[{"id": 355, "slug": "epidemiological-characteristics-of-covid-19-cases-in-italy-and-estimates-of-the-", "title": "Epidemiological characteristics of COVID-19 cases in Italy and estimates of the reproductive numbers one month into the epidemic", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "R\u00e9sumer les donn\u00e9es \u00e9pid\u00e9miologiques nationales italiennes des 60 000 premiers cas confirm\u00e9s de COVID-19 ainsi que les ph\u00e9nom\u00e8nes de transmission observ\u00e9s dans les diff\u00e9rentes r\u00e9gions du pays", "verbose_date": "16.04.2020", "authors": "Riccardo F", "specialties": [{"id": 7, "name": "Transversale"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 85, "name": "Pre-prints"}, "link": "https://www.medrxiv.org/content/10.1101/2020.04.08.20056861v1.full.pdf", "findings": "", "take_away": "", "relevance_level": "Le retard de d\u00e9tection de la transmission locale du SARS-CoV-2 a probablement jou\u00e9 un r\u00f4le important dans l'ampleur de l'\u00e9pid\u00e9mie en Italie. La situation est tr\u00e8s variable selon les r\u00e9gions avec une majorit\u00e9 de cas dans le nord du pays. C'est aussi au nord qu'il semblerait que le taux de reproduction net ait commenc\u00e9 \u00e0 diminuer le plus t\u00f4t mais ces taux ont \u00e9t\u00e9 estim\u00e9s dans seulement 6 r\u00e9gions est le recul est insuffisant sur ces donn\u00e9es. Le taux de l\u00e9talit\u00e9 est \u00e9lev\u00e9 dans cette \u00e9tude mais certainement surestim\u00e9 puisque seuls les cas confirm\u00e9s par RT-PCR sont inclus. N\u00e9anmoins l'\u00e2ge et le sexe masculin paraissent \u00eatre des facteurs de mauvais pronostic. Il y a un grand nombre de cas parmi les soignants.", "objectives": "- pre-print- seulement les cas confirm\u00e9s par RT-PCR sont inclus pouvant expliquer le taux \u00e9lev\u00e9 de l\u00e9talit\u00e9 report\u00e9- d\u00e9finition large du statut de soignant : toute personne ayant d\u00e9j\u00e0 exerc\u00e9 dans le secteur de la sant\u00e9- estimation des taux de reproduction sur les donn\u00e9es de seulement 6 r\u00e9gions\"", "methods": "R\u00e9sumer les donn\u00e9es \u00e9pid\u00e9miologiques nationales italiennes des 60 000 premiers cas confirm\u00e9s de COVID-19 ainsi que les ph\u00e9nom\u00e8nes de transmission observ\u00e9s dans les diff\u00e9rentes r\u00e9gions du pays", "topics": ["Epid\u00e9miologique", "Transversale"], "author_list": [{"id": 342, "name": "Riccardo F"}], "publication_date": "2020-04-16"}, {"id": 508, "slug": "clinical-characteristics-and-outcomes-of-patients-with-severe-covid-19-with-diab", "title": "Clinical characteristics and outcomes of patients with severe covid-19 with diabetes", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Etudier les sp\u00e9cificit\u00e9s cliniques et l'\u00e9volution des patients diab\u00e9tiques atteints par une forme s\u00e9v\u00e8re de COVID-19.", "verbose_date": "02.05.2020", "authors": "Yan Y", "specialties": [{"id": 17, "name": "Cardiologie et maladies m\u00e9taboliques"}], "category": {"id": 6, "name": "Pronostique", "icon": "icon-chat"}, "journal": {"id": 202, "name": "BMJ open diabetes research & care"}, "link": "https://drc.bmj.com/content/bmjdrc/8/1/e001343.full.pdf", "findings": "", "take_away": "", "relevance_level": "Les patients COVID-19 s\u00e9v\u00e8res avec ant\u00e9c\u00e9dent de diab\u00e8te, plus \u00e2g\u00e9s que les non diab\u00e9tiques, semblent pr\u00e9senter une plus importante r\u00e9ponse inflammatoire, \u00eatre plus susceptibles d'\u00eatre admis en soins intensifs et d'\u00eatre ventil\u00e9s. Leur taux de survie est \u00e9galement moins \u00e9lev\u00e9 et pourrait s'expliquer par leur niveau de glyc\u00e9mie.", "objectives": "- \u00e9tude r\u00e9trospective monocentrique- biais de s\u00e9lection li\u00e9 \u00e0 cet h\u00f4pital d\u00e9sign\u00e9 pour le traitement des patients s\u00e9v\u00e8res- faible effectif- l'analyse de la dur\u00e9e d'hospitalisation n'exclue pas les patients d\u00e9c\u00e9d\u00e9s", "methods": "Etudier les sp\u00e9cificit\u00e9s cliniques et l'\u00e9volution des patients diab\u00e9tiques atteints par une forme s\u00e9v\u00e8re de COVID-19.", "pubmed_id": "32345579\n31986261\n21487074\n32125362\n9973685\n21169542\n16759303\n30805712\n21252989\n24002281\n32007143\n9272930\n32007145\n12734147\n31995857\n20587722\n23747244\n32004427\n27820698\n17029568\n30070331\n32031570\n24530745\n27612502\n31986264\n32105632\n28251163\n32003551\n23473035\n24077098", "doi": "10.1136/bmjdrc-2020-001343", "abstract": "This study explores the clinical characteristics of patients with diabetes with severe covid-19, and the association of diabetes with survival duration in patients with severe covid-19.\nIn this single-center, retrospective, observational study, the clinical and laboratory characteristics of 193 patients with severe covid-19 were collected. 48 patients with severe covid-19 had diabetes, and 145 patients (ie, the controls) did not have diabetes. A severe case was defined as including at least one of the following criteria: (1) Respiratory rate >30/min. (2) Oxygen saturation \u226493%. (3) PaO\nOf 193 patients with severe covid-19, 48 (24.9%) had diabetes. Compared with patients with severe covid-19 without diabetes, patients with diabetes were older, susceptible to receiving mechanical ventilation and admission to ICU, and had higher mortality. In addition, patients with severe covid-19 with diabetes had higher levels of leukocyte count, neutrophil count, high-sensitivity C reaction protein, procalcitonin, ferritin, interleukin (IL) 2 receptor, IL-6, IL-8, tumor necrosis factor \u03b1, D-dimer, fibrinogen, lactic dehydrogenase and N-terminal pro-brain natriuretic peptide. Among patients with severe covid-19 with diabetes, more non-survivors were men (30 (76.9%) \nThe mortality rate in patients with severe covid-19 with diabetes is considerable. Diabetes may lead to an increase in the risk of death.", "topics": ["Pronostique", "Cardiologie et maladies m\u00e9taboliques"], "author_list": [{"id": 476, "name": "Yan Y"}], "publication_date": "2020-05-02"}, {"id": 622, "slug": "features-of-20-133-uk-patients-in-hospital-with-covid-19-using-the-isaric-who-cl", "title": "Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study", "has_other_authors": true, "impact_factor": {"id": 3, "name": "Interm\u00e9diaire", "posts_count": 140, "color": "orange", "order": 2}, "goals_plain": "D\u00e9crire les caract\u00e9ristiques cliniques des patients admis \u00e0 l'h\u00f4pital avec la maladie \u00e0 coronavirus 2019 (covid-19) au Royaume-Uni pendant la phase de croissance de la premi\u00e8re vague de cette \u00e9pid\u00e9mie, qui ont \u00e9t\u00e9 recrut\u00e9s dans l'\u00e9tude de l\u2019International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) World Health Organization (WHO) Clinical Characterisation Protocol UK (CCP-UK), et explorer les facteurs de risque associ\u00e9s \u00e0 la mortalit\u00e9 \u00e0 l'h\u00f4pital.\r\n\r\n ", "verbose_date": "30.05.2020", "authors": "Docherty AB", "specialties": [{"id": 7, "name": "Transversale"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 57, "name": "BMJ"}, "link": "https://www.bmj.com/content/bmj/369/bmj.m1985.full.pdf", "findings": "", "take_away": "", "relevance_level": "ISARIC WHO CCP-UK est une vaste \u00e9tude de cohorte prospective sur des patients hospitalis\u00e9s atteints de covid-19. L'\u00e9tude est toujours en cours au moment de la r\u00e9daction de ce rapport.\nLa plupart des patients atteints de covid-19 pr\u00e9sentent une maladie b\u00e9nigne. Cependant, dans cette cohorte, parmi ceux qui ont \u00e9t\u00e9 admis \u00e0 l'h\u00f4pital deux semaines avant l'extraction des donn\u00e9es, moins de la moiti\u00e9 \u00e9taient sortis et un quart \u00e9taient d\u00e9c\u00e9d\u00e9s. Les autres patients ont continu\u00e9 de\u00a0recevoir des soins \u00e0 la date du rapport. 17%\u00a0des patients admis \u00e0 l'h\u00f4pital ont eu besoin de soins\u00a0critiques. Les facteurs associ\u00e9s \u00e0 la mortalit\u00e9 \u00e0 l'h\u00f4pital \u00e9taient l'\u00e2ge croissant, le sexe masculin, l'ob\u00e9sit\u00e9 et les comorbidit\u00e9s majeures.\nCette vaste \u00e9tude men\u00e9e rapidement sur des patients hospitalis\u00e9s en Angleterre, au Pays de Galles et en \u00c9cosse a montr\u00e9 l'importance de la pr\u00e9paration \u00e0 une pand\u00e9mie et la n\u00e9cessit\u00e9 de rester pr\u00eat \u00e0 lancer des \u00e9tudes de recherche en r\u00e9ponse aux \u00e9pid\u00e9mies.", "objectives": "- \u00c9tude de cohorte observationnelle prospective avec collecte rapide de donn\u00e9es et analyse en temps quasi r\u00e9el.- N = 20 133 patients hospitalis\u00e9s atteints du covid-19.- 208 h\u00f4pitaux en Angleterre, au Pays de Galles et en \u00c9cosse", "methods": "D\u00e9crire les caract\u00e9ristiques cliniques des patients admis \u00e0 l'h\u00f4pital avec la maladie \u00e0 coronavirus 2019 (covid-19) au Royaume-Uni pendant la phase de croissance de la premi\u00e8re vague de cette \u00e9pid\u00e9mie, qui ont \u00e9t\u00e9 recrut\u00e9s dans l'\u00e9tude de l\u2019International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) World Health Organization (WHO) Clinical Characterisation Protocol UK (CCP-UK), et explorer les facteurs de risque associ\u00e9s \u00e0 la mortalit\u00e9 \u00e0 l'h\u00f4pital.", "pubmed_id": "32444460\n22407890\n32178769\n32203977\n32109013\n32250385\n32240634\n31006605\n26692185\n32320003\n31986264\n29403115\n32007143\n31488196\n20627925\n32330939", "doi": "10.1136/bmj.m1985", "abstract": "To characterise the clinical features of patients admitted to hospital with coronavirus disease 2019 (covid-19) in the United Kingdom during the growth phase of the first wave of this outbreak who were enrolled in the International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) World Health Organization (WHO) Clinical Characterisation Protocol UK (CCP-UK) study, and to explore risk factors associated with mortality in hospital.\nProspective observational cohort study with rapid data gathering and near real time analysis.\n208 acute care hospitals in England, Wales, and Scotland between 6 February and 19 April 2020. A case report form developed by ISARIC and WHO was used to collect clinical data. A minimal follow-up time of two weeks (to 3 May 2020) allowed most patients to complete their hospital admission.\n20\u2009133 hospital inpatients with covid-19.\nAdmission to critical care (high dependency unit or intensive care unit) and mortality in hospital.\nThe median age of patients admitted to hospital with covid-19, or with a diagnosis of covid-19 made in hospital, was 73 years (interquartile range 58-82, range 0-104). More men were admitted than women (men 60%, n=12\u2009068; women 40%, n=8065). The median duration of symptoms before admission was 4 days (interquartile range 1-8). The commonest comorbidities were chronic cardiac disease (31%, 5469/17\u2009702), uncomplicated diabetes (21%, 3650/17\u2009599), non-asthmatic chronic pulmonary disease (18%, 3128/17\u2009634), and chronic kidney disease (16%, 2830/17\u2009506); 23% (4161/18\u2009525) had no reported major comorbidity. Overall, 41% (8199/20\u2009133) of patients were discharged alive, 26% (5165/20\u2009133) died, and 34% (6769/20\u2009133) continued to receive care at the reporting date. 17% (3001/18\u2009183) required admission to high dependency or intensive care units; of these, 28% (826/3001) were discharged alive, 32% (958/3001) died, and 41% (1217/3001) continued to receive care at the reporting date. Of those receiving mechanical ventilation, 17% (276/1658) were discharged alive, 37% (618/1658) died, and 46% (764/1658) remained in hospital. Increasing age, male sex, and comorbidities including chronic cardiac disease, non-asthmatic chronic pulmonary disease, chronic kidney disease, liver disease and obesity were associated with higher mortality in hospital.\nISARIC WHO CCP-UK is a large prospective cohort study of patients in hospital with covid-19. The study continues to enrol at the time of this report. In study participants, mortality was high, independent risk factors were increasing age, male sex, and chronic comorbidity, including obesity. This study has shown the importance of pandemic preparedness and the need to maintain readiness to launch research studies in response to outbreaks.\nISRCTN66726260.", "topics": ["Epid\u00e9miologique", "Transversale"], "author_list": [{"id": 585, "name": "Docherty AB"}], "publication_date": "2020-05-30"}, {"id": 92, "slug": "substantial-undocumented-infection-facilitates-the-rapid-dissemination-of-novel-", "title": "Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV2)", "has_other_authors": true, "impact_factor": {"id": 3, "name": "Interm\u00e9diaire", "posts_count": 140, "color": "orange", "order": 2}, "goals_plain": "Mod\u00e9liser les infections non document\u00e9es et leurs impacts sur la transmission et la propagation du virus.", "verbose_date": "16.03.2020", "authors": "Li R", "specialties": [{"id": 7, "name": "Transversale"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 66, "name": "Science"}, "link": "https://www.dropbox.com/s/xwl15cxdoni1s0k/science.abb3221.full.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "- Importante proportion de cas non document\u00e9s (a- ou paucisymptomatiques) avant la mise en place d'une surveillance \u00e9tendue (86%), qui ont un r\u00f4le important dans dans la transmission du virus -> n\u00e9cessit\u00e9 de tester et d'\u00e9tendre les mesures restrictives aux personnes ne pr\u00e9sentant pas de sympt\u00f4mes.\r\n- Avant les contr\u00f4les renforc\u00e9s, p\u00e9riode de latence entre le d\u00e9but des sympt\u00f4mes et le diagnostic\r\n- Importance des mesures de restrictions de d\u00e9placements, et du d\u00e9pistage large dans le controle de l'\u00e9pid\u00e9mie, et la pr\u00e9vision de la lev\u00e9e des mesures restrictives\r\n- Le mod\u00e8le ne permet pas de pr\u00e9voir si rebond aura lieu \u00e0 la lev\u00e9e des mesures de restriction\r\n- Extrapolation difficile des r\u00e9sultats \u00e0 d'autre pays", "objectives": "Cet aticle traite d'une mod\u00e9lisation \u00e9pid\u00e9miologique assez avanc\u00e9e. Je n'ai pas les comp\u00e9tences pour \u00e9valuer sa validit\u00e9.Cependant, il semble que le mod\u00e8le donne des r\u00e9sultats concordant avec les observations.----------------Ajout Sol\u00e8ne :Niveau de preuve interm\u00e9diaire:Article tr\u00e8s solide (publi\u00e9 dans Science, m\u00e9thodologie bien d\u00e9crite et coh\u00e9rente, analyses de sensibilit\u00e9) mais : 1. \u00e7a reste de la mod\u00e9lisation 2. les r\u00e9sultats quantitatifs ne sont pas g\u00e9n\u00e9ralisables \u00e0 d'autres populations que la Chine (en particulier tr\u00e8s mesures-d\u00e9pendants)", "methods": "Mod\u00e9liser les infections non document\u00e9es et leurs impacts sur la transmission et la propagation du virus.", "topics": ["Epid\u00e9miologique", "Transversale"], "author_list": [{"id": 98, "name": "Li R"}], "publication_date": "2020-03-16"}, {"id": 431, "slug": "acute-onset-smell-and-taste-disorders-in-the-context-of-covid-19-a-pilot-multice", "title": "Acute-onset smell and taste disorders in the context of Covid-19: a pilot multicenter PCR-based case-control study", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Evaluer si la pr\u00e9sence d'une perte du go\u00fbt et/ou de l'odorat est plus pr\u00e9sente dans l'infection \u00e0 COVID-19 que dans la grippe saisonni\u00e8re et \u00e9valuation des caract\u00e9ristiques associ\u00e9es", "verbose_date": "24.04.2020", "authors": "Beltran-Corbellini A", "specialties": [{"id": 18, "name": "Neurologie"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 181, "name": "Eur J Neurol"}, "link": "https://onlinelibrary.wiley.com/doi/epdf/10.1111/ene.14273", "findings": "", "take_away": "", "relevance_level": "Les troubles du go\u00fbt et de l'odorat semblent significativement plus fr\u00e9quents chez les patients COVID-19 en comparaison des patients infect\u00e9s par la grippe saisonni\u00e8re avec 39% des patients COVID touch\u00e9s contre 12,5% des patients gripp\u00e9s. L'odds-ratio ajust\u00e9 atteint 21,4.\r\nPar ailleurs, ces signes semblent toucher davantage les sujets jeunes et peuvent \u00eatre la pr\u00e9sentation clinique initiale de la maladie dans plus d'un tiers des cas.\r\nToutefois ces donn\u00e9es sont \u00e0 confirmer dans une \u00e9tude de plus haut niveau de preuve.", "objectives": "- \u00c9tude cas-t\u00e9moins- T\u00e9moins historiques avec recueil des donn\u00e9es plusieurs mois apr\u00e8s l'infection (biais de m\u00e9morisation)- Multiplicit\u00e9 des tests dans les recherches d'association avec les caract\u00e9ristiques des patients sans prise en compte de l'inflation du risque alpha- Seulement 5 t\u00e9moins ayant pr\u00e9sent\u00e9 des troubles du go\u00fbt et de l'odorat- Repr\u00e9sentativit\u00e9 de l'\u00e9chantillon difficile \u00e0 \u00e9valuer (pas assez de donn\u00e9es)", "methods": "Evaluer si la pr\u00e9sence d'une perte du go\u00fbt et/ou de l'odorat est plus pr\u00e9sente dans l'infection \u00e0 COVID-19 que dans la grippe saisonni\u00e8re et \u00e9valuation des caract\u00e9ristiques associ\u00e9es", "topics": ["Epid\u00e9miologique", "Neurologie"], "author_list": [{"id": 409, "name": "Beltran-Corbellini A"}], "publication_date": "2020-04-24"}, {"id": 401, "slug": "clinical-characteristics-of-older-patients-the-experience-of-a-geriatric-short-s", "title": "Clinical characteristics of older patients: The experience of a geriatric short-stay unit dedicated to patients with COVID-19 in France", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Pr\u00e9sentation d'un retour d'exp\u00e9rience sur une unit\u00e9 d'hospitalisation de courte dur\u00e9e de g\u00e9riatrie d\u00e9di\u00e9 au patient COVID-19.", "verbose_date": "21.04.2020", "authors": "Godaert L", "specialties": [{"id": 13, "name": "G\u00e9riatrie"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 77, "name": "J infect"}, "link": "https://www.journalofinfection.com/article/S0163-4453(20)30217-6/pdf", "findings": "", "take_away": "", "relevance_level": "Les personnes ag\u00e9es sont fortement touch\u00e9es par le COVID-19, particuli\u00e8rement en fr\u00e9quence mais aussi en gravit\u00e9. Pr\u00e9sence de signe inhabituel chez les personnes ag\u00e9es (fr\u00e9quent pour beaucoup d'infection)", "objectives": "- Lettre \u00e0 l'\u00e9diteur- Faible effectif (n=17)\"", "methods": "Pr\u00e9sentation d'un retour d'exp\u00e9rience sur une unit\u00e9 d'hospitalisation de courte dur\u00e9e de g\u00e9riatrie d\u00e9di\u00e9 au patient COVID-19.", "pubmed_id": "32305489", "doi": "10.1016/j.jinf.2020.04.009", "abstract": null, "topics": ["Epid\u00e9miologique", "G\u00e9riatrie"], "author_list": [{"id": 384, "name": "Godaert L"}], "publication_date": "2020-04-21"}, {"id": 514, "slug": "cardiovascular-disease-drug-therapy-and-mortality-in-covid-19", "title": "Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Etude pronostique de la relation entre les maladies cardiovasculaires ainsi que leur traitement (IEC/ARA2/statines/\u00df-bloquants) avec la mortalit\u00e9 chez des patients COVID-19", "verbose_date": "03.05.2020", "authors": "Mandeep RM", "specialties": [{"id": 17, "name": "Cardiologie et maladies m\u00e9taboliques"}, {"id": 7, "name": "Transversale"}], "category": {"id": 6, "name": "Pronostique", "icon": "icon-chat"}, "journal": {"id": 22, "name": "NEJM"}, "link": "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2007621?articleTools=true", "findings": "", "take_away": "", "relevance_level": "Attention : certains auteurs de cette \u00e9tude se sont r\u00e9tract\u00e9s entra\u00eenant le retrait de la publication du fait de l'impossibilit\u00e9 de v\u00e9rifier la fiabilit\u00e9 des donn\u00e9es sources issues de Surgisphere\nSur une large cohorte de patients hospitalis\u00e9s, les auteurs ont montr\u00e9 un taux de mortalit\u00e9 de 5,8% (4% en conventionnel et 24,7% en r\u00e9animation)\nLes facteurs protecteurs du d\u00e9c\u00e8s semblent \u00eatre la prise d'inhibiteurs de l'enzyme de conversion (IEC) et de statines avec des Odds Ratio inf\u00e9rieurs \u00e0 0,35\nLes facteurs augmentant le risque de d\u00e9c\u00e8s semblent \u00eatre les ant\u00e9c\u00e9dents cardiaques (coronaropathie, arythmie, insuffisance cardiaque) avec un risque multipli\u00e9 par plus de 2 et les pathologies pulmonaires avec la BPCO (risque multipli\u00e9 par 3) et le tabagisme actif (risque multipli\u00e9 par 2)\nL'\u00e2ge sup\u00e9rieur \u00e0 65 ans et le fait d'\u00eatre un homme sont \u00e9galement des facteurs de risque de d\u00e9c\u00e8s", "objectives": "- La plus grande cohorte actuellement \u00e9tudi\u00e9e avec m\u00e9thodologie robuste- Mais donn\u00e9es issues de registres dont la fiabilit\u00e9 n'est pas compl\u00e8tement \u00e9tablie \u00e0 ce jour, entra\u00eenant le retrait de cette publication- Pas de calcul de la puissance de l'\u00e9tude", "methods": "Etude pronostique de la relation entre les maladies cardiovasculaires ainsi que leur traitement (IEC/ARA2/statines/\u00df-bloquants) avec la mortalit\u00e9 chez des patients COVID-19", "pubmed_id": "32356626\n28619367\n32125452\n27546235\n27438105\n15283675\n32362390\n32142651\n32213097\n32219356\n28373583\n32155444\n32211816\n32360242\n15897343\n32293672\n14742282\n32191259\n32171062\n32208485", "doi": "10.1056/NEJMoa2007621", "abstract": "Coronavirus disease 2019 (Covid-19) may disproportionately affect people with cardiovascular disease. Concern has been aroused regarding a potential harmful effect of angiotensin-converting-enzyme (ACE) inhibitors and angiotensin-receptor blockers (ARBs) in this clinical context.\nUsing an observational database from 169 hospitals in Asia, Europe, and North America, we evaluated the relationship of cardiovascular disease and drug therapy with in-hospital death among hospitalized patients with Covid-19 who were admitted between December 20, 2019, and March 15, 2020, and were recorded in the Surgical Outcomes Collaborative registry as having either died in the hospital or survived to discharge as of March 28, 2020.\nOf the 8910 patients with Covid-19 for whom discharge status was available at the time of the analysis, a total of 515 died in the hospital (5.8%) and 8395 survived to discharge. The factors we found to be independently associated with an increased risk of in-hospital death were an age greater than 65 years (mortality of 10.0%, vs. 4.9% among those \u226465 years of age; odds ratio, 1.93; 95% confidence interval [CI], 1.60 to 2.41), coronary artery disease (10.2%, vs. 5.2% among those without disease; odds ratio, 2.70; 95% CI, 2.08 to 3.51), heart failure (15.3%, vs. 5.6% among those without heart failure; odds ratio, 2.48; 95% CI, 1.62 to 3.79), cardiac arrhythmia (11.5%, vs. 5.6% among those without arrhythmia; odds ratio, 1.95; 95% CI, 1.33 to 2.86), chronic obstructive pulmonary disease (14.2%, vs. 5.6% among those without disease; odds ratio, 2.96; 95% CI, 2.00 to 4.40), and current smoking (9.4%, vs. 5.6% among former smokers or nonsmokers; odds ratio, 1.79; 95% CI, 1.29 to 2.47). No increased risk of in-hospital death was found to be associated with the use of ACE inhibitors (2.1% vs. 6.1%; odds ratio, 0.33; 95% CI, 0.20 to 0.54) or the use of ARBs (6.8% vs. 5.7%; odds ratio, 1.23; 95% CI, 0.87 to 1.74).