management of poisoning recommend diazepam, although there are uncertainties in its pharmacology and efficacy in this context. The aim was to assess the effects of diazepam in experimental models of chloroquine cardiotoxicity.\nIn vitro experiments involved cardiac tissues isolated from rats and incubated with chloroquine, alone, or in combination with diazepam. In vivo models of toxicity involved chloroquine administered intravenously to pentobarbitone-anaesthetised rats and rabbits. Randomised, controlled interventional studies in rats assessed diazepam, clonazepam and Ro5-4864 administered: (i) prior, (ii) during, and (iii) after chloroquine; and the effects of diazepam: (iv) at high dose, (v) in urethane-anaesthetised rats, and (vi) co-administered with adrenaline.\nChloroquine decreased the developed tension of left atria, prolonged the effective refractory period of atria, ventricular tissue and right papillary muscles, and caused dose-dependent impairment of haemodynamic and electrocardiographic parameters. Cardiac arrhythmias indicated impairment of atrioventricular conduction. Studies (i), (ii) and (v) showed no differences between interventions and control. Diazepam increased heart rate in study (iv) and, as with clonazepam, also prolonged the QTc interval in study (iii). Combined administration of diazepam and adrenaline in study (vi) improved cardiac contractility but caused hypokalaemia.\nNeither diazepam, nor other ligands for benzodiazepine binding sites, protect against or attenuate chloroquine cardiotoxicity. However, diazepam may augment the effe cts of positive inotropes in reducing chloroquine cardiotoxicity.", "topics": ["Th\u00e9rapeutique", "Infectiologie", "Neurologie", "Cardiologie et maladies m\u00e9taboliques"], "author_list": [{"id": 568, "name": "Hughes DA"}], "publication_date": "2020-05-19"}, {"id": 380, "slug": "correlation-between-relative-nasopharyngeal-virus-rna-load-and-lymphocyte-count-", "title": "Correlation Between Relative Nasopharyngeal Virus RNA Load and Lymphocyte Count Disease Severity in Patients with COVID-19", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Analyse de la corr\u00e9lation entre les changements de la charge virale du SRAS-CoV-2 et les changements du nombre de lymphocytes.", "verbose_date": "19.04.2020", "authors": "Liu Y", "specialties": [{"id": 5, "name": "Virologie"}, {"id": 12, "name": "Infectiologie"}], "category": {"id": 6, "name": "Pronostique", "icon": "icon-chat"}, "journal": {"id": 161, "name": "Viral Immunol"}, "link": "https://www.liebertpub.com/doi/pdf/10.1089/vim.2020.0062", "findings": "", "take_away": "", "relevance_level": "La charge virale ARN relative du SRAS-CoV-2 dans l'\u00e9chantillon oral est \u00e9troitement li\u00e9e \u00e0 la gravit\u00e9 de la COVID-19.\u00a0\r\nSi la charge relative d'ARN de SRAS-CoV-2 est plus \u00e9lev\u00e9e, le nombre de lymphocytes est plus faible, le dommage au myocarde est plus important et le temps\r\npour que le test RT-PCR devienne n\u00e9gatif est plus long.", "objectives": "1) \u00e9tude observationnelle r\u00e9trospective2) petit \u00e9chantillon (n=76) et inclusion limit\u00e9e \u00e0 une partie des patients COVID-19 de l'h\u00f4pital3) \u00e9tude men\u00e9e dans h\u00f4pital provincial d\u00e9sign\u00e9 pour les patients COVID-19 et leurs sympt\u00f4mes graves4) le diagnostic par RT-PCR uniquement et sur des \u00e9chantillons oraux (aucun \u00e9chantillon des voies respiratoires basses n'a \u00e9t\u00e9 test\u00e9)\"", "methods": "Analyse de la corr\u00e9lation entre les changements de la charge virale du SRAS-CoV-2 et les changements du nombre de lymphocytes.", "pubmed_id": "32297828", "doi": "10.1089/vim.2020.0062", "abstract": "The aim of this study was to analyze the correlation between dynamic changes in the nasopharyngeal viral load of patients infected with the new coronavirus causing pneumonia and lymphocyte count disease severity. Cases newly diagnosed with COVID-19 at the First Affiliated Hospital of Nanchang University from January 2020 to February 2020 were analyzed retrospectively. Quantitative real-time polymerase chain reaction was used to determine severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from throat swab sample \u0394CT values; lymphocyte and lymphocyte subset counts, coagulation system factor levels, myocardial injury indexes, and laboratory biochemical indicators were compared between the mild group and the severe group. The correlation between the relative load of nasopharyngeal SARS-CoV-2 RNA and severe disease symptoms was analyzed. Of the 76 patients, 49 were male and 27 were female. The lymphocyte, CD4", "topics": ["Pronostique", "Virologie", "Infectiologie"], "author_list": [{"id": 311, "name": "Liu Y"}], "publication_date": "2020-04-19"}, {"id": 200, "slug": "quantifying-treatment-effects-of-hydroxychloroquine-and-azithromycin-for-covid-1", "title": "Quantifying treatment effects of hydroxychloroquine and azithromycin for COVID-19: \u00e0 secondary analysis of an open label non-randomized clinical trial (Gautret et al, 2020)", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Calculer les \"estimations d'effet de taille\" (effect size estimates) d'un essai clinique non randomis\u00e9 quantifiant l'effet de l'hydroxychloroquine et azithromycine pour le COVID 19", "verbose_date": "31.03.2020", "authors": "Lover AA ", "specialties": [{"id": 12, "name": "Infectiologie"}], "category": {"id": 4, "name": "Th\u00e9rapeutique", "icon": "icon-med"}, "journal": {"id": 85, "name": "Pre-prints"}, "link": "https://www.dropbox.com/s/3beq1bwdz34eka2/2020.03.22.20040949v1.full.