\nOur study confirmed previous observations suggesting that underlying cardiovascular disease is associated with an increased risk of in-hospital death among patients hospitalized with Covid-19. Our results did not confirm previous concerns regarding a potential harmful association of ACE inhibitors or ARBs with in-hospital death in this clinical context. (Funded by the William Harvey Distinguished Chair in Advanced Cardiovascular Medicine at Brigham and Women's Hospital.).", "topics": ["Pronostique", "Cardiologie et maladies m\u00e9taboliques", "Transversale"], "author_list": [{"id": 482, "name": "Mandeep RM"}], "publication_date": "2020-05-03"}, {"id": 555, "slug": "autopsy-findings-and-venous-thromboembolism-in-patients-with-covid-19-a-prospect", "title": "Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study", "has_other_authors": true, "impact_factor": {"id": 3, "name": "Interm\u00e9diaire", "posts_count": 140, "color": "orange", "order": 2}, "goals_plain": "Valider et comparer les donn\u00e9es cliniques du COVID-19 avec les donn\u00e9es d'autopsie m\u00e9dicale, d'autopsie virtuelle et de tests virologiques", "verbose_date": "08.05.2020", "authors": "Wichmann D", "specialties": [{"id": 7, "name": "Transversale"}], "category": {"id": 2, "name": "Autres", "icon": "icon-other"}, "journal": {"id": 41, "name": "Ann Intern Med"}, "link": "https://www.acpjournals.org/doi/10.7326/M20-2003", "findings": "", "take_away": "", "relevance_level": "Les donn\u00e9es cliniques du COVID-19 sont coh\u00e9rentes avec celles retrouv\u00e9es en autopsie chez des patients d\u00e9c\u00e9d\u00e9s de l'infection : infiltrats pulmonaires bilat\u00e9raux et maladies thrombo-emboliques retrouv\u00e9es sur les 12 autopsies r\u00e9alis\u00e9es\nM\u00eame en post-mortem et au moins jusqu'\u00e0 5 jours apr\u00e8s le d\u00e9c\u00e8s, l'ARN du SARS-CoV-2\u00a0reste d\u00e9tectable avec une vir\u00e9mie mod\u00e9r\u00e9e au niveau pulmonaire (100% des cas). Il est fr\u00e9quemment retrouv\u00e9 \u00e9galement au niveau pharyng\u00e9 et parfois au niveau cardiaque, h\u00e9patique ou r\u00e9nal", "objectives": "- Etude de cohorte avec recrutement prospectif, cons\u00e9cutif et syst\u00e9matique de tous les patients avec infection confirm\u00e9e \u00e0 SARS-CoV-2- Protocole d'autopsie satisfaisant et tests virologiques performants- R\u00e9sultats coh\u00e9rents- Mais faible effectif (n=12)- Pas de preuve du risque infectieux repr\u00e9sent\u00e9 par cette vir\u00e9mie mod\u00e9r\u00e9e en post-mortem", "methods": "Valider et comparer les donn\u00e9es cliniques du COVID-19 avec les donn\u00e9es d'autopsie m\u00e9dicale, d'autopsie virtuelle et de tests virologiques", "topics": ["Autres", "Transversale"], "author_list": [{"id": 521, "name": "Wichmann D"}], "publication_date": "2020-05-08"}, {"id": 541, "slug": "high-risk-of-thrombosis-in-patients-with-severe-sars-cov-2-infection-a-multicent", "title": "High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "D\u00e9terminer si les complications thrombotiques sont plus \u00e9lev\u00e9es chez les patients hospitalis\u00e9s pour SDRA \u00e0 COVID-19 par rapport aux patients hospitalis\u00e9s pour SDRA ", "verbose_date": "06.05.2020", "authors": "Helms J", "specialties": [{"id": 4, "name": "Anesth\u00e9sie-R\u00e9animation"}, {"id": 12, "name": "Infectiologie"}, {"id": 17, "name": "Cardiologie et maladies m\u00e9taboliques"}], "category": {"id": 6, "name": "Pronostique", "icon": "icon-chat"}, "journal": {"id": 2, "name": "Intensive Care Med"}, "link": "https://link.springer.com/content/pdf/10.1007/s00134-020-06062-x.pdf", "findings": "", "take_away": "", "relevance_level": "La fr\u00e9quence des complications thrombotiques chez les patients atteints de SDRA \u00e0 COVID-19 semble \u00e9lev\u00e9e et on sugg\u00e8re qu'ils\u00a0d\u00e9veloppent plus de complications thrombotiques par rapport \u00e0 la m\u00eame population non atteinte de COVID-19, malgr\u00e9 une anticoagulation pr\u00e9ventive. Cependant, les\u00a0scores utilis\u00e9s n'ont pas mis en \u00e9vidence de CIVD plus fr\u00e9quente chez les patients atteints de COVID-19 malgr\u00e9 des modifications des param\u00e8tres biologiques de la coagulation.\u00a0\r\nEn comparant les deux populations, cette \u00e9tude met en \u00e9vidence des D-dim\u00e8res plus basses chez les patients atteints de COVID-19, alors que dans les pr\u00e9c\u00e9dentes \u00e9tudes ce marqueur est \u00e9lev\u00e9 et associ\u00e9 \u00e0 un mauvais pronostic.\u00a0\r\nLes m\u00e9canismes des thromboses restent non connus \u00e0 ce jour (hypoxie? pr\u00e9sence d'anticoagulant circulant? inflammation syst\u00e9mique?)\r\nIl pourrait \u00eatre pertinent de monitorer l'efficacit\u00e9 de l'anticoagulation pr\u00e9ventive dans cette population.", "objectives": "Etude de cohorte, seulement deux centres, effectif faible surtout apr\u00e8s appariement, pas de monitoring de l'anticoagulation pr\u00e9ventive", "methods": "D\u00e9terminer si les complications thrombotiques sont plus \u00e9lev\u00e9es chez les patients hospitalis\u00e9s pour SDRA \u00e0 COVID-19 par rapport aux patients hospitalis\u00e9s pour SDRA", "pubmed_id": "32367170", "doi": "10.1007/s00134-020-06062-x", "abstract": "Little evidence of increased thrombotic risk is available in COVID-19 patients. Our purpose was to assess thrombotic risk in severe forms of SARS-CoV-2 infection.\nAll patients referred to 4 intensive care units (ICUs) from two centers of a French tertiary hospital for acute respiratory distress syndrome (ARDS) due to COVID-19 between March 3rd and 31st 2020 were included. Medical history, symptoms, biological data and imaging were prospectively collected. Propensity score matching was performed to analyze the occurrence of thromboembolic events between non-COVID-19 ARDS and COVID-19 ARDS patients.\n150 COVID-19 patients were included (122 men, median age 63 [53; 71] years, SAPSII 49 [37; 64] points). Sixty-four clinically relevant thrombotic complications were diagnosed in 150 patients, mainly pulmonary embolisms (16.7%). 28/29 patients (96.6%) receiving continuous renal replacement therapy experienced circuit clotting. Three thrombotic occlusions (in 2 patients) of centrifugal pump occurred in 12 patients (8%) supported by ECMO. Most patients (>\u200995%) had elevated D-dimer and fibrinogen. No patient developed disseminated intravascular coagulation. Von Willebrand (vWF) activity, vWF antigen and FVIII were considerably increased, and 50/57 tested patients (87.7%) had positive lupus anticoagulant. Comparison with non-COVID-19 ARDS patients (n\u2009=\u2009145) confirmed that COVID-19 ARDS patients (n\u2009=\u200977) developed significantly more thrombotic complications, mainly pulmonary embolisms (11.7 vs. 2.1%, p\u2009<\u20090.008). Coagulation parameters significantly differed between the two groups.\nDespite anticoagulation, a high number of patients with ARDS secondary to COVID-19 developed life-threatening thrombotic complications. Higher anticoagulation targets than in usual critically ill patients should therefore probably be suggested.", "topics": ["Pronostique", "Anesth\u00e9sie-R\u00e9animation", "Infectiologie", "Cardiologie et maladies m\u00e9taboliques"], "author_list": [{"id": 369, "name": "Helms J"}], "publication_date": "2020-05-06"}, {"id": 221, "slug": "absence-of-contamination-of-personal-protective-equipment-ppe-by-severe-acute-re", "title": "Absence of contamination of personal protective equipment (PPE) by severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Evaluer la s\u00e9curit\u00e9 de l'allongement de la dur\u00e9e d'utilisation des \u00e9quipements de protection personnelle", "verbose_date": "31.03.2020", "authors": "Ong S ", "specialties": [{"id": 2, "name": "Hygi\u00e8ne"}], "category": {"id": 2, "name": "Autres", "icon": "icon-other"}, "journal": {"id": 106, "name": "Infect Control Hosp Epidemiol"}, "link": "https://www.dropbox.com/s/uxuj0ivxidyoihk/absence_of_contamination_of_personal_protective_equipment_ppe_by_severe_acute_respiratory_syndrome_coronavirus_2_sarscov2.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Etonnamment dans cette \u00e9tude aucun pr\u00e9l\u00e8vement sur le mat\u00e9riel de protection de soignants s'occupant de malades COVID-19 n'a \u00e9t\u00e9 test\u00e9 positif au SARS-CoV-2. Mais les limites de l'\u00e9tude sont nombreuses et ne permettent pas de conclure \u00e0 l'absence de contamination des masques et lunettes de protection apr\u00e8s soins d'un patient infect\u00e9 et donc \u00e0 l'absence de risque d'allongement de leur dur\u00e9e d'utilisation.", "objectives": "1) Effectif de moyenne importance2) Ne prend pas en compte la contamination par les a\u00e9rosols (patients non ventil\u00e9s, pas de gestes g\u00e9n\u00e9rateurs d'a\u00e9rosols avant les pr\u00e9l\u00e8vements)3) Tous les patients s\u00e9lectionn\u00e9s n'\u00e9taient pas symptomatiques4) Technique de pr\u00e9l\u00e8vement des masques N95 peu sensible5) Patients en chambre \u00e0 pression n\u00e9gative6) Pas de pr\u00e9l\u00e8vement de l'environnement direct du patient dans la chambre pour corr\u00e9lation\"", "methods": "Evaluer la s\u00e9curit\u00e9 de l'allongement de la dur\u00e9e d'utilisation des \u00e9quipements de protection personnelle", "pubmed_id": "32213231", "doi": "10.1017/ice.2020.91", "abstract": null, "topics": ["Autres", "Hygi\u00e8ne"], "author_list": [{"id": 212, "name": "Ong S "}], "publication_date": "2020-03-31"}, {"id": 37, "slug": "hypothesis-for-potential-pathogenesis-of-sars-cov-2-infection-a-review-of-immune", "title": "Hypothesis for potential pathogenesis of SARS-CoV-2 infection - a review of immune changes in patients with viral pneumonia", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Etudier les changements immunitaires s'op\u00e9rant lors de pneumopathies \u00e0 coronavirus SARS, MERS et autres virus proches du SARS-CoV-2", "verbose_date": "20.03.2020", "authors": "Lin L", "specialties": [{"id": 22, "name": "Immunit\u00e9"}, {"id": 12, "name": "Infectiologie"}], "category": {"id": 2, "name": "Autres", "icon": "icon-other"}, "journal": {"id": 32, "name": "Emerg Microbes Infect"}, "link": "https://www.dropbox.com/s/bw6oob150rl1xk3/Hypothesis%20for%20potential%20pathogenesis%20of%20SARS%20CoV%202%20infection%20a%20review.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "La lymphop\u00e9nie et l'\u00e9l\u00e9vation des facteurs pro-inflammatoires seraient de mauvais pronostic dans le COVID-19. Un traitement par immunoglobulines IV \u00e0 haute-dose pourrait \u00eatre une strat\u00e9gie int\u00e9ressante mais se base sur des hypoth\u00e8ses sans preuve d'efficacit\u00e9 \u00e0 ce jour (essai en cours). HBPM \u00e0 envisager \u00e9galement.", "objectives": "1) Bas\u00e9 sur de la bibliographie (MERS et SARS++)2) Manque d'\u00e9tudes sp\u00e9cifiques au SARS-CoV-23) Propositions th\u00e9rapeutiques uniquement bas\u00e9es sur des hypoth\u00e8ses", "methods": "Etudier les changements immunitaires s'op\u00e9rant lors de pneumopathies \u00e0 coronavirus SARS, MERS et autres virus proches du SARS-CoV-2", "pubmed_id": "32196410\n22286307\n27146253\n32017984\n32094589\n26606759\n14585636\n25303830\n27519621\n7815531\n19574348\n24062443\n26583433\n16968120\n23784853\n28778905\n23075143\n14647384\n20003352\n14767818\n16043521\n31706200\n23486063\n30060038\n15527148\n32031570\n20508031\n16733915\n20445182\n26189369\n15527829\n12895318\n21047436\n32146746", "doi": "10.1080/22221751.2020.1746199", "abstract": "Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with droplets and contact as the main means of transmission. Since the first case appeared in Wuhan, China, in December 2019, the outbreak has gradually spread nationwide. Up to now, according to official data released by the Chinese health commission, the number of newly diagnosed patients has been declining, and the epidemic is gradually being controlled. Although most patients have mild symptoms and good prognosis after infection, some patients developed severe and die from multiple organ complications. The pathogenesis of SARS-CoV-2 infection in humans remains unclear. Immune function is a strong defense against invasive pathogens and there is currently no specific antiviral drug against the virus. This article reviews the immunological changes of coronaviruses like SARS, MERS and other viral pneumonia similar to SARS-CoV-2. Combined with the published literature, the potential pathogenesis of COVID-19 is inferred, and the treatment recommendations for giving high-doses intravenous immunoglobulin and low-molecular-weight heparin anticoagulant therapy to severe type patients are proposed.", "topics": ["Autres", "Immunit\u00e9", "Infectiologie"], "author_list": [{"id": 47, "name": "Lin L"}], "publication_date": "2020-03-20"}, {"id": 462, "slug": "eculizumab-treatment-in-patients-with-covid-19-preliminary-results-from-real-lif", "title": "Eculizumab treatment in patients with COVID-19: preliminary results from real life ASL Napoli 2 Nord experience", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Rapporter les donn\u00e9es pr\u00e9liminaires obtenues avec la th\u00e9rapie anti compl\u00e9ment C5 \u00e0 l'eculizumab chez les patients COVID-19 admis \u00e0 l'unit\u00e9 de soins intensifs de l'ASL Napoli 2 Nord.", "verbose_date": "27.04.2020", "authors": "Diurno F", "specialties": [{"id": 12, "name": "Infectiologie"}], "category": {"id": 4, "name": "Th\u00e9rapeutique", "icon": "icon-med"}, "journal": {"id": 188, "name": "Eur Rev Med Pharmacol Sci"}, "link": "https://www.europeanreview.org/wp/wp-content/uploads/4040-4047.pdf", "findings": "", "take_away": "", "relevance_level": "L'eculizumab a le potentiel pour \u00eatre un acteur cl\u00e9 dans le traitement des cas graves de COVID-19. Les r\u00e9sultats de l'\u00e9tude soutiennent l'utilisation de l'eculizumab comme traitement hors \u00e9tiquette des cas graves de COVID-19, en attendant la confirmation par l'essai SOLID-C19 en cours.", "objectives": "-\ts\u00e9rie de cas, monocentrique -\t4 patients", "methods": "Rapporter les donn\u00e9es pr\u00e9liminaires obtenues avec la th\u00e9rapie anti compl\u00e9ment C5 \u00e0 l'eculizumab chez les patients COVID-19 admis \u00e0 l'unit\u00e9 de soins intensifs de l'ASL Napoli 2 Nord.", "pubmed_id": "32329881", "doi": "10.26355/eurrev_202004_20875", "abstract": "SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2)-related pneumonia, referred to as COVID-19 (Coronavirus Disease 19), is a public health emergency as it carries high morbidity, mortality, and has no approved specific pharmacological treatments. In this case series, we aimed to report preliminary data obtained with anti-complement C5 therapy with eculizumab in COVID-19 patients admitted to intensive care unit (ICU) of ASL Napoli 2 Nord.\nThis is a case series of patients with a confirmed diagnosis of SARS-CoV2 infection and severe pneumonia or ARDS who were treated with up to 4 infusions of eculizumab as an off-label agent. Patients were also treated with anticoagulant therapy with Enoxaparin 4000 IU/day via subcutaneous injection, antiviral therapy with Lopinavir 800 mg/day + Ritonavir 200 mg/day, hydroxychloroquine 400 mg/day, ceftriaxone 2 g/day IV, vitamine C 6 g/day for 4 days, and were on Non-Invasive Ventilation (NIV).\nWe treated four COVID-19 patients admitted to the intensive care unit because of severe pneumonia or ARDS. All patients successfully recovered after treatment with eculizumab. Eculizumab induced a drop in inflammatory markers. Mean C Reactive Protein levels dropped from 14.6 mg/dl to 3.5 mg/dl and the mean duration of the disease was 12.8 days.\nEculizumab has the potential to be a key player in treatment of severe cases of COVID-19. Our results support eculizumab use as an off-label treatment of COVID-19, pending confirmation from the ongoing SOLID-C19 trial.", "topics": ["Th\u00e9rapeutique", "Infectiologie"], "author_list": [{"id": 434, "name": "Diurno F"}], "publication_date": "2020-04-27"}, {"id": 109, "slug": "patients-of-covid-19-may-benefit-from-sustained-lopinavir-combined-regimen-and-t", "title": "Patients of COVID-19 may benefit from sustained lopinavir-combined regimen and the increase of eosinophil may predict the outcome of COVID-19 progression", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "D\u00e9crire les caract\u00e9ristiques \u00e9pid\u00e9miologique, cliniques, temporelles et \u00e9volution de patients trait\u00e9s par Lopinavir", "verbose_date": "12.03.2020", "authors": "Liu F", "specialties": [{"id": 7, "name": "Transversale"}], "category": {"id": 4, "name": "Th\u00e9rapeutique", "icon": "icon-med"}, "journal": {"id": 18, "name": "Int J Infect Dis"}, "link": "https://www.dropbox.com/s/t9nepwl1eg6zatj/1-s2.0-S1201971220301326-main.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Lopinavir a eu un effet positif selon les auteurs mais effets ind\u00e9sirables fr\u00e9quents (hypokali\u00e9mie et effets digestifs) Les \u00e9osinophiles pourraient \u00eatre un pr\u00e9dicteur de la progression de COVID-19 (abaiss\u00e9s initial pour remont\u00e9e)", "objectives": "Faible1) Pre-proof2) n=10 & monocentrique, pas control\u00e9 randomise, suivi court (issue non connues pour 3 patients transf\u00e9r\u00e9s", "methods": "D\u00e9crire les caract\u00e9ristiques \u00e9pid\u00e9miologique, cliniques, temporelles et \u00e9volution de patients trait\u00e9s par Lopinavir", "pubmed_id": "32173576", "doi": "10.1016/j.ijid.2020.03.013", "abstract": "To explore the epidemiological information, clinical characteristics, therapeutic outcomes and temporal progression of laboratory findings in 2019-coronavirus disease (COVID-19) patients exposed to lopinavir.\nWe collected data from ten COVID-19 patients admitted between January 22, 2020 and February 11, 2020 at Xixi hospital in Hangzhou, China.\nOf ten patients, secondary, tertiary and quartus patients emerged; the incubation period was 3-7 days. Mainly initial symptoms were cough and low fever (37.3-38.0\u00b0C). An asymptomatic case presented normal radiography, the others had ground glass opacities. All cases (three transferred, seven discharged) were exposed to lopinavir on initial hospitalization. Three patients stopped lopinavir because of adverse effects, two of them deteriorated, one was hospitalized longer than others who with sustained lopinavir use. Levels of potassium, albumin, and lymphocytes were low, but increased persistently after treatment. Eosinophil values were low on initial hospitalization, then all returned to normal before discharge. Viral load of SARS-CoV-2, radiography and eosinophil improved continuously in 3-14, 6-8 and 7-9 days, respectively.\nIncreasing eosinophils may be an indicator of COVID-19 improvement. The COVID-19 patients may benefit from sustained lopinavir use. More research on a larger scale is needed to verify these points.", "topics": ["Th\u00e9rapeutique", "Transversale"], "author_list": [{"id": 115, "name": "Liu F"}], "publication_date": "2020-03-12"}, {"id": 404, "slug": "venous-thrombosis-and-arteriosclerosis-obliterans-of-lower-extremities-in-a-very", "title": "Venous thrombosis and arteriosclerosis obliterans of lower extremities in a very severe patient with 2019 novel coronavirus disease: a case report", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Identification du risque de thrombose veineuse profonde et d'art\u00e9riopathie oblit\u00e9rante des membres inf\u00e9rieurs chez les patients COVID-19.", "verbose_date": "21.04.2020", "authors": "Zhou B", "specialties": [{"id": 7, "name": "Transversale"}, {"id": 17, "name": "Cardiologie et maladies m\u00e9taboliques"}], "category": {"id": 3, "name": "Diagnostique", "icon": "icon-heat"}, "journal": {"id": 96, "name": "J Thromb Haemostasis"}, "link": "https://link.springer.com/content/pdf/10.1007/s11239-020-02084-w.pdf", "findings": "", "take_away": "", "relevance_level": "La stratification du risque de thrombose veineuse profonde et d'art\u00e9riopathie oblit\u00e9rante est essentielle chez les patients atteints de COVID-19 pour r\u00e9duire la morbidit\u00e9 et la mortalit\u00e9.\r\nLes facteurs de risque pour le d\u00e9veloppement de ces pathologies chez les patients COVID-19 sont nombreux: hypercoagulation, stase sanguine, l\u00e9sions endoth\u00e9liales, taux \u00e9lev\u00e9 de cytokines et de TNF\u03b1 (IL 2, IL 7, IL 10, G CSF, IP 10, MCP 1, MIP 1 A), rhabdomyolyse et le d\u00e9s\u00e9quilibre \u00e9lectrolytique et l'acidose qui en r\u00e9sultent.", "objectives": "1) Case report\"", "methods": "Identification du risque de thrombose veineuse profonde et d'art\u00e9riopathie oblit\u00e9rante des membres inf\u00e9rieurs chez les patients COVID-19.", "topics": ["Diagnostique", "Transversale", "Cardiologie et maladies m\u00e9taboliques"], "author_list": [{"id": 386, "name": "Zhou B"}], "publication_date": "2020-04-21"}, {"id": 592, "slug": "the-incubation-period-of-coronavirus-disease-2019-covid-19-from-publicly-reporte", "title": "The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Estimer la dur\u00e9e de la p\u00e9riode d'incubation du COVID-19 et d\u00e9crire ses implications pour la sant\u00e9 publique", "verbose_date": "15.05.2020", "authors": "Lauer SA", "specialties": [{"id": 7, "name": "Transversale"}, {"id": 12, "name": "Infectiologie"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 41, "name": "Ann Intern Med"}, "link": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081172/pdf/aim-olf-M200504.pdf", "findings": "", "take_away": "", "relevance_level": "P\u00e9riode d'incubation moyenne de COVID-19 d'environ 5 jours. 97,5% de ceux qui d\u00e9veloppent des sympt\u00f4mes l'ont fait dans les 11,5 jours apr\u00e8s l'infection (IC95%, 8,2 \u00e0 15,6 jours).", "objectives": "n=181Etude bas\u00e9e sur reportages et communiqu\u00e9s de presse, cas hospitalis\u00e9sChaque rapport de cas est examin\u00e9 par deux auteurs, avec consensus sur les divergencesMod\u00e8le supposant un risque constant", "methods": "Estimer la dur\u00e9e de la p\u00e9riode d'incubation du COVID-19 et d\u00e9crire ses implications pour la sant\u00e9 publique", "pubmed_id": "32150748", "doi": "10.7326/M20-0504", "abstract": "A novel human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was identified in China in December 2019. There is limited support for many of its key epidemiologic features, including the incubation period for clinical disease (coronavirus disease 2019 [COVID-19]), which has important implications for surveillance and control activities.\nTo estimate the length of the incubation period of COVID-19 and describe its public health implications.\nPooled analysis of confirmed COVID-19 cases reported between 4 January 2020 and 24 February 2020.\nNews reports and press releases from 50 provinces, regions, and countries outside Wuhan, Hubei province, China.\nPersons with confirmed SARS-CoV-2 infection outside Hubei province, China.\nPatient demographic characteristics and dates and times of possible exposure, symptom onset, fever onset, and hospitalization.\nThere were 181 confirmed cases with identifiable exposure and symptom onset windows to estimate the incubation period of COVID-19. The median incubation period was estimated to be 5.1 days (95% CI, 4.5 to 5.8 days), and 97.5% of those who develop symptoms will do so within 11.5 days (CI, 8.2 to 15.6 days) of infection. These estimates imply that, under conservative assumptions, 101 out of every 10\u00a0000 cases (99th percentile, 482) will develop symptoms after 14 days of active monitoring or quarantine.\nPublicly reported cases may overrepresent severe cases, the incubation period for which may differ from that of mild cases.\nThis work provides additional evidence for a median incubation period for COVID-19 of approximately 5 days, similar to SARS. Our results support current proposals for the length of quarantine or active monitoring of persons potentially exposed to SARS-CoV-2, although longer monitoring periods might be justified in extreme cases.\nU.S. Centers for Disease Control and Prevention, National Institute of Allergy and Infectious Diseases, National Institute of General Medical Sciences, and Alexander von Humboldt Foundation.", "topics": ["Epid\u00e9miologique", "Transversale", "Infectiologie"], "author_list": [{"id": 556, "name": "Lauer SA"}], "publication_date": "2020-05-15"}, {"id": 550, "slug": "epidemiology-of-and-risk-factors-for-coronavirus-infection-in-health-care-worker", "title": "Epidemiology of and Risk Factors for Coronavirus Infection in Health Care Workers: A Living Rapid Review", "has_other_authors": true, "impact_factor": {"id": 3, "name": "Interm\u00e9diaire", "posts_count": 140, "color": "orange", "order": 2}, "goals_plain": "Examiner l'implication du personnel de sant\u00e9 dans l'infection par SRAS-CoV-2 et les facteurs de risque associ\u00e9s.", "verbose_date": "07.05.2020", "authors": "Chou R", "specialties": [{"id": 7, "name": "Transversale"}, {"id": 2, "name": "Hygi\u00e8ne"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 41, "name": "Ann Intern Med"}, "link": "https://annals.org/aim/fullarticle/2765801/epidemiology-risk-factors-coronavirus-infection-health-care-workers-living-rapid", "findings": "", "take_away": "", "relevance_level": "L'\u00e9tude montre que les travailleurs de\u00a0sant\u00e9 ont une incidence d'infection plus \u00e9lev\u00e9e que la population g\u00e9n\u00e9rale, mais des sympt\u00f4mes moins graves (qui pourraient \u00eatre li\u00e9s \u00e0 un \u00e2ge plus jeune et \u00e0 des comorbidit\u00e9s r\u00e9duites).\u00a0\nLes exp\u00e9riences de d\u00e9pression, d'anxi\u00e9t\u00e9 g\u00e9n\u00e9ralis\u00e9e et de stress psychologique sont courantes chez les professionnels de sant\u00e9 en contact avec des patients atteints de COVID-19, comme cela a \u00e9t\u00e9 constat\u00e9 pr\u00e9c\u00e9demment avec le SRAS-CoV.\nDes preuves ont \u00e9t\u00e9 \u00e9tablies entre l'utilisation correcte des EPI et la r\u00e9duction de l'incidence de l'infection ainsi que l'association entre l'exposition aux liquides biologiques des patients infect\u00e9s/intubation endotrach\u00e9ale et un risque accru d'infection.", "objectives": "Interm\u00e9diaire:1) Revue de la litt\u00e9rature non syst\u00e9matique2) Contraintes m\u00e9thodologiques 3) L'incertitude quant \u00e0 savoir si les donn\u00e9es du SRAS-CoV et du MERS-CoV peuvent \u00eatre appliqu\u00e9es au SRAS-CoV-24) La plupart des informations relatives \u00e0 Chine doivent \u00eatre examin\u00e9es dans d'autres contextes", "methods": "Examiner l'implication du personnel de sant\u00e9 dans l'infection par SRAS-CoV-2 et les facteurs de risque associ\u00e9s.", "topics": ["Epid\u00e9miologique", "Transversale", "Hygi\u00e8ne"], "author_list": [{"id": 515, "name": "Chou R"}], "publication_date": "2020-05-07"}, {"id": 211, "slug": "the-effect-of-human-mobility-and-control-measures-on-the-covid-19-epidemic-in-ch", "title": "The effect of human mobility and control measures on the COVID-19 epidemic in China", "has_other_authors": true, "impact_factor": {"id": 5, "name": "Fort", "posts_count": 5, "color": "green", "order": 1}, "goals_plain": "Estimation de l'impact de la mobilit\u00e9 humaine et des mesures de restrictions de voyage sur l'\u00e9volution de l'\u00e9pid\u00e9mie de Covid 19 en Chine", "verbose_date": "31.03.2020", "authors": "Kraemer MUG ", "specialties": [{"id": 7, "name": "Transversale"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 66, "name": "Science"}, "link": "https://www.dropbox.com/s/42vq9p3m26cdcik/science.abb4218.full.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Importance des restrictions de transports entre ville/\u00e9tat \u00e0 un stade pr\u00e9coce pour mitiger l'\u00e9pid\u00e9mie", "objectives": "Article Science, m\u00e9thodologie qui parait solide, avec donn\u00e9es de plusieurs types et analyses de sensibilit\u00e9", "methods": "Estimation de l'impact de la mobilit\u00e9 humaine et des mesures de restrictions de voyage sur l'\u00e9volution de l'\u00e9pid\u00e9mie de Covid 19 en Chine", "pubmed_id": "32511452\n24239323\n30139911\n15071187\n32019669\n32053479\n31836720\n32046819\n31986261\n10677276\n32023340\n31995857\n20808728\n16055564\n16574822\n31978945\n30833735\n27748685\n23894860\n32014114\n32105609\n27451336\n32064853\n32087115\n19393959", "doi": "10.1101/2020.03.02.20026708", "abstract": "The ongoing COVID-19 outbreak has expanded rapidly throughout China. Major behavioral, clinical, and state interventions are underway currently to mitigate the epidemic and prevent the persistence of the virus in human populations in China and worldwide. It remains unclear how these unprecedented interventions, including travel restrictions, have affected COVID-19 spread in China. We use real-time mobility data from Wuhan and detailed case data including travel history to elucidate the role of case importation on transmission in cities across China and ascertain the impact of control measures. Early on, the spatial distribution of COVID-19 cases in China was well explained by human mobility data. Following the implementation of control measures, this correlation dropped and growth rates became negative in most locations, although shifts in the demographics of reported cases are still indicative of local chains of transmission outside Wuhan. This study shows that the drastic control measures implemented in China have substantially mitigated the spread of COVID-19.", "topics": ["Epid\u00e9miologique", "Transversale"], "author_list": [{"id": 202, "name": "Kraemer MUG "}], "publication_date": "2020-03-31"}, {"id": 323, "slug": "novel-approach-to-reduce-transmission-of-covid-19-during-tracheostomy", "title": "Novel Approach to Reduce Transmission of COVID-19 During Tracheostomy", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Pr\u00e9senter un protocole chirurgical de trach\u00e9otomie permettant de r\u00e9duire le risque de transmission du SARS-CoV-2", "verbose_date": "14.04.2020", "authors": "Foster P", "specialties": [{"id": 4, "name": "Anesth\u00e9sie-R\u00e9animation"}, {"id": 2, "name": "Hygi\u00e8ne"}], "category": {"id": 2, "name": "Autres", "icon": "icon-other"}, "journal": {"id": 145, "name": "J Am Coll Surg"}, "link": "https://reader.elsevier.com/reader/sd/pii/S1072751520303227?token=EA65C2D831AA5BBDE518B98F70DB631C8B703F4362E35FFF7024782B032807AD5C650CF71CECA0AF2D3B57D6E30A93C1", "findings": "", "take_away": "", "relevance_level": "Pr\u00e9sentation d'un protocole chirurgical pour accro\u00eetre la s\u00e9curit\u00e9 de l'op\u00e9rateur lors d'une trach\u00e9otomie via un champ plastique transparent tendu au-dessus du patient et l'utilisation de plusieurs filtres.\r\nToutefois, pas de v\u00e9rification de l'efficacit\u00e9 de ce dispositif.", "objectives": "- Retour d'exp\u00e9rience d'un seul centre- Absence d'exp\u00e9riementation sur la protection r\u00e9elle de ce dispositif, pas de pr\u00e9l\u00e8vements effectu\u00e9s\"", "methods": "Pr\u00e9senter un protocole chirurgical de trach\u00e9otomie permettant de r\u00e9duire le risque de transmission du SARS-CoV-2", "pubmed_id": "32283268\n32102726", "doi": "10.1016/j.jamcollsurg.2020.04.014", "abstract": null, "topics": ["Autres", "Anesth\u00e9sie-R\u00e9animation", "Hygi\u00e8ne"], "author_list": [{"id": 310, "name": "Foster P"}], "publication_date": "2020-04-14"}, {"id": 203, "slug": "a-nationwide-survey-of-psychological-distress-among-chinese-people-in-the-covid-", "title": "A nationwide survey of psychological distress among Chinese people in the COVID-19 epidemic: implications and policy recommendations", "has_other_authors": true, "impact_factor": {"id": 3, "name": "Interm\u00e9diaire", "posts_count": 140, "color": "orange", "order": 2}, "goals_plain": "Mesurer la pr\u00e9valence et la s\u00e9v\u00e9rit\u00e9 de la d\u00e9tresse psychologique g\u00e9n\u00e9r\u00e9e par l'\u00e9pid\u00e9mie de COVID-19 et des mesures de quarantaine en Chine, ainsi que le poids des pathologies mentales sur la soci\u00e9t\u00e9 afin d'adapter efficacement les politiques relatives \u00e0 la sant\u00e9 mentale \u00e0 venir", "verbose_date": "31.03.2020", "authors": "Oiu J ", "specialties": [{"id": 6, "name": "Psychiatrie"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 100, "name": "Gen Psychiatr"}, "link": "https://www.dropbox.com/s/iyt0b8ndzhi2b43/e100213.full.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Il faudrait porter une attention plus particuli\u00e8re \u00e0 la sant\u00e9 mentale des groupes \u00e0 risque : femmes, sujets entre 18-30 ans et > 60 ans, travailleurs immigr\u00e9s. Am\u00e9liorer l'accessibilit\u00e9 aux structures de soin et de sant\u00e9 publique pourrait avoir un effet b\u00e9n\u00e9fique sur la d\u00e9tresse psychologique de la population. Il semble important d'organiser une strat\u00e9gie nationale de mise en place et de coordination de soins psychologiques primaires en cas de crise \u00e9pid\u00e9mique, via la t\u00e9l\u00e9m\u00e9decine notamment.", "objectives": "1) Questionnaire auto-administr\u00e9 (-)2) Effectif cons\u00e9quent (+ mais valeur clinique des r\u00e9sultats statistiquement significatifs \u00e0 bien explorer)3) Probable sous-repr\u00e9sentation des sujets les plus \u00e2g\u00e9s du fait de l'acc\u00e8s \u00e0 l'enqu\u00eate via un code QR, l'\u00e2ge moyen/median des enqu\u00eat\u00e9s n'est d'ailleurs pas indiqu\u00e9", "methods": "Mesurer la pr\u00e9valence et la s\u00e9v\u00e9rit\u00e9 de la d\u00e9tresse psychologique g\u00e9n\u00e9r\u00e9e par l'\u00e9pid\u00e9mie de COVID-19 et des mesures de quarantaine en Chine, ainsi que le poids des pathologies mentales sur la soci\u00e9t\u00e9 afin d'adapter efficacement les politiques relatives \u00e0 la sant\u00e9 mentale \u00e0 venir", "pubmed_id": "32215365\n25962178\n23408506\n25137105\n30134869\n22883254", "doi": "10.1136/gpsych-2020-100213", "abstract": "The Coronavirus Disease 2019 (COVID-19) epidemic emerged in Wuhan, China, spread nationwide and then onto half a dozen other countries between December 2019 and early 2020. The implementation of unprecedented strict quarantine measures in China has kept a large number of people in isolation and affected many aspects of people's lives. It has also triggered a wide variety of psychological problems, such as panic disorder, anxiety and depression. This study is the first nationwide large-scale survey of psychological distress in the general population of China during the COVID-19 epidemic.", "topics": ["Epid\u00e9miologique", "Psychiatrie"], "author_list": [{"id": 195, "name": "Oiu J "}], "publication_date": "2020-03-31"}, {"id": 297, "slug": "four-cases-from-a-family-cluster-were-diagnosed-as-covid-19-after-14-day-of-quar", "title": "Four cases from a family cluster were diagnosed as COVID-19 after 14-day of quarantine period", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "D\u00e9crire 4 cas de contaminations au COVID-19 apr\u00e8s confinement de 14 jours", "verbose_date": "10.04.2020", "authors": "Chen D", "specialties": [{"id": 7, "name": "Transversale"}, {"id": 12, "name": "Infectiologie"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 35, "name": "J Med Virol"}, "link": "https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.25849", "findings": "", "take_away": "", "relevance_level": "Alors que la p\u00e9riode d'incubation est aujourd'hui estim\u00e9e \u00e0 5 jours (2 \u00e0 14), il semblerait que cette p\u00e9riode de confinement de quatorze jours ne semble pas toujours suffisante pour s'assurer de l'absence d'infection, des cas d'apparition des premiers sypt\u00f4mes \u00e0 20 voire m\u00eame 30 jours apr\u00e8s infection ayant \u00e9t\u00e9 d\u00e9crit dans cet article.", "objectives": "- Case report- Peu de donn\u00e9es sur le mode de vie, les contacts potentiels et la situation \u00e9pid\u00e9mique dans cette province chinoise\"", "methods": "D\u00e9crire 4 cas de contaminations au COVID-19 apr\u00e8s confinement de 14 jours", "pubmed_id": "32270500", "doi": "10.1002/jmv.25849", "abstract": null, "topics": ["Epid\u00e9miologique", "Transversale", "Infectiologie"], "author_list": [{"id": 60, "name": "Chen D"}], "publication_date": "2020-04-10"}, {"id": 276, "slug": "transplantation-of-ace2-mesenchymal-stem-cells-improves-the-outcome-of-patients-", "title": "Transplantation of ACE2(-) Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Evaluation de l'efficacit\u00e9 et de la toxicit\u00e9 de la transplantation de cellules souches m\u00e9senchymateuses pour le traitement des infection \u00e0 SARS-CoV-2.", "verbose_date": "08.04.2020", "authors": "Leng Z", "specialties": [{"id": 12, "name": "Infectiologie"}, {"id": 8, "name": "Pneumologie"}], "category": {"id": 4, "name": "Th\u00e9rapeutique", "icon": "icon-med"}, "journal": {"id": 131, "name": "Aging Dis"}, "link": "https://www.dropbox.com/s/1oaijwo97sofwal/Transplantation%20of%20ACE2-%20Mesenchymal%20Stem%20Cells%20Improves%20the%20Outcome.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "L'injection de cellules souches m\u00e9senchymateuse pourrait limiter la r\u00e9ponse inflammatoire d\u00fb \u00e0 l'infection par SARS-CoV-2 et limiter ainsi les d\u00e9g\u00e2ts caus\u00e9s aux organes.\r\nDiminution du taux de TNF-\u03b1, augmentation de l'IL-10. El\u00e9vation moins importante des lymphocytes T r\u00e9gulateurs et des cellules dendritiques.", "objectives": "- Petit effectif (10 patients, 3 dans le groupe contr\u00f4le)- Crit\u00e8re d'efficacit\u00e9 primaire \u00e9valu\u00e9 sur le seul patient grave.\"", "methods": "Evaluation de l'efficacit\u00e9 et de la toxicit\u00e9 de la transplantation de cellules souches m\u00e9senchymateuses pour le traitement des infection \u00e0 SARS-CoV-2.", "topics": ["Th\u00e9rapeutique", "Infectiologie", "Pneumologie"], "author_list": [{"id": 265, "name": "Leng Z"}], "publication_date": "2020-04-08"}, {"id": 600, "slug": "reduction-of-hospitalizations-for-myocardial-infarction-in-italy-in-the-covid-19", "title": "Reduction of hospitalizations for myocardial infarction in Italy in the COVID-19 era", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Rechercher et caract\u00e9riser d'\u00e9ventuelles modifications des admissions en USIC et des complications pour les infarctus du myocarde en Italie durant la p\u00e9riode \u00e9pid\u00e9mique.", "verbose_date": "19.05.2020", "authors": "Rosa S", "specialties": [{"id": 17, "name": "Cardiologie et maladies m\u00e9taboliques"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 34, "name": "Eur Heart J"}, "link": "https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehaa409/5837572", "findings": "", "take_away": "", "relevance_level": "Sur la\u00a0semaine du 12 au 19 mars 2020, par rapport \u00e0 la semaine \u00e9quivalente en mars 2019, en Italie :\n- R\u00e9duction de 48,4% des admissions en USIC pour infarctus du myocarde avec une r\u00e9duction de 26,5% pour les STEMI (r\u00e9duction plus importante parmi les femmes de 41,2%) et une r\u00e9duction de 65,4% pour les NSTEMI.\n- Pour les STEMI : d\u00e9lais entre le premier sympt\u00f4me et la coronarographie et entre le premier contact m\u00e9dical et la coronarographie augment\u00e9s de 39,2% et de 31,5% respectivement.\n- Taux de coronarographie pour STEMI stable mais diminution de 13,3% des angioplasties percutan\u00e9es pour les NSTEMI.\n- Taux de mortalit\u00e9 des STEMI augment\u00e9 \u00e0 13,7% (RR=3,3), ce taux s'\u00e9levant \u00e0 28,6% pour les patients pr\u00e9sentant un STEMI et positifs au SARS-CoV-2. Taux de mortalit\u00e9 des NSTEMI augment\u00e9 \u00e0 3,3% (RR=1,9).\n- Taux de complications majeures major\u00e9 \u00e0 18,8% pour les STEMI (RR=1,8) et \u00e0 10,7% pour les NSTEMI (RR=2,1).", "objectives": "- \u00c9tude observationnelle descriptive transversale - Nombre modeste de cas, une seule semaine d'analyse- Plusieurs biais de confusion non pris en compte (\u00e9tendue de l'infarctus, comorbidit\u00e9s,...etc).", "methods": "Rechercher et caract\u00e9riser d'\u00e9ventuelles modifications des admissions en USIC et des complications pour les infarctus du myocarde en Italie durant la p\u00e9riode \u00e9pid\u00e9mique.", "pubmed_id": "32412631", "doi": "10.1093/eurheartj/ehaa409", "abstract": "To evaluate the impact of the COVID-19 pandemic on patient admissions to Italian cardiac care units (CCUs).\nWe conducted a multicentre, observational, nationwide survey to collect data on admissions for acute myocardial infarction (AMI) at Italian CCUs throughout a 1 week period during the COVID-19 outbreak, compared with the equivalent week in 2019. We observed a 48.4% reduction in admissions for AMI compared with the equivalent week in 2019 (P < 0.001). The reduction was significant for both ST-segment elevation myocardial infarction [STEMI; 26.5%, 95% confidence interval (CI) 21.7-32.3; P = 0.009] and non-STEMI (NSTEMI; 65.1%, 95% CI 60.3-70.3; P < 0.001). Among STEMIs, the reduction was higher for women (41.2%; P = 0.011) than men (17.8%; P = 0.191). A similar reduction in AMI admissions was registered in North Italy (52.1%), Central Italy (59.3%), and South Italy (52.1%). The STEMI case fatality rate during the pandemic was substantially increased compared with 2019 [risk ratio (RR) = 3.3, 95% CI 1.7-6.6; P < 0.001]. A parallel increase in complications was also registered (RR = 1.8, 95% CI 1.1-2.8; P = 0.009).\nAdmissions for AMI were significantly reduced during the COVID-19 pandemic across Italy, with a parallel increase in fatality and complication rates. This constitutes a serious social issue, demanding attention by the scientific and healthcare communities and public regulatory agencies.", "topics": ["Epid\u00e9miologique", "Cardiologie et maladies m\u00e9taboliques"], "author_list": [{"id": 563, "name": "Rosa S"}], "publication_date": "2020-05-19"}, {"id": 455, "slug": "covid-19-one-month-impact-of-the-french-lockdown-on-the-epidemic-burden", "title": "COVID-19: One-month impact of the French lockdown on the epidemic burden", "has_other_authors": true, "impact_factor": {"id": 3, "name": "Interm\u00e9diaire", "posts_count": 140, "color": "orange", "order": 2}, "goals_plain": "Analyser l'effet des mesures de confinement en France sur l'\u00e9pid\u00e9mie du COVID-19 apr\u00e8s 1 mois par mod\u00e9lisation", "verbose_date": "27.04.2020", "authors": "Roux J", "specialties": [{"id": 21, "name": "Confinement/D\u00e9confinement"}, {"id": 7, "name": "Transversale"}], "category": {"id": 8, "name": "Mod\u00e9lisation", "icon": "icon-all"}, "journal": {"id": 85, "name": "Pre-prints"}, "link": "https://www.ehesp.fr/wp-content/uploads/2020/04/Impact-Confinement-EHESP-20200322v1-1.pdf", "findings": "", "take_away": "", "relevance_level": "Bas\u00e9 sur des mod\u00e9lisations, le confinement en France aurait permis d'\u00e9viter 62 000 d\u00e9c\u00e8s (r\u00e9duction de moralit\u00e9 de 83,5%).\r\nLa r\u00e9duction du nombre d'hospitalisations n\u00e9cessaires atteint 88% soit 670 000 fran\u00e7ais et 91% pour les admissions en r\u00e9animation, soit 140 320 fran\u00e7ais.\u00a0\r\nLe confinement a ainsi \u00e9vit\u00e9 la saturation du syst\u00e8me hospitalier qui aurait \u00e9t\u00e9 atteinte d\u00e8s la fin mars avec pr\u00e8s d'un patient sur 2 qui n'aurait pas pu b\u00e9n\u00e9ficier d'un lit d'hospitalisation.", "objectives": "- Mod\u00e9lisation math\u00e9matique bien conduite avec mod\u00e8le compartimental bas\u00e9 sur des donn\u00e9es fiables et prenant en compte les diff\u00e9rents r\u00e9gionales ou li\u00e9es \u00e0 l'\u00e2ge- V\u00e9rification des pr\u00e9dictions du mod\u00e8le utilis\u00e9 par test sur la phase de pr\u00e9 confinement assurant d'une certaine robustesse du mod\u00e8le\"", "methods": "Analyser l'effet des mesures de confinement en France sur l'\u00e9pid\u00e9mie du COVID-19 apr\u00e8s 1 mois par mod\u00e9lisation", "topics": ["Mod\u00e9lisation", "Confinement/D\u00e9confinement", "Transversale"], "author_list": [{"id": 427, "name": "Roux J"}], "publication_date": "2020-04-27"}, {"id": 318, "slug": "severity-of-coronavirus-respiratory-tract-infections-in-adults-admitted-to-acute", "title": "Severity of coronavirus respiratory tract infections in adults admitted to acute care in Toronto, Ontario", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "D\u00e9terminer la proportion et d\u00e9crire l'\u00e9pid\u00e9miologie des infections \u00e0 coronavirus chez des patients admis en soins aigus dans un centre hospitalier de Toronto, sur une p\u00e9riode de 6 ans de 2010 \u00e0 2016, et identifier les facteurs de mauvais pronostic", "verbose_date": "13.04.2020", "authors": "Kozak R", "specialties": [{"id": 5, "name": "Virologie"}, {"id": 4, "name": "Anesth\u00e9sie-R\u00e9animation"}, {"id": 12, "name": "Infectiologie"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 143, "name": "J Clin Virol"}, "link": "https://reader.elsevier.com/reader/sd/pii/S1386653220300809?token=C99B259727B268573A7B87FCC81DD481E16C2CAA3508F4B31B98541B3AF8B1635320F9D3F215C395628C7CE831E7779C", "findings": "", "take_away": "", "relevance_level": "Proportion importante des infections \u00e0 coronavirus parmis les infections respiratoires virales en soins aigus (3\u00e8me ordre de fr\u00e9quence)\r\nTaux d'hospitalisation en soins continus et de mortalit\u00e9 (respectivement 17% et 7%) comparables \u00e0 ceux des virus influenza et VRS\r\nSexe f\u00e9minin (non concordant avec \u00e9tudes pr\u00e9c\u00e9dentes) et tabagisme seraient associ\u00e9s dans cette \u00e9tude \u00e0 des facteurs de s\u00e9v\u00e9rit\u00e9 (hospitalisation en soins intensifs et mortalit\u00e9)", "objectives": "Etude \u00e9pid\u00e9miologique descriptive transversale, monocentrique, n = 226", "methods": "D\u00e9terminer la proportion et d\u00e9crire l'\u00e9pid\u00e9miologie des infections \u00e0 coronavirus chez des patients admis en soins aigus dans un centre hospitalier de Toronto, sur une p\u00e9riode de 6 ans de 2010 \u00e0 2016, et identifier les facteurs de mauvais pronostic", "pubmed_id": "32278299\n30452608\n24915939\n16757599\n6262450\n21849456\n29350887\n28689664\n9431390\n16267760\n28893197\n29170370\n27899100\n31158256\n29427907\n9043091\n29716568\n26668769\n16829999\n31861926\n25863564\n28616442\n18821175\n20554810\n28838146\n28050020\n18689592\n6043624\n28457597\n28329354\n29214503\n15810082", "doi": "10.1016/j.jcv.2020.104338", "abstract": "The World Health Organization has highlighted the need for improved surveillance and understanding of the health burden imposed by non-influenza RNA respiratory viruses. Human coronaviruses (CoVs) are a major cause of respiratory and gastrointestinal tract infections with associated morbidity and mortality.