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Info hors article : Les effects size estimates (EZE) sont calcul\u00e9s pour donner une information sur la direction et la force de la relation entre le traitement et l'outcome. Ils ne sont pas sensibles \u00e0 la taille de l'\u00e9chantillon (contrairement \u00e0 la p value). Ils permettent de comparer les r\u00e9sultats entre \u00e9tudes.\n\r\nIci les mod\u00e8les de survie montrent un effet modeste voir nul du traitement par HCQ, et un effet plus significatif si combinaison HCQ-AZ.\n\r\nToutefois les r\u00e9sultats de l'\u00e9tude initiale avec l'ajout des ESE ne donne pas assez de preuves pour valider l' HCQ en monoth\u00e9rapie dans le traitement du COVID 19.\r\nCependant cette \u00e9tude montre qu'il faut faire d'autres \u00e9tudes sur la combinaison HCQ-AZ rapidement et en priorit\u00e9.", "objectives": "- Pre-print- Charge virale = mauvais crit\u00e8re de jugement car relation inverse entre charge virale et s\u00e9v\u00e9rit\u00e9 d\u00e9montr\u00e9e pour la famille des coronavirus dans une pr\u00e9c\u00e9dente \u00e9tude de 2016 publi\u00e9e dans Nature (\"\"SRAS and MERS: recent insights into emerging coronaviruses\"\")- perte de vue de 6 patients- clairance \u00e0 6 jours de l'\u00e9tude, mais quand les patients ont ils \u00e9t\u00e9 inclus, \u00e0 quel stade de la maladie ?- stratifi\u00e9 sur \u00c2ge, sexe mais pas sur s\u00e9v\u00e9rit\u00e9 (il faudrait voir les crit\u00e8res d'inclusion/exclusion de l'\u00e9tude originale)- se base sur des donn\u00e9es d'une autre \u00e9tude (P. GAUTRET) en reprenant les m\u00eames outcomes et les m\u00eame calculs de puissance (design cas contr\u00f4le) : Toutes les variables n'\u00e9taient pas disponibles dans les donn\u00e9es originales, Essai non randomis\u00e9 en ouvert sur faible effectif, Patients contr\u00f4les et trait\u00e9s dans h\u00f4pitaux diff\u00e9rents, Multiplicit\u00e9 des tests statistiques (inflation risque alpha majeur), et 10 patients t\u00e9moins sur 16 consid\u00e9r\u00e9s comme positif alors que non test\u00e9s.\"", "methods": "Calculer les \"estimations d'effet de taille\" (effect size estimates) d'un essai clinique non randomis\u00e9 quantifiant l'effet de l'hydroxychloroquine et azithromycine pour le COVID 19", "topics": ["Th\u00e9rapeutique", "Infectiologie"], "author_list": [{"id": 193, "name": "Lover AA "}], "publication_date": "2020-03-31"}, {"id": 408, "slug": "a-nicotinic-hypothesis-for-covid-19-with-preventive-and-therapeutic-implications", "title": "A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Etudier le lien entre la nicotine et le COVID-19 via le r\u00e9cepteur nicotine-acetylcholine (nAChR)", "verbose_date": "22.04.2020", "authors": "Changeux JP", "specialties": [{"id": 12, "name": "Infectiologie"}, {"id": 18, "name": "Neurologie"}, {"id": 8, "name": "Pneumologie"}], "category": {"id": 4, "name": "Th\u00e9rapeutique", "icon": "icon-med"}, "journal": {"id": 85, "name": "Pre-prints"}, "link": "https://www.qeios.com/read/article/571", "findings": "", "take_away": "", "relevance_level": "Les auteurs proposent l'hypoth\u00e8se que la voie du r\u00e9cepteur ac\u00e9tylcholine-nicotine (nAChR) joue un r\u00f4le essentiel dans la physiopathologie de l'infection par le SARS-CoV-2 et ils proposent donc que la nicotine ou des agents nicotiniques orthost\u00e9riques et/ou allost\u00e9riques puissent \u00eatre utilis\u00e9s comme th\u00e9rapie possible pour le COVID-19. Une \u00e9tude va d\u00e9buter avec un traitement pr\u00e9ventif et curatif via des patchs nicotiniques en France.\r\nL'hypoth\u00e8se nicotinique doit \u00eatre \u00e9tudi\u00e9 via des \u00e9tudes cliniques suppl\u00e9mentaires et par des observations exp\u00e9rimentales d\u00e9terminant si le SARS-CoV-2 interagit physiquement avec le nAChR. Les auteurs insistent \u00e9galement sur les dangers que repr\u00e9sentent le tabac pour la sant\u00e9 en distinguant l'effet propre de la nicotine et l'impact n\u00e9gatif du tabagisme sur le COVID-19.", "objectives": "- Analyse d'une litt\u00e9rature tr\u00e8s r\u00e9cente et peu abondante (tr\u00e8s peu de donn\u00e9es sur le SARS-CoV-2 soutenant l'hypoth\u00e8se)- Exp\u00e9rimentations encore tr\u00e8s restreintes avec le SARS-CoV-2, uniquement sur la structure du virus pour le moment", "methods": "Etudier le lien entre la nicotine et le COVID-19 via le r\u00e9cepteur nicotine-acetylcholine (nAChR)", "topics": ["Th\u00e9rapeutique", "Infectiologie", "Neurologie", "Pneumologie"], "author_list": [{"id": 389, "name": "Changeux JP"}], "publication_date": "2020-04-22"}]