\nThe objective of our study was to characterize the epidemiology of CoVs in our tertiary care centre, and identify clinical correlates of disease severity.\nA cross-sectional study was performed of 226 patients admitted with confirmed CoV respiratory tract infection between 2010 and 2016. Variables consistent with a severe disease burden were evaluated including symptoms, length of stay, intensive care unit (ICU) admission and mortality.\nCoVs represented 11.3% of all positive respiratory virus samples and OC43 was the most commonly identified CoV. The majority of infections were community-associated while 21.6% were considered nosocomial. The average length of stay was 11.8 days with 17.3% of patients requiring ICU admission and an all-cause mortality of 7%. In a multivariate model, female gender and smoking were associated with increased likelihood of admission to ICU or death.\nThis study highlights the significant burden of CoVs and justifies the need for surveillance in the acute care setting.", "topics": ["Epid\u00e9miologique", "Virologie", "Anesth\u00e9sie-R\u00e9animation", "Infectiologie"], "author_list": [{"id": 305, "name": "Kozak R"}], "publication_date": "2020-04-13"}, {"id": 112, "slug": "clinical-course-and-risk-factors-for-mortality-of-adult-inpatients-with-covid-19", "title": "Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohortstudy", "has_other_authors": true, "impact_factor": {"id": 3, "name": "Interm\u00e9diaire", "posts_count": 140, "color": "orange", "order": 2}, "goals_plain": "Identifier les caract\u00e9ristiques des patients atteint de Covid-19 et les facteurs de risque de d\u00e9c\u00e8s", "verbose_date": "11.03.2020", "authors": "Zhou F", "specialties": [{"id": 7, "name": "Transversale"}], "category": {"id": 6, "name": "Pronostique", "icon": "icon-chat"}, "journal": {"id": 70, "name": "The Lancet"}, "link": "https://www.dropbox.com/s/rf4iygmoz1t637h/PIIS0140673620305663.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "- Facteurs de risque de mortalit\u00e9 : \u00e2ge sup\u00e9rieur \u00e0 70 ans, comorbidit\u00e9s (HTA, diab\u00e8te, coronaropathie)- Signes de gravit\u00e9 : FR > 24, score SOFA > 6, GB>10G, lymphocytes<0,02G, creat>133, lactate>245, tropo>28, D-Dim\u00e8re>1 -> ces 3 derniers marqueurs augmentent au cours du temps chez les patients non survivants- Chronologie d'apparition des sympt\u00f4mes : d'abord toux + fi\u00e8vre, dyspn\u00e9e \u00e0 J6, puis disparition toux + fi\u00e8vre mais besoin de soins intensifs vers J12.", "objectives": "Interm\u00e9diaire :1) Etude \u00e9pid\u00e9miologique de cohorte bien conduite avec nombreux facteurs \u00e9tudi\u00e9s2) Faible effectif de patients d\u00e9c\u00e9d\u00e9s avec h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 importante", "methods": "Identifier les caract\u00e9ristiques des patients atteint de Covid-19 et les facteurs de risque de d\u00e9c\u00e8s", "topics": ["Pronostique", "Transversale"], "author_list": [{"id": 118, "name": "Zhou F"}], "publication_date": "2020-03-11"}, {"id": 593, "slug": "estimating-excess-1-year-mortality-associated-with-the-covid-19-pandemic-accordi", "title": "Estimating excess 1-year mortality associated with the COVID-19 pandemic according to underlying conditions and age: a population-based cohort study", "has_other_authors": true, "impact_factor": {"id": 3, "name": "Interm\u00e9diaire", "posts_count": 140, "color": "orange", "order": 2}, "goals_plain": "Les objectifs \u00e9taient de fournir des param\u00e8tres pour aider \u00e0 la mod\u00e9lisation et de fournir des estimations initiales de l'exc\u00e8s de d\u00e9c\u00e8s li\u00e9s \u00e0 COVID-19 sur une p\u00e9riode d'un an en fonction de diff\u00e9rents taux et niveaux relatifs d'impact de l'infection.", "verbose_date": "16.05.2020", "authors": "Banerjee A", "specialties": [{"id": 7, "name": "Transversale"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 12, "name": "Lancet"}, "link": "https://www.thelancet.com/action/showPdf?pii=S0140-6736%2820%2930854-0", "findings": "", "take_away": "", "relevance_level": "On a produit un mod\u00e8le pour estimer l'exc\u00e8s de mortalit\u00e9 li\u00e9 au COVID-19 en incorporant le taux d'infection de la population dans diff\u00e9rents sc\u00e9narios relatifs au degr\u00e9 d'isolement social, diff\u00e9rents degr\u00e9s d'impact du COVID-19 sur les syst\u00e8mes de sant\u00e9, et la pr\u00e9valence de conditions sous-jacentes. Dans un sc\u00e9nario de suppression totale, m\u00eame si COVID-19 a un impact relatif \u00e9lev\u00e9 sur les syst\u00e8mes de sant\u00e9, la surmortalit\u00e9 sur un an peut \u00eatre minimis\u00e9e. Inversement, avec l'att\u00e9nuation (c'est-\u00e0-dire des mesures moins rigoureuses et volontaires), on pr\u00e9voie entre 18 000 et 37 000 d\u00e9c\u00e8s. On a fourni un prototype de calculateur de risques pour les chercheurs et les d\u00e9cideurs politiques. On souligne \u00e9galement l'int\u00e9r\u00eat des dossiers m\u00e9dicaux \u00e9lectroniques de routine et de l'utilisation de vastes ensembles de donn\u00e9es reli\u00e9es au niveau national pour faire face \u00e0 la pand\u00e9mie.\nCes mod\u00e8les permettent d'estimer les effets globaux (directs et indirects) de la pand\u00e9mie COVID-19 sur la surmortalit\u00e9. On fournisse un mod\u00e8le, un outil et des donn\u00e9es en libre acc\u00e8s pour individualiser la pr\u00e9diction des risques en fonction des conditions sous-jacentes, ce qui pr\u00e9sente des avantages cliniques, de sant\u00e9 publique et de recherche pour les contextes de la pand\u00e9mie et de la postpand\u00e9mie de COVID-19.\nCes r\u00e9sultats montrent la n\u00e9cessit\u00e9 de mesures de r\u00e9pression rigoureuses et durables ainsi que d'efforts soutenus pour cibler les personnes les plus \u00e0 risque en raison de conditions sous-jacentes gr\u00e2ce \u00e0 une s\u00e9rie d'interventions pr\u00e9ventives. Les pays devraient \u00e9valuer les effets globaux (directs et indirects) de la pand\u00e9mie sur la surmortalit\u00e9.", "objectives": "- \u00e9tude de cohorte bas\u00e9e sur la population britannique- n = 3 862 012", "methods": "Les objectifs \u00e9taient de fournir des param\u00e8tres pour aider \u00e0 la mod\u00e9lisation et de fournir des estimations initiales de l'exc\u00e8s de d\u00e9c\u00e8s li\u00e9s \u00e0 COVID-19 sur une p\u00e9riode d'un an en fonction de diff\u00e9rents taux et niveaux relatifs d'impact de l'infection.", "pubmed_id": "32405103\n23419635\n30999919\n30420026\n32214079\n32171390\n32203977\n28619959\n23386360\n29500026\n31748235\n32203360\n31986264\n32439095\n21872920\n24881994\n31329239\n31650125\n29474617", "doi": "10.1016/S0140-6736(20)30854-0", "abstract": "The medical, societal, and economic impact of the coronavirus disease 2019 (COVID-19) pandemic has unknown effects on overall population mortality. Previous models of population mortality are based on death over days among infected people, nearly all of whom thus far have underlying conditions. Models have not incorporated information on high-risk conditions or their longer-term baseline (pre-COVID-19) mortality. We estimated the excess number of deaths over 1 year under different COVID-19 incidence scenarios based on varying levels of transmission suppression and differing mortality impacts based on different relative risks for the disease.\nIn this population-based cohort study, we used linked primary and secondary care electronic health records from England (Health Data Research UK-CALIBER). We report prevalence of underlying conditions defined by Public Health England guidelines (from March 16, 2020) in individuals aged 30 years or older registered with a practice between 1997 and 2017, using validated, openly available phenotypes for each condition. We estimated 1-year mortality in each condition, developing simple models (and a tool for calculation) of excess COVID-19-related deaths, assuming relative impact (as relative risks [RRs]) of the COVID-19 pandemic (compared with background mortality) of 1\u00b75, 2\u00b70, and 3\u00b70 at differing infection rate scenarios, including full suppression (0\u00b7001%), partial suppression (1%), mitigation (10%), and do nothing (80%). We also developed an online, public, prototype risk calculator for excess death estimation.\nWe included 3\u2008862\u2008012 individuals (1\u2008957\u2008935 [50\u00b77%] women and 1\u2008904\u2008077 [49\u00b73%] men). We estimated that more than 20% of the study population are in the high-risk category, of whom 13\u00b77% were older than 70 years and 6\u00b73% were aged 70 years or younger with at least one underlying condition. 1-year mortality in the high-risk population was estimated to be 4\u00b746% (95% CI 4\u00b741-4\u00b751). Age and underlying conditions combined to influence background risk, varying markedly across conditions. In a full suppression scenario in the UK population, we estimated that there would be two excess deaths (vs baseline deaths) with an RR of 1\u00b75, four with an RR of 2\u00b70, and seven with an RR of 3\u00b70. In a mitigation scenario, we estimated 18\u2008374 excess deaths with an RR of 1\u00b75, 36\u2008749 with an RR of 2\u00b70, and 73\u2008498 with an RR of 3\u00b70. In a do nothing scenario, we estimated 146\u2008996 excess deaths with an RR of 1\u00b75, 293\u2008991 with an RR of 2\u00b70, and 587\u2008982 with an RR of 3\u00b70.\nWe provide policy makers, researchers, and the public a simple model and an online tool for understanding excess mortality over 1 year from the COVID-19 pandemic, based on age, sex, and underlying condition-specific estimates. These results signal the need for sustained stringent suppression measures as well as sustained efforts to target those at highest risk because of underlying conditions with a range of preventive interventions. Countries should assess the overall (direct and indirect) effects of the pandemic on excess mortality.\nNational Institute for Health Research University College London Hospitals Biomedical Research Centre, Health Data Research UK.", "topics": ["Epid\u00e9miologique", "Transversale"], "author_list": [{"id": 557, "name": "Banerjee A"}], "publication_date": "2020-05-16"}, {"id": 247, "slug": "favipiravir-pharmacokinetics-and-concerns-about-clinical-trials-for-2019-ncov-in", "title": "Favipiravir: pharmacokinetics and concerns about clinical trials for 2019-nCoV infection", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "R\u00e9sumer, en vue d'un possible essai clinique, les caract\u00e9ristiques pharmacocin\u00e9tiques et les \u00e9ventuelles interactions m\u00e9dicamenteuses du Favipiravir un antiviral envisag\u00e9 dans le traitement de la COVID-19", "verbose_date": "06.04.2020", "authors": "Du YX", "specialties": [{"id": 12, "name": "Infectiologie"}, {"id": 8, "name": "Pneumologie"}], "category": {"id": 4, "name": "Th\u00e9rapeutique", "icon": "icon-med"}, "journal": {"id": 116, "name": "Clin Pharmacol Ther"}, "link": "https://ascpt.onlinelibrary.wiley.com/doi/epdf/10.1002/cpt.1844", "findings": "", "take_away": "", "relevance_level": "Le favipiravir pourrait \u00eatre un bon antiviral pour le traitement de la COVID-19. Les auteurs estiment qu'il pourrait \u00eatre un candidat comme traitement compassionnel mais que davantage de preuves de son efficacit\u00e9 sont n\u00e9cessaires. Ce m\u00e9dicament a principalement \u00e9t\u00e9 utilis\u00e9 et \u00e9tudi\u00e9 dans la population japonaise et sa pharmacocin\u00e9tique doit \u00eatre \u00e9tudi\u00e9e dans d'autres populations.", "objectives": "- revue de petite taille- encore peu d'\u00e9tudes chez l'humain relativement aux \u00e9tudes in vitro ou chez l'animal", "methods": "R\u00e9sumer, en vue d'un possible essai clinique, les caract\u00e9ristiques pharmacocin\u00e9tiques et les \u00e9ventuelles interactions m\u00e9dicamenteuses du Favipiravir un antiviral envisag\u00e9 dans le traitement de la COVID-19", "pubmed_id": "32246834", "doi": "10.1002/cpt.1844", "abstract": "An outbreak of 2019-nCoV infection has spread across the world. No specific antiviral drugs have been approved for the treatment of COVID-2019. In addition to the recommended antiviral drugs, such as interferon-\u0251, lopinavir/ritonavir, ribavirin, and chloroquine phosphate, some clinical trials focusing on virus RNA-dependent RNA polymerase (RdRp) inhibitors have been registered and initiated. Favipiravir, a purine nucleic acid analog and potent RdRp inhibitor approved for use in influenza, is also considered in several clinical trials. Herein, we summarized the pharmacokinetic characteristics of favipiravir and possible drug-drug interactions from the view of drug metabolism. We hope this will be helpful for the design of clinical trials for favipiravir in COVID-2019, as data regarding in vitro virus inhibition and efficacy in preclinical animal studies are still not available.", "topics": ["Th\u00e9rapeutique", "Infectiologie", "Pneumologie"], "author_list": [{"id": 237, "name": "Du YX"}], "publication_date": "2020-04-06"}, {"id": 124, "slug": "rapid-response-to-covid-19-outbreak-in-northern-italy-how-to-convert-a-classic-i", "title": "Rapid response to COVID-19 outbreak in Northern Italy: how to convert a classic infectious disease ward into a COVID-19 response centre", "has_other_authors": false, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Exposer la r\u00e9organisation d'un batiment pour accueillir des patients COVID-19", "verbose_date": "26.03.2020", "authors": "Asperges E", "specialties": [{"id": 7, "name": "Transversale"}], "category": {"id": 2, "name": "Autres", "icon": "icon-other"}, "journal": {"id": 6, "name": "J Hosp Infect"}, "link": "https://www.dropbox.com/s/17kqd91m0lj3cdk/PIIS0195670120301195.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Possibilit\u00e9 de modifier tr\u00e8s rapidement l'organisation et la fonction de service de soins ou d'autres services\r\nEn moins de deux semaines, un batiment de maladies infectieuse a r\u00e9ussi \u00e0 plus que doubler son nombre delits r\u00e9guliers de 44 \u00e0 94, \u00e0 cr\u00e9er un service infectieux sous-intensif et \u00e0 cr\u00e9er un service d'urgence infectieuses avec 16 lits pour les soins aigus.", "objectives": "1) Pre-proof2) Revue d'exp\u00e9rience\"", "methods": "Exposer la r\u00e9organisation d'un batiment pour accueillir des patients COVID-19", "topics": ["Autres", "Transversale"], "author_list": [{"id": 3, "name": "Asperges E"}], "publication_date": "2020-03-26"}, {"id": 339, "slug": "dynamic-estimation-of-epidemiological-parameters-of-covid-19-outbreak-and-effect", "title": "Dynamic Estimation of Epidemiological Parameters of COVID-19 Outbreak and Effects of Interventions on Its Spread", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Estimer les param\u00e8tres de l'\u00e9pid\u00e9mie de Covid-19 \u00e0 Wuhan en fonction du temps entre le 19 Janvier et le 5 mars 2020 et analyser l'effet des diff\u00e9rentes interventions de sant\u00e9 publique sur la propagation de l'\u00e9pid\u00e9mie.", "verbose_date": "15.04.2020", "authors": "Zhang H", "specialties": [{"id": 7, "name": "Transversale"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 85, "name": "Pre-prints"}, "link": "https://www.medrxiv.org/content/10.1101/2020.04.01.20050310v2.full.pdf", "findings": "", "take_away": "", "relevance_level": "-Diff\u00e9rences importantes entre le nombre officiel d'infections \u00e0 Wuhan et le nombre r\u00e9el d'infections, notamment dans la premi\u00e8re p\u00e9riode de l'\u00e9pid\u00e9mie.\r\n-Le nombre de reproduction effectif (Re) varie grandement au cours du temps, et suit l'\u00e9volution des mesures de sant\u00e9 publique.\r\n-Effet tr\u00e8s important des restrictions de transports non essentiels (confinement) et du d\u00e9pistage/hospitalisation massifs.", "objectives": "- Pr\u00e9 print- Etude \u00e9pid\u00e9miologique r\u00e9trospective- Utilisant les donn\u00e9es officielles chinoise pour les comparer \u00e0 leur r\u00e9sultats de mod\u00e9lisation\"", "methods": "Estimer les param\u00e8tres de l'\u00e9pid\u00e9mie de Covid-19 \u00e0 Wuhan en fonction du temps entre le 19 Janvier et le 5 mars 2020 et analyser l'effet des diff\u00e9rentes interventions de sant\u00e9 publique sur la propagation de l'\u00e9pid\u00e9mie.", "topics": ["Epid\u00e9miologique", "Transversale"], "author_list": [{"id": 325, "name": "Zhang H"}], "publication_date": "2020-04-15"}, {"id": 576, "slug": "qt-prolongation-torsades-de-pointes-and-sudden-death-with-short-courses-of-chlor", "title": "QT prolongation, torsades de pointes and sudden death with short courses of chloroquine or hydroxychloroquine as used in COVID-19: a systematic review", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Etudier l'effet arythmog\u00e9nique de la chloroquine et de l'hydroxychloroquine \u00e0 court terme chez les patients Covid-19.", "verbose_date": "12.05.2020", "authors": "Jankelson L", "specialties": [{"id": 17, "name": "Cardiologie et maladies m\u00e9taboliques"}], "category": {"id": 4, "name": "Th\u00e9rapeutique", "icon": "icon-med"}, "journal": {"id": 216, "name": "Heart Rythm"}, "link": "https://www.heartrhythmjournal.com/article/S1547-5271(20)30431-8/pdf", "findings": "", "take_away": "", "relevance_level": "Une part non n\u00e9gligeable des patients COVID-19 trait\u00e9s par hydroxychloroquine d\u00e9veloppent un allongement du segment QT.\r\nCertains patients Covid-19 ayant re\u00e7u de fortes doses de chloroquine ont d\u00e9velopp\u00e9 une arythmie ventriculaire.", "objectives": "Faible- Recherche large de la litt\u00e9rature, non limit\u00e9e \u00e0 l'anglais plus litt\u00e9rature industrielle-L'une des plus importantes \u00e9tudes incluses avait un suivi non clair avec de possibles perdus de vue-Biais de publication et de d\u00e9claration pouvant sous-estimer le risque-La plupart des donn\u00e9es issues de pr\u00e9-prints : possibles biais de ces \u00e9tudes", "methods": "Etudier l'effet arythmog\u00e9nique de la chloroquine et de l'hydroxychloroquine\u00a0\u00e0 court terme chez les patients Covid-19.", "pubmed_id": "32438018\n32187464\n17646028\n30400791\n14999113\n20185054\n32075761\n26660066\n21079043\n27212965\n32391667", "doi": "10.1016/j.hrthm.2020.05.008", "abstract": "Chloroquine and hydroxychloroquine are now being widely used for treatment of COVID-19. Both medications prolong the QT interval and accordingly may put patients at increased risk for torsades de pointes and sudden death. Published guidance documents vary in their recommendations for monitoring and managing these potential adverse effects. Accordingly, we set out to conduct a systematic review of the arrhythmogenic effect of short courses of chloroquine or hydroxychloroquine. We searched on MEDLINE and Embase, as well as in the gray literature up to April 17, 2020, for the risk of QT prolongation, torsades, ventricular arrhythmia, and sudden death with short-term chloroquine and hydroxychloroquine usage. This search resulted in 390 unique records, of which 14 were ultimately selected for qualitative synthesis and which included data on 1515 COVID-19 patients. Approximately 10% of COVID-19 patients treated with these drugs developed QT prolongation. We found evidence of ventricular arrhythmia in 2 COVID-19 patients from a group of 28 treated with high-dose chloroquine. Limitation of these results are unclear follow-up and possible publication/reporting bias, but there is compelling evidence that chloroquine and hydroxychloroquine induce significant QT-interval prolongation and potentially increase the risk of arrhythmia. Daily electrocardiographic monitoring and other risk mitigation strategies should be considered in order to prevent possible harms from what is currently an unproven therapy.", "topics": ["Th\u00e9rapeutique", "Cardiologie et maladies m\u00e9taboliques"], "author_list": [{"id": 540, "name": "Jankelson L"}], "publication_date": "2020-05-12"}, {"id": 17, "slug": "clinical-characteristics-of-novel-coronavirus-disease-2019-covid-19-in-newborns-", "title": "Clinical characteristics of novel coronavirus disease 2019 (COVID-19) in newborns, infants and children", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Descrire les formes p\u00e9diatriques", "verbose_date": "24.03.2020", "authors": "Hong H", "specialties": [{"id": 9, "name": "P\u00e9diatrie"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 13, "name": "Pediatr Neonatol"}, "link": "https://www.dropbox.com/s/oao6kzm1cl7sk6s/PIIS1875957220300267.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Les formes p\u00e9diatriques existent, formes diverses : asymptomatique, fievre, toux seche, fatigue, quelques symptomes respiratoires hauts (congestion nasale, ecoulement nasal), signes gastrointestinaux (inconfort abdominal, naus\u00e9, vomissements, douleur abdo, diarh\u00e9e). La plupart ont des formes legeres et sont de bon prognostic. Ils guerissent en 1\u00e02 semaine. L'infection respi est rare. Les cas severe evoluent vers un SDRA, choc septique, acidose m\u00e9tabolique refractaires, troubels de coag, mais c'est rare.1 cas s\u00e9v\u00e8re decrit chez un garcon de 1 an.Diag infection neonatale SARS-CoV-2 necessite tous ces criteres : au moins 1 symptom + rx pulm patho + membre de la famille infect\u00e9 + contact etroit avec une personne infect\u00e9e ou ayant une pneumopathie ou ayant des animaux sauvages ou du march\u00e9. Si un nouveau n\u00e9 est infect\u00e9 il faut le mettre en USI, si syndromes de detresse respi : surfactant, inhalation d'oxyde nitrique, et une ventilation oscillatoire \u00e0 haute fr\u00e9quence doivent etre consid\u00e9r\u00e9. Dans les formes critiques : glucocorticoide IV ou immunoglobulines, remplacement rein, ECMO doivent etre consid\u00e9r\u00e9", "objectives": "Faible : - lettre a l'editeur- se base sur faibles echantillons", "methods": "Descrire les formes p\u00e9diatriques", "pubmed_id": "32199864\n31986261\n31995857\n32043976\n32151335\n32087114\n31953166\n32045966\n31978293\n32058570\n32154135", "doi": "10.1016/j.pedneo.2020.03.001", "abstract": null, "topics": ["Epid\u00e9miologique", "P\u00e9diatrie"], "author_list": [{"id": 27, "name": "Hong H"}], "publication_date": "2020-03-24"}, {"id": 656, "slug": "effects-of-non-pharmaceutical-interventions-on-covid-19-cases-deaths-and-demand-", "title": "Effects of non-pharmaceutical interventions on COVID-19 cases, deaths, and demand for hospital services in the UK: a modelling study", "has_other_authors": true, "impact_factor": {"id": 3, "name": "Interm\u00e9diaire", "posts_count": 140, "color": "orange", "order": 2}, "goals_plain": "Evaluer l'impact de diff\u00e9rentes mesures de contr\u00f4le pour att\u00e9nuer les cons\u00e9quences du COVID-19 au Royaume-Uni.", "verbose_date": "04.06.2020", "authors": "Davies NG", "specialties": [{"id": 7, "name": "Transversale"}], "category": {"id": 8, "name": "Mod\u00e9lisation", "icon": "icon-all"}, "journal": {"id": 140, "name": "Lancet Public Health"}, "link": "https://www.thelancet.com/pdfs/journals/lanpub/PIIS2468-2667(20)30133-X.pdf", "findings": "", "take_away": "", "relevance_level": "En l'absence de mesures de contr\u00f4le, l'\u00e9pid\u00e9mie de COVID-19 pourrait rapidement submerger le syst\u00e8me de sant\u00e9.\nDans cette \u00e9tude, m\u00eame une combinaison d'interventions mod\u00e9r\u00e9es - telles que les fermetures d'\u00e9coles, la protection des personnes \u00e2g\u00e9es et l'auto-isolement des personnes symptomatiques - serait peu susceptible d'emp\u00eacher une \u00e9pid\u00e9mie exc\u00e9dant la capacit\u00e9 des unit\u00e9s de soins intensifs au Royaume-Uni.\nDes p\u00e9riodes intermittentes de mesures de verrouillage intensives devraient \u00eatre efficaces pour \u00e9viter que le syst\u00e8me de sant\u00e9 ne soit submerg\u00e9.", "objectives": "Prise en compte de la d\u00e9pl\u00e9tion des susceptibles dans le mod\u00e8leValeurs al\u00e9atoires de R0 ont \u00e9t\u00e9 choisies dans une distribution normale avec moyenne de 2,7Taux de l\u00e9talit\u00e9 de base stratifi\u00e9s par \u00e2ge issus de donn\u00e9es chinoises de d\u00e9but f\u00e9vrierAutres param\u00e8tres entr\u00e9s \u00e0 partir d'autres \u00e9tudes chinoises et contenant une forte approximation (d\u00e9finis dans les premiers stades de l\u2019\u00e9pid\u00e9mie)Hypoth\u00e8se d'une immunit\u00e9 protectrice d'1 \u00e0 2 ansHypoth\u00e8se de 0% de contact \u00e0 l'\u00e9cole lors de leur fermeture (ne prenant pas en compte la garde des enfants des travailleurs essentiels)200 simulations pour chacun des 8 mod\u00e8les test\u00e9sDate al\u00e9atoire d'introduction du SRAS-CoV-2 pour chaque unit\u00e9 administrative, les arrondissements de Londres \u00e9tant infect\u00e9s au cours de la premi\u00e8re semaine et toutes les autres unit\u00e9s administratives de Londres infect\u00e9es lors des 4 premi\u00e8res semaines de l'\u00e9pid\u00e9mie.Pas de structuration des individus par m\u00e9nagePas d'\u00e9v\u00e8nement de super-propagation dans le mod\u00e8lePas de prise en compte des infections li\u00e9es aux soinsHypoth\u00e8se probablement erron\u00e9e sur le taux de transmission des individus asymptomatiquesPas de donn\u00e9es suffisantes pour d\u00e9composer explicitement les mesures de distanciation physique, tels que rester \u00e0 2 m l'un de l'autre, augmenter le lavage des mains et le port du masque facial", "methods": "Evaluer l'impact de diff\u00e9rentes mesures de contr\u00f4le pour att\u00e9nuer les cons\u00e9quences du COVID-19 au Royaume-Uni.", "pubmed_id": "32502389\n32220655\n31995857\n16292310\n32171059\n31986264\n18252100\n18366252\n32119825\n32113505\n32164834\n32375776\n32311320", "doi": "10.1016/S2468-2667(20)30133-X", "abstract": "Non-pharmaceutical interventions have been implemented to reduce transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the UK. Projecting the size of an unmitigated epidemic and the potential effect of different control measures has been crucial to support evidence-based policy making during the early stages of the epidemic. This study assesses the potential impact of different control measures for mitigating the burden of COVID-19 in the UK.\nWe used a stochastic age-structured transmission model to explore a range of intervention scenarios, tracking 66\u00b74 million people aggregated to 186 county-level administrative units in England, Wales, Scotland, and Northern Ireland. The four base interventions modelled were school closures, physical distancing, shielding of people aged 70 years or older, and self-isolation of symptomatic cases. We also modelled the combination of these interventions, as well as a programme of intensive interventions with phased lockdown-type restrictions that substantially limited contacts outside of the home for repeated periods. We simulated different triggers for the introduction of interventions, and estimated the impact of varying adherence to interventions across counties. For each scenario, we projected estimated new cases over time, patients requiring inpatient and critical care (ie, admission to the intensive care units [ICU]) treatment, and deaths, and compared the effect of each intervention on the basic reproduction number, R\nWe projected a median unmitigated burden of 23 million (95% prediction interval 13-30) clinical cases and 350\u2008000 deaths (170\u2008000-480\u2008000) due to COVID-19 in the UK by December, 2021. We found that the four base interventions were each likely to decrease R\nThe characteristics of SARS-CoV-2 mean that extreme measures are probably required to bring the epidemic under control and to prevent very large numbers of deaths and an excess of demand on hospital beds, especially those in ICUs.\nMedical Research Council.", "topics": ["Mod\u00e9lisation", "Transversale"], "author_list": [{"id": 617, "name": "Davies NG"}], "publication_date": "2020-06-04"}, {"id": 334, "slug": "covid-19-a-relationship-to-climate-and-environmental-conditions", "title": "COVID-19: A Relationship to Climate and Environmental Conditions?", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Evaluer l'effet des caract\u00e9ristiques climatiques et des processus m\u00e9t\u00e9orologiques dans les mod\u00e8les \u00e9pid\u00e9miologiques de propagation de SARS-CoV-2", "verbose_date": "15.04.2020", "authors": "Kroumpouzos G", "specialties": [{"id": 7, "name": "Transversale"}], "category": {"id": 2, "name": "Autres", "icon": "icon-other"}, "journal": {"id": 127, "name": "Dermatol Ther"}, "link": "https://onlinelibrary.wiley.com/doi/epdf/10.1111/dth.13399", "findings": "", "take_away": "", "relevance_level": "La saisonnalit\u00e9 et la dynamique de diffusion du SARS-CoV-2 li\u00e9es aux conditions environnementales n'ont pas encore \u00e9t\u00e9 d\u00e9termin\u00e9es mais il a \u00e9t\u00e9 d\u00e9montr\u00e9 que des temp\u00e9ratures >38\u00b0C et une humidit\u00e9 relative > 95% r\u00e9duisent la viabilit\u00e9 du SARS-CoV-2.\r\nL'int\u00e9gration des caract\u00e9ristiques climatiques et des processus m\u00e9t\u00e9orologiques dans les mod\u00e8les \u00e9pid\u00e9miologiques de propagation de SARS-CoV-2 peut aider \u00e0 identifier les sc\u00e9narios d'interactions interhumaines les plus \u00e0 risque et \u00e0 am\u00e9liorer les mesures de surveillance ou de contr\u00f4le de la pand\u00e9mie en fonction de la r\u00e9gion g\u00e9ographique d'int\u00e9r\u00eat.", "objectives": "1) Lettre \u00e0 l'editeur2) Bas\u00e9 sur une litt\u00e9rature encore r\u00e9duite", "methods": "Evaluer l'effet des caract\u00e9ristiques climatiques et des processus m\u00e9t\u00e9orologiques dans les mod\u00e8les \u00e9pid\u00e9miologiques de propagation de SARS-CoV-2", "pubmed_id": "32276290\n20228108\n22312351\n31995857\n32112977", "doi": "10.1111/dth.13399", "abstract": null, "topics": ["Autres", "Transversale"], "author_list": [{"id": 321, "name": "Kroumpouzos G"}], "publication_date": "2020-04-15"}, {"id": 623, "slug": "lifestyle-risk-factors-inflammatory-mechanisms-and-covid-19-hospitalization-a-co", "title": "Lifestyle Risk Factors, Inflammatory Mechanisms, and COVID-19 Hospitalization: A Community-Based Cohort Study of 387,109 Adults in UK", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Evaluer l'association entre facteurs de risque li\u00e9s au mode de vie (tabagisme, consommation d'alcool, inactivit\u00e9 physique, surpoids) et risque d'hospitalisation pour infection COVID-19.", "verbose_date": "25.05.2020", "authors": "Hamer M", "specialties": [{"id": 7, "name": "Transversale"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 109, "name": "Brain Behav Immun"}, "link": "https://www.sciencedirect.com/science/article/pii/S088915912030996X", "findings": "", "take_away": "", "relevance_level": "- Les RR pour chaque facteurs de risque li\u00e9s au mode de vie apr\u00e8s ajustement sont : 1,32 pour l'activit\u00e9 physique, 1,42 pour le tabagisme, 2,05 pour l'ob\u00e9sit\u00e9. Pas d'association significative pour la consommation excessive d'alcool.\n- Relation dose-effet entre score de facteurs de risque li\u00e9s au mode de vie et risque d'hospitalisation COVID-19, jusqu'\u00e0 x 4,41.\n- Un syndrome inflammatoire de bas niveau associ\u00e9 aux modes de vie \u00e0 risque pourrait m\u00e9dier ce risque observ\u00e9.\n- Fraction attribuable \u00e0 la population pour la combinaison tabagisme, inactivit\u00e9 physique et IMC>25 s'\u00e9levant \u00e0 51,4%.", "objectives": "- \u00e9tude de cohorte prospective- nombre de cas relativement faible- la p\u00e9riode d'int\u00e9r\u00eat est courte et tr\u00e8s \u00e9loign\u00e9e de la derni\u00e8re \u00e9valuation des facteurs de risque (> 10 ans)- biais de classement tr\u00e8s probable car l'\u00e9v\u00e8nement pris en compte est une hospitalisation avec un test SARS-CoV-2 positif (les tests \u00e9tant r\u00e9serv\u00e9s \u00e0 cette p\u00e9riode \u00e0 des personnes hospitalis\u00e9es et pr\u00e9sentant des sympt\u00f4mes compatibles COVID-19) et non pas des personnes avec diagnostic de COVID-19 s\u00e9v\u00e8re n\u00e9cessitant une hospitalisation au sens strict.- analyse de sous groupe semblant r\u00e9alis\u00e9e \u00e0 posteriori (non d\u00e9taill\u00e9e dans les m\u00e9thodes).- pre-proof", "methods": "Evaluer l'association entre facteurs de risque li\u00e9s au mode de vie (tabagisme, consommation d'alcool, inactivit\u00e9 physique, surpoids) et risque d'hospitalisation pour infection COVID-19.", "pubmed_id": "32454138", "doi": "10.1016/j.bbi.2020.05.059", "abstract": "We conducted the first large-scale general population study on lifestyle risk factors (smoking, physical inactivity, obesity, and excessive alcohol intake) for COVID-19 using prospective cohort data with national registry linkage to hospitalisation. Participants were 387,109 men and women (56.4\u00a0\u00b1\u00a08.8\u00a0yr; 55.1% women) residing in England from UK Biobank study. Physical activity, smoking, and alcohol intake, were assessed by questionnaire at baseline (2006-2010). Body mass index, from measured height and weight, was used as an indicator of overall obesity. Outcome was cases of COVID-19 serious enough to warrant a hospital admission from 16-March-2020 to 26-April-2020. There were 760 COVID-19 cases. After adjustment for age, sex and mutually for each lifestyle factor, physical inactivity (Relative risk, 1.32, 95% confidence interval, 1.10, 1.58), smoking (1.42;1.12, 1.79) and obesity (2.05 ;1.68, 2.49) but not heavy alcohol consumption (1.12; 0.93, 1.35) were all related to COVID-19. We also found a dose-dependent increase in risk of COVID-19 with less favourable lifestyle scores, such that participants in the most adverse category had 4-fold higher risk (4.41; 2.52-7.71) compared to people with the most optimal lifestyle. C-reactive protein levels were associated with elevated risk of COVID-19 in a dose-dependent manner, and partly (10-16%) explained associations between adverse lifestyle and COVID-19. Based on UK risk factor prevalence estimates, unhealthy behaviours in combination accounted for up to 51% of the population attributable fraction of severe COVID-19. Our findings suggest that an unhealthy lifestyle synonymous with an elevated risk of non-communicable disease is also a risk factor for COVID-19 hospital admission, which might be partly explained by low grade inflammation. Adopting simple lifestyle changes could lower the risk of severe infection.", "topics": ["Epid\u00e9miologique", "Transversale"], "author_list": [{"id": 586, "name": "Hamer M"}], "publication_date": "2020-05-25"}, {"id": 526, "slug": "risk-of-qt-interval-prolongation-associated-with-use-of-hydroxychloroquine-with-", "title": "Risk of QT Interval Prolongation Associated With Use of Hydroxychloroquine With or Without Concomitant Azithromycin Among Hospitalized Patients Testing Positive for Coronavirus Disease 2019 (COVID-19)", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Caract\u00e9riser le risque et le degr\u00e9 d'allongement de l'intervalle QT chez les patients atteints de COVID-19 en association avec leur utilisation d'hydroxychloroquine avec ou sans azithromycine concomitante.", "verbose_date": "05.05.2020", "authors": "Mercuro NJ", "specialties": [{"id": 7, "name": "Transversale"}, {"id": 17, "name": "Cardiologie et maladies m\u00e9taboliques"}], "category": {"id": 4, "name": "Th\u00e9rapeutique", "icon": "icon-med"}, "journal": {"id": 99, "name": "JAMA Cardiol"}, "link": "https://www.dropbox.com/s/3bex34dglw0hmyi/10.1001%40jamacardio.2020.1834.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Dans cette \u00e9tude de cohorte, les patients qui ont re\u00e7u de l'hydroxychloroquine pour le traitement de la pneumonie associ\u00e9e \u00e0 COVID-19 pr\u00e9sentaient un risque \u00e9lev\u00e9 d'allongement de l'intervalle QTc, et le traitement concomitant avec l'azithromycine \u00e9tait associ\u00e9 \u00e0 des modifications plus importantes de l'intervalle QTc.\nCertains patients ont eu des effets ind\u00e9sirables des m\u00e9dicaments, dont un cas de torsades de pointes avec administration d'hydroxychloroquine et d'azithromycine.\nIl est absolument n\u00e9cessaire de mener des \u00e9tudes rigoureuses \u00e0 grande \u00e9chelle et de proc\u00e9der \u00e0 une \u00e9valuation des risques et des avantages avant de lancer la th\u00e9rapie COVID-19, en accordant une attention particuli\u00e8re aux interactions m\u00e9dicamenteuses, aux manifestations cardiaques, aux \u00e9lectrocardiogrammes de routine et \u00e0 la surveillance des \u00e9lectrolytes.", "objectives": "-\tEtude observationnelle de cohorte r\u00e9trospective et monocentrique-\tN=90-\tBien que l'administration d'hydroxychloroquine et d'azithromycine ait probablement contribu\u00e9 aux effets ind\u00e9sirables observ\u00e9s des m\u00e9dicaments, on ne peut pas exclure la cardiomyopathie ou la myocardite associ\u00e9es au COVID-19.-\tSans bras de contr\u00f4le, on ne peut pas conclure que l'hydroxychloroquine et l'azithromycine ont conf\u00e9r\u00e9 un risque cardiotoxique accru.-\tIl reste possible que le v\u00e9ritable degr\u00e9 d'allongement de l'intervalle QTc ait \u00e9t\u00e9 sous-estim\u00e9, compte tenu de la variation des pratiques cliniques et d'une p\u00e9riode de suivi limit\u00e9e : 45 patients sont rest\u00e9s hospitalis\u00e9s, et 19 patients n'ont pas subi d'\u00e9lectrocardiogrammes de suivi.-\tIl se peut que les groupes \u00e0 haut risque n'aient pas \u00e9t\u00e9 repr\u00e9sent\u00e9s, car les directives institutionnelles d\u00e9conseillent l'hydroxychloroquine aux personnes dont l'intervalle QTc de base est prolong\u00e9. -\tDe nombreux facteurs dans cette petite cohorte d'adultes atteints de maladies complexes, souvent graves, pourraient \u00e9galement avoir confondu les points terminaux cliniques et de s\u00e9curit\u00e9.", "methods": "Caract\u00e9riser le risque et le degr\u00e9 d'allongement de l'intervalle QT chez les patients atteints de COVID-19 en association avec leur utilisation d'hydroxychloroquine avec ou sans azithromycine concomitante.", "pubmed_id": "32356863\n22591294\n32020029\n23716032\n32205204\n32330277\n32283123\n32200663\n32075365\n32240719", "doi": "10.1001/jamacardio.2020.1834", "abstract": "Administration of hydroxychloroquine with or without azithromycin for the treatment of coronavirus disease 2019 (COVID-19)-associated pneumonia carries increased risk of corrected QT (QTc) prolongation and cardiac arrhythmias.\nTo characterize the risk and degree of QT prolongation in patients with COVID-19 in association with their use of hydroxychloroquine with or without concomitant azithromycin.\nThis was a cohort study performed at an academic tertiary care center in Boston, Massachusetts, of patients hospitalized with at least 1 positive COVID-19 nasopharyngeal polymerase chain reaction test result and clinical findings consistent with pneumonia who received at least 1 day of hydroxychloroquine from March 1, 2020, through April 7, 2020.\nChange in QT interval after receiving hydroxychloroquine with or without azithromycin; occurrence of other potential adverse drug events.\nAmong 90 patients given hydroxychloroquine, 53 received concomitant azithromycin; 44 (48.9%) were female, and the mean (SD) body mass index was 31.5 (6.6). Hypertension (in 48 patients [53.3%]) and diabetes mellitus (in 26 patients [28.9%]) were the most common comorbid conditions. The overall median (interquartile range) baseline QTc was 455 (430-474) milliseconds (hydroxychloroquine, 473 [454-487] milliseconds vs hydroxychloroquine and azithromycin, 442 [427-461] milliseconds; P\u2009<\u2009.001). Those receiving concomitant azithromycin had a greater median (interquartile range) change in QT interval (23 [10-40] milliseconds) compared with those receiving hydroxychloroquine alone (5.5 [-15.5 to 34.25] milliseconds; P\u2009=\u2009.03). Seven patients (19%) who received hydroxychloroquine monotherapy developed prolonged QTc of 500 milliseconds or more, and 3 patients (3%) had a change in QTc of 60 milliseconds or more. Of those who received concomitant azithromycin, 11 of 53 (21%) had prolonged QTc of 500 milliseconds or more and 7 of 53 (13 %) had a change in QTc of 60 milliseconds or more. The likelihood of prolonged QTc was greater in those who received concomitant loop diuretics (adjusted odds ratio, 3.38 [95% CI, 1.03-11.08]) or had a baseline QTc of 450 milliseconds or more (adjusted odds ratio, 7.11 [95% CI, 1.75-28.87]). Ten patients had hydroxychloroquine discontinued early because of potential adverse drug events, including intractable nausea, hypoglycemia, and 1 case of torsades de pointes.\nIn this cohort study, patients who received hydroxychloroquine for the treatment of pneumonia associated with COVID-19 were at high risk of QTc prolongation, and concurrent treatment with azithromycin was associated with greater changes in QTc. Clinicians should carefully weigh risks and benefits if considering hydroxychloroquine and azithromycin, with close monitoring of QTc and concomitant medication usage.", "topics": ["Th\u00e9rapeutique", "Transversale", "Cardiologie et maladies m\u00e9taboliques"], "author_list": [{"id": 493, "name": "Mercuro NJ"}], "publication_date": "2020-05-05"}, {"id": 249, "slug": "incidence-of-novel-coronavirus-2019-ncov-infection-among-people-under-home-quara", "title": "Incidence of novel coronavirus (2019-nCoV) infection among people under home quarantine in Shenzhen, China", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Estimer l'incidence de l'infection par le SRAS-CoV-2 chez les personnes mises en quarantaine dans la ville de Shenzhen, Chine.", "verbose_date": "06.04.2020", "authors": "Wang J", "specialties": [{"id": 7, "name": "Transversale"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 69, "name": "Travel Med Infect Dis"}, "link": "https://www.dropbox.com/s/ev9cm3in2etrhml/1-s2.0-S1477893920301289-main.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "I) l'\u00e9tude a montr\u00e9 que la quarantaine r\u00e9duisait la transmission du SRAS-CoV-2 : 3 personnes positives sur 2004, aucun nouveau cas parmi les personnes incluses dans l'\u00e9tude et leurs contacts au 31 mars 2020.\n\r\nII) la supervision de la population par les agents de sant\u00e9, des instructions compr\u00e9hensibles et applicables doivent \u00eatre mises en place pour rendre la quarantaine efficace.", "objectives": "1) \u00e9tude d'observation prospective2) l'\u00e9chantillon nasopharyng\u00e9 n'a \u00e9t\u00e9 effectu\u00e9 qu'une seule fois pour chaque sujet, les faux n\u00e9gatifs ne peuvent \u00eatre exclus3) la population de l'\u00e9chantillon peut ne pas \u00eatre repr\u00e9sentative de la population totale \"", "methods": "Estimer l'incidence de l'infection par le SRAS-CoV-2 chez les personnes mises en quarantaine dans la ville de Shenzhen, Chine.", "pubmed_id": "32247931\n32027631\n31978945\n22611587\n21073672\n30828672\n31986264\n17662167", "doi": "10.1016/j.tmaid.2020.101660", "abstract": "Since the outbreak of 2019-nCoV in December, Chinese government has implemented various measures including travel bans, centralized treatments, and home quarantines to slowing the transmission across the country. In this study, we aimed to estimate the incidence of 2019-nCoV infection among people under home quarantine in Shenzhen, China.\nWe used a stratified multistage random sampling method to recruit participants and collected demographic information and laboratory results of people under home quarantine. We conducted descriptive analysis to estimate the basic characteristics and to calculate the incidence in out study population.\nA total of 2004 people under home quarantine participated in this study, of which 1637 participants finished the questionnaire with a response rate of 81.7%. Mean age of the participants was 33.7 years, ranging from 0.3 to 80.2 years. Of people who provided clear travel history, 129 people have traveled to Wuhan city and 1,046 people have traveled to other cities in Hubei province within 14 days before the home quarantine. Few (less than 1%) participants reported contact history with confirmed or suspected cases during their trip and most of these arrived at Shenzhen between Jan 24, 2020 to Jan 27, 2020. The incidence of COVID-19 in the sample was 1.5\u2030 (95% CI: 0.31\u2030-4.37\u2030).\nHome quarantine has been effective in preventing the early transmission of COVID-19, but that more needs to be done to improve early detection of COVID-19 infection.", "topics": ["Epid\u00e9miologique", "Transversale"], "author_list": [{"id": 239, "name": "Wang J"}], "publication_date": "2020-04-06"}, {"id": 291, "slug": "covid-19-in-long-term-liver-transplant-patients-preliminary-experience-from-an-i", "title": "COVID-19 in long-term liver transplant patients: preliminary experience from an Italian transplant centre in Lombardy", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Evaluation du risque li\u00e9 au COVID-19 pour des transplant\u00e9s h\u00e9patiques", "verbose_date": "10.04.2020", "authors": "Bhoori S", "specialties": [{"id": 19, "name": "H\u00e9pato-gastro-ent\u00e9rologie"}, {"id": 7, "name": "Transversale"}], "category": {"id": 6, "name": "Pronostique", "icon": "icon-chat"}, "journal": {"id": 19, "name": "Lancet Gastroenrol Hepatol"}, "link": "https://www.thelancet.com/action/showPdf?pii=S2468-1253%2820%2930116-3", "findings": "", "take_away": "", "relevance_level": "Les patients greff\u00e9s h\u00e9patiques ne semblent pas pr\u00e9senter une mortalit\u00e9 augment\u00e9e, l'immunosuppression pouvant \u00eatre un facteur protecteur dans le cadre de l'infection \u00e0 COVID-19. Toutefois, le d\u00e9veloppement des comorbidit\u00e9s cardiovasculaires en post-greffe rend ces patients \u00e0 risque de d\u00e9velopper une forme s\u00e9v\u00e8re.", "objectives": "- Correspondance- Revue d'exp\u00e9rience sur 3 patients d\u00e9c\u00e9d\u00e9s\"", "methods": "Evaluation du risque li\u00e9 au COVID-19 pour des transplant\u00e9s h\u00e9patiques", "pubmed_id": "32278366\n32298473\n32224313\n27917074\n30622369\n32109013\n32170806\n32196933", "doi": "10.1016/S2468-1253(20)30116-3", "abstract": null, "topics": ["Pronostique", "H\u00e9pato-gastro-ent\u00e9rologie", "Transversale"], "author_list": [{"id": 279, "name": "Bhoori S"}], "publication_date": "2020-04-10"}, {"id": 638, "slug": "are-chilblain-like-acral-skin-lesions-really-indicative-of-covid-19-a-prospectiv", "title": "Are chilblain-like acral skin lesions really indicative of COVID-19? A prospective study and literature review", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "- Etablir la pr\u00e9valence d'infection COVID-19 parmi les patients pr\u00e9sentant des l\u00e9sions dermatologiques acrales semblable \u00e0 des engelures.", "verbose_date": "28.05.2020", "authors": "Docampo-Simon A", "specialties": [{"id": 10, "name": "Dermatologie"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 246, "name": "J Eur Acad Dermatol Venerol"}, "link": "https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdv.16665", "findings": "", "take_away": "", "relevance_level": "Il n'existe pas actuellement d'\u00e9l\u00e9ment faisant suspecter une association entre l\u00e9sions dermatologiques acrales \u00e0 type d'engelure et infection \u00e0 SARS-CoV-2.", "objectives": "- Lettre \u00e0 l'\u00e9diteur- \u00c9tude observationnelle transversale coupl\u00e9e \u00e0 une revue de la litt\u00e9rature semblant syst\u00e9matique mais aucun d\u00e9tail m\u00e9thodologique n'est donn\u00e9.", "methods": "- Etablir la pr\u00e9valence d'infection COVID-19 parmi les patients pr\u00e9sentant des l\u00e9sions dermatologiques acrales semblable \u00e0 des engelures.", "pubmed_id": "32452545", "doi": "10.1111/jdv.16665", "abstract": "Recently, young COVID-19 patients have presented with erythematous and purpuric acral lesions similar to chilblains", "topics": ["Epid\u00e9miologique", "Dermatologie"], "author_list": [{"id": 600, "name": "Docampo-Simon A"}], "publication_date": "2020-05-28"}, {"id": 365, "slug": "the-imperfect-cytokine-storm-severe-covid-19-with-ards-in-patient-on-durable-lva", "title": "The Imperfect Cytokine Storm: Severe COVID-19 with ARDS in Patient on Durable LVAD Support", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "D\u00e9velopper les r\u00e9flexions et l'approche syst\u00e9matique utilis\u00e9e pour l'infection \u00e0 COVID grave chez le patient avec assistance circulatoire permanente.", "verbose_date": "17.04.2020", "authors": "Chau VQ", "specialties": [{"id": 4, "name": "Anesth\u00e9sie-R\u00e9animation"}], "category": {"id": 4, "name": "Th\u00e9rapeutique", "icon": "icon-med"}, "journal": {"id": 157, "name": "JACC Case Rep"}, "link": "https://reader.elsevier.com/reader/sd/pii/S2666084920303314?token=A1AB009C80FCD3073829AB5E64C3E57F47B73375E5F76DAEBC6C48D6089843A504403B22885F8F8D2BCA28EBC2891642", "findings": "", "take_away": "", "relevance_level": "Sans surprise r\u00e9animation complexe. Ils proposent un tableau d'aide \u00e0 la prise en charge des patients sous assistance ventriculaire atteints de COVID. Pas de DV du fait de la machine.", "objectives": "Case report.", "methods": "D\u00e9velopper les r\u00e9flexions et l'approche syst\u00e9matique utilis\u00e9e pour l'infection \u00e0 COVID grave chez le patient avec assistance circulatoire permanente.", "pubmed_id": "32292915\n30498496\n10793162\n28267435\n28459724\n22390970\n29495891", "doi": "10.1016/j.jaccas.2020.04.001", "abstract": "As health systems worldwide grapple with the COVID-19 pandemic, patients on durable LVAD support represent a unique population at risk for the disease. We outline such a patient who developed COVID-19 complicated by \"cytokine storm\" with severe ARDS and myocardial injury; and describe the challenges that arose during management.", "topics": ["Th\u00e9rapeutique", "Anesth\u00e9sie-R\u00e9animation"], "author_list": [{"id": 352, "name": "Chau VQ"}], "publication_date": "2020-04-17"}, {"id": 558, "slug": "modeling-shield-immunity-to-reduce-covid-19-epidemic-spread", "title": "Modeling shield immunity to reduce COVID-19 epidemic spread", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Mod\u00e9liser les effets \u00e9pid\u00e9miologiques d\u2019une strat\u00e9gie de barri\u00e8re immunologique consistant en une substitution des contacts de fa\u00e7on pr\u00e9f\u00e9rentielle vers des personnes s\u00e9ropositives.", "verbose_date": "08.05.2020", "authors": "Weitz J", "specialties": [{"id": 22, "name": "Immunit\u00e9"}, {"id": 5, "name": "Virologie"}, {"id": 12, "name": "Infectiologie"}], "category": {"id": 8, "name": "Mod\u00e9lisation", "icon": "icon-all"}, "journal": {"id": 115, "name": "Nature Med"}, "link": "https://www.nature.com/articles/s41591-020-0895-3.pdf", "findings": "", "take_away": "", "relevance_level": "La barri\u00e8re immunologique ne devra pas \u00eatre vue comme une strat\u00e9gie unique mais un outil suppl\u00e9mentaire pour enrayer la pand\u00e9mie.\nCombin\u00e9e avec les distanciations sociales, cette barri\u00e8re pourrait r\u00e9duire l\u2019impact n\u00e9gatif des politiques de distanciation sur la suppression (et donc le retardement dans le temps de l\u2019atteinte d\u2019une immunit\u00e9 collective).\nDes tests s\u00e9rologiques \u00e0 l\u2019\u00e9chelle des populations sont n\u00e9cessaires \u00e0 la gestion de la crise et \u00e0 la mise en place de strat\u00e9gies adapt\u00e9es telles que la barri\u00e8re immunologique.", "objectives": "Les conclusions des auteurs se basent sur des hypoth\u00e8ses tr\u00e8s fortes et non d\u00e9montr\u00e9es \u00e0 ce jour. En particulier, le d\u00e9veloppement de d\u00e9fenses immunisantes permanentes pour les individus ayant r\u00e9cup\u00e9r\u00e9 de leur maladie est loin d\u2019\u00eatre d\u00e9montr\u00e9 \u00e0 ce jour.", "methods": "Mod\u00e9liser les effets \u00e9pid\u00e9miologiques d\u2019une strat\u00e9gie de barri\u00e8re immunologique consistant en une substitution des contacts de fa\u00e7on pr\u00e9f\u00e9rentielle vers des personnes s\u00e9ropositives.", "pubmed_id": "32382154", "doi": "10.1038/s41591-020-0895-3", "abstract": "The COVID-19 pandemic has precipitated a global crisis, with more than 1,430,000 confirmed cases and more than 85,000 confirmed deaths globally as of 9 April 2020", "topics": ["Mod\u00e9lisation", "Immunit\u00e9", "Virologie", "Infectiologie"], "author_list": [{"id": 524, "name": "Weitz J"}], "publication_date": "2020-05-08"}, {"id": 472, "slug": "covid19-coagulopathy-in-caucasian-patients", "title": "COVID\u201019 Coagulopathy in Caucasian patients", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Description de la coagulopathie chez les patients caucasiens.", "verbose_date": "28.04.2020", "authors": "Fogarty H", "specialties": [{"id": 12, "name": "Infectiologie"}, {"id": 17, "name": "Cardiologie et maladies m\u00e9taboliques"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 68, "name": "Br J Haematol"}, "link": "https://www.dropbox.com/s/wcl7e1dnvdytuoi/10.1111%40bjh.16749.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "L'origine ethnique est importante quant au risque thrombotique, moindre chez les chinois (x3-4) et plus \u00e9lev\u00e9e chez les afro-am\u00e9ricains. Les formes graves de COVID chez les caucasiens sont associ\u00e9es \u00e0 une coagulopathie. Malgr\u00e9 des D-dim\u00e8res \u00e9lev\u00e9s, l'\u00e9volution vers la CIVD des patients caucasiens sous HBPM est rare. Les donn\u00e9es sugg\u00e8rent l'association d'une inflammation pulmonaire bilat\u00e9rale et d'une vasculopathie sp\u00e9cifique du poumon appel\u00e9e dans cet article Coagulopathie intra-vasculaire pulmonaire. Peut-\u00eatre \u00e0 l'origine de l'explication de la diff\u00e9rence de mortalit\u00e9 inter-ethnique?", "objectives": "Etude observationnelle avec un petit effectif. Les calculs des r\u00e9sultats sont faits sur toute la cohorte. Comment comparent-ils les diff\u00e9rences interethniques qui n'apparaissent pas dans les r\u00e9sultats? Le titre traite de la coagulopathie chez les caucasiens et les r\u00e9sultats montrent que plus il y a de troubles de coagulation plus le pronostic est engag\u00e9 mais sur toute la cohorte! Quid de la comparaison interethnique?", "methods": "Description de la coagulopathie chez les patients caucasiens.", "topics": ["Epid\u00e9miologique", "Infectiologie", "Cardiologie et maladies m\u00e9taboliques"], "author_list": [{"id": 440, "name": "Fogarty H"}], "publication_date": "2020-04-28"}, {"id": 311, "slug": "covid-xpert-an-ai-powered-population-screening-of-covid-19-cases-using-chest-rad", "title": "COVID-Xpert: An AI Powered Population Screening of COVID-19 Cases Using Chest Radiography Images", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Evaluer une m\u00e9thode diagnostique via la radiographie thoracique et l'intelligence artificielle", "verbose_date": "13.04.2020", "authors": "Li x", "specialties": [{"id": 3, "name": "Radiologie"}], "category": {"id": 3, "name": "Diagnostique", "icon": "icon-heat"}, "journal": {"id": 85, "name": "Pre-prints"}, "link": "https://arxiv.org/pdf/2004.03042.pdf", "findings": "", "take_away": "", "relevance_level": "Pr\u00e9sentation d'un mod\u00e8le d'intelligence artificielle permettant le diagnostic de cas COVID bas\u00e9 sur la radiographie thoracique avec une bonne efficacit\u00e9 diagnostique : aire sous la courbe de 97,3 pour diff\u00e9rencier une pneumopathie \u00e0 COVID d'une pneumopathie classique ou d'un patient sain.\r\nMais n\u00e9cessit\u00e9 de test sur un plus large \u00e9chantillon pour valider ce mod\u00e8le.", "objectives": "- Pre-prints- Echantillon pour apprentissage et validation assez restreint dans le contexte de deep learning- Algorithme non test\u00e9 sur un nouvel \u00e9chantillon prospectif", "methods": "Evaluer une m\u00e9thode diagnostique via la radiographie thoracique et l'intelligence artificielle", "topics": ["Diagnostique", "Radiologie"], "author_list": [{"id": 298, "name": "Li x"}], "publication_date": "2020-04-13"}, {"id": 487, "slug": "early-risk-factors-for-the-duration-of-sars-cov-2-viral-positivity-in-covid-19-p", "title": "Early risk factors for the duration of SARS-CoV-2 viral positivity in COVID-19 patients", "has_other_authors": true, "impact_factor": {"id": 3, "name": "Interm\u00e9diaire", "posts_count": 140, "color": "orange", "order": 2}, "goals_plain": "Etude des facteurs de risque pr\u00e9coces en lien avec la dur\u00e9e de positivit\u00e9 virale du SRAS-CoV-2 chez les patients COVID-19.", "verbose_date": "29.04.2020", "authors": "Lin A", "specialties": [{"id": 5, "name": "Virologie"}, {"id": 12, "name": "Infectiologie"}], "category": {"id": 6, "name": "Pronostique", "icon": "icon-chat"}, "journal": {"id": 24, "name": "Clin Infect Dis"}, "link": "https://www.dropbox.com/s/ugzuge2emxh5paf/ciaa490.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Un taux de lymphocytes CD8+\u00a0 (seuil 238/\u00b5L) est le seul facteur de risque en lien avec dur\u00e9e de positivit\u00e9 du COVID-19.", "objectives": "Etude de Cohorte Faible effectif R\u00e9sultats similaires \u00e0 d'autre \u00e9tudes pour la dur\u00e9e moyenne de positivit\u00e9 et similaire pour le facteur de risque de dur\u00e9e de positivit\u00e9", "methods": "Etude des facteurs de risque pr\u00e9coces en lien avec la dur\u00e9e de positivit\u00e9 virale du SRAS-CoV-2 chez les patients COVID-19.", "pubmed_id": "32337591", "doi": "10.1093/cid/ciaa490", "abstract": "Pneumonia COVID-19 has became a pandemic. However, information on early risk factors for the duration of SARS-CoV-2 viral positivity is unavailable yet.\nIn this prospective study, a cohort of 137 patients with confirmed SARS-CoV-2 infection were enrolled. Clinical information and laboratory data were retrieved from electronic medical records. Viral positivity duration was calculated by an interval from the day SARS-CoV-2 positive confirmed to the day SARS-CoV-2 returned to negative in these 137 COVID-19 patients. Early risk factors for the duration of SARS-CoV-2 viral positivity were evaluated.\nThe median SARS-CoV-2 viral positivity duration is 12 days (range: 4 days ~ 45 days) for this cohort. Cox regression results showed a significantly shorter viral positivity duration was related to younger [hazard ratio (HR) = 0.658, p = 0.017], not severe patient (HR = 0.653, p = 0.076), higher count of lymphocytes (HR = 1.464, p = 0.033), eosinophils (HR = 1.514, p = 0.020) and CD8+ T cells (HR=1.745, p=0.033), and lower IL-6 (HR = 0.664, p = 0.036) and IL-10 (HR = 0.631, p = 0.021). Multivariate analysis with covariables adjusted results showed that the count of CD8+ T cells (HR=2.376, p=0.114) was a predominant risk factor for the SARS-CoV-2 viral positivity duration.\nOur findings firstly provided early laboratory parameters such as count of CD8+ T cells, as risk factors for the duration of SARS-CoV-2 viral positivity, which have significance in control and prevention of the disease.", "topics": ["Pronostique", "Virologie", "Infectiologie"], "author_list": [{"id": 455, "name": "Lin A"}], "publication_date": "2020-04-29"}, {"id": 450, "slug": "association-of-renin-angiotensin-system-inhibitors-with-severity-or-risk-of-deat", "title": "Association of Renin-Angiotensin System Inhibitors With Severity or Risk of Death in Patients With Hypertension Hospitalized for Coronavirus Disease 2019 (COVID-19) Infection in Wuhan, China", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Etudier l'association entre la prise de traitements hypertenseurs de type inhibiteurs de l'enzyme (IEC) de conversion et antagonistes des r\u00e9cepteurs de l'angiotensine (ARA) et la s\u00e9v\u00e9rit\u00e9 et mortalit\u00e9 chez les patients hypertendus hospitalis\u00e9s pour COVID-19", "verbose_date": "25.04.2020", "authors": "Li J", "specialties": [{"id": 12, "name": "Infectiologie"}, {"id": 17, "name": "Cardiologie et maladies m\u00e9taboliques"}], "category": {"id": 6, "name": "Pronostique", "icon": "icon-chat"}, "journal": {"id": 99, "name": "JAMA Cardiol"}, "link": "https://www.dropbox.com/s/48qsnr3y5gzmmax/10.1001%40jamacardio.2020.1624.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Pas de diff\u00e9rence sur la s\u00e9v\u00e9rit\u00e9 de la maladie entre les patients, complications, et risque de d\u00e9c\u00e8s entre les patients hypertendus trait\u00e9s par inhibiteurs de l'enzyme de conversion (IEC) / antagonistes des r\u00e9cepteurs de l'angiotensine (ARA) et les patients non trait\u00e9s par ces classes de m\u00e9dicaments", "objectives": "1) S\u00e9rie de cas, monocentrique, analyse r\u00e9trospective2) 362 patients hypertendus dont 115 sous IEC ou ARA3) Comparaison avec patients non hypertendus, diff\u00e9rents en \u00e2ge, sexe, comorbidit\u00e9s \"", "methods": "Etudier l'association entre la prise de traitements hypertenseurs de type inhibiteurs de l'enzyme (IEC) de conversion et antagonistes des r\u00e9cepteurs de l'angiotensine (ARA) et la s\u00e9v\u00e9rit\u00e9 et mortalit\u00e9 chez les patients hypertendus hospitalis\u00e9s pour COVID-19", "pubmed_id": "32324209\n32170560\n32109013\n32125455\n32091533\n16001071\n32031570\n31986264\n15897343\n25766467\n29102084\n32171076\n32051365\n16007097\n32171062", "doi": "10.1001/jamacardio.2020.1624", "abstract": "Data are lacking whether patients with hypertension who are taking angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) have increased severity or risk of mortality during hospitalization for coronavirus disease 2019 (COVID-19).\nTo investigate the association between ACEIs/ARBs and severity of illness and mortality in patients with hypertension hospitalized for COVID-19 infection.\nRetrospective, single-center case series of the 1178 hospitalized patients with COVID-19 infections at the Central Hospital of Wuhan, China, from January 15 to March 15, 2020.\nCOVID-19 was confirmed by real-time reverse transcription-polymerase chain reaction and epidemiologic, clinical, radiologic, laboratory, and drug therapy data were analyzed in all patients. The percentage of patients with hypertension taking ACEIs/ARBs was compared between those with severe vs nonsevere illness and between survivors vs nonsurvivors.\nOf the 1178 patients with COVID-19, the median age was 55.5 years (interquartile range, 38-67 years) and 545 (46.3%) were men. The overall in-hospital mortality was 11.0%. There were 362 patients with hypertension (30.7% of the total group; median age, 66.0 years [interquartile range, 59-73 years]; 189 [52.2%] were men), of whom 115 (31.8%) were taking ACEI/ARBs. The in-hospital mortality in the patients with hypertension was 21.3%. The percentage of patients with hypertension taking ACEIs/ARBs did not differ between those with severe and nonsevere infections (32.9% vs 30.7%; P\u2009=\u2009.65) nor did it differ between nonsurvivors and survivors (27.3% vs 33.0%; P\u2009=\u2009.34). Similar findings were observed when data were analyzed for patients taking ACEIs and those taking ARBs.\nThis study provides clinical data on the association between ACEIs/ARBs and outcomes in patients with hypertension hospitalized with COVID-19 infections, suggesting that ACEIs/ARBs are not associated with the severity or mortality of COVID-19 in such patients. These data support current guidelines and societal recommendations for treating hypertension during the COVID-19 pandemic.", "topics": ["Pronostique", "Infectiologie", "Cardiologie et maladies m\u00e9taboliques"], "author_list": [{"id": 255, "name": "Li J"}], "publication_date": "2020-04-25"}, {"id": 589, "slug": "severe-covid-19-in-children-and-young-adults-in-the-washington-dc-metropolitan-r", "title": "Severe COVID-19 in Children and Young Adults in the Washington, DC Metropolitan Region", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "L'objectif de l'\u00e9tude \u00e9tait de d\u00e9terminer si des caract\u00e9ristiques \u00e9pid\u00e9miologiques et cliniques sp\u00e9cifiques des enfants et jeunes adultes \u00e9taient plus susceptibles d'\u00eatre associ\u00e9es \u00e0 l'hospitalisation et/ou aux soins intensifs.", "verbose_date": "14.05.2020", "authors": "DeBiasi RL", "specialties": [{"id": 9, "name": "P\u00e9diatrie"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 232, "name": "J Pediatr"}, "link": "https://www.sciencedirect.com/science/article/pii/S0022347620305813", "findings": "", "take_away": "", "relevance_level": "Cette \u00e9tude souligne le potentiel de maladies graves chez les enfants et les jeunes adultes.\nBien que tous les groupes d'\u00e2ge aient \u00e9t\u00e9 infect\u00e9s par le SARS-CoV-2, les enfants/jeunes adultes les plus jeunes (<1 an) et les plus \u00e2g\u00e9s (15-25 ans) \u00e9taient plus susceptibles d'\u00eatre hospitalis\u00e9s, et les plus \u00e2g\u00e9s \u00e9taient les plus susceptibles de n\u00e9cessiter des soins intensifs. Les conditions sous-jacentes \u00e9taient pr\u00e9sentes chez 39% des patients, mais les patients hospitalis\u00e9s et gravement malades \u00e9taient plus susceptibles de pr\u00e9senter des conditions sous-jacentes. Inversement, environ 55% dans l'ensemble, 37% des patients hospitalis\u00e9s et 22% des patients gravement malades ne pr\u00e9sentaient aucune affection sous-jacente, ce qui renforce le concept selon lequel la distanciation sociale et les mesures d'hygi\u00e8ne visant \u00e0 \u00e9viter l'infection doivent \u00eatre prises au s\u00e9rieux dans le groupe d'\u00e2ge p\u00e9diatrique, ainsi que chez les adultes. Seuls les diagnostics neurologiques, cardiaques, h\u00e9matologiques et oncologiques sous-jacents \u00e9taient significativement plus fr\u00e9quents dans la cohorte hospitalis\u00e9e par rapport \u00e0 la cohorte non hospitalis\u00e9e, et aucun n'\u00e9tait plus fr\u00e9quent dans la cohorte gravement malade par rapport \u00e0 la cohorte non gravement malade.", "objectives": "-\tPre-proof-\tEtude de cohorte r\u00e9trospective observationnelle monocentrique", "methods": "L'objectif de l'\u00e9tude \u00e9tait de d\u00e9terminer si des caract\u00e9ristiques \u00e9pid\u00e9miologiques et cliniques sp\u00e9cifiques des enfants et jeunes adultes \u00e9taient plus susceptibles d'\u00eatre associ\u00e9es \u00e0 l'hospitalisation et/ou aux soins intensifs.", "topics": ["Epid\u00e9miologique", "P\u00e9diatrie"], "author_list": [{"id": 553, "name": "DeBiasi RL"}], "publication_date": "2020-05-14"}, {"id": 246, "slug": "medical-masks-vs-n95-respirators-for-preventing-covid-19-in-health-care-workers-", "title": "Medical Masks vs N95 Respirators for Preventing COVID-19 in Health Care Workers A Systematic Review and Meta-Analysis of Randomized Trials", "has_other_authors": true, "impact_factor": {"id": 3, "name": "Interm\u00e9diaire", "posts_count": 140, "color": "orange", "order": 2}, "goals_plain": "Comparer les masques m\u00e9dicaux aux N95 dans la pr\u00e9vention de l'infection virale chez les soignants", "verbose_date": "06.04.2020", "authors": "Bartoszko JJ", "specialties": [{"id": 2, "name": "Hygi\u00e8ne"}], "category": {"id": 2, "name": "Autres", "icon": "icon-other"}, "journal": {"id": 94, "name": "Influenza Other Respir Viruses"}, "link": "https://onlinelibrary.wiley.com/doi/pdf/10.1111/irv.12745", "findings": "", "take_away": "", "relevance_level": "Faible certitude dans les preuves\r\nLes masques m\u00e9dicaux et les N95 offrent une protection similaire contre les infections respiratoires virales chez les soignants pendant les soins ne g\u00e9n\u00e9rant pas d'a\u00e9rosols.\r\nLa pr\u00e9servation des N95 pour les situations\u00a0\u00e0 haut risque (soins produisants des a\u00e9rosols) devrait \u00eatre pris en compte en cas de p\u00e9nurie.\r\nL'utilisation des N95 pour les proc\u00e9dures g\u00e9n\u00e9rant des a\u00e9rosols est unanimement recommand\u00e9e par les guidelines nationaux et internationnaux.", "objectives": "- randomisation par cluster et exhaustivit\u00e9 des \u00e9tudes - m\u00e9thodologie pr\u00e9cise - preuves indirectes et impr\u00e9cises, - niveau de certitude faible des articles - aucun des essais dans la m\u00e9ta-analyse ne concernait le SARS-CoV2 - seulement 1 article a \u00e9tudi\u00e9 \u00e0 l'\u00e9chelle individuelle les masque m\u00e9dicaux et N95 dans les infections \u00e0 coronavirus - outcome composite : infections respiratoires confirm\u00e9es au laboratoire qui incluent les infections au coronavirus - donn\u00e9es agr\u00e9g\u00e9es et pas individuelles", "methods": "Comparer les masques m\u00e9dicaux aux N95 dans la pr\u00e9vention de l'infection virale chez les soignants", "topics": ["Autres", "Hygi\u00e8ne"], "author_list": [{"id": 236, "name": "Bartoszko JJ"}], "publication_date": "2020-04-06"}, {"id": 466, "slug": "aerodynamic-analysis-of-sars-cov-2-in-two-wuhan-hospitals", "title": "Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Evaluer la potentielle transmission a\u00e9roport\u00e9e du SARS-CoV-2 par pr\u00e9l\u00e8vements dans l'air et sur des surfaces \u00e0 l'h\u00f4pital et dans des lieux fr\u00e9quent\u00e9s par le public", "verbose_date": "28.04.2020", "authors": "Liu Y", "specialties": [{"id": 2, "name": "Hygi\u00e8ne"}], "category": {"id": 2, "name": "Autres", "icon": "icon-other"}, "journal": {"id": 189, "name": "Nature"}, "link": "https://www.nature.com/articles/s41586-020-2271-3_reference.pdf", "findings": "", "take_away": "", "relevance_level": "De fa\u00e7on globale,\u00a0une tr\u00e8s faible concentration ou aucun virus n'a \u00e9t\u00e9 d\u00e9tect\u00e9 dans l'air, en particulier \u00e0 l'ext\u00e9rieur. La concentration varie selon les sites de pr\u00e9l\u00e8vements, elle est plus \u00e9lev\u00e9e dans des petites zones non ventil\u00e9es, comme les toilettes.\u00a0\r\nL'\u00e9tude sugg\u00e8re donc que le risque d'infection par voie a\u00e9roport\u00e9e est tr\u00e8s faible \u00e0 l'ext\u00e9rieur ou dans des pi\u00e8ces bien ventil\u00e9es. Mais le risque de d\u00e9p\u00f4t sur les surfaces puis de contagion jusqu'\u00e0 3 m\u00e8tres de la personne infect\u00e9e existe, encourageant le port du masque par l'ensemble de la population et la bonne ventilation de toutes les pi\u00e8ces.", "objectives": "- Faible nombre de pr\u00e9l\u00e8vements - Pas de pr\u00e9cision sur le nombre de patients infect\u00e9s, leurs caract\u00e9ristiques cliniques ou le port d'un \u00e9ventuel masque- Pas d'\u00e9valuation de l'infectiosit\u00e9 du virus : la pr\u00e9sence du virus en faible concentration n'\u00e9tant pas ien corr\u00e9l\u00e9 \u00e0 la contagiosit\u00e9", "methods": "Evaluer la potentielle transmission a\u00e9roport\u00e9e du SARS-CoV-2 par pr\u00e9l\u00e8vements dans l'air et sur des surfaces \u00e0 l'h\u00f4pital et dans des lieux fr\u00e9quent\u00e9s par le public", "pubmed_id": "32340022", "doi": "10.1038/s41586-020-2271-3", "abstract": "The ongoing outbreak of coronavirus disease (COVID)-19 has spread rapidly on a global scale. Although it is clear that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted through human respiratory droplets and direct contact, the potential for aerosol transmission is poorly understood", "topics": ["Autres", "Hygi\u00e8ne"], "author_list": [{"id": 311, "name": "Liu Y"}], "publication_date": "2020-04-28"}, {"id": 31, "slug": "the-potential-added-value-of-fdg-petct-for-covid-19-pneumonia", "title": "The potential added value of FDG PET/CT for COVID-19 pneumonia", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Proposer une m\u00e9thode diagnostique par TEP/FDG", "verbose_date": "21.03.2020", "authors": "Deng Y", "specialties": [{"id": 3, "name": "Radiologie"}], "category": {"id": 3, "name": "Diagnostique", "icon": "icon-heat"}, "journal": {"id": 27, "name": "Eur j Nucl Med Mol Imaging"}, "link": "https://link.springer.com/article/10.1007%2Fs00259-020-04767-1", "findings": "", "take_away": "", "relevance_level": "Utilit\u00e9 possible de la TEP FDG pour le diagnostic, le suivi et la recherche de complications dans le cadre d'une infection au COVID-19.N\u00e9cessite une \u00e9tude clinique pour le d\u00e9montrer !", "objectives": "Faible :1) lettre \u00e0 l'\u00e9diteur sans processus de blind reviewing2) bas\u00e9 sur une dizaine de r\u00e9f\u00e9rences de niveau de preuve assez faible", "methods": "Proposer une m\u00e9thode diagnostique par TEP/FDG", "pubmed_id": "32198615", "doi": "10.1007/s00259-020-04767-1", "abstract": null, "topics": ["Diagnostique", "Radiologie"], "author_list": [{"id": 41, "name": "Deng Y"}], "publication_date": "2020-03-21"}, {"id": 566, "slug": "prognostic-value-of-leukocytosis-and-lymphopenia-for-coronavirus-disease-severit", "title": "Prognostic Value of Leukocytosis and Lymphopenia for Coronavirus Disease Severity", "has_other_authors": true, "impact_factor": {"id": 3, "name": "Interm\u00e9diaire", "posts_count": 140, "color": "orange", "order": 2}, "goals_plain": "Evaluation de la valeur prognostique de la lymphop\u00e9nie et leucocytose sur les infections \u00e0 SARS-CoV-2.", "verbose_date": "11.05.2020", "authors": "Huang G", "specialties": [{"id": 15, "name": "H\u00e9matologie"}], "category": {"id": 6, "name": "Pronostique", "icon": "icon-chat"}, "journal": {"id": 225, "name": "EID"}, "link": "https://doi.org/10.3201/eid2608.201160", "findings": "", "take_away": "", "relevance_level": "La s\u00e9v\u00e9rit\u00e9 de l'infection \u00e0 SARS-CoV-2 semble corr\u00e9l\u00e9e \u00e0 la lymphop\u00e9nie / leucocytose. Le m\u00e9canisme de ce lien reste inconnu.", "objectives": "- M\u00e9ta analyse bien men\u00e9e portant sur 8 articles et regroupant 1289 cas.- H\u00e9t\u00e9rog\u00e9nicit\u00e9 de la d\u00e9finition de la s\u00e9v\u00e9rit\u00e9- H\u00e9t\u00e9rog\u00e9nicit\u00e9 des donn\u00e9es de lymphop\u00e9nie/leucocytose entre les \u00e9tudes (possiblement du \u00e0 leurs faible effectif)", "methods": "Evaluation de la valeur prognostique de la lymphop\u00e9nie et leucocytose sur les infections \u00e0 SARS-CoV-2.", "pubmed_id": "32384045", "doi": "10.3201/eid2608.201160", "abstract": "To evaluate lymphopenia as a marker for coronavirus disease severity, we conducted a meta-analysis of 10 studies. Severe illness was associated with lower lymphocyte and higher leukocyte counts. Using these markers for early identification of patients with severe disease may help healthcare providers prioritize the need to obtain therapy.", "topics": ["Pronostique", "H\u00e9matologie"], "author_list": [{"id": 531, "name": "Huang G"}], "publication_date": "2020-05-11"}, {"id": 145, "slug": "predicting-the-angiotensin-converting-enzyme-2-ace-2-utilizing-capability-as-the", "title": "Predicting the angiotensin converting enzyme 2 (ACE 2) utilizing capability as the receptor of SRAS-CoV-2", "has_other_authors": true, "impact_factor": {"id": 3, "name": "Interm\u00e9diaire", "posts_count": 140, "color": "orange", "order": 2}, "goals_plain": "Pr\u00e9dire les esp\u00e8ces animales qui poss\u00e8dent des r\u00e9cepteurs ACE 2 (Enzyme de Conversion de l'Angiotensine 2) auxquels le SRAS-CoV-19 est capable de se lier.\r\nCette pr\u00e9diction peut aider \u00e0 s\u00e9lectionner les h\u00f4tes interm\u00e9diaires du SRAS-CoV-19.\r\n ", "verbose_date": "24.03.2020", "authors": "Qiu Y ", "specialties": [{"id": 7, "name": "Transversale"}], "category": {"id": 4, "name": "Th\u00e9rapeutique", "icon": "icon-med"}, "journal": {"id": 17, "name": "Microb Infect"}, "link": "https://www.dropbox.com/s/i7houmen11kkwh7/1-s2.0-S1286457920300496-main.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Il a \u00e9t\u00e9 d\u00e9montr\u00e9 que le SRAS-CoV-2 utilise le r\u00e9cepteur ACE 2 comme r\u00e9cepteur cellulaire mais n'est pas capable de se lier au r\u00e9cepteur de toutes les esp\u00e8ces.\u00a0\r\nPour identifier d'\u00e9ventuels h\u00f4tes interm\u00e9diaires du virus, les s\u00e9quences d'acides amin\u00e9s du r\u00e9cepteur ACE 2 ont \u00e9t\u00e9 analys\u00e9es pour 250 esp\u00e8ces, identifiant 9 polymorphismes aa qui r\u00e9duisent ou inhibent la liaison.\r\nUne valeur (entre 0 et 100) a \u00e9t\u00e9 attribu\u00e9e \u00e0 chaque esp\u00e8ce pour la force de liaison entre le r\u00e9cepteur ACE 2 et SRAS-CoV-2 en fonction des polymorphismes.\u00a0\r\nLes esp\u00e8ces ayant une force de liaison r\u00e9cepteur-virus >50 sont consid\u00e9r\u00e9es comme des esp\u00e8ces susceptibles d'\u00eatre des h\u00f4tes interm\u00e9diaires du virus: le pangolin, le chat, la vache, le buffle, la ch\u00e8vre et le mouton (mammif\u00e8res avec score=100) et pigeons (oiseaux, score=70).", "objectives": "", "methods": "Pr\u00e9dire les esp\u00e8ces animales qui poss\u00e8dent des r\u00e9cepteurs ACE 2 (Enzyme de Conversion de l'Angiotensine 2) auxquels le SRAS-CoV-19 est capable de se lier.\r\nCette pr\u00e9diction peut aider \u00e0 s\u00e9lectionner les h\u00f4tes interm\u00e9diaires du SRAS-CoV-19.", "topics": ["Th\u00e9rapeutique", "Transversale"], "author_list": [{"id": 142, "name": "Qiu Y "}], "publication_date": "2020-03-24"}, {"id": 278, "slug": "risk-of-nosocomial-transmission-of-coronavirus-disease-2019-an-experience-in-a-g", "title": "Risk of nosocomial transmission of coronavirus disease 2019: an experience in a general ward setting in Hong Kong", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "D\u00e9crire l'investigation d'un cas de COVID-19 hospitalis\u00e9 dans un espace ouvert avant le diagnostic.", "verbose_date": "08.04.2020", "authors": "Wong SC", "specialties": [{"id": 2, "name": "Hygi\u00e8ne"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 6, "name": "J Hosp Infect"}, "link": "https://www.journalofhospitalinfection.com/article/S0195-6701(20)30174-2/pdf", "findings": "", "take_away": "", "relevance_level": "Les auteurs sugg\u00e8rent que l'infection n'est pas a\u00e9roport\u00e9e avec l'investigation de ce cas. Les mesures d'hygi\u00e8ne basiques avec hygi\u00e8ne des mains, masque chirurgical et hygi\u00e8ne de l'environnement ont \u00e9t\u00e9 appliqu\u00e9es avant le diagnostic de COVID-19 pour le cas index et absence de contacts infect\u00e9s.", "objectives": "1) Pre-proof2) Revue d'exp\u00e9rience d'un cas index et de l'investigation des contacts3) Tests uniquement des personnes symptomatiques\"", "methods": "D\u00e9crire l'investigation d'un cas de COVID-19 hospitalis\u00e9 dans un espace ouvert avant le diagnostic.", "topics": ["Epid\u00e9miologique", "Hygi\u00e8ne"], "author_list": [{"id": 267, "name": "Wong SC"}], "publication_date": "2020-04-08"}, {"id": 585, "slug": "longitudinal-hematologic-and-immunologic-variations-associated-with-the-progress", "title": "Longitudinal hematologic and immunologic variations associated with the progression of COVID-19 patients in China", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Cette \u00e9tude r\u00e9trospective vise \u00e0 aborder les changements dynamiques des biomarqueurs h\u00e9matologiques et immunologiques et leurs associations avec la gravit\u00e9 et l\u2019issue de la maladie.", "verbose_date": "13.05.2020", "authors": "Chen R", "specialties": [{"id": 22, "name": "Immunit\u00e9"}, {"id": 15, "name": "H\u00e9matologie"}, {"id": 4, "name": "Anesth\u00e9sie-R\u00e9animation"}, {"id": 12, "name": "Infectiologie"}, {"id": 8, "name": "Pneumologie"}], "category": {"id": 6, "name": "Pronostique", "icon": "icon-chat"}, "journal": {"id": 233, "name": "J Allergy Clin Immunol"}, "link": "https://www.dropbox.com/s/dl1bf73ik3q5uka/1-s2.0-S0091674920306382-main.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Les d\u00e9ficiences h\u00e9matologiques et immunologiques ont montr\u00e9 un profil significativement diff\u00e9rent entre les survivants et les non-survivants chez les patients atteints de COVID-19 avec une gravit\u00e9 diff\u00e9rente. Depuis le stade pr\u00e9coce de la maladie, non seulement les lymphocytes et les sous-ensembles de cellules T, mais aussi les \u00e9osinophiles pr\u00e9sentent une diminution marqu\u00e9e, associ\u00e9e \u00e0 la gravit\u00e9 de la maladie et \u00e0 l'issue clinique. L'alt\u00e9ration des interactions immunologiques entre les sous-ensembles de cellules T et les indices h\u00e9matologiques sugg\u00e8re une alt\u00e9ration de la r\u00e9ponse immunitaire depuis le d\u00e9but de la maladie. Les changements dynamiques des indices h\u00e9matologiques et immunologiques ont vari\u00e9 chez les survivants et les non-survivants, et pourraient servir de pr\u00e9dicteurs du r\u00e9tablissement ou de l'issue fatale du COVID-19.", "objectives": "-\tPre-proof-\tEtude r\u00e9trospective-\tPuisqu'il s'agit d'une \u00e9tude r\u00e9trospective, certains indices n'ont pas \u00e9t\u00e9 d\u00e9tect\u00e9s chez tous les patients, comme les donn\u00e9es de suivi des sous-ensembles de cellules T.-\tA l'exception de l\u2019IL-6 et de certains indices d'infection clinique, d'autres cytokines pro-inflammatoires ou chimiokines associ\u00e9es aux lymphocytes n'ont pas \u00e9t\u00e9 d\u00e9tect\u00e9es : d'autres \u00e9tudes sont n\u00e9cessaires pour caract\u00e9riser le r\u00f4le de la r\u00e9ponse immunitaire des cellules T dans le COVID-19. -\tLes donn\u00e9es sur le profil d'excr\u00e9tion du virus ou de vir\u00e9mie ne sont pas disponibles : des \u00e9tudes suppl\u00e9mentaires sont n\u00e9cessaires pour d\u00e9crire l'association entre la cin\u00e9tique de charge du virus et les r\u00e9ponses immunitaires dynamiques.", "methods": "Cette \u00e9tude r\u00e9trospective vise \u00e0 aborder les changements dynamiques des biomarqueurs h\u00e9matologiques et immunologiques et leurs associations avec la gravit\u00e9 et l\u2019issue de la maladie.", "pubmed_id": "32407836\n32109013\n32171076\n26857507\n27287409\n32203188\n31986264\n32048163\n12955652\n28541437\n12816821\n24845462\n15657466\n32187464\n24912383\n26867177\n32085846\n12890367\n32178975\n31978945\n15105985\n15200814\n16019455\n17374415\n32173576\n12837163\n27671972\n15364884\n8810592\n32217834\n16095942\n28466096\n28787295\n27573114\n29846635\n26203058\n16618789\n27087246\n16174304\n22809390\n12899763\n32007143\n17031779\n30584196", "doi": "10.1016/j.jaci.2020.05.003", "abstract": "Crucial roles of hematologic and immunologic responses in progression of coronavirus disease 2019 (COVID-19) remain largely unclear.\nWe sought to address the dynamic changes in hematologic and immunologic biomarkers and their associations with severity and outcomes of COVID-19.\nA retrospective study including 548 patients with COVID-19 with clarified outcome (discharged or deceased) from a national cohort in China was performed. Cross-sectional and longitudinal variations were compared and the associations with different severity and outcomes were analyzed.\nOn admission, the counts of lymphocytes, T-cell subsets, eosinophils, and platelets decreased markedly, especially in severe/critical and fatal patients. Increased neutrophil count and neutrophils-to-lymphocytes ratio were predominant in severe/critical cases or nonsurvivors. During hospitalization, eosinophils, lymphocytes, and platelets showed an increasing trend in survivors, but maintained lower levels or dropped significantly afterwards in nonsurvivors. Nonsurvivors kept a high level or showed an upward trend for neutrophils, IL-6, procalcitonin, D-dimer, amyloid A protein, and C-reactive protein, which were kept stable or showed a downward trend in survivors. Positive correlation between CD8\nHematologic and immunologic impairment showed a significantly different profile between survivors and nonsurvivors in patients with COVID-19 with different severity. The longitudinal variations in these biomarkers could serve to predict recovery or fatal outcome.", "topics": ["Pronostique", "Immunit\u00e9", "H\u00e9matologie", "Anesth\u00e9sie-R\u00e9animation", "Infectiologie", "Pneumologie"], "author_list": [{"id": 122, "name": "Chen R"}], "publication_date": "2020-05-13"}, {"id": 410, "slug": "airborne-transmission-of-severe-acute-respiratory-syndrome-coronavirus-2-to-heal", "title": "Airborne transmission of severe acute respiratory syndrome coronavirus-2 to healthcare workers: a narrative review", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Revue sur la transmission a\u00e9rienne du SARS-CoV-2 aux soignants.", "verbose_date": "22.04.2020", "authors": "Wilson N", "specialties": [{"id": 4, "name": "Anesth\u00e9sie-R\u00e9animation"}, {"id": 12, "name": "Infectiologie"}, {"id": 2, "name": "Hygi\u00e8ne"}], "category": {"id": 2, "name": "Autres", "icon": "icon-other"}, "journal": {"id": 129, "name": "Anaesthesia"}, "link": "https://onlinelibrary.wiley.com/doi/abs/10.1111/anae.15093", "findings": "", "take_away": "", "relevance_level": "Hypoth\u00e8se que le temps \u00e0 proximit\u00e9 d'un malade est plus important que la proc\u00e9dure en soi. Un patient en d\u00e9tresse respiratoire aigu\u00eb nous para\u00eet plus a\u00e9rosolisant que certaines proc\u00e9dures. Actuellement pr\u00e9cautions gouttelettes pour tous et a\u00e9riennes pour proc\u00e9dures a\u00e9rosolisantes. Pas assez de donn\u00e9es pour pr\u00e9ciser la transmission a\u00e9rienne de ce virus (ou gouttelettes seules?), il manque des informations sur le timing et la cause de la transmission pendant les proc\u00e9dures. Les pr\u00e9cautions a\u00e9riennes devraient donc peut-\u00eatre \u00eatre \u00e0 tout moment. Mais les contraintes mat\u00e9rielles rendent importante la rationalisation l'utilisation des EPI au risque local de transmission.", "objectives": "Revue de la litt\u00e9rature mais peu de donn\u00e9es physiques sur l'actuel virus, analogies avec SARS COV 1.", "methods": "Revue sur la transmission a\u00e9rienne du SARS-CoV-2 aux soignants.", "pubmed_id": "32311771\n17283614\n15030699\n29878137\n24789791\n30705129\n20475760\n15102999\n15141377\n15583121\n15030698\n23418548\n12651864\n22156667\n14990393\n32094336\n32232685\n3745978\n15030692\n28373015\n17542834\n19133798\n5773092\n5918954\n31815775\n27590694\n25523206\n23505369\n15364765\n25578684\n15030686\n10168531\n15030696\n22563403\n20056850\n22651099\n21094184\n30634967\n15809906", "doi": "10.1111/anae.15093", "abstract": "Healthcare workers are at risk of infection during the severe acute respiratory syndrome coronavirus-2 pandemic. International guidance suggests direct droplet transmission is likely and airborne transmission occurs only with aerosol-generating procedures. Recommendations determining infection control measures to ensure healthcare worker safety follow these presumptions. Three mechanisms have been described for the production of smaller sized respiratory particles ('aerosols') that, if inhaled, can deposit in the distal airways. These include: laryngeal activity such as talking and coughing; high velocity gas flow; and cyclical opening and closure of terminal airways. Sneezing and coughing are effective aerosol generators, but all forms of expiration produce particles across a range of sizes. The 5-\u03bcm diameter threshold used to differentiate droplet from airborne is an over-simplification of multiple complex, poorly understood biological and physical variables. The evidence defining aerosol-generating procedures comes largely from low-quality case and cohort studies where the exact mode of transmission is unknown as aerosol production was never quantified. We propose that transmission is associated with time in proximity to severe acute respiratory syndrome coronavirus-1 patients with respiratory symptoms, rather than the procedures per se. There is no proven relation between any aerosol-generating procedure with airborne viral content with the exception of bronchoscopy and suctioning. The mechanism for severe acute respiratory syndrome coronavirus-2 transmission is unknown but the evidence suggestive of airborne spread is growing. We speculate that infected patients who cough, have high work of breathing, increased closing capacity and altered respiratory tract lining fluid will be significant producers of pathogenic aerosols. We suggest several aerosol-generating procedures may in fact result in less pathogen aerosolisation than a dyspnoeic and coughing patient. Healthcare workers should appraise the current evidence regarding transmission and apply this to the local infection prevalence. Measures to mitigate airborne transmission should be employed at times of risk. However, the mechanisms and risk factors for transmission are largely unconfirmed. Whilst awaiting robust evidence, a precautionary approach should be considered to assure healthcare worker safety.", "topics": ["Autres", "Anesth\u00e9sie-R\u00e9animation", "Infectiologie", "Hygi\u00e8ne"], "author_list": [{"id": 391, "name": "Wilson N"}], "publication_date": "2020-04-22"}, {"id": 216, "slug": "performance-of-vivadiagtm-covid-19-igmigg-rapid-test-is-inadequate-for-diagnosis", "title": "Performance of VivaDiagTM COVID-19 IgM/IgG Rapid Test Is Inadequate for Diagnosis of COVID-19 in Acute Patients Referring to Emergency Room Department", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Valider l'utilisation du test rapide VivaDiagTM COVID-19 IgM/IgG Rapid Test lateral flow immunoassay (LFIA) pour le diagnostic rapide de COVID-19 dans le service des urgences", "verbose_date": "01.04.2020", "authors": "Cassaniti I ", "specialties": [{"id": 5, "name": "Virologie"}], "category": {"id": 3, "name": "Diagnostique", "icon": "icon-heat"}, "journal": {"id": 35, "name": "J Med Virol"}, "link": "https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.25800", "findings": "", "take_away": "", "relevance_level": "Selon cette \u00e9tude in vivo, la sensibilit\u00e9 du test rapide VivaDiagTM COVID-19 IgM/IgG est de 18,4 %.\r\nUne sensibilit\u00e9 aussi faible conduit au non-diagnostic de la plupart des patients, c'est pourquoi les auteurs\u00a0ne recommandent pas l'utilisation du test rapide VivaDiagTM COVID-19 IgM/IgG pour le triage des patients suspects de COVID-19\u00a0aux urgences.", "objectives": "1) lettre \u00e0 l'\u00e9diteur2) \u00e9tude in vivo sur 110 patients de l'h\u00f4pital Fondazione IRCCS Policlinico San Matteo (Pavia, Italie)\"", "methods": "Valider l'utilisation du test rapide VivaDiagTM COVID-19 IgM/IgG Rapid Test lateral flow immunoassay (LFIA) pour le diagnostic rapide de COVID-19 dans le service des urgences", "topics": ["Diagnostique", "Virologie"], "author_list": [{"id": 207, "name": "Cassaniti I "}], "publication_date": "2020-04-01"}, {"id": 62, "slug": "covid-19-in-a-long-term-care-facility-king-county", "title": "COVID-19 in a Long-Term Care Facility \u2014 King County", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "D\u00e9crire la survenue de cas dans les EHPAD parmi les r\u00e9sidents, les membres du personnel et les visiteurs", "verbose_date": "18.03.2020", "authors": "McMichael TM", "specialties": [{"id": 13, "name": "G\u00e9riatrie"}], "category": {"id": 2, "name": "Autres", "icon": "icon-other"}, "journal": {"id": 52, "name": "MMWR Morb Mortal Wkly Rep"}, "link": "https://www.dropbox.com/s/susq4hy9qm2tjl4/mm6912e1-H.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Facteurs pouvant contribuer \u00e0 la propagation de cas dans les EHPAD1) Personnel qui travaille alors que symptomatique + 2) Personnel qui travaille dans plusieurs EHPAD 3) Mauvaise connaissance et adh\u00e9rence des mesures de pr\u00e9cautions d'hygi\u00e8ne + 4) Fourniture insuffisante en \u00e9quipements de protection individuelle et GHA5) Retard au diagnostic du fait d'une faible suspicion de COVID 19, de la disponibilit\u00e9 limit\u00e9e des tests et difficult\u00e9 \u00e0 identifier les cas Covid-19 sur les signes et des sympt\u00f4mes seuls", "objectives": "Faible 1) Quelques donn\u00e9es descriptives sur 129 cas dans 2 EHPAD \u00e0 Wahsington2) Uniquement descriptive", "methods": "D\u00e9crire la survenue de cas dans les EHPAD parmi les r\u00e9sidents, les membres du personnel et les visiteurs", "topics": ["Autres", "G\u00e9riatrie"], "author_list": [{"id": 72, "name": "McMichael TM"}], "publication_date": "2020-03-18"}, {"id": 413, "slug": "safety-and-immunogenicity-of-a-modified-vaccinia-virus-ankara-vector-vaccine-can", "title": "Safety and immunogenicity of a modified vaccinia virus Ankara vector vaccine candidate for Middle East respiratory syndrome: an open-label, phase 1 trial", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "\u00c9valuer la s\u00e9curit\u00e9 et la tol\u00e9rance d'un vaccin candidat contre le MERS-CoV chez des adultes en bonne sant\u00e9 bas\u00e9 sur le virus modifi\u00e9 anti-MERS-CoV Ankara (MVA) qui exprime la glycoprot\u00e9ine de pointe MVA-MERS-S.", "verbose_date": "22.04.2020", "authors": "Koch T", "specialties": [{"id": 22, "name": "Immunit\u00e9"}, {"id": 5, "name": "Virologie"}, {"id": 12, "name": "Infectiologie"}], "category": {"id": 4, "name": "Th\u00e9rapeutique", "icon": "icon-med"}, "journal": {"id": 74, "name": "Lancet Infect Dis"}, "link": "https://www.thelancet.com/pdfs/journals/laninf/PIIS1473-3099(20)30248-6.pdf", "findings": "", "take_away": "", "relevance_level": "La vaccination avec virus modifie d'Ankara-MERS-S avait un profil de s\u00e9curit\u00e9 favorable sans \u00e9v\u00e9nements ind\u00e9sirables graves ou s\u00e9v\u00e8res.\r\nLes participants qui ont re\u00e7u la dose \u00e9lev\u00e9e de 1 \u00d7 10^8 unit\u00e9 formant plages (UFP) ont connu des \u00e9v\u00e9nements ind\u00e9sirables l\u00e9gers \u00e0 mod\u00e9r\u00e9s et 100% ont pr\u00e9sent\u00e9 une s\u00e9roconversion. 91% de ces patients ont pr\u00e9sent\u00e9 des r\u00e9ponses des lymphocytes T. Le groupe \u00e0 faible dose (1 \u00d7 10^7 UFP) a montr\u00e9 un profil d'innocuit\u00e9 similaire, une s\u00e9roconversion chez 75% des participants et une immunit\u00e9 aux lymphocytes T chez 83% des participants.\r\nL'immunisation homologue \u00e0 stimulation primaire induit des r\u00e9ponses humorales et \u00e0 m\u00e9diation cellulaire contre le MERS-CoV. Une relation dose-effet a \u00e9t\u00e9 d\u00e9montr\u00e9e pour la r\u00e9actog\u00e9nicit\u00e9, mais pas pour les r\u00e9ponses immunitaires induites par le vaccin.", "objectives": "1) Etude de phase I en ouvert, peu de participants (26 participants vaccin\u00e9s, dont 23 participants avec rappel 28 jours plus tard. 6 participants t\u00e9moins.2) Tous les patients vaccin\u00e9s inclus dans l'\u00e9tude de s\u00e9curit\u00e93) 6 mois de suivi", "methods": "\u00c9valuer la s\u00e9curit\u00e9 et la tol\u00e9rance d'un vaccin candidat contre le MERS-CoV chez des adultes en bonne sant\u00e9 bas\u00e9 sur le virus modifi\u00e9 anti-MERS-CoV Ankara (MVA) qui exprime la glycoprot\u00e9ine de pointe MVA-MERS-S.", "pubmed_id": "32325037\n29329957\n29514901\n31423970\n30938227\n23986586\n23075143\n30060038\n25787284\n27760761\n31351922\n28057259\n25714162\n24168097\n26678878\n23523410\n26565003\n27387881\n26124093\n30377284\n25455987\n26018172\n24766432\n24599590", "doi": "10.1016/S1473-3099(20)30248-6", "abstract": "The Middle East respiratory syndrome coronavirus (MERS-CoV) causes a respiratory disease with a case fatality rate of up to 35%. Given its potential to cause a public health emergency and the absence of efficacious drugs or vaccines, MERS is one of the WHO priority diseases warranting urgent research and development of countermeasures. We aimed to assess safety and tolerability of an anti-MERS-CoV modified vaccinia virus Ankara (MVA)-based vaccine candidate that expresses the MERS-CoV spike glycoprotein, MVA-MERS-S, in healthy adults.\nThis open-label, phase 1 trial was done at the University Medical Center Hamburg-Eppendorf (Hamburg, Germany). Participants were healthy men and women aged 18-55 years with no clinically significant health problems as determined during medical history and physical examination, a body-mass index of 18\u00b75-30\u00b70 kg/m\nVaccination with MVA-MERS-S had a favourable safety profile without serious or severe adverse events. Homologous prime-boost immunisation induced humoral and cell-mediated responses against MERS-CoV. A dose-effect relationship was demonstrated for reactogenicity, but not for vaccine-induced immune responses. The data presented here support further clinical testing of MVA-MERS-S in larger cohorts to advance MERS vaccine development.\nGerman Center for Infection Research.", "topics": ["Th\u00e9rapeutique", "Immunit\u00e9", "Virologie", "Infectiologie"], "author_list": [{"id": 394, "name": "Koch T"}], "publication_date": "2020-04-22"}, {"id": 82, "slug": "sex-difference-and-smoking-predisposition-in-patients-with-covid-19", "title": "Sex difference and smoking predisposition in patients with COVID-19", "has_other_authors": false, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Trouver lien pr\u00e9valence/severit\u00e9 du COVID et fumeur et sexe", "verbose_date": "16.03.2020", "authors": "Cai H", "specialties": [{"id": 8, "name": "Pneumologie"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 1, "name": "Lancet Repir Med"}, "link": "https://www.dropbox.com/s/qiuuot5iazp57c9/10.1016%40S2213-26002030117-X.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "2 \u00e9tudes sur 3 montrent un sex ratio en faveur des hommes1 \u00e9tude (pr\u00e9print) ne montre pas de diff\u00e9rence de taux d'ACE2 entre les fumeurs et non fumeurs caucasiens, mais diff\u00e9rence entre les fumeurs/non fumeurs asiatiques (taux plus elev\u00e9 chez fumeurs asiatiques)Etude sur fumeur/severit\u00e9 COVID : association non significative\nDonc : pas d'\u00e9vidence d'association entre fumeurs et pr\u00e9valence/s\u00e9v\u00e9rit\u00e9 du COVID", "objectives": "Faible : 1) lettre a l'editeur", "methods": "Trouver lien pr\u00e9valence/severit\u00e9 du COVID et fumeur et sexe", "pubmed_id": "32171067", "doi": "10.1016/S2213-2600(20)30117-X", "abstract": null, "topics": ["Epid\u00e9miologique", "Pneumologie"], "author_list": [{"id": 92, "name": "Cai H"}], "publication_date": "2020-03-16"}, {"id": 506, "slug": "elevations-of-serum-cancer-biomarkers-correlate-with-severity-of-covid-19", "title": "Elevations of serum cancer biomarkers correlate with severity of COVID-19", "has_other_authors": true, "impact_factor": {"id": 3, "name": "Interm\u00e9diaire", "posts_count": 140, "color": "orange", "order": 2}, "goals_plain": "Comparer les dosages de biomarqueurs tumoraux chez des patients atteints de SARS-CoV-2 selon 3 stades de s\u00e9v\u00e9rit\u00e9 \u00e0 ceux r\u00e9alis\u00e9s chez des patients non atteints de SARS-CoV-2 (qui pr\u00e9sentaient des dosages consid\u00e9r\u00e9s comme normaux)", "verbose_date": "01.05.2020", "authors": "Wei X", "specialties": [{"id": 7, "name": "Transversale"}, {"id": 5, "name": "Virologie"}], "category": {"id": 6, "name": "Pronostique", "icon": "icon-chat"}, "journal": {"id": 35, "name": "J Med Virol"}, "link": "https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.25957", "findings": "", "take_away": "", "relevance_level": "Augmentation significative de certains biomarqueurs tumoraux HE4, CYFRA21-1, CEA, CA 125 et CA 153\u00a0dans le COVID-19, proportionnellement \u00e0 la CRP et \u00e0 la s\u00e9v\u00e9rit\u00e9, chez des patients a priori indemnes de pathologie tumorale. Cette augmentation est coh\u00e9rente avec des \u00e9tudes pr\u00e9c\u00e9dentes qui sugg\u00e8rent une augmentation de certains de ces marqueurs dans les \u00e9tats inflammatoires pulmonaires. Ces r\u00e9sultats n\u00e9cessiteraient des investigations suppl\u00e9mentaires pour voir en quoi ces marqueurs pourraient refl\u00e9ter les l\u00e9sions pulmonaires associ\u00e9es au COVID-19 et une aide \u00e0 l'\u00e9valuation pronostique des patients.", "objectives": "Etude r\u00e9trospective, monocentrique, biais de genre pour l'HE4 o\u00f9 tous les patients contr\u00f4les sont des femmes, pas de suivi au long cours des patients, pas de nouveau dosage pour voir une \u00e9ventuelle corr\u00e9lation avec la r\u00e9ponse th\u00e9rapeutique", "methods": "Comparer les dosages de biomarqueurs tumoraux chez des patients atteints de SARS-CoV-2 selon 3 stades de s\u00e9v\u00e9rit\u00e9 \u00e0 ceux r\u00e9alis\u00e9s chez des patients non atteints de SARS-CoV-2 (qui pr\u00e9sentaient des dosages consid\u00e9r\u00e9s comme normaux)", "pubmed_id": "32347972", "doi": "10.1002/jmv.25957", "abstract": "In this retrospective study, we evaluated the levels of a series of serum biomarkers in coronavirus disease 2019 (COVID-19) patients (mild: 131; severe: 98; critical: 23). We found that there were significant increases in levels of human epididymis protein 4 (HE4) (73.6\u2009\u00b1\u200938.3 vs 46.5\u2009\u00b1\u200914.7 pmol/L; P\u2009<\u2009.001), cytokeratin-19 fragment (CYFRA21-1) (2.2\u2009\u00b1\u20090.9 vs 1.9\u2009\u00b1\u20090.8 \u03bcg/L; P\u2009<\u2009.001), carcinoembryonic antigen (CEA) (3.4\u2009\u00b1\u20092.2 vs 2.1\u2009\u00b1\u20091.2 \u03bcg/L; P\u2009<\u2009.001), carbohydrate antigens (CA) 125 (18.1\u2009\u00b1\u200913.5 vs 10.5\u2009\u00b1\u20094.6 \u03bcg/L; P\u2009<\u2009.001), and 153 (14.4\u2009\u00b1\u20098.9 vs 10.1\u2009\u00b1\u20094.4 \u03bcg/L; P\u2009<\u2009.001) in COVID-19 mild cases as compared to normal control subjects; their levels showed continuous and significant increases in severe and critical cases (HE4, CYFRA21-1, and CA125: P\u2009<\u2009.001; CEA and CA153: P\u2009<\u2009.01). Squamous cell carcinoma antigen (SCC) and CA199 increased significantly only in critical cases of COVID-19 as compared with mild and severe cases and normal controls (P\u2009<\u2009.01). There were positive associations between levels of C-reactive protein and levels of HE4 (R\u2009=\u2009.631; P\u2009<\u2009.001), CYFRA21-1 (R\u2009=\u2009.431; P\u2009<\u2009.001), CEA (R\u2009=\u2009.316; P\u2009<\u2009.001), SCC (R\u2009=\u2009.351; P\u2009<\u2009.001), CA153 (R\u2009=\u2009.359; P\u2009<\u2009.001) and CA125 (R\u2009=\u2009.223; P\u2009=\u2009.031). We concluded that elevations of serum cancer biomarkers positively correlated with the pathological progressions of COVID-19, demonstrating diffuse and acute pathophysiological injuries in COVID-19.", "topics": ["Pronostique", "Transversale", "Virologie"], "author_list": [{"id": 474, "name": "Wei X"}], "publication_date": "2020-05-01"}, {"id": 565, "slug": "kidney-manifestations-of-mild-moderate-and-severe-coronavirus-disease-2019-a-ret", "title": "Kidney manifestations of mild, moderate and severe coronavirus disease 2019: a retrospective cohort study", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Cette \u00e9tude visait \u00e0 \u00e9valuer l'incidence, les facteurs de risque et les issues cliniques de l\u2019insuffisance r\u00e9nale aigu\u00eb chez les patients atteints de COVID-19.", "verbose_date": "11.05.2020", "authors": "Hong D", "specialties": [{"id": 20, "name": "N\u00e9phrologie"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 224, "name": "CKJ"}, "link": "https://doi.org/10.1093/ckj/sfaa083", "findings": "", "take_away": "", "relevance_level": "La prot\u00e9inurie et l'h\u00e9maturie microscopique ne sont pas rares chez les patients atteints d'une infection par COVID-19, en particulier dans les cas graves ou critiques. Des \u00e9chantillons plus importants sont n\u00e9cessaires pour clarifier la relation entre COVID-19 et l'atteinte r\u00e9nale, et un suivi \u00e0 long terme des patients atteints de COVID-19 doit \u00eatre effectu\u00e9 pour \u00e9tudier son impact sur l'atteinte r\u00e9nale.", "objectives": "-\t\u00c9tude de cohorte r\u00e9trospective-\tN=168-\tDeux h\u00f4pitaux-\tOn n'a pas pu obtenir les r\u00e9sultats des analyses d'urine effectu\u00e9es avant l'admission et, par cons\u00e9quent, on n'a pas pu confirmer la pr\u00e9sence ou non de prot\u00e9inurie et d'h\u00e9maturie microscopique avant l'admission. -\tOn n'a utilis\u00e9 la bandelette urinaire que pour tester l'h\u00e9maturie et n'a pas pu diff\u00e9rencier l'h\u00e9maturie r\u00e9elle de l'h\u00e9moglobinurie ou de la myoglobinurie. -\tLes donn\u00e9es de suivi \u00e9taient de petite taille et de courte dur\u00e9e, et il n'y avait pas de donn\u00e9es de suivi pour la prot\u00e9inurie ou l'h\u00e9maturie microscopique. -\tLa pr\u00e9valence de la prot\u00e9inurie et de l'h\u00e9maturie microscopique chez les patients de l\u2019\u00e9tude \u00e9tait beaucoup plus \u00e9lev\u00e9e que le 15,1% observ\u00e9 dans la population g\u00e9n\u00e9rale du Sichuan, mais les patients atteints de COVID-19 dans les deux cohortes \u00e9taient plus \u00e2g\u00e9s que la moyenne de la population. -\tLe RR a \u00e9t\u00e9 estim\u00e9 par une analyse univari\u00e9e ; il n'a pas pu \u00e9liminer l'influence des facteurs de confusion.", "methods": "Cette \u00e9tude visait \u00e0 \u00e9valuer l'incidence, les facteurs de risque et les issues cliniques de l\u2019insuffisance r\u00e9nale aigu\u00eb chez les patients atteints de COVID-19.", "topics": ["Epid\u00e9miologique", "N\u00e9phrologie"], "author_list": [{"id": 530, "name": "Hong D"}], "publication_date": "2020-05-11"}, {"id": 378, "slug": "a-longitudinal-study-on-the-mental-health-of-general-population-during-the-covid", "title": "A Longitudinal Study on the Mental Health of General Population during the COVID-19 Epidemic in China", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Evaluer l'impact psychologique temporel et l'\u00e9tat de sant\u00e9 mentale d\u00e9favorable pendant l'\u00e9pid\u00e9mie initiale et le pic de l'\u00e9pid\u00e9mie de COVID-19, ainsi que le risque identitaire et les facteurs de protection au sein de la population g\u00e9n\u00e9rale en Chine.", "verbose_date": "18.04.2020", "authors": "Wang C", "specialties": [{"id": 6, "name": "Psychiatrie"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 109, "name": "Brain Behav Immun"}, "link": "https://reader.elsevier.com/reader/sd/pii/S0889159120305110?token=6DEE3D192B2C1EF9B595FFFC85BFC0CD3BAD3B6C4FA87363D0C3979F14007CF6149D0992D57224E3A1E425AD348D0620", "findings": "", "take_away": "", "relevance_level": "Les diff\u00e9rents gouvernements devraient se concentrer sur des m\u00e9thodes efficaces de diffusion de connaissances impartiales sur la maladie, enseigner des m\u00e9thodes correctes de confinement, assurer la disponibilit\u00e9 des services et des produits essentiels, fournir un soutien financier suffisant pour le pr\u00e9sent et l'avenir.", "objectives": "-\t\u00c9tude longitudinale prospective-\tLa population g\u00e9n\u00e9rale \u00e9chantillonn\u00e9e lors des deux enqu\u00eates n'\u00e9tait pas la m\u00eame-\tL'auto-\u00e9valuation des niveaux d'impact psychologique, d'anxi\u00e9t\u00e9, de d\u00e9pression et de stress-\tOn ne peut pas exclure la possibilit\u00e9 que certaines des personnes interrog\u00e9es aient \u00e9t\u00e9 infect\u00e9es par le COVID-19 et aient pr\u00e9sent\u00e9 de l\u00e9gers sympt\u00f4mes de COVID-19-\tLa compr\u00e9hension du COVID-19 \u00e9tait limit\u00e9e lorsque nous avons con\u00e7u cette \u00e9tude (les sympt\u00f4mes neurologiques n'ont pas \u00e9t\u00e9 mesur\u00e9s)", "methods": "Evaluer l'impact psychologique temporel et l'\u00e9tat de sant\u00e9 mentale d\u00e9favorable pendant l'\u00e9pid\u00e9mie initiale et le pic de l'\u00e9pid\u00e9mie de COVID-19, ainsi que le risque identitaire et les facteurs de protection au sein de la population g\u00e9n\u00e9rale en Chine.", "pubmed_id": "32298802", "doi": "10.1016/j.bbi.2020.04.028", "abstract": "In addition to being a public physical health emergency, Coronavirus disease 2019 (COVID-19) affected global mental health, as evidenced by panic-buying worldwide as cases soared. Little is known about changes in levels of psychological impact, stress, anxiety and depression during this pandemic. This longitudinal study surveyed the general population twice - during the initial outbreak, and the epidemic's peak four weeks later, surveying demographics, symptoms, knowledge, concerns, and precautionary measures against COVID-19. There were 1738 respondents from 190 Chinese cities (1210 first-survey respondents, 861\u00a0s-survey respondents; 333 respondents participated in both). Psychological impact and mental health status were assessed by the Impact of Event Scale-Revised (IES-R) and the Depression, Anxiety and Stress Scale (DASS-21), respectively. IES-R measures PTSD symptoms in survivorship after an event. DASS -21 is based on tripartite model of psychopathology that comprise a general distress construct with distinct characteristics. This study found that there was a statistically significant longitudinal reduction in mean IES-R scores (from 32.98 to 30.76, p\u00a0<\u00a00.01) after 4\u00a0weeks. Nevertheless, the mean IES-R score of the first- and second-survey respondents were above the cut-off scores (>24) for PTSD symptoms, suggesting that the reduction in scores was not clinically significant. During the initial evaluation, moderate-to-severe stress, anxiety and depression were noted in 8.1%, 28.8% and 16.5%, respectively and there were no significant longitudinal changes in stress, anxiety and depression levels (p\u00a0>\u00a00.05). Protective factors included high level of confidence in doctors, perceived survival likelihood and low risk of contracting COVID-19, satisfaction with health information, personal precautionary measures. As countries around the world brace for an escalation in cases, Governments should focus on effective methods of disseminating unbiased COVID-19 knowledge, teaching correct containment methods, ensuring availability of essential services/commodities, and providing sufficient financial support.", "topics": ["Epid\u00e9miologique", "Psychiatrie"], "author_list": [{"id": 365, "name": "Wang C"}], "publication_date": "2020-04-18"}, {"id": 657, "slug": "analysis-of-the-covid-19-epidemic-in-french-overseas-department-mayotte-based-on", "title": "Analysis of the COVID-19 epidemic in french overseas department Mayotte based on a modified deterministic and stochastic SEIR model", "has_other_authors": true, "impact_factor": {"id": 4, "name": "Ind\u00e9termin\u00e9", "posts_count": 12, "color": "gray", "order": 4}, "goals_plain": "", "verbose_date": "29.04.2020", "authors": "Manou-Abi S", "specialties": [{"id": 21, "name": "Confinement/D\u00e9confinement"}, {"id": 12, "name": "Infectiologie"}], "category": {"id": 8, "name": "Mod\u00e9lisation", "icon": "icon-all"}, "journal": {"id": 85, "name": "Pre-prints"}, "link": "https://www.medrxiv.org/content/10.1101/2020.04.15.20062752v2.full.pdf", "findings": "", "take_away": "", "relevance_level": "", "objectives": "", "methods": "", "topics": ["Mod\u00e9lisation", "Confinement/D\u00e9confinement", "Infectiologie"], "author_list": [{"id": 618, "name": "Manou-Abi S"}], "publication_date": "2020-04-29"}, {"id": 575, "slug": "viral-dynamics-in-asymptomatic-patients-with-covid-19", "title": "Viral dynamics in asymptomatic patients with COVID-19", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "Caract\u00e9riser la charge virale et le risque d'infection pour les patients COVID-19 asymptomatiques.", "verbose_date": "12.05.2020", "authors": "Zhou R", "specialties": [{"id": 5, "name": "Virologie"}], "category": {"id": 5, "name": "Epid\u00e9miologique", "icon": "icon-virus"}, "journal": {"id": 18, "name": "Int J Infect Dis"}, "link": "https://www.ijidonline.com/article/S1201-9712(20)30337-4/pdf", "findings": "", "take_away": "", "relevance_level": "L'\u00e9tude fait \u00e9tat d'une plus grande diff\u00e9rence de charge virale chez les patients asymptomatique en phase d'incubation (APIs) que chez les patients asymptomatiques (APs),\u00a0toutefois, aucune diff\u00e9rence significative n'a \u00e9t\u00e9 constat\u00e9e pour la dur\u00e9e de la p\u00e9riode de contagiosit\u00e9 entre les deux \u00e9chantillons.\u00a0\nCela sugg\u00e8re que les patients asymptomatiques peuvent \u00eatre une source importante d'infection et doivent \u00eatre suivis longitudinalement pour d\u00e9tecter la pr\u00e9sence d'acides nucl\u00e9iques viraux.\u00a0Rappelons toutefois les limites de l'\u00e9tude, men\u00e9e sur un tr\u00e8s petit \u00e9chantillon et sans surveillance longitudinale \u00e0 long terme des patients asymptomatiques.", "objectives": "Faible:1) Article pre-proof2) Petit \u00e9chantillon (n=31)3) Manque de suivi longitudinal des patients asymptomatiques", "methods": "Caract\u00e9riser la charge virale et le risque d'infection pour les patients COVID-19 asymptomatiques.", "pubmed_id": "32437933", "doi": "10.1016/j.ijid.2020.05.030", "abstract": "Data are limited on the viral load, viral shedding patterns, and potential infectivity of asymptomatic patients (APs) with coronavirus disease 2019 (COVID-19). This study included 31 adult patients who were virologically confirmed to have COVID-19 but were asymptomatic on admission. Among these 31 patients, 22 presented symptoms after admission and were defined as asymptomatic patients in the incubation period (APIs); the other nine patients remained asymptomatic during hospitalization and were defined as asymptomatic patients (APs). The median cycle threshold (Ct) value of APs (39.0, interquartile range (IQR) 37.5-39.5) was significantly higher than that of APIs (34.5, IQR 32.2-37.0), indicating a lower viral load in APs. However, the duration of viral shedding remained similar in the two groups (7 days, IQR 5-14 days vs. 8 days, IQR 5-16 days). The study findings demonstrated that although APs with COVID-19 have a lower viral load, they still have certain period of viral shedding, which suggests the possibility of transmission during their asymptomatic period. Further longitudinal surveillance of these asymptomatic cases via virus nucleic acid testing are warranted.", "topics": ["Epid\u00e9miologique", "Virologie"], "author_list": [{"id": 539, "name": "Zhou R"}], "publication_date": "2020-05-12"}, {"id": 157, "slug": "lianhuaqingwen-exerts-anti-viral-and-anti-inflammatory-activity-against-novel-co", "title": "Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SRAS-CoV-2)", "has_other_authors": true, "impact_factor": {"id": 2, "name": "Faible", "posts_count": 485, "color": "red", "order": 3}, "goals_plain": "D\u00e9montrer l'activit\u00e9 antivirale du Lianhuaqingwen contre le nouveau virus SRAS-CoV-2 et son effet potentiel dans la r\u00e9gulation de la r\u00e9ponse immunitaire", "verbose_date": "26.03.2020", "authors": "Runfeng L ", "specialties": [{"id": 7, "name": "Transversale"}, {"id": 12, "name": "Infectiologie"}], "category": {"id": 4, "name": "Th\u00e9rapeutique", "icon": "icon-med"}, "journal": {"id": 82, "name": "Pharmacol Res"}, "link": "https://www.dropbox.com/s/gx3tqrmshb1sp5d/1-s2.0-S104366182030743X-main.pdf?dl=0", "findings": "", "take_away": "", "relevance_level": "Le Lianhuaqingwen (LH) qui est issu de la m\u00e9decine chinoise semble diminuer la r\u00e9plication virale IN VITRO avec un profil assez proche du remdesivir en terme d'efficacit\u00e9", "objectives": "- Etude in vitro uniquement- Bas\u00e9 sur quelques exp\u00e9rimentations contr\u00f4l\u00e9es- N\u00e9cessite de conna\u00eetre la s\u00e9curit\u00e9 du produit et son efficacit\u00e9 in vivo", "methods": "D\u00e9montrer l'activit\u00e9 antivirale du Lianhuaqingwen contre le nouveau virus SRAS-CoV-2 et son effet potentiel dans la r\u00e9gulation de la r\u00e9ponse immunitaire", "topics": ["Th\u00e9rapeutique", "Transversale", "Infectiologie"], "author_list": [{"id": 153, "name": "Runfeng L "}], "publication_date": "2020-03-26"}]